Reposted by @zion123.bsky.socialStructural Biology Communications @actacrystf.iucr.org · 13/08/2026Presenting the first article in our new 'Protocols' category: Helical reconstruction of amyloids in cryoSPARC #Amyloids #CryoEM #HelicalReconstruction doi.org/10.1107/S205... 0114
Reposted by @zion123.bsky.socialJeremy Berg @jeremymberg.bsky.social · 03/07/2026Hugely important point! Industry takes risks in developing drug candidates and then bringing chosen ones into clinical trials. Academia takes risks in developing students and helping them become more capable of being independent scientists in industry, academia, and other sectors. 06410
Reposted by @zion123.bsky.socialMatteo Carandini @carandinilab.net · 26/06/2026"NIH officials are telling grantees who submitted annual progress reports [...] to remove papers that name co-authors affiliated with foreign institutions if NIH had not previously approved a foreign component." Sad and absurd in so many ways. 58536
Reposted by @zion123.bsky.socialJeremy Berg @jeremymberg.bsky.social · 03/06/2026My quote of the day Science doesn't care, by and large, what the answers are. It's only interested in getting the right answer. And journalism should be very much that way. Scott Pelley 424762
Reposted by @zion123.bsky.socialMax Perutz Labs Vienna @maxperutzlabs.ac.at · 03/06/2026One frame. Many voices. 💪 Ursula Schöberl (Ameres lab) studied Molecular Biology at the University of Vienna. Since joining the Ameres lab in 2024, she has been exploring miRNA biogenesis – bringing the same endurance and persistence to science that she sees in sports 🏃♀️ 152
Reposted by @zion123.bsky.socialMatthew Bowler @mattbowler.bsky.social · 03/06/2026This was a game changer for our 88 kDa kinase complex www.biorxiv.org/content/10.6...biorxiv.org 0143
Reposted by @zion123.bsky.socialProf Gavin Yamey MD MPH @gavinyamey.bsky.social · 11/05/2026The one other thing I would say: I’ve never seen a better example of how NOT to do public health & infectious disease communications Bhattacharya broke literally every single rule of Comms 101 & we’re going to be using this interview for teaching purposes for generations Utter train wreck 🤦♂️ 571423380
Reposted by @zion123.bsky.socialPujuan Poppy Deng @poppy-pujuan-deng.bsky.social · 16/04/2026I am so excited to share our new findings with you! We provide the structural evidence for a direct protein-to-DNA information pathway, showing how a bacterial enzyme 'reads' its own structure to 'write' DNA. www.science.org/doi/10.1126/... 7231101
Reposted by @zion123.bsky.socialStephen Curry @scurry.bsky.social · 18/04/2026Paper in Science: “Protein-templated synthesis of dinucleotide repeat DNA by an antiphage reverse transcriptase.” A funky finding, though Crick’s Central Dogma remains intact. www.science.org/doi/10.1126/... 051
zion123.bsky.social @zion123.bsky.social · 18/04/2026www.science.org/content/arti...science.orgScience | AAAS 000
Reposted by @zion123.bsky.socialKarolin Luger @nucleosomepolice.bsky.social · 11/04/2026this 👇🧪👇🧪👇🧪👇🧪👇🧪 agree 💯 04212
Reposted by @zion123.bsky.socialAlisia Fadini @alisiafadini.bsky.social · 01/04/2026ROCKET 🚀 inference-time optimization of AlphaFold to fit structural data is published! rdcu.be/fa9YH Since our preprint, we’ve pushed it to regimes where other methods break: low resolution, weak signal, real experimental edge cases. Here’s what we learned: 1/15rdcu.beAlphaFold as a prior: experimental structure determination conditioned on a pretrained neural networkNature Methods - ROCKET improves experimental structure elucidation by integrating implicit structural knowledge from OpenFold, a trainable reimplementation of AlphaFold2, with X-ray... 112751
