iiinova — where your digital self keeps evolving

Wouter De Coster @wdecoster.bsky.social · 28/09/2026

We, internationally, have failed so many people.

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Common Tern Project @commonternproject.bsky.social · 10/08/2026

Question: do I know anyone near Nantes who would be willing to pick up a dead gull-billed tern and its logger? L49 has sadly been killed near a road. I’d be very grateful for a picture and the logger and would of course reimburse postage.

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Fritz Sedlazeck @sedlazeck.bsky.social · 26/06/2026

Four days, one whiteboard, forty open browser tabs, and against all odds, something that actually makes an impact in the field :). Hackathon @bcmhgsc.bsky.social Aug 25-28 Register:https://fritzsedlazeck.github.io/blog/2026/hackathon-2026/ @dnanexus.bsky.social @dcgenomics.bsky.social

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Wouter De Coster @wdecoster.bsky.social · 25/06/2026

Ported the aSTRonaut tool for visualizing tandem repeat sequence composition to Rust using the amazing kuva library from @psy-fer.bsky.social. Blog post at wdecoster.github.io/gigabaseorgi..., documentation at github.com/wdecoster/aS.... Feedback appreciated!

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James Ferguson @psy-fer.bsky.social · 19/06/2026

kuva v0.3.0 release! - New raster backend: faster than the old one, dropped dep. - New QuiverPlot type - Pre-compiled release binaries (thanks @wdecoster.bsky.social ) - .parquet input for all CLI subcommands Also lots of fixes and other features crates.io/crates/kuva github.com/Psy-Fer/kuva

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bioRxiv Bioinfo @biorxiv-bioinfo.bsky.social · 11/06/2026

inquiSTR: a toolkit for accurate and efficient population-scale tandem repeat genotyping and analysis www.biorxiv.org/content/10.64898/20…

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Element Biosciences @elembio.bsky.social · 29/05/2026

🧬 Repeat expansions cause 50+ monogenic disorders and many workflows miss them. 🔬 See how we developed a PCR-free hybrid capture with Trinity™ to retain representation of repetitive loci, enabling accurate genotyping at these expansions on short-read platforms. Poster here: bit.ly/4oFuPZo

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Trish Greenhalgh @trishgreenhalgh.bsky.social · 23/05/2026

Every summer I repost this article on how to spot drowning. Please read it and pass on. In the last few years I’ve had SIX messages from people who saved a kid’s life after clicking on the link from my feed. slate.com/technology/2...

slate.com

Drowning Doesn’t Look Like Drowning

Drowning is not the violent, splashing call for help that most people expect.

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James Ferguson @psy-fer.bsky.social · 07/05/2026

kuva v0.2.0 Now over 60 plots! New plot types: Gantt, Network, Waffle, Horizon, PopulationPyramid, Joint, Clustermap, ROC, PR, Lollipop, Survival, Raincloud, Slope, Venn, Parallel, Mosaic, Streamgraph, Radar, Treemap, Sunburst, Bump, Funnel, Rose, Calendar, Legend, Text github.com/Psy-Fer/kuva

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Wouter De Coster @wdecoster.bsky.social · 05/05/2026

The year is 2026. It is now easier to vibe-rewrite a Python tool in Rust than to figure out how to get the dependencies installed.

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The Obama Foundation @obamafoundation.bsky.social · 04/05/2026

May the Fourth be with YOU, from the Obama Presidential Center. Opening June 19.

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Barry Butler Photography @barrybutler9.bsky.social · 19/04/2026

On this day in 2019, I witnessed one of the coolest things ever. A lenticular cloud lit-up by a setting sun over the Perito Morena Glacier in Argentina.

