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Yevgeniy Serebrenik

@ysereb.bsky.social
153 followers 161 following 4 posts

Assistant professor @rwjms.bsky.social in Biochemistry and Molecular Biology. We study proteostasis using cutting-edge genomics. serebreniklab.org

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Reposted by Yevgeniy Serebrenik
Journal of Cell Science @jcellsci.bsky.social · 29/05/2026
Gina Simon, Doris Hellerschmied @hellerschmiedlab.bsky.social and colleagues @unidue-zmb.bsky.social dissect stress-induced proteome remodelling at the Golgi–endosome interface. Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...
Figure showing that FAM129A localises to the secretory pathway during stress.
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Reposted by Yevgeniy Serebrenik
Wallace Marshall @wallaceucsf.bsky.social · 05/05/2026
If you are interested in how single cells are able to learn, check out this beautiful article by @niko-kukushkin.bsky.social www.sciencedirect.com/science/arti...
sciencedirect.com
Cellular memory: Learning without building
A new study reveals that habituation in the single-celled ciliate Stentor coeruleus uses the same calcium and kinase signaling as animal memory but do…
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George Burslem @gburslem.bsky.social · 03/03/2026
Thank you to all the friends, collaborators, lab members and mentors who made this happen!
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Ophir Shalem @ophirshalem.bsky.social · 02/03/2026
As we are sending back the revised version of our pooled prime editing gene tagging paper, I am happy to share a website for design of prime tagging libraries, including some images, all generated from a single pooled transduction and in situ sequencing. primetagging.org
primetagging.org
Prime Tagging
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Hellerschmied Lab @hellerschmiedlab.bsky.social · 06/02/2026
Very happy to share our recent preprint describing #Golgi protein quality control #PQC in mammalian cells. #proteasome #ubiquitin #ChemBio Fantastic work by @joaodiamantino.bsky.social and team! #proudPI @unidue-zmb.bsky.social @imprs-lm.bsky.social
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Eleanna Kara @eleannak.bsky.social · 22/11/2025
The latest preprint from our lab! Lipid droplets promote the aberrant liquid-liquid phase separation of alpha-synuclein leading to impaired energy homeostasis www.biorxiv.org/content/10.1...
biorxiv.org
Lipid droplets promote the aberrant liquid-liquid phase separation of alpha-synuclein leading to impaired energy homeostasis
Alpha-synuclein (αSyn) inclusions, termed Lewy bodies, are the characteristic neuropathological feature of Parkinson's disease. Growing evidence points towards a role of aberrant liquid-liquid phase s...
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Reposted by Yevgeniy Serebrenik
Craig M. Crews @craigmcrews.bsky.social · 30/10/2025
www.oncologypipeline.com/apexonco/tri...
oncologypipeline.com
Triple meeting 2025 – Halda’s proximity play in prostate
Early data with the RIPTAC HLD-0915 look competitive.
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Reposted by Yevgeniy Serebrenik
Natasha O'Brown @natashaobrown.bsky.social · 27/10/2025
Very happy to be in Nashville today for #zebrafishzunday before my talk @vanderbilt.edu tomorrow, so here's a sneak preview of differential clearance of monomeric (turquoise) vs. oligomeric (red) amyloid beta from the zebrafish brain
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Dan Grabarczyk @dangrabarczyk.bsky.social · 28/08/2025
Glad to share the final version of our story about the UBR4 complex, an E4 ligase protein quality control hub @science.org. Now with more cryo-EM structures and a deeper dive into substrate recognition, especially escaped mitochondrial proteins @clausenlab.bsky.social www.science.org/doi/10.1126/...
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Wallace Marshall @wallaceucsf.bsky.social · 19/08/2025
Cells can form patterns within themselves just like embryos do. How? Connie Yan's new preprint shows how the anterior-posterior cytoskeleton pattern in Stentor is dictated by regionalized scaffolding proteins www.biorxiv.org/content/10.1...
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Aaron Milstein @neurosutras.bsky.social · 20/08/2025
Be my neighbor! @rwjms.bsky.social Neuroscience is hiring! jobs.rutgers.edu/postings/258...
jobs.rutgers.edu
Assistant or Associate Professor (Tenured or Tenure-Track)
The Department of Neuroscience and Cell Biology at Rutgers Robert Wood Johnson Medical School (RWJMS), the Rutgers Child Health Institute (CHI), and the Rutgers Brain Health Institute (BHI) seek appli...
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Fran Bottanelli @franbottanelli.bsky.social · 13/08/2025
Our protocol for gene editing is online and all plasmids are on @addgene.bsky.social! CRISPR away everybody and get in touch if you need anything 🤩
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Hellerschmied Lab @hellerschmiedlab.bsky.social · 15/07/2025
Very happy to see our contribution to a better understanding of Hsp70/90 #chaperones online! Congrats and a big thank you to all co-authors, collaborators and reviewers! #proteostasis @poepsel-lab.bsky.social @crc1430.bsky.social @unidue-zmb.bsky.social
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Yevgeniy Serebrenik @ysereb.bsky.social · 24/06/2025
Excited to share our lab’s first publication! A review on how pooled protein tagging with ligandable domains is unlocking proteome-scale biology. Spearheaded by the talented @kelarrimore.bsky.social. www.frontiersin.org/articles/10....
frontiersin.org
Frontiers | Utilizing small molecules to probe and harness the proteome by pooled protein tagging with ligandable domains
Multifunctional ligand-binding domains have revolutionized cell biology by enabling the precise visualization and manipulation of fused proteins of interest ...
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Natasha O'Brown @natashaobrown.bsky.social · 18/06/2025
So excited to share that I am one of the new @hhmi.org freeman hrabowsi scholars with so many other amazing new PIs. Check out the full list here www.hhmi.org/programs/fre...
hhmi.org
The 2025 Freeman Hrabowski Scholars | HHMI
Freeman Hrabowski Scholars are outstanding early career faculty who have the potential to become leaders in their research fields.
