Theory can help address cell and molecular biology’s major challenges, particularly those arising from large omics datasets.

Fecal microbiome transplant up-regulates immune tolerance pathways in food allergy.

Croll lab at University of Neuchatel. The lab of Daniel Croll wants to understand how pathogens evolve to cause disease. For this, we mainly focus on major crop pathogens to unravel mechanisms of rapi...

Macrophage-derived oxysterols recruit GPR183+ TH2 cells into fungal lesions, suppressing type 1 immunity and promoting pathogen persistence.

This Perspective by the LRS-RED consortium discusses methodological, bioinformatic and diagnostic advances in long-read sequencing (LRS) for repeat-expansion disorders, highlighting the potential of L...

Nature Reviews Immunology - Adaptive immunity is indispensable to vertebrates, yet most living organisms defend themselves perfectly well without it. Here, I ask why somatically diversified antigen...

Groups of immunologists are advancing recommendations to address nomenclature challenges in their subfields.

Nature Reviews Immunology, Published online: 15 June 2026; doi:10.1038/s41577-026-01324-zA preprint by Teodoro-Castro et al. reports a nuclear role for STING in impairing DNA replication and contributing to replication stress in ageing pathologies.

Duodenum-localized IL-25–inflammatory type 2 innate lymphoid cells axis disseminates type 2 immunity to remote lung in a mouse food allergy model.

During latent pulmonary cryptococcal infection, Zheng et al. show that TH2-driven STAT6 signaling in monocyte-derived myeloid cells suppresses extracellula

Type 2 immunity protects against helminths and venoms, yet its dysregulation drives allergic diseases. Initiation occurs at barrier tissues, where epithelial cells detect perturbations and release alarmins, activating type 2 innate lymphoid cells and conditioning dendritic cells for T helper 2 priming. However, the framework of type 2 innate immune sensing remains largely incomplete. Critical gaps include the core immunostimulatory components of many stimuli and their host detection pathways. Recent advances, including tuft cell chemosensation, membrane pore formation as a common trigger, and the role of protein crystals and proteases in allergic inflammation, highlight emerging molecular principles. Unlike bacterial, viral, and fungal recognition via conserved molecular patterns, type 2 immunity often involves the sensing of perturbations and stress signals.

Allergen-specific CD4+ T cells are a highly heterogenous population. Depletion of these cells has been proposed as essential to achieve allergen desensitization in allergen immunotherapy.

A preprint by Villazala-Merino et al. shows that allergen-specific memory B cells must re-enter germinal centres to differentiate into IgE-producing plasma cells, which occurs in lymph nodes but not a...

Human genetic variation influences instability of DNA repeats that commonly expand as we age.

A conjugate vaccine targeting human IgE induces long-term production of neutralizing antibodies and protects against anaphylaxis in humanized mice.

Single-cell transcriptomics resolves mononuclear phagocyte diversity in the human intestine in health and inflammatory bowel disease.

Background The incidence of lung allergies is reduced in countries with higher prevalence of infection and environmental exposure to microbes. However, enteric bacterial infections do not always corre...

One of the 15 publications that put out the most studies globally has been expelled from the indexing system for irregularities. Its publisher, Elsevier, has a 38% profit margin that reached $1.5 bill...