Reposted by @zion123.bsky.socialPrism Science @prismscienceorg.bsky.social · 11/03/2026Radial is live! A new organization at @asterainstitute.bsky.social bringing together structural biologists, engineers, and ML scientists to redesign how we do science. @statnews.com has the story: www.statnews.com/2026/03/11/r...statnews.comNew nonprofit launches with at least $500 million to modernize scientific process for AI eraA new nonprofit called Radial is launching with at least $500 million to modernize the scientific process for the AI era. 116
Reposted by @zion123.bsky.socialStephanie Wankowicz @stephanieaw.bsky.social · 12/03/2026Excited to share Sampleworks led by @karsonchrispens.bsky.social with @diffuseproject.bsky.social. It's a modular framework connecting structure predictors to experimental data and guidance methods. Swap predictors or guidance methods. All open and made to be built upon. t.co/fvNHH3gfVut.cohttps://diffuse.science/posts/sampleworks/ 1209
Reposted by @zion123.bsky.socialJeremy Berg @jeremymberg.bsky.social · 25/03/2026Good discussion of the disappearing NIH Notices of Funding Opportunity (NOFOs). elizabethginexi.substack.com/p/the-nofo-g...elizabethginexi.substack.comThe NOFO GraveyardA Response to NIH's Defense of Its Vanishing Funding Opportunities 32914
Reposted by @zion123.bsky.socialCarter Lab @carter-lab.bsky.social · 24/03/2026Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6... 620684
Reposted by @zion123.bsky.socialLeah Lavery @helloleahlavery.bsky.social · 23/03/2026Congratulations to Dr. Julia Mahamid on receiving the 2026 Gottfried Wilhelm Leibniz Prize! 🎉 Her pioneering work in cryo-ET is reshaping our understanding of how molecular architecture drives cellular processes and disease. #teamtomo #LeibnizPrize #StructuralBiology #LifeSciences #Innovationdfg.deJulia Mahamid, Ph.D. – Gottfried Wilhelm Leibniz Prizewinner 2026 06111
Reposted by @zion123.bsky.socialJeremy Berg @jeremymberg.bsky.social · 24/03/2026My quote of the day When we were children, we used to think that when we were grown-up we would no longer be vulnerable. But to grow up is to accept vulnerability... To be alive is to be vulnerable. Madeleine L'Engle 531039
Reposted by @zion123.bsky.socialEle Willoughby @minouette.bsky.social · 20/03/2026Happy birthday to 🇨🇦Canadian medical researcher & #biochemist Maud Menten (1879-1960). 👩🏼🔬🧪🐡 #histsci Not only was she an author of Michaelis-Menten equation for enzyme kinetics, she invented the azo-dye coupling for alkaline phosphatase, 1st example of enzyme histochemistry, still used in imaging of 210235
Reposted by @zion123.bsky.socialNicholas Scott Baker @renhistorian.bsky.social · 20/03/2026"Based on this study, as more of the global population begins to rely on artificial intelligence to complete complex tasks, our cognitive abilities and creative capacities appear poised to take a nosedive into oblivion." publichealthpolicyjournal.com/mit-study-fi...publichealthpolicyjournal.comMIT Study Finds Artificial Intelligence Use Reprograms the Brain, Leading to Cognitive Decline - Science, Public Health Policy and the LawBy Nicolas Hulscher, MPH 54527
Reposted by @zion123.bsky.socialDavide Mercadante @mercadantelab.bsky.social · 19/03/2026Now published in JACS🚨!! We introduce Martini3-NMR: a framework that can incorporate NMR observables directly into coarse-grained Martini models. This enables experimentally driven, high-efficiency & high-accuracy simulations in the wake of integrative biophysics! pubs.acs.org/doi/10.1021/...pubs.acs.orgIntegrating NMR Restraints into Coarse-Grained Simulations: Toward Accurate Conformational Ensembles of Complex Protein SystemsStructural dynamics play critical roles for the biological activity of protein molecules. Characterizing the inherent conformational landscapes of these macromolecules remains a major experimental and... 1209
