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Amanda Sierra

@sierralab.bsky.social
940 followers 209 following 60 posts

Research professor at Achucarro Basque Center for Neuroscience. Microglial lover, passionate about science outreach. ORCID: 0000-0001-8415-096X Lab website: www.achucarro.org/es/laboratory/gli…

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Amanda Sierra @sierralab.bsky.social · 19/12/2025
Our recent review on #microglia and brain #organoids is getting a good reception! 🧠🧪 onlinelibrary.wiley.com/doi/full/10....
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Amanda Sierra @sierralab.bsky.social · 04/09/2025
🧠🧪Funded PhD job offer ok neddylation in glial cells @achucarro.bsky.social Pls repost
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Amanda Sierra @sierralab.bsky.social · 13/08/2025
Join us if you want to learn about #microglia!
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Amanda Sierra @sierralab.bsky.social · 08/08/2025
"Sisterly love" Proliferating neural stem cells🧪🧠
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Amanda Sierra @sierralab.bsky.social · 24/07/2025
Are you interested in human brain #organoids to study #microglia but don't know where to start?🧠🧪 #neuroskyence Here's our piece of advice on "Building Immunocompetent Cerebral Organoids From a Developmental Perspective" onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Building Immunocompetent Cerebral Organoids From a Developmental Perspective
Conventional cerebral organoids do not contain microglia, which must be added. We propose recommendations to assess microglial immunocompetence using quantitative approaches and stringent statist...
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Ʌʗʜʋʗɑɼɼʘ @achucarro.bsky.social · 14/07/2025
The @sierralab.bsky.social lab is hiring! Postdoctoral position in #microglial development (#IKUR) www.achucarro.org/job/postdoct...
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Amanda Sierra @sierralab.bsky.social · 11/07/2025
Reaching Marseille was quite an odissey because of the wildfires, but the #Euroglia meeting was quite a success! Tons of science, friends and fun!
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Ʌʗʜʋʗɑɼɼʘ @achucarro.bsky.social · 02/06/2025
@sierralab.bsky.social reflexiona sobre si se puede parar la #menopausia www.elcorreo.com/vivir/salud/...
elcorreo.com
¿Y si pudiéramos evitar la menopausia? | El Correo
Se están desarrollando terapias para rejuvenecer los ovarios y evitar los efectos negativos sobre la salud
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Amanda Sierra @sierralab.bsky.social · 04/05/2025
This sounds sooo familiar So, maybe, "The next time we hear a crazy/bitch narrative about a senior woman, let's ask ourselves: How much first-hand evidence do we personally have to back it up -- does it resonate with our own direct observations and interactions with her?"
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Carsen Stringer @computingnature.bsky.social · 12/02/2025
#Cellpose 3 paper now out. Not all images are perfect. Restore your images with Cellpose3 to get better segmentations, w/ @marius10p.bsky.social www.nature.com/articles/s41...
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The Transmitter @thetransmitter.bsky.social · 25/03/2025
Even in the absence of formal instruction to do so, we should continue to hold ourselves and our neuroscience colleagues accountable for “Sex as a Biological Variable” practices, writes @docbecca.bsky.social. #neuroskyence www.thetransmitter.org/sex-differen...
thetransmitter.org
Amid NIH upheaval, how to keep sex as a biological variable
Even in the absence of formal instruction to do so, we should continue to hold our colleagues accountable for SABV practices.
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Eric Topol @erictopol.bsky.social · 01/03/2025
Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter www.nytimes.com/2025/03/01/u...
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Nuno Miguel Gonçalves @scinuno.bsky.social · 25/02/2025
🗣️ℹ️How do we prevent misinformation? By talking about it, without reservations and full openness. 🧫🐁It is the same with science communication and #AnimalResearch specifically. 💉💡Even if you somehow oppose it… know why it is still needed.
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Federico Soria @soriafn.bsky.social · 04/02/2025
This is today. No recording, so it won't be available in our website. Don't miss it!
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Christian Frezza @frezzalab.bsky.social · 31/01/2025
I would love to hear your views on this article. I discuss some hurdles I faced when thinking about experiments and projects design. This is something no one formally teaches you. network.febs.org/posts/thinki...
network.febs.org
Thinking like a scientist: not that trivial
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Amanda Sierra @sierralab.bsky.social · 02/02/2025
🧪🧠
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Agnes Nadjar @agnesnadjar.bsky.social · 30/01/2025
Interested in pursuing a PhD in neuroimmunology and metabolism? Apply to this call to work on a collaborative project between my group and @cmadore.bsky.social !
