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Will Oldham

@willoldham.bsky.social
1.2K followers 1.2K following 48 posts

Scientist, physician, husband, father of daughters. I study how cell metabolism contributes to the lung diseases pulmonary hypertension and fibrosis. oldhamlab.org

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Reposted by Will Oldham
JCI insight @insight.jci.org · 16/07/2026
William M. Oldham @willoldham.bsky.social & team discover scar-forming cells in pulmonary fibrosis rely on alanine as a metabolic building block and simultaneously blocking its synthesis & uptake suppresses fibrosis in lung tissue: doi.org/10.1172/jci.... with @edykimlab.bsky.social
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Will Oldham @willoldham.bsky.social · 26/04/2026
Proud to share that our first paper from the lab's new home at The Warren Alpert Medical School of Brown University and Brown University Health is now in press at @insight.jci.org! insight.jci.org/articles/vie...
We identify alanine as an essential metabolite for fibroblast-to-myofibroblast differentiation. TGF-β engages two parallel mechanisms to maintain intracellular alanine: synthesis by GPT2 and uptake by SLC38A2. Both are upregulated. Disrupting either depletes alanine, stalls glycolysis, and blunts the fibrotic response. The redundancy underscores how central alanine is to activated fibroblast function and suggests a new avenue of exploration for metabolic therapies in pulmonary fibrosis.
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Reposted by Will Oldham
@IM_Crit_ @imcrit.bsky.social · 22/02/2026
The evolution of acute pulmonary embolism classification (including the recently published 2026AHA/ACC/ACCP/ACEP/CHEST/ SCAI/SHM/SIR/SVM/SVN Guideline): #foamed #foamcc #meded #Medsky #emimcc
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Jeremy Allen @jeremy-data.bsky.social · 15/02/2026
Are you in the terminal a lot with Claude but work a lot with markdown files? I am using glow to see rendered markdown in the terminal. They have a great tagline, too. Anyone using anything else? github.com/charmbracele...
github.com
GitHub - charmbracelet/glow: Render markdown on the CLI, with pizzazz! 💅🏻
Render markdown on the CLI, with pizzazz! 💅🏻. Contribute to charmbracelet/glow development by creating an account on GitHub.
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Reposted by Will Oldham
Navneet Singh, MD, ScM @navneetsinghmd.bsky.social · 01/02/2026
#PVRI2026 was incredible! Got to catch up with friends & colleagues, hear exciting science, share our own (PAEC biopsies & systems pharmacology for precision PAH care) and applaud @brownpvd.bsky.social colleagues @willoldham.bsky.social & Dr. Klinger who were recognized for their own stellar work!
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Will Oldham @willoldham.bsky.social · 22/01/2026
📣 We are recruiting a post-doctoral fellow! Join an interdisciplinary, NIH-funded research program studying metabolic reprogramming in pulmonary fibrosis with strong translational focus and collaborative environment. Apply here: jobs.brownhealth.org/search/jobde...
jobs.brownhealth.org
Post Doctoral Rsrch Assoc at Brown University Health
Brown University Health is Hiring! Search available jobs or submit your resume now by visiting this link. Please share with anyone you feel would be a great fit.
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Reposted by Will Oldham
Jason Cantor @jasonrcantor.bsky.social · 16/01/2026
For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵
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Reposted by Will Oldham
😱 Spooky SpectreKILLoquy 🔪 🩸 @caulimovirus.bsky.social · 09/01/2024
When I ask a patient what medicines they take and they wave their hands and say “it’s in the chart” I need them to understand that “the patient’s chart” is a mythical concept, more akin to the scattered scribblings of the British constitution rather than a single, comprehensive document.
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Reposted by Will Oldham
Ben-Sahra Lab @bensahralab.bsky.social · 28/10/2025
Excited to share our latest work out today in @cp-molcell.bsky.social, revealing a molecular link between succinate dehydrogenase and purine synthesis, connecting two fundamental metabolic pathways. Huge congratulations to the first author, Mushtaq Nengroo! www.sciencedirect.com/science/arti... !
sciencedirect.com
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle
The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…
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Reposted by Will Oldham
Jack Iwashyna @iwashyna.bsky.social · 12/08/2025
Handed out, yet again, the basic #ScrawledGrantAdvice Aims page structure
sharpie on white paper:

Paragraph 1: we have a big problem
P2: considering new thing X reveals pivotal, newly tractable gaps in our knowledge of the big problems
P3: So our unifying scientific goal is...

