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Journal of Leukocyte Biology

@jlbjournal.bsky.social
24 followers 23 following 126 posts

🔗 academic.oup.com/jleukbio Since 1964, JLB has published first-rate research on immunology-related topics, with emphasis on leukocyte physiology and behavior within the immune system.

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Journal of Leukocyte Biology @jlbjournal.bsky.social · 7h
Carlos Blanco-Camarillo and colleagues report that #Obesity induces elevated numbers of low-density #Neutrophils (LDN), but these perform #Phagocytosis and #NETosis less efficiently than LDN from individuals with normal weight
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Diminished FcγRIIa expression reduces antibody-mediated phagocytosis by low-density neutrophils in obesity
Obesity reduces phagocytosis by low-density neutrophils.
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 30/09/2026
Young Jun Kang shows that mitochondrial phosphatase #PGAM5 negatively regulates #IL4-induced anti-inflammatory responses and metabolic reprogramming of #Macrophages by controlling #JAK1-#STAT6 signaling
doi.org
Mitochondrial phosphatase PGAM5 negatively regulates the induction of anti-inflammatory macrophages
Mitochondrial phosphatase PGAM5 negatively regulates IL-4-induced anti-inflammatory responses and metabolic reprogramming of macrophages by controlling JAK
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 28/09/2026
Nahuel Ko and colleagues propose that #TissueResidency should be incorporated into next-generation #Immunotherapy to achieve durable responses in #SolidTumors
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From sentinels to soldiers: tissue-resident cells for next-generation immunotherapy
Tissue-resident inspired immunotherapy.
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 26/09/2026
@leukocytebiology.bsky.social and #JLB are pleased to announce the first JLB Impact Award, which celebrates and acknowledges the contributions of high-impact authors to the journal!
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JLB Impact Award 2026
SLB and JLB are pleased to announce the first annual JLB Impact Awardees. Rupesh Srivastava and Asha Bhardwaj are recognized for their publication “Gut-resident regulatory T cells (GTregs) play a…
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 25/09/2026
Capucine Bourel and colleagues @umontreal.ca @umontreal-en.bsky.social report that #MHC I shapes mouse #NKcell functional maturation
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Mouse NK cell functional maturation is dependent on MHC I
MHC I shapes mouse NK cell functional maturation stages independently of effector protein expression. In other words, the expression of effector proteins c
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 23/09/2026
Xiaoling Li and colleagues @loyolachicago.bsky.social show that #MyD88 deficiency protects against intestinal barrier damage after ethanol and #BurnInjury, and suppresses #Neutrophil extracellular trap formation
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MyD88 promotes neutrophil extracellular trap formation and gut leakiness after ethanol and burn injury
MyD88 deficiency protects against intestinal barrier damage after ethanol and burn injury and suppresses neutrophil extracellular traps.
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 21/09/2026
Burcu Al and colleagues @unibonn.bsky.social report that loss of Kmt2c and Kmt2d histone methyltransferases in #Macrophages leads to impaired pro-inflammatory cytokine responses, reduced phagocytotic capacity and skewed energy metabolism toward glycolysis doi.org/10.1093/jleu...
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Kmt2c and Kmt2d histone methyltransferase deficiencies compromise macrophage function
Loss of Kmt2c and Kmt2d histone methyltransferases in macrophages leads to impaired pro-inflammatory cytokine response and phagocytotic capacity, as well a
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 18/09/2026
Jiongming He, Shan Liu, Lingying Wang & Fei Xiong report that #EsophagealCancer cells impair #NKcell function via the downregulation of #ZNF600 expression through the ligation of #CEACAM1 with #TIM3
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Zinc finger protein 600 is essential for the cytotoxic function of esophageal cancer-associated natural killer cells
ZNF600 enhances the cytolytic activity of NK cells. EC cells downregulate ZNF600 expression in EC-associated NK cells via the ligation of CEACAM1 to TIM-3
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 16/09/2026
@brita-o.bsky.social and colleagues @gwibs.bsky.social show that platelet activation due to #HIV infection increases #Platelet-#NKcell complexes, which have distinct phenotypes and may alter the total NK cell population in people living with the virus
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Circulating platelet-natural killer cell complexes are elevated in people living with human immunodeficiency virus on antiretroviral therapy
Platelet activation due to human immunodeficiency virus infection increases platelet-natural killer (NK) complexes, which have distinct phenotypes and may
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 14/09/2026
Gerardo Ortiz and colleagues @imii.cl review the the interplay between heat shock factor 1 (#HSF1) and heat shock proteins in the context of #Inflammation caused by infectious and non-infectious diseases
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Beyond proteostasis: the HSF1–Hsp axis in inflammation
Abstract. Inflammation is a multifaceted response involving molecular and cellular components triggered by diverse stimuli, including physical, chemical, a
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 12/09/2026
Carlos Silvestre-Roig and colleagues @uni-muenster.de report that nuclear factor-Y (NF-Y) controls #Myeloid survival and inflammatory state during #VascularInflammation
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The transcription factor NF-Y promotes myeloid cell survival and protects from inflammatory vascular disease
NF-Y controls myeloid survival and inflammatory state during vascular inflammation.
