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SinghLab@SNIoE

@singhlab.bsky.social
896 followers 1.2K following 61 posts

Regenerative & Stress Biology Lab, Shiv Nadar University, Delhi-NCR, India Regenerative Plasticity | Zebrafish | In vivo Fluorescent Imaging | Liver Regeneration | Starvation Response | Alcoholic Liver Disease

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SinghLab@SNIoE @singhlab.bsky.social · 31/07/2025
As part of the Faculty Development Program at Shiv Nadar University , received these 10 commandments for faculty. This is the best advice I have seen, and certainly hits the nail on the head. Especially about focusing and getting the first study out early on.
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SinghLab@SNIoE @singhlab.bsky.social · 06/06/2025
🚨 Just out in Nature Communications: Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish We challenge old assumptions on liver regeneration! 🔗 nature.com/articles/s41... 🧵(1/8)
nature.com
Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish - Nature Communications
During partial liver injury in growing zebrafish, cholangiocytes regenerate hepatocytes through transdifferentiation, revealing a stage-specific regeneration mechanism regulated by mTORC1 signaling.
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Filipa Simões @simoesfilipa.bsky.social · 16/05/2025
🫀Job alert 🧬 come and be our colleague! Join a BBSRC-funded consortium aiming to understand how the human heart develops - you will be contributing multimodal single cell & spatial transcriptomics data using zebrafish and human cardiac organoids as models. Learn more: www.heartdevelopment.org (1/4)
heartdevelopment.org
CellTalk HHD | Human Heart Development Research
CellTalk-Human Heart Development is a BBSRC funded consortium established to find out more about how cells come together to build the heart as it grows inside the womb.
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SinghLab@SNIoE @singhlab.bsky.social · 02/06/2025
Pleased to have contributed commentary to this recent article by Maria Bolevich for Interesting Engineering, which explores the science of tissue #regeneration and its potential applications in medicine. Read the full article here: interestingengineering.com/health/body-...
interestingengineering.com
Why the body's natural regeneration isn't enough to stop chronic disease
From skin renewal to liver repair, the body is rebuilding itself. Scientists are now uncovering why some organs heal and others don’t.
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SinghLab@SNIoE @singhlab.bsky.social · 28/05/2025
We just posted our new preprint, spearheaded by Garnik Hovhannisyan in collaboration with Esteban Gurzov Lab! biorxiv.org/content/10.1... #zebrafish #liverregeneration #DevBio #LineageTracing
biorxiv.org
CellCousin2: An Optimized System for Partial Ablation and Tracing of Regenerative Lineages
Regeneration can rely on multiple cellular sources, including stem cells, self-duplicating cells, and transdifferentiating cells. A central question in regenerative biology is how these distinct linea...
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SinghLab@SNIoE @singhlab.bsky.social · 16/05/2025
Stunning 3D fluorescent images of the human #tooth and the first cellular/molecular map of tooth #decay! Hoang Thai Ha from Nicolas Baeyens Lab nails it with tissue clearing + imaging. www.biorxiv.org/content/10.1...
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Carol Yang @yhcarolyang.bsky.social · 14/05/2025
Interested in understanding how neural-pancreas interplay contributes to blood sugar control? We have an exciting PhD project to study galanin regulation of pancreatic #islet hormone secretion in live #zebrafish www.exeter.ac.uk/research/ins...
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SinghLab@SNIoE @singhlab.bsky.social · 14/05/2025
Liver regeneration after killing part of the liver! In this image, the same liver from same #zebrafish is imaged before (left) and after (right) regeneration. The newly born liver cells are in blue. Project led by @selifeski.bsky.social
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SinghLab@SNIoE @singhlab.bsky.social · 03/05/2025
We celebrated a big milestone in our lab: our first #Undergrad intern presented her work at lab meeting! She helped develop two new #liver #injury models, and is on her way to becoming a fantastic scientist. Thanks to PhD student Garnik for mentoring her so well! 👏🧪 #TeamScience
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SinghLab@SNIoE @singhlab.bsky.social · 12/04/2025
Whole mount EdU staining of 5 day old #zebrafish.
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SinghLab@SNIoE @singhlab.bsky.social · 08/04/2025
I'm excited to share that I will join School of Natural Sciences, Shiv Nadar University as an Associate Professor! Looking forward to working with amazing students and being part of a thriving research community.
