SinghLab@SNIoE @singhlab.bsky.social · 31/07/2025As part of the Faculty Development Program at Shiv Nadar University , received these 10 commandments for faculty. This is the best advice I have seen, and certainly hits the nail on the head. Especially about focusing and getting the first study out early on. 040
SinghLab@SNIoE @singhlab.bsky.social · 06/06/2025🚨 Just out in Nature Communications: Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish We challenge old assumptions on liver regeneration! 🔗 nature.com/articles/s41... 🧵(1/8)nature.comCholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish - Nature CommunicationsDuring partial liver injury in growing zebrafish, cholangiocytes regenerate hepatocytes through transdifferentiation, revealing a stage-specific regeneration mechanism regulated by mTORC1 signaling. 3208
Reposted by SinghLab@SNIoEFilipa Simões @simoesfilipa.bsky.social · 16/05/2025🫀Job alert 🧬 come and be our colleague! Join a BBSRC-funded consortium aiming to understand how the human heart develops - you will be contributing multimodal single cell & spatial transcriptomics data using zebrafish and human cardiac organoids as models. Learn more: www.heartdevelopment.org (1/4)heartdevelopment.orgCellTalk HHD | Human Heart Development ResearchCellTalk-Human Heart Development is a BBSRC funded consortium established to find out more about how cells come together to build the heart as it grows inside the womb. 11626
SinghLab@SNIoE @singhlab.bsky.social · 02/06/2025Pleased to have contributed commentary to this recent article by Maria Bolevich for Interesting Engineering, which explores the science of tissue #regeneration and its potential applications in medicine. Read the full article here: interestingengineering.com/health/body-...interestingengineering.comWhy the body's natural regeneration isn't enough to stop chronic diseaseFrom skin renewal to liver repair, the body is rebuilding itself. Scientists are now uncovering why some organs heal and others don’t. 020
SinghLab@SNIoE @singhlab.bsky.social · 28/05/2025We just posted our new preprint, spearheaded by Garnik Hovhannisyan in collaboration with Esteban Gurzov Lab! biorxiv.org/content/10.1... #zebrafish #liverregeneration #DevBio #LineageTracingbiorxiv.orgCellCousin2: An Optimized System for Partial Ablation and Tracing of Regenerative LineagesRegeneration can rely on multiple cellular sources, including stem cells, self-duplicating cells, and transdifferentiating cells. A central question in regenerative biology is how these distinct linea... 130
SinghLab@SNIoE @singhlab.bsky.social · 16/05/2025Stunning 3D fluorescent images of the human #tooth and the first cellular/molecular map of tooth #decay! Hoang Thai Ha from Nicolas Baeyens Lab nails it with tissue clearing + imaging. www.biorxiv.org/content/10.1... 052
Reposted by SinghLab@SNIoECarol Yang @yhcarolyang.bsky.social · 14/05/2025Interested in understanding how neural-pancreas interplay contributes to blood sugar control? We have an exciting PhD project to study galanin regulation of pancreatic #islet hormone secretion in live #zebrafish www.exeter.ac.uk/research/ins... 045
SinghLab@SNIoE @singhlab.bsky.social · 14/05/2025Liver regeneration after killing part of the liver! In this image, the same liver from same #zebrafish is imaged before (left) and after (right) regeneration. The newly born liver cells are in blue. Project led by @selifeski.bsky.social 070
SinghLab@SNIoE @singhlab.bsky.social · 03/05/2025We celebrated a big milestone in our lab: our first #Undergrad intern presented her work at lab meeting! She helped develop two new #liver #injury models, and is on her way to becoming a fantastic scientist. Thanks to PhD student Garnik for mentoring her so well! 👏🧪 #TeamScience 030
SinghLab@SNIoE @singhlab.bsky.social · 12/04/2025Whole mount EdU staining of 5 day old #zebrafish. 1150
SinghLab@SNIoE @singhlab.bsky.social · 08/04/2025I'm excited to share that I will join School of Natural Sciences, Shiv Nadar University as an Associate Professor! Looking forward to working with amazing students and being part of a thriving research community. 3130
Reposted by SinghLab@SNIoEZebrafish Rock! @zebrafishrock.bsky.social · 05/03/2025Come help us build an inclusive community, for those finterested! Did they mention it’s FREE?!? 🧪 032
SinghLab@SNIoE @singhlab.bsky.social · 03/03/2025Delighted to receive FOXO Transcription Factors edited by Dr. Wolfgang Link! FOXO genes are key in stress response & metabolism. Inés Garteizgogeascoa Suñer details a knock-in #zebrafish foxo1a reporter: pubmed.ncbi.nlm.nih.gov/39565585/ Check out the book for key advances! 071