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 10/09/2026
The September Issue of #JLB kicks off with a Review from Marlene Starr and colleagues @ukresearch.bsky.social that examines whether new approaches and methodologies can adequately replace animal models in #CriticalCareResearch
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New approach methodologies complement but cannot replace animal models in critical care medicine research
New approach methodologies offer opportunity for methodological pluralism but cannot replace animal models due to their limitations in providing systemic o
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Reposted by Journal of Leukocyte Biology
Society for Leukocyte Biology @leukocytebiology.bsky.social · 08/09/2026
We are less than a week away from our conference!! What are you most excited about for #SLB2026? Answer in the replies below 👇
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 04/09/2026
Essi Tchalla, @elsaawesomepmns.bsky.social and colleagues @ubuffalo.bsky.social present that #Neutrophils induce formation of protective #Antibodies in response to the #PneumococcalConjugateVaccine by controlling #RegulatoryTcell numbers
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Neutrophils induce effective antibody responses to the pneumococcal conjugate vaccine by inhibiting T regulatory cells
Neutrophils induce formation of protective antibodies in response to the pneumococcal conjugate vaccine by controlling T regulatory cell numbers.Created in
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 02/09/2026
Adrita Guha, Praneet Wahi & Girdhari Lal review how #Complement components regulate bone remodeling by influencing the differentiation and function of #Osteoclasts, #Osteoblasts, and #Osteocytes
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Complement system in bone inflammation and autoimmunity
Complement components regulate bone remodeling by influencing the differentiation and function of osteoclasts, osteoblasts, and osteocytes.
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 31/08/2026
Nathalia Naranjo-Pinto, Carlos Rosales and colleagues show that obesity drives #Neutrophil activation while impairing pathogen-specific antimicrobial responses
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Obesity hampers bacteria killing by human neutrophils
Obesity drives neutrophil activation while impairing pathogen-specific antimicrobial responses
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 27/08/2026
Carlos Ventura-Martínez, Linda Kempis-Calanis and colleagues report that neonatal CD4+ #Tcell trajectories are established during fetal life and are shaped at birth by the mode of delivery, influencing early immune responsiveness
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Premature birth and Cesarean section are associated with significant differences in neonatal CD4+ T cell gene expression and function
Neonatal CD4+ T cell trajectories are established during fetal life and further shaped at birth by the mode of delivery, influencing early immune responsiv
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 21/08/2026
Rachel Loo & John Blazeck @gtresearch.bsky.social review how modulations to the #PentosePhosphatePathway impact #Tcell activation, exhaustion and differentiation in the context of #AdoptiveCellTherapies for #Cancer treatment
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The pentose phosphate pathway in immunotherapy
This review discusses how modulations to the pentose phosphate pathway affects T cell activation, exhaustion, and differentiation in regard to adoptive cel
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 20/08/2026
Luca Russo, Marta Sampietro and colleagues present #HS1 as a potential regulator linking #Bcell receptor signaling, cytoskeletal remodeling, #Leukemia progression, and response to therapy
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HS1 loss drives cytoskeletal dysregulation and reduces sensitivity to BTK inhibition in chronic lymphocytic leukemia
HS1 depletion may be associated with altered leukocyte maturation and changes in splenic architecture in mouse models, potentially leading to impaired chro
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 19/08/2026
Jessica Silva, Ashina Nagra and colleagues show that a 2-step OP9-DLL1 culture system generates functional patrolling #Monocytes in vitro that retain vascular immune surveillance functions and inhibit lung metastasis following adoptive transfer
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A DLL1-culture system to propagate murine patrolling monocytes from bone marrow progenitors
A 2-step OP9-DLL1 culture system generates functional patrolling monocytes in vitro that retain vascular immune surveillance functions and inhibit lung met
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 18/08/2026
Alejandra Sánchez-Santos and colleagues present the clinical utility of #TRBC1/2-based flow cytometry as a rapid and straightforward approach for the assessment of #Tcell clonality in individuals presenting with #Hypereosinophilia and suspected #HypereosinophilicSyndrome
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Evaluation of T-cell clonality by T-cell constant β chain (TRBC)1 and TRBC2 expression flow cytometry in hypereosinophilic syndrome
The clinical utility of TRBC1/2-based flow cytometry as a rapid and straightforward approach for the assessment of T-cell clonality in individuals presenti
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 17/08/2026
Huan Qi, Keqian Xu and colleagues identify aberrant lysosomal expansion in leukocytes in #Sepsis and propose this as a potential morphological biomarker for early detection
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Lysosome-induced increase in intracellular granularity of leukocytes: a key morphological biomarker for early sepsis in cell population data
Sepsis-induced alterations in leukocytes are hematological manifestations of aberrant lysosomal expansion, providing novel mechanistic insights for sepsis
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 15/08/2026
Grace Filbertine, Helen Wright and colleagues @livuni-ilcams.bsky.social provide evidence that small non-coding RNAs (#sncRNAs) and alternative gene splicing may regulate #Neutrophils in systemic lupus erythematosus (#SLE)
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A role for noncoding RNAs and alternative splicing in the regulation of neutrophil activation and gene expression in systemic lupus erythematosus
SLE neutrophil transcriptome and activated phenotype is regulated by small noncoding RNAs and alternative splicing of genes.
