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Shannon McKinney-Freeman

@smckinneyfreeman.bsky.social
295 followers 298 following 109 posts

Member in Hematology at St. Jude Children’s Research Hospital. Interested in hematopoietic stem cells, hematopoiesis, ontogeny and development, aging, transplant, sickle cell disease, and my four kids. Yay ISEH!

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Reposted by Shannon McKinney-Freeman
edwardevansjr.bsky.social @edwardevansjr.bsky.social · 27/06/2026
Excellent review in #ExpHem on senescence in HSCs from the @smckinneyfreeman.bsky.social lab at @stjuderesearch.bsky.social. Being able to distinguish cell state at the molecular level is needed to identify these cells and prevent them from contributing to disease. www.exphem.org/article/S030...
exphem.org
Hematopoietic stem cell senescence and opportunities for intervention
Cellular senescence is a fundamental stress response program involved in embryonic development, wound healing, immunity, disease pathologies, and aging, which alongside apoptosis, serves as a protecti...
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Shannon McKinney-Freeman @smckinneyfreeman.bsky.social · 22/07/2026
Our paper on the potential of senescence-targeting therapies to restore function to the bone marrow in sickle cell disease is finally out! Congrats to all the amazing people who worked on this story! @stjuderesearch.bsky.social www.science.org/eprint/CUFEJ...
science.org
Premature senescence impairs hematopoietic stem cell function during sickle cell disease in mice and humans
Sickle cell disease–induced hematopoietic stem cell senescence and loss of function are reversed in SCD mice by treatments targeting senescence.
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Mick Milsom @milsommick.bsky.social · 16/06/2026
Following some amazing discussions with colleagues at EHA about our recent publication in @natcellbio.nature.com, here are some important points showing why considering HSC reconstitution kinetics will make you re-think the concept of lineage biases rdcu.be/fkASJ 1/9
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Shannon McKinney-Freeman @smckinneyfreeman.bsky.social · 12/05/2026
RIP Brandon Clarke. So sad.
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Shannon McKinney-Freeman @smckinneyfreeman.bsky.social · 28/02/2026
'The US National Institutes of Health (NIH) has so far not received approval to spend any of the research funding allocated in a budget bill signed into law on 3 February.' www.nature.com/articles/d41...
nature.com
White House stalls release of approved US science budgets
The US Congress rejected sweeping cuts to science agencies. But the NIH, the NSF and NASA have had their spending slowed.
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Jeremy Berg @jeremymberg.bsky.social · 27/02/2026
Thanks to the Nature team for digging into this. Apportionment is one of those inside-baseball issues that I hoped never to need to learn about... But here was are.
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Reposted by Shannon McKinney-Freeman
Lars Velten @larsplus.bsky.social · 27/02/2026
Insightful seminar by Roderic Guigó: Figure 1 of the Craig Venter human genome paper (Science, 2001) was made by a Spanish PhD student who had no salary and earned his living serving tables in a Pizzeria.
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Reposted by Shannon McKinney-Freeman
Alejo Rodriguez-Fraticelli @alejofraticelli.bsky.social · 27/02/2026
INTERESTED IN SINGLE-CELL LINEAGE TRACING? Check our new review @naturerevgenet.bsky.social from the @alejofraticelli.bsky.social lab 🎉🎉 nature.com/articles/s41... With Victoria Parreno, we tried to update the modern manual for genetic tracing and clonal analysis. Read link: rdcu.be/e50gy
nature.com
Charting single-cell lineages with synthetic and natural barcodes - Nature Reviews Genetics
In this Review, Rodriguez-Fraticelli and Parreno discuss advances in single-cell lineage-tracing methods and how their application to diverse biological processes, such as development, ageing and canc...
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Shannon McKinney-Freeman @smckinneyfreeman.bsky.social · 16/02/2026
I have a picture of her in my lecture to the Dev Bio students about embryonic stem cells. A pioneer in the field. Thank you for your work. RIP.
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Reposted by Shannon McKinney-Freeman
In Otter News @in-otter-news.bsky.social · 16/02/2026
Please can you all stop calling him Steve. This phase will probably only last a day or two. Thanks.
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Reposted by Shannon McKinney-Freeman
Edoardo Gianni @edogia.bsky.social · 13/02/2026
How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller? Excited to share our latest work in @science.org on a new small polymerase. 1/n
science.org
A small polymerase ribozyme that can synthesize itself and its complementary strand
The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...
