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Rupert Beale

@bealelab.bsky.social
6.5K followers 1.3K following 295 posts

Group Leader, Cell Biology of Infection Lab @thecrick; Nephrologist @Royal Free Hospital. Own views etc.

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Rupert Beale @bealelab.bsky.social · 25/09/2026
I know I’m very late to this particular party, but I just wanted to point out that the Toyota Verso implies the existence of a Toyota Recto.
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Rupert Beale @bealelab.bsky.social · 07/09/2026
This is a chicken curry that my son made. Banging!
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Kristian G. Andersen @kgandersen.bsky.social · 05/09/2026
Important context missing from all the reporting I have seen so far is the fact that Kadlec is a major Lab Leaker and with one of the craziest “hypotheses” to boot - that SARS-CoV-2 was a bioweapon, specifically created to target the brain but, weirdly, also a vaccine… That’s critical context.
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Rupert Beale @bealelab.bsky.social · 23/08/2026
Barbecue.
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Rupert Beale @bealelab.bsky.social · 29/07/2026
Lab retreat last week - we had some really delicious food prepared by various different lab members. My contribution was Pasta alla Norma (yes, that’s Ricotta Salata). Many thanks to University of Bristol people (Jon, Berni, Harriet) for hosting!
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I Fagiolini @ifagiolini.bsky.social · 24/07/2026
Took us 40 years but here it is: Monteverdi 1610 recording with @ecse1610.bsky.social Buy it (buy it?) here or stream for free of course... orcd.co/ifagmont1610 (Actual release Sep 4th but a few films are appearing now.
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Rupert Beale @bealelab.bsky.social · 20/07/2026
On the plus side this doesn’t look like a cabinet prepared to spend political capital on the so called assisted dying bill. Let’s hope.
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Rupert Beale @bealelab.bsky.social · 20/07/2026
In the past 10 years there have been 10 education Secretaries of State and 9 for health. This is no way to run anything, leadership of my second XI village cricket team has been more stable (and probably on average more able individuals).
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Rupert Beale @bealelab.bsky.social · 25/05/2026
Super happy to be here!
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Rupert Beale @bealelab.bsky.social · 06/05/2026
Went to an incredible concert tonight at Sir Ian McKellan’s house. Simon O’Neill singing Dichterliebe accompanied by my father. Surreal, in the best way.
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Rupert Beale @bealelab.bsky.social · 24/04/2026
Fantastic paper, found out about it from @dalan-bailey.bsky.social himself today!
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Rupert Beale @bealelab.bsky.social · 17/04/2026
Paccheri stuffed with aubergine, spinach and ricotta in tomato sauce with scamorza affumicato.
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Rupert Beale @bealelab.bsky.social · 05/04/2026
Really extraordinary Easter Vigil Mass I sang at: 37 confirmations!!!! Mostly also getting baptised rather than switching denominations. Nothing like it in my lifetime. We sang Byrd Haec Dies.
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Antonia Bance MP @antoniabance.bsky.social · 17/03/2026
Wonderful news from Scotland. So many congratulations to my colleagues campaigning against assisted dying who never gave up.
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Rupert Beale @bealelab.bsky.social · 16/02/2026
Am at the Old Vic. Lady behind me is recounting how she went to the opening night of Arcadia with Isaiah Berlin. Who apparently remarked “oh it’s just too clever clever clever”.
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Rupert Beale @bealelab.bsky.social · 02/02/2026
Good thread. The bill is really, really bad.
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Rupert Beale @bealelab.bsky.social · 02/02/2026
Fresh from organising #ksautophagy25 with Christie and Leon I’m now off to #ksautophagy26 - doesn’t seem that long ago! Hopefully people will be interested to hear about viruses and CASM.
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Flo Débarre @flodebarre.eurosky.social · 16/01/2026
Did they read what they cite? In @natmed.nature.com, NIH& NIAID leaders complain about a decrease in public trust, and cite a survey pointing to the Republicain administration as responsible for the recent decrease! www.nature.com/articles/s41... www.annenbergpublicpolicycenter.org/public-confi...
quotes from the linked websites: 
" We recognize that much of the American public lost trust in the NIAID, the National Institutes of Health (NIH; of which the NIAID is a part), and in the greater scientific community.
Taubenberger, Powers & Bhattacharya, Nature Medicine
https://www.nature.com/articles/s41591-025-04160-1

Reference 4: Public confidence in U.S. health agencies slides, fueled by declines among Democrats. ASAPH/Annenberg Science Knowledge surveys (Annenberg Public Policy
Center, 2025).
https://www.annenbergpublicpolicycenter.org/public-confidence-in-u-s-health-agencies-slides-fueled-by-declines-among-democrats/
"The decline in confidence among Democrats comes amid
persistent attacks by leaders in the Republican administration about the competence and integrity of the health agencies.
