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Paradoxical responses, in which excitatory perturbations of inhibitory neurons reduce their firing rates, are widely regarded as a hallmark of inhibition-stabilized networks (ISNs) and have been obser...

Nature Neuroscience - Senne, Suthard and colleagues show that dorsal hippocampal astrocytes display time-compressed calcium-event sequences after foot shock and upon context re-exposure, and that...

Using a combined approach of monkey electrophysiology, artificial neural networks and human psychophysics, Xue et al. show that neuronal interference from irrelevant information underlies behavioral e...

In mice, a sparse population of sleep-active long-range inhibitory neurons in the neocortex promote widespread cortical synchronization and sleep, revealing a cortical mechanism that co...

Neural sequences, characterized by neurons or groups of neurons that fire one after the other, have been observed in multiple brain regions, across species, and are known to underlie a diversity of br...

I use birdsong to understand how the brain learns complex skills across molecules, synapses, circuits, behavior, and computation. On the 2026–27 faculty job market.

Join the Department of Experimental and Applied Psychology (Vrije Universiteit Amsterdam) as Assistant Professor in cognitive neuroscience.

GNB1 encephalopathy (GNB1-E) is a rare neurodevelopmental disorder associated with motor dysfunction, epilepsy and learning disability caused by mutations in the gene encoding the G protein subunit Gβ...

Retinal ganglion cells (RGCs) are the sole output neurons of the retina, responsible for transmitting visual information to the brain. Recent transcriptomic studies have revealed extensive molecular d...

Kim, Geiger et al. report that early-life stress increases the chromatin modification H3K4me1 and its enzymatic writer, SETD7, in the ventral tegmental area. They show that this form of epigenetic pri...

Both aging and a high-fat diet (HFD) dampen circadian gene transcription rhythms and promote chronic inflammation. How aging and HFD interact to affect peripheral molecular clocks and circadian behavi...

Forgotten memories in Drosophila persist as silent memory traces and can be recovered by reminder cues. Manipulating reminders can create false memories, showing that memory reconstruction flexibly in...

Language is included to delay the president’s move to put political appointees in charge of grant approval.

Basement membranes are scaffolds of proteins, like collagen, that give organs shape. During development, basement membranes must adapt to the growing organ. We infer how fast the basement membrane ada...

Functional MRI provides a powerful way to characterize the architecture of the human brain. Yet individual brains often vary in the exact anatomic locations of functionally specific regions; as a resu...

Mice are motivated to seek information of no extrinsic value. Recording neural activity in orbitofrontal cortex reveals a representation of the value of information that is distinct from the value of ...

At excitatory synapses, glutamate activates receptors in the postsynaptic membrane including the AMPA receptor. Usually considered to be the fastest receptor in the brain, AMPA receptors can produce m...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

In daily life, we often draw inferences about novel associations from prior experiences. This ability, associative inference, is thought to be a ke...

Here authors show that the synaptic vulnerability of auditory neurons in the mouse cochlea can be tuned via genetic reprogramming. This discovery fills a critical gap in efforts to identify the underl...

Author summary Vision doesn’t happen instantaneously, but unfolds over time. While we understand a lot about how the brain processes visual space, understanding how the brain processes information ove...

Modern artificial intelligence (AI) systems have achieved remarkable capabilities, but at an extraordinary energy cost. Training and running large-sca…

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...