Aim N: Active Verb. Method to test interesting (not null) hypothesis in data
.
.
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Impact: This will make the world better and open up new research frontiers via...
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Reposted by Will Oldham
Emil Hvitfeldt @emilhvitfeldt.bsky.social · 12/08/2025
some light teasing for an upcoming quarto revealjs plugin I have been working on
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Will Oldham @willoldham.bsky.social · 30/07/2025
Looking for the hay bales at the base of the tower… #IYKYK #grclung2025
Picture of the tall, square, brick tower of one of many palazzos in the old walled city of Lucca, Italy.
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Will Oldham @willoldham.bsky.social · 24/07/2025
Woohoo! Latest preprint from the lab describing how fibroblasts can use alanine to bypass glutamine requirements for differentiation and ECM production. It's a lovely example of metabolic flexibility with implications for how we study cell metabolism. Shout out to Fei Li, who led this work! #cureipf
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Will Oldham @willoldham.bsky.social · 25/06/2025
Still regretting the 4 month period 13 years ago when I went all in on the Mac office suite...
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Reposted by Will Oldham
PVRI @pvrinstitute.bsky.social · 11/06/2025
📢 Get ready to submit your abstract to PVRI 2026 Dublin — registrations & the abstract portal will open on 1 July! Stay tuned for full details on how to register and submit your abstract! pvrinstitute.org/pvri2026 #PVRI2026 #PulmonaryHypertension #GlobalScience #Congress
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Reposted by Will Oldham
Andrea Howard @drandreahoward.bsky.social · 10/06/2025
This JUST came up again and @ruben.the100.ci pointed me to the @malte.the100.ci blog explaining how to do it:
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Reposted by Will Oldham
Mike Feigin 🥯 @mikefeigin.bsky.social · 04/06/2025
Are you looking for a faculty job? We are hiring in my department at Roswell Park NOW. Contact me for details as I await the formal ad. (Please RT.)
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Prasad Jallepalli, MD, PhD @prasad.bsky.social · 05/06/2025
our lightsaber
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Will Oldham @willoldham.bsky.social · 05/05/2025
Excited to announce that, In 26 days, I will be joining Brown University Health! Excited for new colleagues, new opportunities, and renewed energy to advance our work toward a cure for pulmonary fibrosis!
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Will Oldham @willoldham.bsky.social · 02/05/2025
Such a great meeting! Looking forward to #PVRI2026 in Dublin!
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Reposted by Will Oldham
Peter Dalgaard @pdalgd.bsky.social · 24/04/2025
#rstats folks: If you have a habit of updating your library after an R upgrade by copying the old one and run update.packages(). --> DON'T DO THAT <-- Especially not with 4.5.0. You will overwrite base packages with ones from a previous version and as these are not on CRAN, things go bad.
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Sasha Prisco, MD, PhD @sashaprisco.bsky.social · 14/04/2025
Thanks so much @navneetsinghmd.bsky.social @brownpvd.bsky.social for the opportunity to visit and hospitality! Wonderful to be able to see you all! @gauravchoudhury.bsky.social @willoldham.bsky.social
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Max kuhn @topepo.bsky.social · 03/04/2025
This helped me a lot: www.tidyverse.org/blog/2020/08...
tidyverse.org
Taking Control of Plot Scaling
Learn how to control scaling of the content in your plot when you render plots to different sizes.
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Will Oldham @willoldham.bsky.social · 03/04/2025
#rstats folks! Does anyone have workflow tips on using ggplot2 in both manuscripts and slide presentations? Currently using targets to generate panels/figures themed for manuscript. These are not easy to port to slides given size of points, fonts, etc. Any advice appreciated!
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Will Oldham @willoldham.bsky.social · 26/03/2025
Breaking in a new column today and, gosh, sometimes it’s nice to be able to SEE the science! #scienceincolor
A clear glass chromatography column oriented vertically filled with white matrix striped with a red and a brown band separating along the column.