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Zebrafish Rock! @zebrafishrock.bsky.social · 05/03/2025
Come help us build an inclusive community, for those finterested! Did they mention it’s FREE?!? 🧪
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SinghLab@SNIoE @singhlab.bsky.social · 03/03/2025
Delighted to receive FOXO Transcription Factors edited by Dr. Wolfgang Link! FOXO genes are key in stress response & metabolism. Inés Garteizgogeascoa Suñer details a knock-in #zebrafish foxo1a reporter: pubmed.ncbi.nlm.nih.gov/39565585/ Check out the book for key advances!
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SinghLab@SNIoE @singhlab.bsky.social · 12/02/2025
Had a great time meeting the students at Freedom Employability Academy (FEA: feaindia.org ) today! Inspiring to see their enthusiasm and growth. Excited to support their journey towards meaningful careers! #Mentorship #Education
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Wehner lab | Neuroregeneration @wehnerlab.bsky.social · 27/01/2025
We demonstrate that this biphasic regulation limits the neutrophil-driven acute inflammatory phase, preventing chronic inflammation, fostering a lesion environment with mechano-structural properties conducive to regeneration.
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Wehner lab | Neuroregeneration @wehnerlab.bsky.social · 27/01/2025
Excited to share the latest work from our lab: www.biorxiv.org/content/10.1...
biorxiv.org
Biphasic inflammation control by dedifferentiated fibroblasts enables axon regeneration after spinal cord injury in zebrafish
Fibrosis and persistent inflammation are interconnected processes that inhibit axon regeneration in the mammalian central nervous system (CNS). In zebrafish, by contrast, fibroblast-derived extracellu...
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Wehner lab | Neuroregeneration @wehnerlab.bsky.social · 27/01/2025
Fantastic collaboration with the labs of Sven Falk, @singhlab.bsky.social, Jochen Guck, @franzelab.bsky.social, Kanwarpal Singh, and Federico Marini. @fau.de @mpi-scienceoflight.bsky.social Johannes Gutenberg University University of Cambridge @iribhm.bsky.social, @mcmasteruniversity.bsky.social
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Valerie Tornini @valetornini.bsky.social · 09/12/2024
We are openly recruiting at all levels at the Tornini Lab at the University of California, Los Angeles (UCLA)! Please share with your networks. For more information, please check the info below, visit www.torninilab.org, or email me directly at vtornini at ucla dot edu. Thank you in advance!
Open recruitment for the Tornini Lab
Department of Integrative Biology and Physiology & Institute for Society and Genetics
Hispanic Serving Institution Infrastructure Initiative
University of California, Los Angeles (UCLA)
www.torninilab.org
We are a new developmental, cell, and molecular biology lab interested in understanding the
genetics of vertebrate neurodevelopment.
We use genome engineering, single-cell technologies, behavioral analyses, pharmacological
profiling, confocal imaging, genomics, and computational biology using the vertebrate
zebrafish (Danio rerio) system and other models (like sea lamprey) for evolutionary studies.
Our work is driven by curiosity, independence and teamwork, fun, a sense of urgency, and a
desire to understand how networks of genes regulate brain and organismal development. This
work can help us better understand basic mechanisms of what happens in human
developmental disorders or diseases and can inform novel therapeutic strategies.
We are recruiting across all levels.
Our lab works in multiple complementary areas (please see below).
We’re looking to match motivated people with what motivates them in a supportive and
engaging environment.
We are recruiting staff research scientists (1-2 years after undergrad+), graduate students (open
rotation positions), postdocs, and other positions as relevant.
While multiple of our projects are already funded, we strongly support candidates to identify
and apply for your own fellowships/grants with the full mentorship and resources of the lab.
Like our research? Think you might be a good fit?
Consider joining us!
For more information, please visit our website, the next page, or contact Val at: vtornini at ucla
dot edu
UCLA is an equal opportunity employer. Novel micropeptides in vertebrate neurodevelopment
 Using zebrafish models, we
ask: what are these proteins; what are their functions in neurodevelopment; what are other
“ignored” or “dark proteome” genes we are missing; and what can they reveal about human
neurodevelopmental disorders or diseases?