SinghLab@SNIoE @singhlab.bsky.social · 12/02/2025Had a great time meeting the students at Freedom Employability Academy (FEA: feaindia.org ) today! Inspiring to see their enthusiasm and growth. Excited to support their journey towards meaningful careers! #Mentorship #Education 020
Reposted by SinghLab@SNIoEWehner lab | Neuroregeneration @wehnerlab.bsky.social · 27/01/2025We demonstrate that this biphasic regulation limits the neutrophil-driven acute inflammatory phase, preventing chronic inflammation, fostering a lesion environment with mechano-structural properties conducive to regeneration. 111
Reposted by SinghLab@SNIoEWehner lab | Neuroregeneration @wehnerlab.bsky.social · 27/01/2025Excited to share the latest work from our lab: www.biorxiv.org/content/10.1...biorxiv.orgBiphasic inflammation control by dedifferentiated fibroblasts enables axon regeneration after spinal cord injury in zebrafishFibrosis and persistent inflammation are interconnected processes that inhibit axon regeneration in the mammalian central nervous system (CNS). In zebrafish, by contrast, fibroblast-derived extracellu... 22810
Reposted by SinghLab@SNIoEWehner lab | Neuroregeneration @wehnerlab.bsky.social · 27/01/2025Fantastic collaboration with the labs of Sven Falk, @singhlab.bsky.social, Jochen Guck, @franzelab.bsky.social, Kanwarpal Singh, and Federico Marini. @fau.de @mpi-scienceoflight.bsky.social Johannes Gutenberg University University of Cambridge @iribhm.bsky.social, @mcmasteruniversity.bsky.social 111
Reposted by SinghLab@SNIoEValerie Tornini @valetornini.bsky.social · 09/12/2024We are openly recruiting at all levels at the Tornini Lab at the University of California, Los Angeles (UCLA)! Please share with your networks. For more information, please check the info below, visit www.torninilab.org, or email me directly at vtornini at ucla dot edu. Thank you in advance! 03329
Reposted by SinghLab@SNIoESofia de Oliveira, Ph.D. @sdeoliveira.bsky.social · 08/11/2024Our debut here 🥰 Non-invasive intravital imaging of wound in skin epithelium of a juvenille zebrafish fed with a High-Cholesterol diet (HCD) versus a Normal Diet (ND) Zebrafish is an outstanding model to study how diet and metabolic disease impact neutrophils Keep following us, spread the word! 05110
Reposted by SinghLab@SNIoEOlov Andersson @o-andersson-lab.bsky.social · 14/01/2025Fancy joining our lab? apply here for a PhD student position, (DM me for potential postdoc opportunities) www.uu.se/en/about-uu/...uu.sePhD student in regeneration of insulin-producing beta-cells in diabetes models - Uppsala UniversityPhD student in regeneration of insulin-producing beta-cells in diabetes models, Institutionen för medicinsk cellbiologi, Uppsala University 075
Reposted by SinghLab@SNIoEOlov Andersson @o-andersson-lab.bsky.social · 10/01/2025Check out our preprint about liver regeneration, showing hepatic duct heterogeneity and cell plasticity using lineage tracing and single-cell transcriptomics. @zebrafishrock.bsky.social @biorxivpreprint.bsky.social @the-node.bsky.social www.biorxiv.org/content/10.1... 1205
SinghLab@SNIoE @singhlab.bsky.social · 10/01/2025Excited to share our latest work on #liver #regeneration in @biorxiv-devbio.bsky.social ! We uncover how cholangiocytes contribute to hepatocyte regeneration, even in the presence of spared hepatocytes, using our novel CellCousin model in #zebrafish: www.biorxiv.org/content/10.1... 🐟✨ A 🧵👇 (1/12)biorxiv.orgCholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafishThe liver's regenerative ability depends on injury extent. Minor injuries are repaired by hepatocyte self-duplication, while severe damage triggers cholangiocyte involvement in hepatocyte recovery. Th... 12913
Reposted by SinghLab@SNIoENikolai Slavov @slavov-n.bsky.social · 08/01/20255,562 proteins were found to have tissue-specific enrichment across 32 human tissues. The majority of them (3,088) are enriched at the protein but not RNA level. The brain hosts the largest number of proteins that are only enriched at the protein level but not RNA level. 36424