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Reposted by Shannon McKinney-Freeman
Colette Delawalla, PhD @cdelawalla.bsky.social · 12/02/2026
Jamie Raskin not only graduated from Harvard with his JD, (editor of the Harvard Law Review)...he is so dedicated to our country and our constitution that this man BURIED HIS SON, came into work the next day to experience an insurrection, and started writing articles of impeachment THAT DAY. 1/
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American Society of Hematology @ash.hematology.org · 11/02/2026
Roses are red, platelets are too, Hematology keeps thriving with every breakthrough. 🩸💌 This Valentine’s Day, show some love by supporting hematology research through the ASH Foundation: ow.ly/9v8r50YcZaK #ValentinesDay #Hematology #Donate #Fight4Hematology
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Reposted by Shannon McKinney-Freeman
Blood Journals Portfolio @bloodjournals.hematology.org · 11/02/2026
In honor of Blood's 80th anniversary, we're looking back at all of the journal's past Editors in Chief. Today we're kicking off with our Founding Editor, Dr. William Dameshek (served 1946-1969). Learn more about him in this special feature: linkedin.com/feed/update/...
linkedin.com
#history #scientifichistory #bloodjournal #hematology #editorinchief #eic #founder | Blood Journals Portfolio
In honor of Blood’s 80th anniversary, we’re looking back at all the past Editors-in-Chief, starting with our Founding Editor! Dr. William Dameshek (1900–1969) was a pioneering American hematologist ...
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Reposted by Shannon McKinney-Freeman
Jeremy Berg @jeremymberg.bsky.social · 09/02/2026
You don't really want to know, but... 2021: 412 awards 2022: 430 awards 2023: 442 awards 2024: 497 awards 2025: 252 awards 2026 (to date): 0 awards
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In Otter News @in-otter-news.bsky.social · 09/02/2026
BREAKING NEWS: Steve has had a shower. He's got a busy week ahead (his words, not mine).
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Shannon McKinney-Freeman @smckinneyfreeman.bsky.social · 03/02/2026
Noooooo!!!! Not JJJ!!!!!!
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Reposted by Shannon McKinney-Freeman
Oded Rechavi @odedrechavi.bsky.social · 03/02/2026
When you agree to serve in a committee
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Shannon McKinney-Freeman @smckinneyfreeman.bsky.social · 01/02/2026
Judge Biery is a badass and my hero
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Laurence H. Tribe @tribelaw.bsky.social · 26/01/2026
“I just checked—it turns out that Art. II, Sec. 1 of the Constitution of the United States does *not* say ‘The executive Power shall be vested in a bunch of sociopaths who think they can do whatever the f*ck they want and make sh*t up as they go along.’” — George Conway
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Vikram Paralkar @paralkarlab.bsky.social · 25/01/2026
If this nation has a conscience, what will it take to shake it from its slumber?
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Laura Rustarazo-Calvo @laura-rustarazo.bsky.social · 20/01/2026
An unexpected topic I encountered during my PhD: tricellular junctions. I first knew them as local regulators of tissue mechanics, but over time have realised their broader impact at the tissue scale. I wrote a brief overview of this in a thread for @epimechfc.bsky.social.
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Reposted by Shannon McKinney-Freeman
In Otter News @in-otter-news.bsky.social · 17/01/2026
Here is a picture of a baby otter for no good reason.
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Igor Brodsky @brodskyigorlab.bsky.social · 17/01/2026
Lots of problems with multi year funding mechanism. Far fewer grants can be funded and they can only be funded for 4, not 5 years even though most grants funded by the normal mechanism are 5 years. It’s a back door way for Russell Vought to choke off science funding
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Shannon McKinney-Freeman @smckinneyfreeman.bsky.social · 17/01/2026
Have you ever wondered about Pig HSCs? Today is your lucky day! Check out this excellent work from @ganuzalab.bsky.social. Well done! Pig and human adult hematopoietic stem and progenitor cells are overall transcriptionally similar. www.exphem.org/article/S030... @isehsociety.bsky.social
exphem.org
Pig and human adult hematopoietic stem and progenitor cells are overall transcriptionally similar
Allotransplantation provides a lifesaving treatment to hundreds of thousands of patients worldwide every year, including among others heart, kidney, liver and bone marrow (BM) transplants [1,2]. Yet, ...