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 14/08/2026
Hui Jin, Monowar Aziz, Ping Wang and colleagues @northwellhealth.bsky.social show that DLL4+ #Neutrophils promote endothelial barrier disruption and neutrophil subset generation via the DLL4-Notch1-ADAM17 pathway in #Sepsis
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DLL4+ neutrophils induce alveolar macrophages to cause ADAM-17–mediated endothelial barrier disruption and the increase of ICAM1hiCXCR1lo neutrophils in sepsis
DLL4+ neutrophils promote endothelial barrier disruption and ICAM1hiCXCR1lo neutrophils generation through the DLL4-Notch1-ADAM17 pathway during sepsis. DL
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 13/08/2026
Longying Liang, Tingting Li and colleagues show that #Interleukin-32γ promotes #Macrophage phagocytosis of #StreptococcusPneumoniae through NF-κB–dependent upregulation of soluble #EpoxideHydrolase
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Recombinant human interleukin-32γ facilitates macrophage phagocytosis of Streptococcus pneumoniae by activating nuclear factor kappa B-soluble epoxide hydrolase pathway
IL-32γ promotes macrophage phagocytosis of S.pn through NF-κB–dependent upregulation of soluble epoxide hydrolase.
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 12/08/2026
Thoh Maikho, Santosh Sandur and colleagues report that #ColdAtmosphericPlasma protects against graft-vs-host disease (#GVHD)–induced death
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Cold atmospheric plasma as an immunomodulator: suppression of T-cell hyperactivation and graft-vs-host disease via redox regulation
Cold atmospheric plasma protects against graft-vs-host disease–induced death by inhibiting redox-sensitive transcription factors, suppressing cytokine secr
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 11/08/2026
Praveen Krishna Veerasubramanian, Timothy Downing, Wendy Liu and colleagues @uci-bme.bsky.social show that the YAP/TAZ-BRD4 axis is involved in #Macrophage inflammation and lipid accumulation
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BET inhibition curbs macrophage inflammation, lipid accumulation, and atherogenesis by disrupting the YAP/TAZ-BRD4 axis
YAP/TAZ-BRD4 regulates macrophage inflammation and lipid accumulation
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 10/08/2026
Vojtěch Graman, Adéla Jílková and colleagues @friclab.bsky.social report that #TLR stimulation of #NKcells modulates cytosolic Ca2+ levels and influences NK cell #Degranulation and #Cytotoxicity
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TLR-mediated calcium signaling regulates killing capacity of expanded NK cells: challenges for potential AML immunotherapy
TLR stimulation of NK cells modulates cytosolic Ca2+ levels and influences NK cell degranulation and cytotoxicity.
