Metabolic control is an integral component of B cell physiology, shaping fate decisions and effector functions, while also driving maladaptive programmes that contribute to diverse pathologies. This R...

The Rhodes Trust is an educational charity which brings together and develops exceptional people who are impatient with the way things are and have the courage to act.

Systemic lupus erythematosus is a chronic autoimmune disease that mostly affects women and it is associated with genetic variants in the X-linked gene encoding the adaptor protein TASL. This study…

Juvenile idiopathic arthritis (JIA) associated uveitis can cause vision loss in children, but mechanisms remain unclear. The authors here identify elevated CD19+IgD-CD27- double negative type 1 B cell...

Assays to monitor the metabolic state or nutrient uptake capacity of immune cells at a single cell level are increasingly in demand. One assay, used by many immunologists, employs 2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose ...

OverviewLymph node (LN) metastasis is a hallmark of disease progression in most solid tumors and remains one of the most consistent predictors of poor prognosis and reduced overall survival. In partic...

Prof Alex Clarke, Associate Professor at the Kennedy Institute and Honorary Consultant Rheumatologist, has received a prestigious €2m European Research Council (ERC) Consolidator Grant to study cellul...

α/β-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase, and its expression in CD4 + T-cells has been linked to remission status in rheumatoid arthritis. Here the authors repo...

T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy commonly driven by NOTCH1 activating mutations. A concomitant feature asso…

Functional and metabolic properties of innate-like T cells — namely, iNKT cells, MAIT cells and some γδ T cells — differ from those of conventional T cells. This Review describes how metabolic pathway...

Apply for a PhD: MRC CoRE in Exposome Immunology at The University of Manchester

The Administrative Assistant will lead the scheduling and administration of external and internal seminars, with management and faculty meetings, social events, and special events such as institute re...

Metabolic reprogramming is a well-established hallmark of macrophage activation, coordinating bioenergetic and biosynthetic pathways to support immune effector functions. A new study now reveals a pre...

Immune checkpoint blockade influences the genetically determined relationship between TCR repertoire and HLA alleles in cancer.

A new Medical Research Council Centre of Research Excellence (MRC CoRE) will investigate how the environment interacts with our immune system to trigger chronic inflammatory diseases, such as asthma, ...

Immune responses lie at the heart of almost every aspect of human health, including host responses to infection, autoimmunity, cancer, metabolism and aging. While adaptive immune responses by B and T…

The lungs are constantly exposed to the external environment and a myriad of antigenic challenges within the air. Chronic exposure to allergens and...