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Will Oldham

@willoldham.bsky.social

1.2K followers 1.2K following 48 posts

Scientist, physician, husband, father of daughters. I study how cell metabolism contributes to the lung diseases pulmonary hypertension and fibrosis. oldhamlab.org

Posts Replies Media

Will Oldham @willoldham.bsky.social · 26/04/2026

Proud to share that our first paper from the lab's new home at The Warren Alpert Medical School of Brown University and Brown University Health is now in press at @insight.jci.org! insight.jci.org/articles/vie...

We identify alanine as an essential metabolite for fibroblast-to-myofibroblast differentiation. TGF-β engages two parallel mechanisms to maintain intracellular alanine: synthesis by GPT2 and uptake by SLC38A2. Both are upregulated. Disrupting either depletes alanine, stalls glycolysis, and blunts the fibrotic response. The redundancy underscores how central alanine is to activated fibroblast function and suggests a new avenue of exploration for metabolic therapies in pulmonary fibrosis.

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Will Oldham @willoldham.bsky.social · 30/07/2025

Looking for the hay bales at the base of the tower… #IYKYK #grclung2025

Picture of the tall, square, brick tower of one of many palazzos in the old walled city of Lucca, Italy.

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Will Oldham @willoldham.bsky.social · 26/03/2025

Breaking in a new column today and, gosh, sometimes it’s nice to be able to SEE the science! #scienceincolor

A clear glass chromatography column oriented vertically filled with white matrix striped with a red and a brown band separating along the column.

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Will Oldham @willoldham.bsky.social · 28/11/2024

Obligatory 🥧 post. Happy 🦃 Day!

Photo of deepest dish apple pie in front right, chocolate silk pie mid left, and the Smitten Kitchen cookbook by Deb Perelman that contains the recipes for both in the background.

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Will Oldham @willoldham.bsky.social · 24/09/2023

I’d love to see the autosampler that uses these! Lovely dinner with great friends at the Paviilion in Wolfeboro, NH. www.pavilionwolfeboro.com

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