The human macula, a high-acuity retinal region essential for central vision, emerges early in development, but the cellular basis of its regional specialisation remains incompletely resolved. Building...

 Journal of Regeneration is an international peer-reviewed, Open Access journal aiming to provide a platform for the dissemination of research results on regeneration and tissue repair across phy...

The injury responses of tissue-resident macrophages in the CNS (microglia) and blood-derived macrophages (BDMs) play key roles in successful regeneration of the zebrafish spinal cord, but the origins ...

After spinal injury, zebrafish, in contrast to mammals, show regenerative neurogenesis, characterized by enhanced injury-induced proliferation of ependymo-radial glial cells (ERGs) and an increase in ...

Zebrafish can regenerate neurons after spinal cord injury, but the mechanisms influencing this ability remain unknown. This study shows that Sema4ab, a protein expressed in lesion-reactive microglia, attenuates regenerative neurogenesis by directly regulating neural progenitors and altering cytokine signaling in the niche.

In mammals, a dysregulated immune response is detrimental to spinal cord repair. In zebrafish, which are capable of spinal cord regeneration, the immune response promotes regeneration. Neutrophils are...

JOB OPPORTUNITY 🦈 🧠 🔬. We are looking for a Lab Manager to help establish a new group studying shark embryos to understand the origin of the vertebrate brain. Reach out if this motivates you. We’re ba...

During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...

CellTalk-Human Heart Development is a BBSRC funded consortium established to find out more about how cells come together to build the heart as it grows inside the womb.

The heart is composed of multiple cell types, including cardiomyocytes, endothelial/endocardial cells, fibroblasts, resident immune cells and epicardi…

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The emergence of predation and associated complex behaviors in jawed vertebrates (gnathostomes) have been major driving forces in brain evolution. To gain insight into the neuronal complexity of the l...

A balanced immune response after cardiac injury is crucial to successful heart regeneration, but knowledge of what distinguishes a regenerative from a scarring response is still limited. The Mexican c...

Nature Communications - Adult zebrafish are capable of heart regeneration, but how the collagenous injury site is replaced remains unclear. Here they provide an in-depth analysis of cardiomyocyte...

The axolotl is a highly regenerative species, capable of restoring full limbs, regardless of the amputation site. However, the regeneration rate is adjusted with the plane of amputation along the prox...

Microglia have key roles in CNS development and neurodegeneration. Here, the authors provide an overview of microglia heterogeneity, cell-state annotation and model systems.

The Sonic Hedgehog (Shh) pathway is a key regulator of feather development. These authors show that in vivo Shh inhibition during early chicken embryogenesis temporarily results in unbranched and non-...

We are looking for a Postdoctoral Research Associate to join our group at the Centre for Regenerative Medicine (CRM) and the Institute for Regeneration and Repair (IRR), The University of Edinburgh.

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

imageimageDuring islet development, beta-cell death, rather than proliferation alone, regulates beta-cell mass and shapes the immune environment. This process triggers immune system crosstalk, influen...

Chez de nombreux vertébrés, y compris l’humain, l’épithalamus, une région clé du cerveau régulant les émotions et les comportements, présente des asymét

Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...