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Amanda Sierra @sierralab.bsky.social · 29/01/2025
"The human mind is not, like ChatGPT a lumbering statistical engine for pattern matching, gorging on terabytes of data and extrapolating the most likely conversational response, most probable answer to a scientific question" Noam Chomsky: The False Promise of ChatGPT www.nytimes.com/2023/03/08/o...
nytimes.com
Opinion | Noam Chomsky: The False Promise of ChatGPT (Published 2023)
The most prominent strain of A.I. encodes a flawed conception of language and knowledge.
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European Microglia Webinar Series @microgliaseries.bsky.social · 28/01/2025
📢New webinar coming soon📢  Dr. Gilbert Di Paolo from Denali Therapeutics will be our next speaker on February 4th. Check all the information in the flyer and add it to your calendar!
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Amanda Sierra @sierralab.bsky.social · 16/01/2025
Contact me if you are interested in pursuing an independent position in Neuroscience 🧪🧠 at Achucarro @achucarro.bsky.social calls.ikerbasque.net
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Amanda Sierra @sierralab.bsky.social · 15/01/2025
Any #SpatialTranscriptomics people out there interested in studying #microglial development? We need a collaborator based in the Americas or Asia to apply for a #HSPF grant www.hfsp.org/funding/hfsp...
hfsp.org
Research Grants | Human Frontier Science Program
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Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · 12/01/2025
“‘It’s very easy to assume that science is going to change organically towards equality — and what this study shows is that that’s not happening…It is an ‘important reminder for us that we need to stay vigilant in working towards equality in science’” @crsugimoto.bsky.social 🧪 #AcademicSky 👩🏽‍🔬
nature.com
Who’s quitting academia? Data reveal gender gaps in surprising fields
Even in scientific areas in which women are well represented, they are up to 40% more likely than men to leave research within 20 years.
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Amanda Sierra @sierralab.bsky.social · 08/01/2025
I think the field needs to reconsider the widespread concept that microglia are The most important factor controlling synaptic pruning.🧠🧪 We offered our Perspective on whether they are hunters or gatherers of synaptic debris here www.nature.com/articles/s41...
nature.com
Microglia as hunters or gatherers of brain synapses - Nature Neuroscience
How microglia sculpt brain circuits is not clear. Here, the authors propose that their contribution to synapse removal may occur by severing synapses (culling) or collecting synapses shed off by neuro...
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Amanda Sierra @sierralab.bsky.social · 11/12/2024
Happy to share our Perspective on #microglia #pruning and help to answer the questions of whether they are hunters or gatherers of brain #synapses 🧠🧪 #neuroskyence nature.com/articles/s4159…
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Amanda Sierra @sierralab.bsky.social · 09/12/2024
The call is now open! Junior postdocs deadline: Jan 17 Senior postdocs deadline: Jan 21
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Amanda Sierra @sierralab.bsky.social · 05/12/2024
#Microglia lovers, winter is coming and along will come the #JuanDeLaCierva and #RamonyCajal calls for junior and senior postdocs! DM or email me if you are interested in learning how risk genes for neurodegenerative diseases affect microglial early development.
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Amanda Sierra @sierralab.bsky.social · 05/12/2024
Here is the new account in Bluesky that every #microglia lover or afficionado should follow.🧪 You can find a repository of previous talks at www.achucarro.org/es/european-...
achucarro.org
European Microglia Webinar Series - Achucarro Basque Center for Neuroscience
European Microglia Webinar Series As from October 2023 a group of researchers of the University of Lausanne (CH) and ACHUCARRO have taken over the organization of the European Microglia webinar series...
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Amanda Sierra @sierralab.bsky.social · 03/12/2024
Anybody else experiencing problems with #primerblast? It takes forever or doesn't work at all! Alternatives for designing #qPCR primers, anybody? 🧪
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Amanda Sierra @sierralab.bsky.social · 03/12/2024
Look @eara.eu , another example of animal research succesfully leading to human therapies
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GalhardoLab @galhardolab.bsky.social · 02/12/2024
The Era-Net NEURON has produced a series of 4 short videos on #PainScience 🧠 ✨ Leading neuroscientists discuss the science of pain and the evolution of research in this field. #PainScience #Neuroscience #Research www.youtube.com/watch?v=ubGH...