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James Ferguson @psy-fer.bsky.social · 31/03/2026

I got a little carried away making interactive plots using native SVG features. Then @jpelbers.bsky.social asked if it could run DOOM. It was probably a joke...but I took it as more of a challenge. Anyway. kuva doom -o doom.svg Fully playable and fully contained DOOM inside an SVG

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Wouter De Coster @wdecoster.bsky.social · 27/03/2026

The registration deadline for the Flanders Nanopore Day with @nanoporetech.com is quickly approaching, and the program suggests it will be an amazing event! All information is available at nanoporeflanders.be

nanoporeflanders.be

Flanders Nanopore Day 2026 - Flanders Nanopore Day

The Flanders Nanopore Day - April 17th, 2026

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Mariko Bennett @nachoriko.bsky.social · 24/03/2026

I defended my PhD 10 years ago today. That was the least remarkable thing that happened that day. Sharing something I wrote about it last year. Since then "the horrors persist but so do we." And with dignity.

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Wouter De Coster @wdecoster.bsky.social · 12/03/2026

Thrilled to see our work from the past years finally published! We found a novel repeat expansion in the GOLGA8A gene in 60% of the aFTLD-U patients, a rare subtype of frontotemporal dementia. Huge thanks to all collaborators and patients for making this possible. www.nature.com/articles/s41...

nature.com

A repeat expansion in GOLGA8A is a major risk factor for atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions - Nature Genetics

Genome-wide analysis coupled with long-read sequencing identifies a repeat expansion in GOLGA8A associated with high risk for atypical frontotemporal lobar degeneration with ubiquitin-positive inclusi...

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Reposted by Wouter De Coster

Harriet Dashnow @hdashnow.bsky.social · 06/03/2026

Wonder which tandem repeat genotyper to use on your Oxford Nanopore genomes? We benchmarked 7 tools on >100 ONT genomes. We assessed usability, assembly concordance, Mendelian consistency, and sensitivity to pathogenic expansions. www.biorxiv.org/content/10.6... 🖥️ 🧬 @cubiomedinfo.bsky.social

biorxiv.org

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Keith @minguseyes.bsky.social · 24/02/2026

"The men implicated in the Epstein files reinforces that I spend half my life explaining to men that their simplified, optimistic view of other men doesn’t line up with the experience of women and girls trying to dodge sexual harassment, assault and abuse attempts." - Leslie Morgan Steiner

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James Ferguson @psy-fer.bsky.social · 22/02/2026

Building a new plotting library in pure Rust. Making themes and colourblind mode available on every plot type from day 1. What other accessibility options can I add?

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Wouter De Coster @wdecoster.bsky.social · 20/02/2026

It seems like @psy-fer.bsky.social is on fire - rewriting the STAR aligner in Rust 🔥

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NY Times Pitchbot @nytpitchbot.bsky.social · 14/02/2026

Doctors say that vaccines protect children from dangerous diseases. A nepo baby who barbecues dogs and snorts cocaine off toilet seats says that vaccines make children vulnerable to 5G radiation. For busy parents, it can be hard to know who to trust.

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Adam Ameur @adameur.bsky.social · 12/02/2026

Save the date! The Long‑Read Sequencing Uppsala Meeting (#LRUA26) is happening Nov 2–4, with a great lineup of invited and selected speakers Stay tuned — registration and abstract submission will open soon🧬🖥️ lrua.se

lrua.se

Long-Read Sequencing Uppsala, November 2–4, 2026

#LRUA26: Empower your research with long-read sequencing technologies and connect with experts, peers, and industry leaders in Uppsala this November.

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Wouter De Coster @wdecoster.bsky.social · 05/02/2026

I am fetching reads from cram files in Rust, using rust-htslib and a rayon thread pool. It surprises me that memory use is flat up to 5 threads, but then takes off linearly. Does anyone have a clue what is going on? @robp.bsky.social @johanneskoester.bsky.social Code: github.com/wdecoster/in...

graph showing memory use of parsing a CRAM file using rust-htslib

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NY Times Pitchbot @nytpitchbot.bsky.social · 02/02/2026

Whether it's Donald Trump getting half a billion dollars from United Arab Emirates or Joe Biden getting free ice cream from a shop in Delaware, influence peddling has been a problem for both men.

