Over the past decade, advances in single-cell genomics, lineage tracing, and computational phylogenetics have transformed our understanding of hematopoiesi

Multimodal lineage tracing links heritable ancestry with single-cell molecular states to reveal how cell fates emerge during development, regeneration and disease. In this Review, the authors survey k...

Clonal hematopoiesis of Indeterminant Potential (CHIP) is an age-related phenomenon characterized by clonal expansion of hematopoietic stem cells (HSCs)1. CHIP results from a fitness advantage conferr...

Molecular and functional diversification of spinal cord output neurons by a conserved sequence of transcription factors.

Allotransplantation provides a lifesaving treatment to hundreds of thousands of patients worldwide every year, including among others heart, kidney, liver and bone marrow (BM) transplants [1,2]. Yet, ...

Interactions with haematopoietic and stromal cells in the thymus are essential for T cell development. Here, the authors develop an unbiased genetic system based on synthetic Notch receptors to label ...

Ageing reprograms the evolutionary trajectory of KRAS-driven lung adenocarcinoma, limiting primary tumour growth while promoting metastatic dissemination through epigenetic activation of the integrate...

Summary: This Editorial announces a call for Preprint Editors in Development to help expand the journal's relationship with preprints by curating our ‘In preprints’ articles.

In this Review, Rodriguez-Fraticelli and Parreno discuss advances in single-cell lineage-tracing methods and how their application to diverse biological processes, such as development, ageing and canc...