" Confidence in Fauci, who stepped down from his NIAID post at the end of 2022, is statistically unchanged since
October
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Gregg Gonsalves @gregggonsalves.bsky.social · 16/01/2026
João Monteiro and the editorial board of @naturemedicine.bsky.social should be ashamed of themselves for publishing this trash. www.nature.com/articles/s41...
nature.com
The new vision from the National Institute of Allergy and Infectious Diseases (NIAID) - Nature Medicine
Preparing for tomorrow’s threats by enhancing our ability to help patients today.
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Jon Lim, FRCP PhD @drjonlim.bsky.social · 02/01/2026
My main PhD paper is finally out! 🎉 After ~5 years, it’s published today in 𝘕𝘢𝘵𝘶𝘳𝘦 𝘐𝘮𝘮𝘶𝘯𝘰𝘭𝘰𝘨𝘺. @natimmunol.nature.com It all started with an unexpected observation 🔍: 👉 Mice lacking the dendritic cell receptor DNGR-1 developed tumours earlier ⏩ and more frequently 📈 than wild-type mice. 1/11 🧵
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Stephen Royle @steveroyle.bsky.social · 16/12/2025
Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there?? #CellBiology #WTFology www.biorxiv.org/content/10.6...
biorxiv.org
The vault associates with membranes in situ
The eukaryotic vault particle is a giant ribonucleoprotein complex that assembles into an iconic barrel-like cage. Its cellular function has remained elusive despite extensive characterization. Using ...
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Lucy Fishwife 🥐 @lucyfishwife.bsky.social · 13/12/2025
Oh! And happy St Lucy’s Day, one and all, may your eyes be healthy and free of infection
St Lucy with her eyes on a plate, Muppet stylee
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Rupert Beale @bealelab.bsky.social · 25/11/2025
Lamb Koftas (before and after).
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Stefan Marciniak @profmarciniak.bsky.social · 11/11/2025
From the Rare Kidney Disease Centre
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Stefan Marciniak @profmarciniak.bsky.social · 11/11/2025
In London for the @lifearc.bsky.social annual meeting
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The Francis Crick Institute @crick.ac.uk · 30/10/2025
Just a few weeks left to apply for our clinical PhD programme. We're looking for clinicians who are passionate about research to join the 3-year fully funded programme. Learn more and see what positions are available ⬇️ www.crick.ac.uk/careers-and-...
crick.ac.uk
Doctoral clinical fellows
The Crick's clinical PhD programme.
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Rupert Beale @bealelab.bsky.social · 30/10/2025
Are you a clinician who wants to do a PhD? Come to @crick.ac.uk (you can even come to my lab).
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Angie Rasmussen @angierasmussen.bsky.social · 11/10/2025
I don’t know who needs to hear this but the CDC is being eviscerated right now. America is not going to have any kind of outbreak response capacity after tonight. Americans’ health data is no longer secure. Say goodbye to federal public health in any capacity. It’s a disaster. We won’t recover.
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Rupert Beale @bealelab.bsky.social · 10/10/2025
Do you want to do a PhD with me and Mike Devine? Of course you do! Or if not, maybe you know someone who does? @devinelab.bsky.social www.crick.ac.uk/careers-stud...
crick.ac.uk
Beale & Devine Lab | Role of the V1H subunit of the V-ATPase in neurons and cell-autonomous immune responses
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Rupert Beale @bealelab.bsky.social · 14/09/2025
Carbonara.
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Rupert Beale @bealelab.bsky.social · 13/09/2025
@southlondongirl.bsky.social right so I don’t recommend swimming with your iPhone in your pocket. Long story, also boring. But Sicily, excellent, @flossieteacake.bsky.social said I should share this pasta alla Norma with you. It’s got Ricotta Salata and everything. Aces. Shall we do dinner sometime?
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Kristian G. Andersen @kgandersen.bsky.social · 15/08/2025
The main thing - is it not already clear - RFKr Jr is uniquely unqualified to lead the HHS. All main agencies under his watch - NIH, FDA, CMS - are also headed by incompetent contrarian peddlers of disinformation, conspiracy theories, and pseudoscience. This will, and already does, cost lives.
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Simon Fisher @profsimonfisher.bsky.social · 07/08/2025
If someone you know buys into claims about "genetic optimization" of embryos using polygenic scores of cognition, just send them our 2024 paper on Beethoven & musicality. We wrote it to help communicate limits of individual-level genetic predictions & complexity of links between DNA & behaviour. 🧪👇
cell.com
Notes from Beethoven’s genome
Wesseldijk et al. compare the genomic information collected from Ludwig van Beethoven with population-based datasets used to quantify musical achievement.
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Dana Stevens @thehighsign.bsky.social · 13/08/2025
I know we're supposed to reflexively dismiss the loss of any niche subject in the humanities, but this is a big part of why the university exists: so a student who wants to learn Basque can learn Basque. & the reason a school can offer that class is because THEY HAVE A ROMANCE LANGUAGES DEPARTMENT.
