iiinova — where your digital self keeps evolving

Reposted by Brian Clark

Phil Ruzycki @phruzycki.bsky.social · 08/09/2026

🚨 New preprint 👀! Led by Sohini Rebba in the lab, a collaboration with @clark-lab-retina.bsky.social & @macdonaldlab.bsky.social to improve the reference transcriptome for our studies of the killifish retina. 🐟

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Reposted by Brian Clark

Kristen Kwan @blockintheback.bsky.social · 21/08/2026

📣 The Department of Ophthalmology and Visual Sciences @utah.edu is recruiting! We seek researchers addressing exciting questions in vision science using innovative approaches. Join our community @moraneyecenter.bsky.social! Repost and contact me with questions! utah.peopleadmin.com/postings/206...

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Reposted by Brian Clark

Anna La Torre @latorrelab.bsky.social · 13/05/2026

Excited to share our new paper! This work explores how Sonic hedgehog signaling helps coordinate retinal patterning and neurogenesis, including regulation of both cell cycle exit and progenitor competence during mammalian eye development journals.biologists.com/dev/article/...

journals.biologists.com

Roles of sonic hedgehog signaling in retinal patterning and neurogenesis during mammalian eye development

Summary: Temporal disruption of sonic hedgehog signaling reveals stage-specific roles in eye cup patterning and in regulating proliferation, progenitor competence and fate specification during retinal...

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Reposted by Brian Clark

Anna La Torre @latorrelab.bsky.social · 21/04/2026

Our new paper is out! 🎉 Let-7 doesn’t act through a single pathway: it controls neocortical neuron fate and migration via distinct downstream mechanisms, with RBX2 dedicated to migration. A new layer of post-transcriptional control shaping cortical development www.pnas.org/doi/10.1073/...

pnas.org

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

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Brian Clark @clark-lab-retina.bsky.social · 14/04/2026

We’ve reached a milestone in the lab! Congrats to Dr. Jade Hostetler for a fantastic thesis defense and becoming the first PhD graduate of the Clark lab! Jade has been leading all of our work on RNA biology including studies of Peanut (Gm11454) pubmed.ncbi.nlm.nih.gov/41573818/ and more to come.

Picture of Jade presenting during her thesis defense.

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Reposted by Brian Clark

Phil Ruzycki @phruzycki.bsky.social · 09/04/2026

New paper out 🚨! Excited to share this collab between my lab and @kerschensteiner.bsky.social's group, expertly led by Ning Shen. We used a genome-wide in vivo CRISPR screen to uncover novel neuroprotective strategies in the P23H mouse retina, with validation in a new human retina culture model.

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Reposted by Brian Clark

Ryan MacDonald @macdonaldlab.bsky.social · 03/03/2026

Excited to share our new manuscript from the Yoshimatsu and MacDonald labs. www.biorxiv.org/content/10.6.... We found that my favourite glial cells can regulate local retinoic acid signalling to specialise cone photoreceptors for high acuity visual function.

Muller glia (green) regulate local retinoic acid signalling to specialise photoreceptor outer segments (magenta)for high acuity visual function

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Brian Clark @clark-lab-retina.bsky.social · 06/08/2025

Our work on the TET enzymes in retinal development is out. We identified that rod fate is inhibited when DNA demethylation is prevented by removal of the TET enzymes. Interestingly, photoreceptor numbers are normal. We utilized WGBS and bACE-seq to profile the precise localization of 5mC and 5hmC,…

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Reposted by Brian Clark

Kristen Kwan @blockintheback.bsky.social · 26/02/2025

Well, the Biology and Development of the Eye (BDE) study section has been postponed (previously scheduled for Thurs/Fri). I’m very disappointed on behalf of the applicants and reviewers, who all want this meeting to happen. I’m also grateful to the NIH staff who work so hard to make science happen.

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Brian Clark @clark-lab-retina.bsky.social · 04/02/2025

First post on this platform is to announce that our preprint is posted to bioRxiv: bioRxiv 2025.02.03.636318; doi: doi.org/10.1101/2025...

doi.org

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