Reposted by @zion123.bsky.socialDerek Lowe @dereklowe.bsky.social · 17/03/2026What goes on in a collection of assays in purified proteins can be very different from what happens in a living well. Case in point:science.orgIn Cells and Outside of Them 2297
Reposted by @zion123.bsky.socialGeorge O'Toole (he/him/his) @geiselbiofilm.bsky.social · 17/03/2026The society journals are established, the editors and reviewers are actual working scientists, there are outstanding staff and infrastructure to handle submissions. Publishing is complicated - so why reinvent the wheel, again (i.e., we tried preprint servers - helpful but not the answer) 012
Reposted by @zion123.bsky.socialSTCmicrobeblog @stcmicrobeblog.bsky.social · 16/03/2026@geiselbiofilm.bsky.social @richardsever.bsky.social this 👇 might be of interest to you (if you don't already know about it) bjoern.brembs.net/2026/02/afte...bjoern.brembs.netAfter decades of debating the “scientific publishing crisis”, the time has come to decide.This is an English translation of my original German contribution to the Merkur Blog in response to the contributions by Gehring and Tautz. “Scientific publishing” may sound like a minor rung in the i... 223
Reposted by @zion123.bsky.socialbioRxiv Microbiology @biorxiv-microbiol.bsky.social · 17/03/2026Non-canonical peptidoglycan cross-linking is essential for Mycobacterium tuberculosis acid resistance www.biorxiv.org/content/10.64898/20… 042
Reposted by @zion123.bsky.socialMartin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 17/03/2026AlphaFold database has entered the era of complexes. Together with NVIDIA, DeepMind and EBI, we use ColabFold, OpenFold and MMseqs2-GPU to predict ~31 million complexes (homo & hetro-dimers) resulting in 1.8 million high-quality predictions 📄 research.nvidia.com/labs/dbr/ass... 🌐 alphafold.ebi.ac.uk 8263110
Reposted by @zion123.bsky.socialRoland Dunbrack 🏳️🌈 @rolanddunbrack.bsky.social · 05/09/2025Honored to receive the 2026 DeLano Award from @asbmb.bsky.social. Warren wrote PyMOL which I spend several hours a day with -- a hero for open & accessible software. Helen Berman, another of my heroes, nominated me (with help from Ruth Nussinov & Janet Thornton), three women I admire tremendously. 96811
Reposted by @zion123.bsky.socialKathleen Bachynski @bachynski.bsky.social · 06/09/2025Keep advocating! “Kerry Kennedy, sister of Robert F. Kennedy Jr., has joined her nephew, former Massachusetts Rep. Joseph P. Kennedy III, calling on her brother to resign… “Medical decisions belong in the hands of trained and licensed professionals, not incompetent and misguided leadership”statnews.comRFK Jr.’s sister, nephew call for him to resign from HHS“Enough is enough”: RFK Jr.’s sister and other Kennedy family members are calling for the HHS secretary to step down. 11936621
Reposted by @zion123.bsky.socialSam Bagenstos @sbagen.bsky.social · 06/09/2025A really good explanation of why relying on cherry-picked science to draw a Tylenol-autism link (as RFK seems poised to do) is really harmful, along with a reminder that Tylenol deserves a lot of scrutiny for other reasons. open.substack.com/pub/insideme...open.substack.comTylenol has entered the chat: RFK Jr. wants to link it to autism, even though the best evidence says otherwise.It's not pseudoscience. But it's not settled either, nor is it "safe" to assume otherwise. 57423
Reposted by @zion123.bsky.socialJeremy Berg @jeremymberg.bsky.social · 01/09/2025My quote of the day Nobody ever thanks you for saving them from the disease they didn't know they were going to get. William Foege 61139208
Reposted by @zion123.bsky.socialAtul Gawande @agawande.bsky.social · 01/09/20259 CDC Directors going back to 1977 speak out. What RFK Jr has done to our nation’s public health system "should alarm every American." It "is unlike anything we have ever seen at the agency, and unlike anything our country has ever experienced." www.nytimes.com/2025/09/01/o...nytimes.comOpinion | We Ran the C.D.C.: Kennedy Is Endangering Every American’s Health 321117985124