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 07/08/2026
Rossana Melo and Peter Weller present a comprehensive Review of #SombreroVesicles - a distinct #Eosinophil vesicular system with important roles in activation and secretion
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Sombrero vesicles: from overlooked structures to primary mediators of eosinophil secretion
This review focuses on the distinct eosinophil vesicular system—the sombrero vesicles—highlighting their role in activation and secretion, and as potential
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 06/08/2026
Laurent Ehrlich, John Schroeder and colleagues @jhu.edu explore the interaction between #IgE and #Galectin3 in the context of #Basophil activation, and propose that this interplay may be involved in #Asthma, #WoundHealing and #Cancer
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Sialylation modulates basophil responsiveness to galectin-3–dependent activation
These findings provide further mechanistic insight into the role that IgE and Gal-3 play in basophil activation, potentially linking these cells to a host
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 05/08/2026
Paul Fichtinger, Sameer Mathur and colleagues @uwmadison.bsky.social present that #Rhinovirus infection of esophageal epithelial cells may contribute to esophageal #Inflammation in eosinophil esophagitis (#EoE)
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Rhinovirus infection may contribute to esophageal inflammation in eosinophilic esophagitis
Our demonstration of viral infection of an esophageal epithelial cell line and detection of overlapping viral-induced gene expression signature from previo
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 04/08/2026
Masashi Akiyama & Koichi Kokame show that released #Eosinophil granules lose FITC staining and gain autofluorescence during EETosis, enabling label-free detection of #EETosis in human leukocyte cultures
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Autofluorescence enables detection and quantification of EETosis in human leukocyte cultures
Released eosinophil granules lose FITC staining and gain autofluorescence during EETosis, enabling label-free detection of EETosis in human leukocyte cultu
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 03/08/2026
Samuel Collie, Carole Parent & colleagues @umich.edu provide an improved method to differentiate #HL60 cells into neutrophil-like cells that faithfully recapitulates the morphology and functionality of mature human #Neutrophils
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An optimized method to differentiate HL60 cells into neutrophil-like cells
The authors provide an improved method to differentiate HL60 cells into neutrophil-like cells that faithfully recapitulates the morphology and functionalit
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 31/07/2026
Carmela De Santo, Aimee Jackson, Francis Mussai & colleagues @unibirmingham.bsky.social report that the anti-#CD33 antibody drug conjugate #Gemtuzumab #Ozogamicin depletes and functionally resets CD33+ myeloid-derived suppressor cells in patients with #MetastaticCancer
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The anti-CD33 antibody drug conjugate gemtuzumab ozogamicin depletes and functionally resets CD33+ myeloid-derived suppressor cells in patients with metastatic cancer: a phase 2 single-arm, open-label trial
In people with cancer, the generation of myeloid-derived suppressor cells (MDSCs) is driven by myeloid cell expansion and conditioning in bone marrow and s
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 30/07/2026
Yvonne Pang, Susan Menzies & Laura Sly report that SHIP negatively regulates synergy for #Macrophage #Interleukin1β production during #NOD2−#TLR4 co-stimulation
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SHIP blocks (MDP + LPS)-induced synergy in macrophages independent of catalytic activity
SHIP negatively regulates synergy for macrophage IL-1β production during NOD2−TLR4 co-stimulation.
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 28/07/2026
Xiaoya Wang, Yunpeng Jia, Xinyi Yan & Youwei Wang discuss the metabolic and epigenetic mechanisms that govern #TrainedImmunity, immune #Tolerance and immune #Exhaustion in the context of #Microglia
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Metabolic and epigenetic regulation of microglia memory in neurological disorders
Microglial innate immune memory in the CNS is governed by metabolic and epigenetic mechanisms that drive 3 distinct phenotypes, namely trained immunity, im
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 26/07/2026
Ran Lu, Xin Luo and colleagues @virginiatech.bsky.social show that differences in cell wall architecture may drive strain-specific #IgA induction by #LimosilactobacillusReuteri / #LactobacillusReuteri
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Differences in the cell wall architecture drive strain-specific IgA induction by Limosilactobacillus reuteri
IgA induction by L. reuteri is strain-specific, possibly due to cell wall architecture, and our data support a role for TLR2 but not TGF-β or BLyS in media
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 24/07/2026
Mariana Diupotex, Yvonne Rosenstein and colleagues discuss the regulation, structural organization and ligand interactions of #CD43, and its potential role across different disease settings
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CD43: recent advances and emerging functions
CD43 is a multifunctional, highly glycosylated membrane protein that orchestrates cell trafficking, adhesion, and signaling, serving as a key immunomodulat
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Reposted by Journal of Leukocyte Biology
Society for Leukocyte Biology @leukocytebiology.bsky.social · 23/07/2026
Our second issue of iSLB for 2026 is out! Check it out here: www.leukocytebiology.org/assets/docs/...
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 22/07/2026
Shusu Liu, Zhichao Ai and colleagues present a novel #TNFR2 biparatopic antagonist that can reverse immune suppression
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A TNFR2 biparatopic antagonist reverses immune suppression through a crosslinking-resistant and ADCC-independent mechanism
TNFR2 antagonists reverse immunosuppression.