SinghLab@SNIoE @singhlab.bsky.social · 07/01/2025What shapes the #immune profile of organs? Study from Ninov Lab #CRTD, led by Nadeem, find that developmental #celldeath define the immune cells of the pancreatic #islet in #zebrafish ! 🎉👏 Read more @embojournal.bsky.social : embopress.org/doi/full/10.... #Diabetesembopress.orgDevelopmental beta-cell death orchestrates the islet’s inflammatory milieu by regulating immune system crosstalk | The EMBO JournalimageimageDuring islet development, beta-cell death, rather than proliferation alone, regulates beta-cell mass and shapes the immune environment. This process triggers immune system crosstalk, influen... 031
Reposted by SinghLab@SNIoEPhil Campbell @pdcampbell.bsky.social · 06/01/2025We are looking to hire at all levels - undergrads, research technicians, graduate students, postdocs. Experience with zebrafish, induced pluripotent stem cell models, molecular genetic approaches, imaging, or programming is desirable but not required. 163
Reposted by SinghLab@SNIoEPrakash Lab @ Miami @vprakashlab.bsky.social · 24/12/2024🥳 We got our Christmas present - our paper was accepted in PNAS!! @pnas.org 😀🎄🎅 Congrats to my student Shubham Sinha, collabs. Rieko Asai, Takashi Mikawa 😀 We showed that cellular flows initiate L-R patterning prior to laterality gene expression in amniotes! 🐣 www.biorxiv.org/content/10.1... 27419
Reposted by SinghLab@SNIoELionel Christiaen, PhD (he/him/his) @lionlchristiaen.bsky.social · 23/12/2024Xmas teaser: Mike Dorrity @mwdorr.bsky.social and I are looking for a joint postdoc to study "The Hallmarks of Thermal Adaptation" in Aquatic Chordates as part of the EIPOD-LinC program www.embl.org/about/info/p... and the partnership between @embl.org and @msarscentre.bsky.social.embl.orgEIPOD-LinC Fellowship Programme – Postdoctoral Programme 1148
Reposted by SinghLab@SNIoE Sepand Rastegar @rastapopolus.bsky.social · 18/12/2024Calcium release in #Zebrafish muscle 031
SinghLab@SNIoE @singhlab.bsky.social · 10/12/2024Thank you FNRS for supporting our research for two more years! We recieved funding to look into #starvation-induced #fattyliver in #zebrafish. All the credit goes to PhD students who worked hard to get the data for the grant! 150
Reposted by SinghLab@SNIoEKevin Thiessen, PhD @kevinthiessen.bsky.social · 07/12/2024While our F1 outgrew their ugly Fishmas onesie years ago, I remain as Papa Zebrafish for another season! Designed by fish fan Priyanka Oberoi. Available on lots of different items Mama: www.redbubble.com/i/sweatshirt... Papa: www.redbubble.com/i/sweatshirt... Baby: www.redbubble.com/i/baby-onesi... 0242
SinghLab@SNIoE @singhlab.bsky.social · 03/12/2024Delighted with two PhD students, Elif and Gabriel, who proudly represented the lab at Belgian Society of Stem Cell Research (BeSSCR) annual meeting, with Elif winning the best talk award!! 070
Reposted by SinghLab@SNIoEAnchel de Jaime-Soguero @ancheldjs.bsky.social · 26/11/2024 🚨 🚨 Job Alert! I am currently opening my research lab at @iribhm.bsky.social @ulbruxelles.bsky.social in Belgium and I am seeking for an enthusiastic PhD candiate to study cellular stress across mammalian development and lineage specification! If you are interested, info below. Please RT! 2410
SinghLab@SNIoE @singhlab.bsky.social · 28/11/2024Thank you Gilbert Weidinger Lab, University Ulm, for hosting me for a seminar and exciting discussion! It was great to walk around the city of Ulm as well and visit the Christmas market. 150
Reposted by SinghLab@SNIoEPeter Fabian @fabianlab.bsky.social · 21/11/2024Check out how #neuralcrest cells 🔬 migrate (animal= #zebrafish, white cells=sox10+, start=10 somites stage, anterior=top) 417834
Reposted by SinghLab@SNIoEbioRxiv Developmental Biology @biorxiv-devbio.bsky.social · 27/01/2024A new genetically tractable non-vertebrate system to study complete camera-type eye regeneration www.biorxiv.org/content/10.1101/202… biorxiv.orgA new genetically tractable non-vertebrate system to study complete camera-type eye regeneration https://www.biorxiv.org/content/10.1101/2024.01.26.577494v1 Camera-type eyes are complex sensory organs susceptible to irreversible damage. Their repair is diff 086
SinghLab@SNIoE @singhlab.bsky.social · 12/01/2024Fatty Liver is linked with a high fat diet and obesity. But 90 years ago, Dr Cicely Williams, found that malnourished babies develop fatty liver. Now, @rohner.bsky.social , Hua Bai and our lab found the gene responsible for starvation-induced fatty liver from flies to fish! A 🧵(1/5) 1118
SinghLab@SNIoE @singhlab.bsky.social · 24/11/2023Was a pleasure to meet with @simoesfilipa.bsky.social and listen about the role of macrophages in heart #regeneration in #zebrafish! Lots of interesting things to come from her group!! 060