Chromatin regulators in vertebrate development and behavior
A growing group of evolutionarily conserved chromatin regulators have been identified as
genes linked with neurodevelopmental disorders, such as autism. In many cases, patients may
struggle with co-occurring conditions that impact daily life in childhood and adulthood,
including seizures, sleeplessness or sleep disruptions, and autoimmune disruptions. How do
these genes work to establish and maintain neural cell types during development, and in turn
shape circuits during early critical periods, including interactions with the environment, to
establish organismal physiological processes? 

Non-neuronal regulation during development and aging
Non-neuronal cell types, including oligodendrocytes and microglia, have emerged as key
players in shaping neurodevelopment and into adulthood. How are the cellular, molecular, and
physiological dynamics of these cell types in developing and aging brains affected in mutant
genetic models linked to neurodevelopmental disorders? Can we target these cells to
modulate neural dysregulation and resulting behaviors in these mutant models?

Evolution of vertebrate brain cell states
We seek to understand the principles of how novel genes co-evolve with the emergence of
neural cell types found only in vertebrates.
We use cross-species genomics and functional approaches with the jawless vertebrate model,
sea lamprey, to elucidate the roles of vertebrate-specific genes on the gene regulatory
networks.
Bioethics, neuroethics, and genetics
We seek to integrate evidence-based methods throughout our projects to investigate and address bioethical considerations in this research domain.
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Sofia de Oliveira, Ph.D. @sdeoliveira.bsky.social · 08/11/2024
Our debut here 🥰 Non-invasive intravital imaging of wound in skin epithelium of a juvenille zebrafish fed with a High-Cholesterol diet (HCD) versus a Normal Diet (ND) Zebrafish is an outstanding model to study how diet and metabolic disease impact neutrophils Keep following us, spread the word!
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Olov Andersson @o-andersson-lab.bsky.social · 14/01/2025
Fancy joining our lab? apply here for a PhD student position, (DM me for potential postdoc opportunities) www.uu.se/en/about-uu/...
uu.se
PhD student in regeneration of insulin-producing beta-cells in diabetes models - Uppsala University
PhD student in regeneration of insulin-producing beta-cells in diabetes models, Institutionen för medicinsk cellbiologi, Uppsala University
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Olov Andersson @o-andersson-lab.bsky.social · 10/01/2025
Check out our preprint about liver regeneration, showing hepatic duct heterogeneity and cell plasticity using lineage tracing and single-cell transcriptomics. @zebrafishrock.bsky.social @biorxivpreprint.bsky.social @the-node.bsky.social www.biorxiv.org/content/10.1...
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SinghLab@SNIoE @singhlab.bsky.social · 10/01/2025
Excited to share our latest work on #liver #regeneration in @biorxiv-devbio.bsky.social ! We uncover how cholangiocytes contribute to hepatocyte regeneration, even in the presence of spared hepatocytes, using our novel CellCousin model in #zebrafish: www.biorxiv.org/content/10.1... 🐟✨ A 🧵👇 (1/12)
biorxiv.org
Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish
The liver's regenerative ability depends on injury extent. Minor injuries are repaired by hepatocyte self-duplication, while severe damage triggers cholangiocyte involvement in hepatocyte recovery. Th...
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Nikolai Slavov @slavov-n.bsky.social · 08/01/2025
5,562 proteins were found to have tissue-specific enrichment across 32 human tissues. The majority of them (3,088) are enriched at the protein but not RNA level. The brain hosts the largest number of proteins that are only enriched at the protein level but not RNA level.
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SinghLab@SNIoE @singhlab.bsky.social · 07/01/2025
What shapes the #immune profile of organs? Study from Ninov Lab #CRTD, led by Nadeem, find that developmental #celldeath define the immune cells of the pancreatic #islet in #zebrafish ! 🎉👏 Read more @embojournal.bsky.social : embopress.org/doi/full/10.... #Diabetes
embopress.org
Developmental beta-cell death orchestrates the islet’s inflammatory milieu by regulating immune system crosstalk | The EMBO Journal
imageimageDuring islet development, beta-cell death, rather than proliferation alone, regulates beta-cell mass and shapes the immune environment. This process triggers immune system crosstalk, influen...