Reposted by @zion123.bsky.socialEric Topol @erictopol.bsky.social · 02/09/2025Good news. The House of Representatives stands behind the NIH budget with no cuts. 211053142
Reposted by @zion123.bsky.socialJeremy Berg @jeremymberg.bsky.social · 29/08/2025I stand with Joachim Frank. I would hope that others would have had a better understanding of history. 2/2 313130
Reposted by @zion123.bsky.socialStefano Canossa @stecanossa.bsky.social · 26/08/2025"Success for all", from his University's motto to a life that changed everyone else's... Today's #ECM35 starts with a lecture filled with emotions and anecdotes by Isabel Usón, remembering George Sheldrick #crystallography 0153
Reposted by @zion123.bsky.socialDerek Lowe @dereklowe.bsky.social · 14/08/2025No matter how hard you try, you simply cannot guess the journal withe the highest “impact factor” in organic chemistry last year. Really. Nor will you guess many of the other “winners”:science.orgJournal Impact Nonsense 147626
Reposted by @zion123.bsky.socialChimeraX @chimerax.ucsf.edu · 20/08/2025Here's how to predict binding of tens or hundreds of small molecules to protein assemblies using Boltz 2 in ChimeraX. Accuracy depends on how similar the ligands and binding pockets are to existing experimental structures. www.rbvi.ucsf.edu/chimerax/dat... 0279
Reposted by @zion123.bsky.socialBarbara Neuhoff @barbaraneuhoff.bsky.social · 23/08/2025Neil deGrass Tyson: "How sad it must be believing that scientists, historians, scholars, economists, journalists devoted their entire lives to deceiving you, but a reality-TV star proven in court to be a lying felon is your beacon of truth & honesty" 284179925346
Reposted by @zion123.bsky.socialGregg Gonsalves @gregggonsalves.bsky.social · 23/08/2025Want to see the economic impact of #NIH grant cuts in your community? Check out @joshuasweitz.bsky.social and colleagues' project here. Tell your friends and neighbors what is happening. scienceimpacts.orgscienceimpacts.orgSCIMaP - Impacts of Federal Cuts to Science and Medical ResearchDeveloped by an interdisciplinary research team, this website shows how funding cuts reduce economic activity and employment nationwide 7342238
Reposted by @zion123.bsky.socialStephen Curry @scurry.bsky.social · 24/08/2025And a further report on his use of made-up science to attack climate change policies. www.nature.com/articles/d41... 3/4nature.comOutrage over Trump team’s climate report spurs researchers to fight backThe authors welcome ‘serious’ scientific rebuttals to report that some say misrepresents decades of climate science. 222
Reposted by @zion123.bsky.socialStephen Curry @scurry.bsky.social · 24/08/2025Three pieces in Nature this week on Trump’s assaults on science. An editorial on the cancellation of $500m funding for mRNA vaccine research www.nature.com/articles/d41... 1/4nature.comCancelling mRNA studies is the highest irresponsibilityThe rest of the world is not following the US government’s dangerous path, and will stick with the technology that helped the world out of the COVID-19 pandemic. 175
Reposted by @zion123.bsky.socialeLife @elife.bsky.social · 24/08/2025Cryogenic electron microscopy has been used to determine the detailed structure of an intermediate state called a “D-loop” that forms when strands of DNA are exchanged during homologous recombination. buff.ly/ofD02RD 0297