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Shannon McKinney-Freeman @smckinneyfreeman.bsky.social · 17/01/2026
The struggle is real! Studying HSCs during inflammatory is a challenge as their phenotype changes. Check out this excellent new work in Experimental Hematology reporting another useful tool for identifying HSCs under these conditions. www.exphem.org/article/S030... @isehsociety.bsky.social
exphem.org
Endothelial protein C receptor CD201 is a better marker than stem cell antigen-1 to identify mouse long-term reconstituting hematopoietic stem cells following septic challenge
Stem cell antigen 1 (SCA1) has been used for decades to separate mouse hematopoietic stem and progenitor cell subsets; however, it fails to do so when mice are challenged by pathogens, interferons, or...
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Shannon McKinney-Freeman @smckinneyfreeman.bsky.social · 17/01/2026
It’s so special to be nominated for this by my trainees. Their hard work makes my job easy and I am so grateful to work with them every day. Mentorship is hard and I benefit from the awesome example of my own fantastic mentors. Thank you Colleen, Peggy @goodell-lab.bsky.social and George!
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Dr Kathleen Millen @neurodevkathy.bsky.social · 05/12/2025
Gratitutde to all NIH study section participants who are participating in rescheduled meetings now and in January. Thank you for your service and thanks also to the hard working NIH staff who are making these happen. 🥰🧪
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St. Jude Children's Research Hospital @stjuderesearch.bsky.social · 09/01/2026
For decades, the mystery of how DICER1 mutations promote pediatric rhabdomyosarcoma remained unsolved. Mark Hatley, MD, PhD, and his lab cracked the case, powered by advancements in single-cell RNA sequencing, revealing new paths for intervention. ow.ly/UiCG50XU294
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Sofiya Hupalo @sofiyahupalo.bsky.social · 14/11/2025
NIH grant applicants: October and November grant application submission *deadlines* will be rescheduled (🤯). Specific dates TBD. grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-26-005: Interim Guidance on Reopening of NIH Extramural Activities
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Interim Guidance on Reopening of NIH Extramural Activities NOT-OD-26-005. NIH
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Shannon McKinney-Freeman @smckinneyfreeman.bsky.social · 19/11/2025
New issue of Experimental Hematology out! Check it out! Articles on novel molecular markers of HSCs, engineering red cells from sickle cell disease-derived iPSCs, and classifying HSPCs in LR-MDS. www.exphem.org/issue/S0301-...
exphem.org
Current Issue Table of Contents: Experimental Hematology
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ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · 17/09/2025
Join the Junior Faculty Career Session: Meet the Editors: Insights from Behind the Scenes. Attend this free session during the lunch hour on Thursday, 25 September at #ISEH2025 🏯! iseh.org/Annual-Meeting/54th-Annual-Meeting/Registration
Pictured and labeled left to right: Lev Kats (Science Advances),  Keisuke Ito (Experimental Hematology), Cristina Pina (PLoS One), Katrin Ottersbach (Blood), Toshio Suda (Exp Hem, Cell Stem Cell, JEM)
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ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · 18/09/2025
Join the Junior Faculty Committee at their FREE 22 October webinar on Responsible AI in Research and Publishing featuring Laura Watts, PhD from @lumanity.bsky.social and @p4sc4l.substack.com from Wiley. Learn more and register 👉 iseh.org/Webinars-Eve...
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edwardevansjr.bsky.social @edwardevansjr.bsky.social · 18/09/2025
Super excited to attend the 54th @isehsociety.bsky.social conference in Japan next week! First time in Japan. First time at a hematology conference. Great chance to network with the world's best and share our CH work in Down Syndrome. @crnicinstitute.bsky.social @cuanschutz.bsky.social
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Keisuke Ito @keisukeito-lab.bsky.social · 24/09/2025
Enjoying Japan’s autumn flavors together yesterday after a full day of teamwork & remarkable effort toward multi-year strategic planning for @isehsociety.bsky.social, future scientists, and the prestige of #ExpHem. @thekinglab.bsky.social @smckinneyfreeman.bsky.social @einsteinmededu.bsky.social
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Shannon McKinney-Freeman @smckinneyfreeman.bsky.social · 24/09/2025
Hard to think of a better group of people to work with towards a strong future for the ISEH. The BEST society for folks interested in the fundamentals of hematopoiesis and HSC Biology. @isehsociety.bsky.social
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WKNO-FM | Public Radio for the Mid-South @wkno.bsky.social · 12/09/2025
Memphis Mayor Paul Young confirmed reports that Gov. Bill Lee and the White House were in talks to send National Guard troops to Memphis.
buff.ly
WKNO Daily Newscast | Friday, September 12, 2025
Memphis Mayor Paul Young confirmed reports that Gov. Bill Lee and the White House were in talks to send National Guard troops to Memphis.
