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Seemay Chou

@seemaychou.bsky.social
1.6K followers 838 following 55 posts

Scientist. Co-founder/CEO @ Arcadia Science. Board @ Astera and The Navigation Fund. Texan in CA.

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Reposted by Seemay Chou
Astera Institute @asterainstitute.bsky.social · 11/03/2026
We're expanding our life sciences work through a new division Radial led by @beckypferdehirt.bsky.social as CEO. Becky will work closely w @pracheeac.bsky.social & @seemaychou.bsky.social to lead experiments with approaches to enabling and publishing science 1/ www.statnews.com/2026/03/11/r...
statnews.com
New nonprofit launches with at least $500 million to modernize scientific process for AI era
A new nonprofit called Radial is launching with at least $500 million to modernize the scientific process for the AI era.
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Seemay Chou @seemaychou.bsky.social · 06/11/2025
We’ve been heads down @ArcadiaScience for a bit but the @arenabioworks news this week caused me to dump thoughts. hard things are hard; don’t be such a fucking hater. Reflections on parallels w our own institutional experiment here seemay.substack.com/p/big-experi...
seemay.substack.com
Big experiments are only big if they can fail
Some reflections on Arena Bioworks' unexpected wind down as a fellow institutional experimentalist
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Seemay Chou @seemaychou.bsky.social · 21/10/2025
I spend a lot of time talking to potential grantees about our open science policy. Some field notes here: open.substack.com/pub/seemay/p...
open.substack.com
Why careerism can be bad for science training
Some field notes from scholarly publishing discussions with scientists
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Reposted by Seemay Chou
Prism Science @prismscienceorg.bsky.social · 14/08/2025
Want to get involved, share your ideas, or just stay in the loop with email updates? Let us know here: forms.gle/37pK2smABwbg...
forms.gle
Diffuse Project Interest Form
Interested in the Diffuse Project? Please provide your information to help us shape community engagement and potentially direct you to the right project member.
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Seemay Chou @seemaychou.bsky.social · 13/08/2025
A note in here for other science philanthropists… we have a chance rn to help scientists rethink systems, technical & operational. They’re game to take useful risks, let’s help them. Coming soon: more open science research, experimenting outside journals… seemay.substack.com/p/from-syste...
seemay.substack.com
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Reposted by Seemay Chou
Stephanie Wankowicz @stephanieaw.bsky.social · 12/08/2025
We are thrilled to be part of Project Diffuse, building infrastructure for the dynamic future of structural biology. We are helping to lead the modeling and encoding efforts of this project, including designing infrastructure that allows AI to learn from the full complexity of experimental data.
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Reposted by Seemay Chou
Prism Science @prismscienceorg.bsky.social · 12/08/2025
Announcing the Diffuse Project! We're unlocking protein dynamics through diffuse X-ray scattering - the overlooked signal that could revolutionize how we understand protein motion. seemay.substack.com/p/from-syste...
seemay.substack.com
From systems operators to systems architects
Going up a level from data generation to think about the data systems we design and embed
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Seemay Chou @seemaychou.bsky.social · 12/08/2025
What’s the next PDB? Maybe it’s …the PDB. We just launched @diffuseproject.bsky.social a structural biology initiative exploring protein motion & rethinking how we generate and use experimental data. Quick 🧵👇 www.diffuse.science
diffuse.science
The Diffuse Project
The Diffuse Project
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Seemay Chou @seemaychou.bsky.social · 05/08/2025
After many yrs building internally @arcadiascience.com we're now able to partner more with others on cool organisms. You won't hurt my feelings if you don't read my post, but don't miss out on our first organismal spotlight animation featuring sea squirts -- just skip to the bottom! 🧵
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Seemay Chou @seemaychou.bsky.social · 05/06/2025
A v common suggestion I get re: publishing work outside journals is "if you just get some elite scientists to do it, everyone else will do it." This is an instinct that may seem sound, but here's what I've found irl:
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Seemay Chou @seemaychou.bsky.social · 03/06/2025
We did something radical that shouldn’t feel radical: we stopped funding science built for journals so that we can reimagine scientific publishing. First @arcadiascience.com. Now at @asterainstitute.bsky.social.
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Seemay Chou @seemaychou.bsky.social · 25/04/2025
We @navigation.org are looking for proposals on how to move scientific publishing into the future. If you think we can do better, stop complaining and come build by applying AI towards open science os.nav.fund/ai-for-os/
os.nav.fund
AI for Open Science - Request for Proposals
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Seemay Chou @seemaychou.bsky.social · 12/02/2025
Zoogle! Our new tool from @arcadiascience for picking research organisms. Even if you’re not a scientist, you should care that we spend >$50B/yr on clinical trials based on organismal models (>90% failure rate). Read more about Zoogle here: arcadiascience.com/blog/zoogle
