iiinova — where your digital self keeps evolving

Ophir Shalem @ophirshalem.bsky.social · 13/06/2026

New preprint led by @camarapg.bsky.social lab as part of our ongoing collaboration to develop the essential tools for pooled scalable optical profiling of the neuronal proteome

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Ophir Shalem @ophirshalem.bsky.social · 02/03/2026

As we are sending back the revised version of our pooled prime editing gene tagging paper, I am happy to share a website for design of prime tagging libraries, including some images, all generated from a single pooled transduction and in situ sequencing. primetagging.org

primetagging.org

Prime Tagging

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Reposted by Ophir Shalem

John Murray @jisaacmurray.bsky.social · 20/06/2025

Happy to announce our paper comparing embryonic gene expression between C. elegans and C. briggsae, work led by Christopher Large with Rupa Khanal and in collaboration with Junhyong Kim and Bob Waterston. www.science.org/doi/10.1126/...

science.org

Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae

The constraints that govern the evolution of gene expression patterns across development remain unclear. Single-cell RNA sequencing can detail these constraints by systematically profiling homologous ...

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Ophir Shalem @ophirshalem.bsky.social · 01/05/2025

Excited to to see our collaboration with @gburslem.bsky.social published today! This is part of our ongoing long term goal of achieving scalable non-disruptive and direct imaging and perturbation of the endogenous proteome

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Reposted by Ophir Shalem

Arjun Raj @arjunraj.bsky.social · 17/03/2025

Super excited to be launching NimbusImage.com! Cloud-based image analysis to democratize machine learning! Documentation here! docs.nimbusimage.com

nimbusimage.com

NimbusImage

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Reposted by Ophir Shalem

George Burslem @gburslem.bsky.social · 25/02/2025

We have a postdoc position available for a very cool collaborative project! Synthetic chemistry expertise is a must! Unfortunately due to the funding source, this position is only available to US citizens or permanent residents. chemistryjobs.acs.org/job/postdoct...

chemistryjobs.acs.org

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Ophir Shalem @ophirshalem.bsky.social · 05/02/2025

Pooled optical screening bootcamp!

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Ophir Shalem @ophirshalem.bsky.social · 23/12/2024

Huge congratulations to former lab postdoc @ysereb.bsky.social for starting his own independent lab! Make sure to follow him for exciting future science and check out his lab if you are looking for opportunities in the NJ/NY area!

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Reposted by Ophir Shalem

Doug Epstein @epsteind.bsky.social · 22/11/2024

Our study with @ericjoyce.bsky.social led by Jailynn Harke is out. We show that allelic configurations at the Shh locus are predominately compact in the mouse forebrain, and that long range E-P interactions rely on transcription dependent and independent mechanisms. www.cell.com/molecular-ce...

cell.com

Multiple allelic configurations govern long-range Shh enhancer-promoter communication in the embryonic forebrain

Harke et al. use sequential DNA-FISH to achieve single-allele resolution of the Sonic hedgehog (Shh) regulatory domain in the mouse forebrain. They show that multiple allelic configurations occur inde...

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Reposted by Ophir Shalem

Struan Grant @struangrant.bsky.social · 25/11/2024

Late-stage graduate students and junior postdoctoral fellows are invited to attend the 2025 Recruitment Summit for CHOP/Penn Postdoctoral Scholars in Cell Biology and Genomics careers.chop.edu/us/en/event/...

careers.chop.edu

Recruitment Summit for Postdoctoral Scholars in Cell Biology and Genomics | Children’s Hospital of Philadelphia

Recruitment Summit for Postdoctoral Scholars in Cell Biology and Genomics in Philadelphia, Pennsylvania, United States. null at Children’s Hospital of Philadelphia

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Ophir Shalem @ophirshalem.bsky.social · 15/11/2024

Fascinating work from Jongens and @erikaholzbaur.bsky.social labs showing that FMRP granules mark mitochondrial fission sites in axons and dendrites and serve as sites of local translation! t.co/wXqtte3pqp

t.co

https://www.nature.com/articles/s41556-024-01544-2

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