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Carl Zimmer @carlzimmer.com · 11/09/2025
This year's Lasker Awards went to scientists who studied the wiring diagram of life, a new state of biological matter, and a potent treatment for cystic fibrosis. Here's my story with Gina Kolata. Gift link: nyti.ms/4mZlH1F
nyti.ms
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Shannon McKinney-Freeman @smckinneyfreeman.bsky.social · 10/09/2025
This is a really important analysis. Scientists in the US need to pay attention.
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Shannon McKinney-Freeman @smckinneyfreeman.bsky.social · 10/09/2025
The ISEH just launched a brand new website! Check it out and join our society today to network with your colleagues and keep abreast of the latest advances in basic and translational experimental hematology research! iseh.org
iseh.org
Home
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Shannon McKinney-Freeman @smckinneyfreeman.bsky.social · 08/09/2025
Still time to register for the annual ISEH meeting! No better place to learn about the latest advances in fundamental HSC biology!
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Blood Journals Portfolio @bloodjournals.hematology.org · 05/09/2025
Targeted therapeutic disruption of ribosome biogenesis is a potential strategy against NPM1-mutant AML. buff.ly/UFBcfEZ #hemesky
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ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · 05/09/2025
Hitoshi Takizawa, PhD from Kumamoto University recommends attending the awards sessions at #ISEH2025 🏯. Visit ISEH's blog at www.simplyblood.org and view the 2025 Interview Spotlight Series to learn more about our award winners!
Q: What is one session you recommend a first-time attendee go to? 
A: “It is hard for me to recommend only one session amongst many great sessions with distinguished speakers. Nevertheless, I would definitely suggest to go to the Award Sessions, speakers of which represent ISEH community.”
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Shannon McKinney-Freeman @smckinneyfreeman.bsky.social · 20/08/2025
Some great content In latest issue of Experimental Hematology! www.exphem.org/issue/S0301-...
exphem.org
Current Issue Table of Contents: Experimental Hematology
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Alessandro Donada @alessandrodonada.bsky.social · 01/08/2025
media.tenor.com
a man in a helmet is looking at the camera with the words `` desire to know more intensifies '' written below him .
ALT: a man in a helmet is looking at the camera with the words `` desire to know more intensifies '' written below him .
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ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · 07/08/2025
This week on #SimplyBlood we're highlighting the first study to demonstrate that both the SARS-CoV-2 spike (S) protein and BNT162b2 mRNA vaccine can inhibit (HbF) production by and reduce γ-globin mRNA accumulation in β-thalassemic (ErPCs). Read on www.simplyblood.org
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ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · 14/08/2025
This week on #SimplyBlood🩸 we're delighted to share an inspiring conversation with Dr. Toshio Suda, Editor-in-Chief of ExpHem! @keisukeito-lab.bsky.social had the unique opportunity to discuss the journal’s evolution including its future vision and ongoing efforts➡️https://www.simplyblood.org/
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Raquel Espin @espinlab.bsky.social · 19/08/2025
Looking forward to this #ISEH webinar by two amazing women in the field
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David Green, PhD @ecologistgreen.bsky.social · 20/08/2025
Not every study needs to be a 20-page paper that takes months—or years—to write. Negative results, small studies, and datasets deserve a home, too. That’s why we created the 2-pager at @StacksJournal.bsky.social — a simple format to share all credible findings. 🧪 #SciPub #AcademicPublishing
stacksjournal.org
The Two-Pager | Stacks Journal
Easily share your research with a 2-Pager in Stacks Journal. Peer review and publish datasets, small studies, null results, and more in a quick, concise format.
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Jeremy Berg @jeremymberg.bsky.social · 29/07/2025
My quote of the day We the people are the rightful masters of both Congress and the courts, not to overthrow the Constitution but to overthrow the men who pervert the Constitution. Abraham Lincoln
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