youtube.com
What About Pain: What is Pain
YouTube video by ERA-Net NEURON
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Canadian Neuroscience Seminars – Postdoctoral Series (CNS-PDS) @cns-pds.bsky.social · 02/12/2024
‼️LAST CHANCE‼️ 🇨🇦 🧠 Are you a #neuroscience #Postdoc in #Canada or #Canadian abroad? We are selecting #speakers for the 2025 Canadian Neuroscience Seminars: Postdoctoral Series. Apply by 23:59 PT TODAY. docs.google.com/document/d/1... docs.google.com/forms/d/e/1F... Questions? seminars@can-acn.org
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Amanda Sierra @sierralab.bsky.social · 02/12/2024
Wondering if AI-based compilations could ever replace metastudies... Probably not, as flaws in experimental design are not easy to identify 🧪
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Sociedad Española de Bioquímica y Biología Molecular (SEBBM) @sebbm.bsky.social · 29/11/2024
ℹ️El próximo lunes a las 11h tendrá lugar la presentación del Informe sobre transparencia en experimentación animal 2024 de COSCE en el que estarán @isabelfabregat.bsky.social @sierralab.bsky.social ,Javier Guillén @lluismontoliu.bsky.social y Sergi Vila Podéis seguirlo aquí 👇 i.mtrbio.com/xpddeznamd
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Amanda Sierra @sierralab.bsky.social · 28/11/2024
Useful read on statistics and o values!🧪🧠 In my opinion (as a user, not an statistics expert), the p value is a tool to agree that something may be going on. Without context or further confirmation by independent experimental approaches, it means nothing. It is not sacred evidence of an effect.
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Amanda Sierra @sierralab.bsky.social · 27/11/2024
Yet another reason to be on Bluesky
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Carmen Sandi @carmensandi10.bsky.social · 26/11/2024
Neuroscientists! A key message from the ALBA Network Please help us spread the word and share this with your network!!! Nominate (self-n allowed) a mid-career neuroscientist (5+ years post-PhD) for the ALBA-Roche Research Prize for Excellence in Neuroscience! 🔎http://loom.ly/_EvQvm4 🗓️20 January 2025
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Amanda Sierra @sierralab.bsky.social · 26/11/2024
"The timing of microglial sample collection influences the transcriptomic changes in a mouse model of maternal immune activation"
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Amanda Sierra @sierralab.bsky.social · 26/11/2024
I don't understand the mechanism or the rationale but looks interesting
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Johanna Joyce @johannajoyce.bsky.social · 25/11/2024
Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️ So how can we ever achieve #gender #equality? We discuss various strategies in this #Cell Commentary #WomeninSTEM www.cell.com/cell/fulltex... 🧵 1/
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Amanda Sierra @sierralab.bsky.social · 23/11/2024
"There is always an excuse masquerading as a reason given for a women about why she's not quite right for any role" The factors include: Accent Age Attractiveness Body size Class Color Communication style Marital status Pregnancy Sexual orientation
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Amanda Sierra @sierralab.bsky.social · 22/11/2024
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Amanda Sierra @sierralab.bsky.social · 22/11/2024
Very interesting group of people here
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Joachim Goedhart @joachimgoedhart.bsky.social · 22/11/2024
Reminder to update the "social links" in your ORCiD profile with your Bluesky handle:
ORCiD profile screenshot
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Amanda Sierra @sierralab.bsky.social · 22/11/2024
I used to hate ginger (it is not traditionally used in Spain) but now I use it all the time when I cook, from mashed burgers to stewed lentils.
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Amanda Sierra @sierralab.bsky.social · 21/11/2024
"Culturing microglia induces rapidly increased growth, protein content, and inflammatory protein expression. These changes are restored by engrafting in vitro cells into the brain, with xenografted human embryonic stem cell (hESC)-derived microglia closely resembling microglia from the human brain."
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Amanda Sierra @sierralab.bsky.social · 21/11/2024
Useful tool
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Patricia Fernández de Lis @pflis.bsky.social · 20/11/2024
Hola, estoy intentando hacer una lista de ciencia institucional que resulte útil a científicos periodistas y divulgadores. ¿Me ayudáis? bsky.app/profile/did:...
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Andrew Mendiola @andrewmendiola.bsky.social · 20/11/2024
I created a simple flow chart to help my lab trainees choose the most appropriate stats test in Prism (*for single-factor comparisons only). Feel free to share with your group if you think it could be helpful first start.
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Amanda Sierra @sierralab.bsky.social · 20/11/2024
"A journal name or its Impact Factor says little about the quality of any individual research article" is so true, yet so often forgotten when evaluating researchers careers...
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