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Reposted by Will Oldham
Micah @rincewind.run · 23/03/2025
I do not pay the kind of attention to college basketball that I once did but it is still important to take time out of my day to root against Duke
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Leticia Kawano-Dourado @leticiakawano.bsky.social · 20/03/2025
🏋️‍♀️ Strength training is vital for women entering #menopause - boosting metabolic, mental, & bone health. But like any intervention, it needs proper assessment & guidance. I started at 43, lifting heavy: no injuries. The secret? Good coaching, mobility, movement literacy, slow progression, and rest.
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Reposted by Will Oldham
Mark Sanborn @sanbomics.bsky.social · 24/02/2025
Senescent cells contribute to disease and are found in many tissues but are hard to analyze because markers have been derived in culture and do not account for cell-type differences. Here, we define new signatures based on millions of single cells (1/5) www.nature.com/articles/s41...
nature.com
Unveiling the cell-type-specific landscape of cellular senescence through single-cell transcriptomics using SenePy - Nature Communications
Senescent cells accumulate in tissues with aging and disease but are difficult to detect due to distinct cell-type-specific senescence phenotypes. Here, the authors present the SenePy algorithm to ide...
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Reposted by Will Oldham
Mareike Lehmann @mareikelehmann.bsky.social · 18/02/2025
Happy to share our work on cold storage of pcls. Hoping this will be of interest to many and will help to store, share and expand the use of PCLS in #lungresearch. Kudoz to Camila and Fee who Share first authorship. @atscommunity.bsky.social respiratory-research.biomedcentral.com/articles/10....
respiratory-research.biomedcentral.com
Cold storage of human precision-cut lung slices in TiProtec preserves cellular composition and transcriptional responses and enables on-demand mechanistic studies - Respiratory Research
Background Human precision-cut lung slices (hPCLS) are a unique platform for functional, mechanistic, and drug discovery studies in the field of respiratory research. However, tissue availability, gen...
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Reposted by Will Oldham
Nick Banovich @nebanovich.bsky.social · 04/02/2025
Excited to post my first #skySplain about our recent work published yesterday in Nature Genetics! www.nature.com/articles/s41.... One of the first authors of this study - Annika Vannan – actually wrote this breakdown, but she's not yet over here on bluesky and asked me to post!
nature.com
Spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis - Nature Genetics
Xenium spatial transcriptomic profiling of pulmonary fibrosis characterizes cell composition dynamics and histopathological features associated with the disease.
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😱 Spooky SpectreKILLoquy 🔪 🩸 @caulimovirus.bsky.social · 20/01/2025
Say what you will about the antiquity of beepers as a technology, but when that’s the only number anyone can reach you at, then the person holding the beeper is the only person who gets disturbed by the beeping.
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Reposted by Will Oldham
That Anonymous Coward @thatac.bsky.social · 15/01/2025
How to snipe techie people of a certain age...
Photo of a fridge door, there are some of them word magnet things where you can make a story or poem, there is a 3.5 in disk held in place with a large magnet. Written on the disk...

System Restore Disk Do No Erase
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Reposted by Will Oldham
ATS Assemblies @ats-assemblies.bsky.social · 13/01/2025
The Grover Conference Planning Committee is now inviting proposals for the 21st Grover Conference, to be held Sept. 3-7, 2025. Topic proposals should include a tentative schedule and speakers. All proposal submissions are due by 11:59 p.m., Friday, Jan. 31, 2025. Submit proposal here: bit.ly/4hbGr2V
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Will Oldham @willoldham.bsky.social · 11/01/2025
Boosting for the weekend crowd...
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Will Oldham @willoldham.bsky.social · 10/01/2025
We are interested in purchasing a system for primary cell electroporation. Any recommendations? We are looking for a "good enough" system at a low price. Thanks! 🧪
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Will Oldham @willoldham.bsky.social · 08/01/2025
#cureIPF
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Reposted by Will Oldham
Mason McNair, PhD (he/him) @sarraceniamason.bsky.social · 07/01/2025
The flat one we made is here www.printables.com/model/45750-...
printables.com
COBLE - Collection Of Bespoke Laboratory Equipment by Plants X Tech | Download free STL model | Printables.com
Multiple pieces of 3D printed lab equipment tested in actual lab settings! | Download free 3D printable STL models
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Reposted by Will Oldham
Anupam Patgiri @apatgiri.bsky.social · 04/01/2025
AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress www.nature.com/articles/s41...
nature.com
AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress - Nature Cell Biology
Zhai, Yang et al. report a central role for AMPK in regulating aldolase B-mediated glycerol synthesis and excretion under hypoxia as a mechanism to balance the trade-off between reductive and energy s...