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Phil Campbell @pdcampbell.bsky.social · 06/01/2025
We are looking to hire at all levels - undergrads, research technicians, graduate students, postdocs. Experience with zebrafish, induced pluripotent stem cell models, molecular genetic approaches, imaging, or programming is desirable but not required.
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Prakash Lab @ Miami @vprakashlab.bsky.social · 24/12/2024
🥳 We got our Christmas present - our paper was accepted in PNAS!! @pnas.org 😀🎄🎅 Congrats to my student Shubham Sinha, collabs. Rieko Asai, Takashi Mikawa 😀 We showed that cellular flows initiate L-R patterning prior to laterality gene expression in amniotes! 🐣 www.biorxiv.org/content/10.1...
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Lionel Christiaen, PhD (he/him/his) @lionlchristiaen.bsky.social · 23/12/2024
Xmas teaser: Mike Dorrity @mwdorr.bsky.social and I are looking for a joint postdoc to study "The Hallmarks of Thermal Adaptation" in Aquatic Chordates as part of the EIPOD-LinC program www.embl.org/about/info/p... and the partnership between @embl.org and @msarscentre.bsky.social.
embl.org
EIPOD-LinC Fellowship Programme – Postdoctoral Programme
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Sepand Rastegar @rastapopolus.bsky.social · 18/12/2024
Calcium release in #Zebrafish muscle
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SinghLab@SNIoE @singhlab.bsky.social · 10/12/2024
Thank you FNRS for supporting our research for two more years! We recieved funding to look into #starvation-induced #fattyliver in #zebrafish. All the credit goes to PhD students who worked hard to get the data for the grant!
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Kevin Thiessen, PhD @kevinthiessen.bsky.social · 07/12/2024
While our F1 outgrew their ugly Fishmas onesie years ago, I remain as Papa Zebrafish for another season! Designed by fish fan Priyanka Oberoi. Available on lots of different items Mama: www.redbubble.com/i/sweatshirt... Papa: www.redbubble.com/i/sweatshirt... Baby: www.redbubble.com/i/baby-onesi...
Ugly Christmas sweater with a festive zebrafish. With the phrase: “Merry Christmas, Do I have fish feeding duty today”
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SinghLab@SNIoE @singhlab.bsky.social · 03/12/2024
Delighted with two PhD students, Elif and Gabriel, who proudly represented the lab at Belgian Society of Stem Cell Research (BeSSCR) annual meeting, with Elif winning the best talk award!!
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Anchel de Jaime-Soguero @ancheldjs.bsky.social · 26/11/2024
🚨 🚨 Job Alert! I am currently opening my research lab at @iribhm.bsky.social @ulbruxelles.bsky.social in Belgium and I am seeking for an enthusiastic PhD candiate to study cellular stress across mammalian development and lineage specification! If you are interested, info below. Please RT!
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SinghLab@SNIoE @singhlab.bsky.social · 28/11/2024
Thank you Gilbert Weidinger Lab, University Ulm, for hosting me for a seminar and exciting discussion! It was great to walk around the city of Ulm as well and visit the Christmas market.
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Peter Fabian @fabianlab.bsky.social · 21/11/2024
Check out how #neuralcrest cells 🔬 migrate (animal= #zebrafish, white cells=sox10+, start=10 somites stage, anterior=top)
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bioRxiv Developmental Biology @biorxiv-devbio.bsky.social · 27/01/2024
A new genetically tractable non-vertebrate system to study complete camera-type eye regeneration www.biorxiv.org/content/10.1101/202…
biorxiv.org
A new genetically tractable non-vertebrate system to study complete camera-type eye regeneration https://www.biorxiv.org/content/10.1101/2024.01.26.577494v1
Camera-type eyes are complex sensory organs susceptible to irreversible damage. Their repair is diff
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SinghLab@SNIoE @singhlab.bsky.social · 12/01/2024
Fatty Liver is linked with a high fat diet and obesity. But 90 years ago, Dr Cicely Williams, found that malnourished babies develop fatty liver. Now, @rohner.bsky.social , Hua Bai and our lab found the gene responsible for starvation-induced fatty liver from flies to fish! A 🧵(1/5)
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SinghLab@SNIoE @singhlab.bsky.social · 24/11/2023
Was a pleasure to meet with @simoesfilipa.bsky.social and listen about the role of macrophages in heart #regeneration in #zebrafish! Lots of interesting things to come from her group!!
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