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 20/07/2026
Catherine Montenegro, Manuel Franco and colleagues show that early-life oral #Rotavirus #Vaccination induces intestinal resident memory #Tcells that may contribute to protection against infection
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Rotavirus-specific intestinal resident memory T cells induced by oral vaccination in early-life mice may contribute to protective immunity
Early-life oral rotavirus vaccination induces intestinal resident memory T cells that may contribute to protection against infection.
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 18/07/2026
Dongye Li, Dadong Guo and colleagues review how the crosstalk between #HIF-1α and #ROS can drive #Inflammation-associated functional states and influence #Macrophage function
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HIF-1α in macrophage polarization: roles in immunometabolism and autoimmune diseases
Under hypoxic conditions, crosstalk between HIF-1α and ROS exacerbates inflammatory responses, aggravating inflammation-associated functional states and in
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 16/07/2026
Dong-Hai Han, Da Gao, Hong-Yan Zhao and colleagues show that a higher proportion of CD163+ CD206+ #Macrophages are present in the #BoneMarrow of newly diagnosed #MultipleMyeloma patients
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High CD163+CD206+ macrophage infiltration in the bone marrow microenvironment of newly diagnosed multiple myeloma patients
A higher proportion of bone marrow CD163+CD206+ macrophages are involved in newly diagnosed multiple myeloma patients.
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 14/07/2026
Shuqi Ma, Rui Chen, Jun Li and colleagues review the mitochondrial DNA (#mtDNA)–stimulated inflammatory axis in #Sepsis-induced #AcuteLungInjury
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A narrative review of the mitochondrial DNA–stimulated inflammatory axis in sepsis-induced acute lung injury: cellular mechanisms and therapeutic targeting
Cell type–specific roles of the mitochondrial DNA–stimulated cyclic GMP-AMP synthase-stimulator of interferon genes inflammatory axis in sepsis-induced acu
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 12/07/2026
Timothy Snow, Nishkantha Arulkumaran and colleagues @ucl.ac.uk report that recombinant IL-7 elicited a greater spectrum of changes in the #Tcell response compared to #Nivolumab in patients with #Sepsis
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Distinct lymphocyte immune signatures to nivolumab and recombinant IL-7 ex vivo in patients with sepsis
In patients with sepsis, recombinant IL-7 elicited a greater distinct T lymphocyte immune response compared with nivolumab, which may influence the choice
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 11/07/2026
Daniel Petkov, Elizabeth Didier, Marcelo Kuroda and colleagues @tulaneu.bsky.social @ucdavis.bsky.social identify that #SIV infection induces #aging-like alterations in cardiac cellularity and #Macrophage populations
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SIV infection induces aging-like alterations in cardiac cellularity and macrophage populations of rhesus macaques
The increased percent of macrophages in the heart with decreased number of heart cells in aged macaques is also observed in young macaques with SIV infecti
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 10/07/2026
Hongjiu Wang, Na Wang, Siyu He and colleagues show that immune infiltration–based classification defines hot and cold #TumorSubtypes with distinct prognostic outcomes, mutation patterns and #Immunotherapy responses
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Immune cell landscape reveals 5 immune-related subtypes and molecular characteristics with prognostic and therapeutic implications in pan-cancer
Immune infiltration–based classification defines hot and cold tumor subtypes with distinct prognostic outcomes, mutation patterns (notably IDH1), and immun
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 09/07/2026
Blanca Callejas, Derek McKay and colleagues @ucalgary.bsky.social show that IL-4 treatment expands a population of #Macrophages with anticolitic properties
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High-dimensional single-cell mass cytometry analysis of IL-4 treated human macrophages reveals heterogeneity and a CD206high anticolitic subset
A CD206high meta-cluster that predominates in IL-4-treated human macrophages (M(IL4)) from healthy donors and individuals with Crohn's disease reduces the
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Reposted by Journal of Leukocyte Biology
Society for Leukocyte Biology @leukocytebiology.bsky.social · 08/07/2026
We will be accepting late breaking abstracts for #SLB2026 starting on July 22nd through August 19th. Find out more here: www.leukocytebiology.org/abstracts--l...
leukocytebiology.org
Abstracts (Late Breaking)
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Journal of Leukocyte Biology @jlbjournal.bsky.social · 08/07/2026
Javier Orozco-Cordoba, Nora Fierro and colleagues present that conjugated #Bilirubin exerts an immunometabolic-mediated #Antiviral effect on #HepatitisE viral infection
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Conjugated bilirubin reduces hepatitis E virus infectivity by modulating immunometabolic processes
Conjugated bilirubin exerts an immunometabolic-mediated antiviral effect on hepatitis E viral infection.
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