Reposted by @zion123.bsky.socialZeynep Baharoglu @zeynepbaharoglu.bsky.social · 13/08/20255-Methyluridine is Ubiquitous in Pseudomonas aeruginosa tRNA and Modulates Antimicrobial Resistance and Virulence www.sciencedirect.com/science/arti...sciencedirect.com5-Methyluridine is Ubiquitous in Pseudomonas aeruginosa tRNA and Modulates Antimicrobial Resistance and VirulenceBuilding on decades of work in characterizing the dozens of RNA modifications in the microbial epitranscriptome, recent advances in analytical technol… 022
Reposted by @zion123.bsky.socialDerek Lowe @dereklowe.bsky.social · 13/08/2025It’s certainly Not Good. 1288
Reposted by @zion123.bsky.socialSjors Scheres @sjorsscheres.bsky.social · 12/08/2025Sofia Lövestam's vault structure is now online in Structure @cellpress.bsky.social. 🥳 How beautifully explorative is #cryoEM! We never planned to do this. The vaults just came down with #amyloids from human brain tissue, and Sofia decided to have a closer look. www.cell.com/structure/fu...cell.comCryo-EM structure of the vault from human brain reveals symmetry mismatch at its capsLövestam and Scheres present a cryo-EM structure of vault particles, found during tau filament extraction from progressive supranuclear palsy (PSP) brain tissue. They reveal a symmetry shift at the va... 312529
Reposted by @zion123.bsky.socialSeemay Chou @seemaychou.bsky.social · 12/08/2025What’s the next PDB? Maybe it’s …the PDB. We just launched @diffuseproject.bsky.social a structural biology initiative exploring protein motion & rethinking how we generate and use experimental data. Quick 🧵👇 www.diffuse.sciencediffuse.scienceThe Diffuse ProjectThe Diffuse Project 45315
Reposted by @zion123.bsky.socialAndo Lab @andolab.bsky.social · 13/08/2025We are proud to announce our newest adventure! Introducing the Diffuse Project, a community-driven effort to predict protein dynamics using the subtle diffuse scattering signal from protein crystals. This collaboration marks a new era for the Ando lab! as.cornell.edu/news/philant... 🧪 🧬🧶 💫as.cornell.eduPhilanthropic support accelerates infrastructure for the future of structural biologyA new $5 million initiative, funded by the Astera Institute with experimental work conducted at the Cornell High Energy Synchrotron Source, aims to make diffuse scattering accessible to the public and... 184
Reposted by @zion123.bsky.socialCarolyn Bertozzi @carolynbertozzi.bskyverified.social · 13/08/2025"meaningful and innovative health research has never flourished amid constraints on language and free exchange of ideas" 18629
Reposted by @zion123.bsky.socialDr. Rabbithole @drrabbithole.bsky.social · 12/08/2025The mRNA vaccines were miraculous. It lost public trust because there was a calculated campaign to undermine it. Jay Bhattacharya, RFK & Vinay Prasad were all accomplices in destroying trust in vaccines & science in general. More people will die as a result. www.washingtonpost.com/opinions/202...washingtonpost.comOpinion | Jay Bhattacharya: Why the NIH is pivoting away from mRNA vaccinesAs a vaccine for broad public use, mRNA technology has failed to earn the public’s trust. 1308
Reposted by @zion123.bsky.socialChristine Dunham @dunhamlab.bsky.social · 12/08/2025Our new research was just published in Nature Communications! Graduate student Evy Kimbrough, Ha An Nguyen and Jacob Mattingly contributed to this work, Our results directly answer a long-standing and fundamental question in biology of how tRNA modifications influence mRNA reading frame maintenance. 195
Reposted by @zion123.bsky.socialGéraldine Laloux @lalouxlab.bsky.social · 29/07/2025Bacterial cell wall & periplasm paradigm shift - important read #MicroSky www.nature.com/articles/s41...nature.comPeptidoglycan–outer membrane attachment generates periplasmic pressure to prevent lysis in Gram-negative bacteria - Nature MicrobiologyOuter membrane attachment to peptidoglycan enables periplasmic pressure to build up and counter cytoplasmic turgor pressure, preventing lysis during osmotic challenges in Escherichia coli. 13318