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Will Oldham @willoldham.bsky.social · 02/01/2025
An unexpected and delightful consequence of growing up studying PAH before focusing on pulmonary fibrosis is being invited to think a little about the role of myofibroblasts in the heart! Grateful to write this editorial and to see it in print at the start of the New Year!
ahajournals.org
American Heart Association Journals
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Will Oldham @willoldham.bsky.social · 02/01/2025
📌
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Reposted by Will Oldham
William Feldman @wbfeldman.bsky.social · 30/12/2024
I'm excited to share a new study out today in @bmj.com comparing the two single-inhaler triple therapies on the US market. Brief thread below! www.bmj.com/content/387/...
bmj.com
Comparative effectiveness and safety of single inhaler triple therapies for chronic obstructive pulmonary disease: new user cohort study
Objective To compare the effectiveness and safety of budesonide-glycopyrrolate-formoterol, a twice daily metered dose inhaler, and fluticasone-umeclidinium-vilanterol, a once daily dry powder inhaler,...
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Joseph W. Brown @josephwb.bsky.social · 28/12/2024
I made this over the break. Why would I do such a thing? Am I some sort of #phylogenetics dork? Well... yes, but that's not why. To fully explain I'll have to do one of those sewing-strings-wrapped-around-a-spool dealies. 1/ 🧪
A cross-stitched logo for the phylogenetic inference program PAUP. In yellow are the letters P-A-U-P, attached at the base in the pattern of a phylogenetic tree. The "tree" is outlines in dark blue, with light blue in the background. The counters in the Ps and A are orange.
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Leticia Kawano-Dourado @leticiakawano.bsky.social · 27/12/2024
I am honored to be listed there among so many brilliant and passionate researchers in the field of #PulmonaryFibrosis #ILD #Cure4IPF. If you're interested in the topic you should definitely follow those people 💥
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ATS Blue Journal @atsblueeditor.bsky.social · 23/12/2024
The Blue Journal thanks Jonathan Rose, MD, MS, for his contribution to the December 15 issue Development, Progression, and Mortality of Suspected Interstitial Lung Disease in COPDGene www.atsjournals.org/doi/full/10....
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Chris @heycg.bsky.social · 19/12/2024
Carolina hoops point differential by "quarter" or 10 minute segment through 11 games this season -25 in the 1st half +103 in the 2nd half -3 in overtime #Rstats #collegebasketball
North Carolina men's basketball point differential by quarter
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Will Oldham @willoldham.bsky.social · 17/12/2024
@atspc.bsky.social what took y’all so long?! Nice to see you here! #pulmsky
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Will Oldham @willoldham.bsky.social · 11/12/2024
Just discovered this #rstats package by @ethanbass.bsky.social for reproducible chromatogram analysis. Looking forward to trying it out. It was good timing as I was fixing to throw my Agilent ChemStation computer out of the window! ethanbass.github.io/chromatograp...
ethanbass.github.io
Chromatographic Data Analysis Toolset
Tools for high-throughput analysis of HPLC-DAD/UV chromatograms (or similar data). Includes functions for preprocessing, alignment, peak-finding and fitting, peak-table construction, data-visualizatio...
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Leticia Kawano-Dourado @leticiakawano.bsky.social · 11/12/2024
1/10 🔥 Hot off the press #RENOVATEtrial has been published on @jama.com. RENOVATE was an adaptive RCT testing the noninferiority of the HFNO vs NIV in 1,766 pts with ARF of different causes. HFNO was noninferior to NIV for some but not all causes of ARF jamanetwork.com/journals/jam...
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Will Oldham @willoldham.bsky.social · 08/12/2024
I made it through the first week all by myself! I just completed "Bridge Repair" - Day 7 - Advent of Code 2024 #AdventOfCode adventofcode.com/2024/day/7
adventofcode.com
Day 7 - Advent of Code 2024
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