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Rupert Beale @bealelab.bsky.social · 14/08/2025
Surely you meant to write ‘formerly a world class institution’?
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Keystone Symposia @keystonesymposia.bsky.social · 17/07/2025
🎥 The Keystone Symposium on Autophagosomes & Endolysosomes is now on demand! Watch talks on lysosome‑mediated quality control, nutrient regulation & cell signaling—insights from leaders in the field . 👉 keysym.us/KSAutophagy2... #KSAutophagy25 #autophagosome #endolysosomes @bealelab.bsky.social
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Keystone Symposia @keystonesymposia.bsky.social · 28/06/2025
The Autophagosomes & Endolysosomes meeting wraps today in Whistler, capping days of deep insight into lysosomal biology & autophagy. 👏 Congrats to our Keystone scholarship awardees—your future in science is bright! 🔗 keysym.us/scholarships... #KSAutophagy25 @bealelab.bsky.social
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Rupert Beale @bealelab.bsky.social · 20/06/2025
Cheering myself up by reminding myself this is happening next week.
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Harvard Med Cell Biology @harvardcellbio.bsky.social · 17/06/2025
Chan Lee @harperlabhms.bsky.social reports CASM-driven V-ATPase recruitment to lysosomes for acidification upon TRPML1 activation via DMXL1-RAVE loader. With Magdalene Moran(Caraway), Sophie Helaine lab, Joao Paulo, & HarperLab teams(HMS). Funds: Warren Alpert FND/NIH www.nature.com/articles/s41...
nature.com
DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation - Nature Structural & Molecular Biology
Lee et al. show that DMXL1, a regulator of V-ATPase assembly, is recruited to lysosomes upon TRPML1 activation in a manner dependent on conjugation of ATG8 proteins on lysosomal membranes (CASM) and p...
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Dr Rachel Clarke @drrachelclarke.com · 19/06/2025
Sharing this on the eve of tomorrow's vote. I am a palliative care doctor who is not opposed to AD. But enshrining in law a state-funded right to die, while not enshrine a similar right to the palliative care that might make life worth living, is so very wrong. www.theguardian.com/commentisfre...
theguardian.com
MPs have personal beliefs, but also solemn duties: that’s why they must reject the assisted dying bill this week | Gordon Brown
Our obligations to each other are ill served if laws focus unduly on those who want assisted dying. The priority should be the best palliative care, says former prime minister Gordon Brown
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Stefan Marciniak @profmarciniak.bsky.social · 10/06/2025
Robert F Kennedy Jr said he is “retiring” all 17 members of a crucial government panel of vaccine advisors He is removing all members of the Advisory Committee on Immunization Practices, which advises the CDC and Prevention This could serious damage US health www.cnbc.com/2025/06/09/r...
cnbc.com
RFK Jr. removes all members of CDC panel advising U.S. on vaccines
It's the latest move by Kennedy – a prominent vaccine skeptic – to change and potentially undermine vaccinations in the U.S. since he took the helm at HHS.
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Royal College of Physicians @rcphysicians.bsky.social · 09/06/2025
We have raised concerns about existing deficiencies in the Terminally Ill Adults (End of Life) Bill. We believe the bill in its current form lacks adequate protections for patients and professionals. Full statement: ow.ly/EOhP50W692q
ow.ly
‘Deficiencies in protecting patients and professionals’ - RCP publishes its position on the Terminally Ill Adults (End of Life) Bill
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Rupert Beale @bealelab.bsky.social · 05/06/2025
Well this wasn’t at all 100% predictable.
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Rupert Beale @bealelab.bsky.social · 26/05/2025
Bank holiday Beef Wellington. And yes I am wearing cricketing whites.
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Rupert Beale @bealelab.bsky.social · 14/05/2025
So important.
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The Royal College of Psychiatrists @rcpsych.bsky.social · 13/05/2025
@rcpsych.bsky.social cannot support the Terminally Ill Adults (End of Life) Bill for England and Wales in its current form and is once again urging MPs to look at our concerns ahead of the pivotal Commons Report stage debate and Third Reading. More here: www.rcpsych.ac.uk/news-and-fea...
rcpsych.ac.uk
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Dr Rachel Clarke @drrachelclarke.com · 12/05/2025
1 in 5 of the UK’s care workforce have a non-British passport. Starmer would have us believe these carers are the “squalid” result of a “failed experiment”. I say they do vital, necessary, humane, skilled work and they are worth their weight in gold.
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Rupert Beale @bealelab.bsky.social · 12/05/2025
Also birth rate would need to go up. Currently very difficult economically for young couples to have kids.
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Rupert Beale @bealelab.bsky.social · 01/05/2025
Worth a follow!
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Rupert Beale @bealelab.bsky.social · 21/04/2025
Pie.
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