06-07 July 2026 | Munich, GermanyDNA Replication and Its Impact on Genome and Chromatin MaintenanceWe are RepliFate, a European Training Doctoral Network dedicated to understanding how DNA replication...

Accurate reconstruction of gene regulatory networks (GRNs) from single-cell transcriptomic data remains a major methodological challenge. Recent machine learning approaches, particularly graph neural ...

Pioneer transcription factors are crucial for regulating zygotic genome activation and cell differentiation during mouse pre-implantation development. However, how pioneer factors function collectivel...

Nature Communications - Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon

Nature Communications - Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon

Thank you for your interest in our seminar series! We use a variety of different session formats but, in general, trainees can plan for a ~15 min talk + 5min Q/A and PIs can plan for a ~25min talk +...

Genome Biology is calling for submissions to our Collection on enhancer-promoter interactions. Enhancer–promoter interactions are central to the regulation ...

His work in the manipulation of cells laid the foundation for stem cell biology and regenerative medicine and led to the first cloned large mammal, a sheep named Dolly.

In mammals, repression of germline-specific gene expression is essential for preserving somatic cell identity and preventing disease. Germline gene silencing is often dependent on the presence of prom...

The FEBS Advanced Lecture Course: 6th Danube Conference on Epigenetics will take place 19–22 October 2026 in Budapest, Hungary. Here we give a taste of the scientific content, flag some of the speaker...

Two young scientists from the Max Planck Institute in Freiburg, Juliane Glaser and Valentin Flury, have each received €1.5 million in ERC Starting Grants to conduct research into epigenetic mechanisms...

Wesseldijk et al. compare the genomic information collected from Ludwig van Beethoven with population-based datasets used to quantify musical achievement.

An infant with an inherited life-threatening metabolic condition has responded to a tailored therapy that uses the gene-editing tool CRISPR to correct a specific mutation.

A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

Podcast Episode · Night Science · 02/13/2023 · 28m

A study reveals progressive cohesin loading and a hypertranscription state responsible for the formation of genic cohesin islands at active regulatory genes in mouse embryos, highlighting an interplay between chromatin architecture and transcription as they are established for the first time.

Kefalopoulou, Rullens et al. develop Dam&ChIC to assay chromatin state at two different time points in the same cell. The method was used to study the reorganization of LADs during cell division a...

Hanna and colleagues show that signaling pathway modulation amplifies the inherent flexibility of genetically unmodified mouse naive PSCs to adopt extra-embryonic cell fate potential. This endows them...

Maintaining cellular proliferation necessitates the synchronized activity of diverse molecular machineries operating in parallel on the genome. Wide-spread transcription and R-loop formation can inter...

Understanding the conflicts that happen within our cells could shed new light not only on disease progression, but also on how our bodies...

Joaquín Navajas Acedo is a Postdoc in the lab of Dr Alexander Schier in Biozentrum at the University of Basel, Switzerland. He is interested in how the nervous system evolves and develops at the singl...

In this review, Peng Du and Jun Wu present a detailed overview of the growth conditions, molecular characteristics, and functional attributes of totipotent and pluripotent stem cells generated in vitr...

Nucleosomes are thought to be structural barriers to transcription, establishing a restrictive ground state that must be destabilized for gene express…

Chemical reprogramming offers an innovative approach for cell fate manipulation. Here, Deng and colleagues developed a robust chemical reprogramming method to convert human blood cells to pluripotent stem cells.