iiinova — where your digital self keeps evolving

Reposted by Matthew Bowler

Pierre Maisonneuve @pierre-maisonneuve.bsky.social · 03/09/2026

🧬 Announcing the French Kinase Conference - 1st edition! Nov 9–10, 2026, @iecb.bsky.social We aim to bring together the French community of biologists, structural biologists, and medicinal chemists working on protein kinases. 🔗 fkc2026.sciencesconf.org #Kinases #cellsignaling #DrugDiscovery

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EMBL @embl.org · 29/06/2026

What happens when AI and biology accelerate each other? EMBL Acting Head of AI Centre, Oliver Stegle, discusses how closer integration of these fields could transform the life sciences. Watch this video to learn more. #EMBL_AI

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Science X / Phys.org @sciencex.bsky.social · 23/06/2026

An automated cryo-EM sample-prep workflow achieved a sevenfold improvement in vitrification quality inside large human cell nuclei versus traditional plunge-freezing. It also screens grids before microscope time is used. doi.org/hb8jvv

phys.org

Unique instruments automate sample preparation, quality control for cryo-electron microscopy

Cryo-electron microscopy (cryo-EM) can help scientists determine the three-dimensional structure of proteins in unprecedented detail.

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EMBL @embl.org · 23/06/2026

The Papp team has developed EasyGrid and EasyGrid Control, new instruments for automated cryo-EM sample preparation and quality control. These systems, recently described in the journal Nature Methods, are improving and accelerating microscopy and imaging studies. bit.ly/4wbhj3L

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Matthew Bowler @mattbowler.bsky.social · 16/06/2026

Such a pleasure to see stellar PhD student Jill Von Velsen present and defend her thesis yesterday on the MEK1-ERK2 complex 👉 www.biorxiv.org/content/10.6... Many thanks to the Jury @pierre-maisonneuve.bsky.social Katia Zanier Malene Jensen Gilles Labesse and Franck Fieschi @embl.org

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Matthew Bowler @mattbowler.bsky.social · 03/06/2026

This was a game changer for our 88 kDa kinase complex www.biorxiv.org/content/10.6...

biorxiv.org

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Oli Clarke @olibclarke.bsky.social · 27/03/2026

Added a little script to chimerax-trimmings to automate the creation of panels for model-map fit figures. It zones the map around (by default) 40aa parts of each chain (but doesn't cut in the middle of helices). Saves each as a png, metadata to csv. Saves each view as a scene for tweaking views.

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Dimitry Tegunov @dtegunov.bsky.social · 03/05/2026

We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

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Protein Data Bank in Europe (PDBe) @pdbeurope.bsky.social · 27/04/2026

🚨July 21, 2027: PDB Beta Archive replaces current PDB archive. Key updates: • Extended IDs (1ABC → pdb_00001abc). • Only 12-char IDs issued. • Data in PDBx/mmCIF & PDBML only. All PDB users must transition to extended IDs and PDBx/mmCIF. www.wwpdb.org/news/news?ye... #PDB

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Carter Lab @carter-lab.bsky.social · 24/03/2026

Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...

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Roland Dunbrack 🏳️‍🌈 @rolanddunbrack.bsky.social · 22/02/2026

Great work from post-doctoral fellow @joanzone.bsky.social: New preprint on identifying active structures of protein kinases -- capable of binding ATP, Mg ions & especially substrates -- +modeling all 437 human catalytic protein kinase domains in their active conformation. doi.org/10.64898/202...

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Reposted by Matthew Bowler

MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 24/02/2026

Are you a structural biologist pushing the boundaries of molecular science with an ambitious research programme? Join our Structural Studies Division as a tenure-track Group Leader, with core funding, world-leading facilities & enthusiastic colleagues. Apply by 16 MAR www.nature.com/naturecareer...

Job opening for Research Group Leader in Structural Studies at MRC Laboratory of Molecular Biology, focusing on macromolecular structures.

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Sjors Scheres @sjorsscheres.bsky.social · 16/02/2026

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...

mrc.tal.net

Research Group Leader Tenure Track - Structural Studies - LMB 2775 - Medical Research Council

Location: Cambridge. Vacancy: Research Group Leader Tenure Track - Structural Studies - LMB 2775. Closing Date: 16/03/2026, 23:55

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Matthew Bowler @mattbowler.bsky.social · 11/02/2026

One week left to apply - get writing!

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cryoEM papers @cryoempapers.bsky.social · 20/01/2026

Molecular basis of mitogen-activated protein kinase ERK2 activation by its upstream kinase MEK1 www.biorxiv.org/content/10.64898/2026.01.19.700303v1 #cryoEM

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bioRxivpreprint @biorxivpreprint.bsky.social · 20/01/2026

Molecular basis of mitogen-activated protein kinase ERK2 activation by its upstream kinase MEK1 www.biorxiv.org/content/10.64898/20…

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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 20/01/2026

Molecular basis of mitogen-activated protein kinase ERK2 activation by its upstream kinase MEK1 www.biorxiv.org/content/10.64898/20…

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Matthew Bowler @mattbowler.bsky.social · 22/01/2026

New Preprint alert! Excited to share our latest work on the #MAPKinases from stellar PhD student Jill von Velsen. First structures of the MAP2K MEK1 activating its substrate MAPK between 2.9 and 3.6A - amazing resolutions for such a small and mobile complex! www.biorxiv.org/content/10.6...

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John Rubinstein @johnrubinstein.bsky.social · 09/01/2026

I'm looking forward to speaking at this course (and finally seeing my PhD-labmate @mattbowler.bsky.social's institute in Grenoble)!