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Journal of Cell Science @jcellsci.bsky.social · 04/06/2025
Our ‘Cell Scientist to Watch’ is Francesca Bottanelli @franbottanelli.bsky.social‬. We discover more about Fran’s career path, her approach to scientific mentorship and her dream to start a band! journals.biologists.com/jcs/article/...
Francesca Bottanelli
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George Burslem @gburslem.bsky.social · 01/05/2025
Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...
science.org
Intracellular protein editing enables incorporation of noncanonical residues in endogenous proteins
The ability to study proteins in their native cellular context is crucial to our understanding of biology. In this work, we report a technology for intracellular protein editing, drawing from split in...
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Reposted by Yevgeniy Serebrenik
Ophir Shalem @ophirshalem.bsky.social · 01/05/2025
Excited to to see our collaboration with @gburslem.bsky.social published today! This is part of our ongoing long term goal of achieving scalable non-disruptive and direct imaging and perturbation of the endogenous proteome
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Yevgeniy Serebrenik @ysereb.bsky.social · 23/04/2025
Thrilled to see our work now in @cp-molcell.bsky.social! It was an incredible privilege to do my postdoc with @ophirshalem.bsky.social and work alongside the super talented Steph Sansbury and our amazing co-authors. Excited to keep building on this research in our new lab at @rwjms.bsky.social!
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Reposted by Yevgeniy Serebrenik
Richard Sever @richardsever.bsky.social · 11/03/2025
Bsky vs Twitter engagement difference now 50-fold...
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Yevgeniy Serebrenik @ysereb.bsky.social · 07/03/2025
#StandUpForScience2025
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George Burslem @gburslem.bsky.social · 06/03/2025
New paper online today! Check out @cewc9.bsky.socials review on how acetylation mediated protein degradation impacts cancer! Thanks for the invite to contribute to the 10th anniversary special issue of Trends in Cancer! www.sciencedirect.com/science/arti...
sciencedirect.com
Acetylation: a new target for protein degradation in cancer
Acetylation is an increasing area of focus for cancer research as it is closely related to a variety of cellular processes through modulation of histo…
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Reposted by Yevgeniy Serebrenik
George Burslem @gburslem.bsky.social · 25/02/2025
We have a postdoc position available for a very cool collaborative project! Synthetic chemistry expertise is a must! Unfortunately due to the funding source, this position is only available to US citizens or permanent residents. chemistryjobs.acs.org/job/postdoct...
chemistryjobs.acs.org
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Yael David @yaeldavidmsk.bsky.social · 21/02/2025
I am extremely proud to see our work about Hepatitis B now published in @cellpress.bsky.social From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵 www.cell.com/cell/fulltex...
cell.com
A nucleosome switch primes hepatitis B virus infection
A reconstituted cccDNA platform facilitated the discovery of an early chromatinization event that promotes transcription of the hepatitis B virus (HBV) regulatory X gene. The use of a small-molecule c...
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Fran Bottanelli @franbottanelli.bsky.social · 19/02/2025
Long in the making but our protocol for gene editing is online! FAB CRISPR is super easy and allows the generation of N and C terminal fusions with TurboID, SNAP, Halo and mStayGold. A single cloninf step to generate HDR templates! arxiv.org/abs/2502.12675 1/n
arxiv.org
Fast Antibiotic resistance-Based gene editing of mammalian cells with CRISPR-Cas9 (FAB-CRISPR)
Protein tagging with CRISPR-Cas9 enables the investigation of protein function in its native environment but is limited by low homology-directed repair (HDR) efficiency causing low knock-in rates. We ...
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Mir Lab @mirlab.bsky.social · 12/02/2025
1/n Excited to share our new preprint! Using live imaging in Drosophila embryos, we show that RNA Pol II clusters switch from sites of initiation to elongation during zygotic genome activation and that they are stably associated with an active gene: www.biorxiv.org/content/10.1...
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 10/02/2025
The Trump NIH is banning hires of new students and postdocs. This is devastating for NIH research and will result in a lost generation of researchers at the institution. Heard from a applicant today: "A lot of people are banking their entire careers on the [NIH student programs]..." #NIH 🧪 1/
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Yevgeniy Serebrenik @ysereb.bsky.social · 23/12/2024
The Serebrenik Lab is hiring! Join us in unraveling proteostasis with pooled protein tagging and manipulation! Interested postdocs can learn more & meet other excellent labs at the Rutgers Postdoc Peek (Apr 3-4, 2025). Apply by 1/8/25: rutgers.ca1.qualtrics.com/jfe/form/SV_...
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Wallace Marshall @wallaceucsf.bsky.social · 21/11/2024
Single cells can learn without a brain, but how? Our new preprint from @deeparajan.bsky.social describes a model for habituation in Stentor coeruleus, based on receptor internalization and recycling, along with new experiments inspired by the model. 1/n www.biorxiv.org/content/10.1...
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Ophir Shalem @ophirshalem.bsky.social · 10/11/2024
Happy to share our new paper where we explore why dCas9-KRAB protein levels drop so drastically after neuronal differentiation in WTC11 and KOL2.1J iPSC lines. www.biorxiv.org/content/10.1...
biorxiv.org
CRISPR associated enzymes are mislocalized to the cytoplasm in iPSC-derived neurons resulting in KRAB-specific degradation
The use of CRISPR-associated enzymes in iPSC-derived neurons for precise gene targeting and high-throughput gene perturbation screens offers great potential but presents unique challenges compared to ...
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