arcadiascience.com
Introducing Zoogle: An Organismal Search Tool
Arcadia Science is pushing the boundaries of open science and innovating at every step in the research, development, and commercialization process.
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Seemay Chou @seemaychou.bsky.social · 23/01/2025
Today we're sharing a new data initiative @asterainstitute.bsky.social near and dear to my microbiologist heart. W all the chatter about predictive models, what would it actually take to generate data that are broadly useful/interoperable for predicting functions? astera.org/request-for-...
astera.org
Request for Information - Astera Institute
Data Requirements for Microbial Machine Learning Models What microbes can do Microbes have fundamentally shaped our bodies, our environment, and our understanding of biology. As a window into living s...
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Seemay Chou @seemaychou.bsky.social · 24/12/2024
I’ll forgive @wilbanks.bsky.social for dropping the P-word (just this once) — if you’re curious about what kinds of data initiatives we’re gettin after @asterainstitute.bsky.social give his talk a listen. More deets on some big projects coming soon 👀 youtu.be/4Xnlf-sI0DM
youtu.be
Building scalable public data sets for scientific innovation
YouTube video by Roots of Progress Institute
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Reposted by Seemay Chou
Prachee Avasthi @pracheeac.bsky.social · 22/12/2024
An example of how the limited and biased availability of data narrows the range of functional biology PLMs tap into for prediction and design research.arcadiascience.com/pub/result-p...
research.arcadiascience.com
The known protein universe is phylogenetically biased
Many protein prediction and design models rely on evolutionary comparisons. We show that popular databases are phylogenetically biased, influencing the statistical utility of the known protein univers...
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Seemay Chou @seemaychou.bsky.social · 22/12/2024
Here's another cool example from Matt Daugherty's group on how tracing evolutionary signal gives us insights into how bio inventions like vertebrate eyes were "engineered" in the wild (my only complaint is that there is no preprint for this Matt 😉). www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Seemay Chou @seemaychou.bsky.social · 22/12/2024
Picking the right research organisms/models in a data-driven way is a huge problem that will require all of us to fix -- no one denies this is a problem, no matter who you talk to (academia, pharma, etc). Yet we pour BILLIONS each year into clinical trials based on faulty animal models.
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Seemay Chou @seemaychou.bsky.social · 22/12/2024
Another way to structure data is thru lens of evolution. People forget this was a key unlock for protein predictions (MSAs). There's not enough data/compute/$ for big AI promises without. Why I've devoted all my energy to old school, open evo tools @arcadiascience.com -- that's "big bio" IMO
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Seemay Chou @seemaychou.bsky.social · 15/11/2024
The last 2 weeks have brought so many changes, I’ve found it hard to say anything that encapsulates — taking a work hiatus for the first time in my adult life, the election, giving birth. For now I’ll just intro to my latest biology experiment. Meet Hazel everyone👇🥰
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Seemay Chou @seemaychou.bsky.social · 15/11/2024
Finally stepping into the 🔵 here, looking for people to follow. Interested in science, startups, and a sense of humor - recs?
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Seemay Chou @seemaychou.bsky.social · 16/02/2024
1 more week before we dig into EA apps @ArcadiaScience. Know someone unapologetically TypeA who wants front row seats to building a new science org/biotech start-up? I hope they quickly grow into Chief of Staff. I value drive/generalist competence >>> experience/polish. jobs.lever.co/arcadiascien...
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Seemay Chou @seemaychou.bsky.social · 02/12/2023
entrepreneurs also know about failing fast, but it sucks to not share learnings. i'm interested in funding ~10 icebox experiments thru @AsteraInstitute for start-ups that want to publish their science as/after they ramp down. hit me up: docs.google.com/forms/d/e/1F...
docs.google.com
Icebox: Biotech Start-up Edition
Information gathering on biotech start-ups that are ramping down and want to publish their results.
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Seemay Chou @seemaychou.bsky.social · 06/11/2023
I’m bullish on the future of science, and we are putting money where our mouth is. Know someone stellar who can help us accelerate progress in open science? boards.greenhouse.io/navigationfu...
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Reposted by Seemay Chou
Clement Chow @clementychow.bsky.social · 08/08/2023
The Chow Lab is looking for multiple postdocs to work on Precision Medicine for rare disease! Opportunities to work with industry, patient foundations and physicians. Starting pay will be substantially higher than NIH minimum. DM or email me! t.co/gQA8peq22G
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Seemay Chou @seemaychou.bsky.social · 15/09/2023
Do you know of any important scientific or public health efforts that are currently blocked by access to compute? (ie need cards in next 6 months) #plzRP
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