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Reposted by Matthew Bowler

EMBL Events @events.embl.org · 09/01/2026

Are you working on challenging projects in structural biology? #EMBOMacromolecular will highlight the strategic use of cutting-edge protein structure prediction methods, and recent advances in in situ structural biology. Apply by 18 Feb to join us at EMBL Grenoble! 🧬 s.embl.org/mmo26-01-bl

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Matthew Bowler @mattbowler.bsky.social · 09/01/2026

Very pleased to be on the organizing committee of the EMBO course Structural Characterization of Macromolecular Complexes in 2026! We have a fantastic line up of speakers and tutors, please share widely! 👉apply here: www.embl.org/about/info/c...

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EMBL Events @events.embl.org · 11/12/2025

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Matthew Bowler @mattbowler.bsky.social · 05/11/2025

Another amazing drug repurposing study from Silvia Diaz Martin Alexandre Bougdour Christopher Swale and @hakimi.bsky.social Very pleased to have supported the structural work on our favorite protein family - the kinases!

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 05/11/2025

Nature Com. now live! 🎉 Silvia’s amazing PhD supervised by Alex “the Greatest” & Christopher’s big-bang contribution. Huge thanks to our stellar team & collaborators. We went fishing in the FDA pond and hooked LY2090314 🎣 Blocks GSK3 🎯in #Toxoplasma & #Crypto www.nature.com/articles/s41...

nature.com

Structural and functional characterization of TgGSK3, a druggable kinase in Toxoplasma gondii - Nature Communications

Researchers identify the cancer drug LY2090314 as a potent inhibitor of Toxoplasma gondii and Cryptosporidium and report the first crystal structure of the parasite kinase TgGSK3 bound to it, validati...

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Reposted by Matthew Bowler

Sophie Pedder @sophiepedder.bsky.social · 08/10/2025

For sure, Macron’s troubles are partly of his own making. But there is something immensely sad about a pro-European leader and standard-bearer for the democratic centre ending up with such a political mess

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Sjors Scheres @sjorsscheres.bsky.social · 21/09/2025

These results are truly impressive! But I do worry that #cryoEM is moving into a phase where progress is made by optimizing parameter settings for black box programs. The devil is often in the details, and I am not sure how this could be implemented in #relion, as stated, without more info.

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 06/09/2025

Zeus had his Hydra ⚔️, now Toxoplasma has its own. Meet Hydra: not a monster, but a brand-new protein domain. It multimerizes like crazy & rewrites the chromatin landscape 🧬 in Toxoplasma. Our team and colleagues from @embl.org #Grenoble just dropped the preprint 👉 www.biorxiv.org/content/10.1...

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Matthew Bowler @mattbowler.bsky.social · 20/08/2025

In our new paper @asbmb.bsky.social JBC we detail our surprising discovery that the MAP2Ks can use ADP to phosphorylate their substrate MAPKs – driven by @paulineJYX @ErikaPellegri13 and @jvonvelsen t.co/spLZbaz5Wk

t.co

https://www.jbc.org/article/S0021-9258(25)02429-9/fulltext

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EMBL @embl.org · 25/04/2025

1/ Today is #WorldMalariaDay. At EMBL, we join the global efforts to control malaria with innovative biological approaches. 👉 Swipe through to discover how scientists at EMBL study the malaria parasite and drive progress in global health. 🔗 Read more: www.embl.org/news/tag/mal...

A visual with blue and green colours with a text saying "World Malaria Day".

A visual with blue and green background with a image on the left showing red lights. Bellow the image is shown a photo of a man. On the right a text about malaria and EMBL is presented.

A visual with blue and green background with a image on the bottom showing a hand with gloves golding a glass system. In the middle of the image is shown a photo of a woman. At the top a text about malaria and EMBL is presented.

A visual with blue and green background saying in the middle "Check out more in EMBL news using #malaria".

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Gavi @gavirius.bsky.social · 04/02/2025

We are very happy. The Editors of Journal of Applied Crystallography have chosen figures from our article (journals.iucr.org/j/issues/202...) to feature as the cover image for the February 2025 issue. THANKS

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Matthew Bowler @mattbowler.bsky.social · 04/01/2025

RIP Sine. She hired me as beamline scientist on ID14 @esrfsynchrotron 17 years ago and was a great director putting automation to the fore ultimately leading to @ID30_MASSIF1

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EMBL @embl.org · 18/12/2024

EMBL scientists discovered that dextromethorphan (DXM) may treat lung #fibrosis. 🫁 DXM is an @fda.gov-approved active ingredient in nonprescription cough syrups. This study, published in Science Translational Medicine, shows how this drug may reduce lung scars. 🧪💊 www.embl.org/news/science...

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ChimeraX @chimerax.ucsf.edu · 13/12/2024

ChimeraX 1.9 has been released and is available now on our website

cgl.ucsf.edu

Download UCSF ChimeraX

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François Leulier @francoisleulier.bsky.social · 22/11/2024

A top european science job opened to applications: Scientific director @pasteur.fr research.pasteur.fr/en/job/insti...

research.pasteur.fr

The Institut Pasteur is looking for a Scientific Director | Research - Institut Pasteur

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Matthew Bowler @mattbowler.bsky.social · 18/11/2024

📢This year marks 10 years of fully automatic data collection @esrfsynchrotron @EMBLGrenoble ! Join us on the 5th Dec to celebrate the technical developments and scientific successes of @ID30_MASSIF1 👉 esrf.fr/home/events/co…

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Martin Walsh @walshdls.bsky.social · 15/11/2024

ok to all synchrotron and cryoEM people out there ...a hastily put together starter pack! go.bsky.app/UThze5z

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