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Wouter De Coster @wdecoster.bsky.social · 23/01/2026

We are excited to have @minomatt.bsky.social as a keynote speaker at the Flanders Nanopore Day, alongside a wide range of @nanoporetech.com topics, spanning from microbes to plants to humans. All information - including free registration and free PromethION sequencing - at nanoporeflanders.be

nanoporeflanders.be

Flanders Nanopore Day 2026 - Flanders Nanopore Day

The Flanders Nanopore Day - April 17th, 2026

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Iain Roberts @slowbikeiain.bsky.social · 20/01/2026

Yesterday it was cows using tools, today its penguins using satellite imagery.

Headline: "Scientists discover emperor penguin colony in Antarctica using satellite images"

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Pvnk'd @cynickal.bsky.social · 16/01/2026

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Sjors Scheres @sjorsscheres.bsky.social · 13/01/2026

Oh wow: Cryo-EM structure of #TAF15 filaments from postmortem #FTLD brains by the group of Ben Ryskeldi-Falcon at the @mrclmb.bsky.social. What an amazing tour-de-force!! 🤯 www.biorxiv.org/content/10.6...

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Wouter De Coster @wdecoster.bsky.social · 13/01/2026

Join us at the Flanders Nanopore Day conference on April 17th in Antwerp, organized together with @nanoporetech.com! Details are available at nanoporeflanders.be, including registration (free), abstract submission, and project prizes with free PromethION sequencing for two selected projects.

nanoporeflanders.be

Flanders Nanopore Day 2026 - Flanders Nanopore Day

The Flanders Nanopore Day - April 17th, 2026

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Sara_Ald @saraalidadiani.bsky.social · 10/01/2026

#Iran is in the middle of #REVOLUTION. This isn't about inflation. It's about 47 years of oppression. Listen to the chants: "death to the dictator," calls for regime change, and demands for the Shah's return. Be the voice of the Iranian people. #DigitalBlackoutIran

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Michael Hoffman @michaelhoffman.bsky.social · 10/01/2026

What genetic change to Indian wheat led to superior baking in a tandoor? A naan sense mutation

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The Onion @theonion.com · 05/01/2026

Nicolás Maduro Charged With Felony Oil Possession

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Kai Kupferschmidt @kakape.bsky.social · 05/01/2026

„Never forget: whenever Elon Musk walks up to a podium to bullshit you about colonizing Mars or whatever, he is walking on the bodies of dead children. He yanked their food and medicine away while telling lies and cracking stupid jokes.“ @dereklowe.bsky.social as usual not pulling any punches

science.org

Last Year, and the Year to Come

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Russ Fischer @superelastic.bsky.social · 23/12/2025

and the winner of the "2025 best thing on Internet" has just arrived neal.fun/size-of-life/ @carlbergstrom.com

neal.fun

Size of Life

From an amoeba to a blue whale

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The Wall Street Journal @wsj.com · 18/12/2025

AI ran our office vending machine for several weeks. It lost hundreds of dollars, gave away a PlayStation, bought a live fish—and taught us a lot about AI agents, writes Joanna Stern.

on.wsj.com

We Let AI Run Our Office Vending Machine. It Lost Hundreds of Dollars.

An AI agent ran a snack operation in the WSJ newsroom. It gave away a free PlayStation, ordered a live fish—and taught us lessons about the future of AI.

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Sleegers Lab @sleegerslab.bsky.social · 03/12/2025

HIRING ALERT!!! 💥 We are looking for an enthusiastic postdoctoral researcher to uncover Alzheimer's disease mechanisms using state-of-the-art technologies! 🧠🧬 jobs.vib.be/j/128109/pos...

jobs.vib.be

Postdoctoral Researcher in Computational Genomics of Alzheimers Disease - VIB

Description TheSleegers labat the VIB-UAntwerp Center for Molecular Neurology Belgium, is seeking a highly motivated and talented postdoctoral r

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Aaron Quinlan (he/him) @aaronquinlan.bsky.social · 02/12/2025

We are thrilled to announce the first official release (v0.1.8) of #𝗯𝗲𝗱𝗱𝗲𝗿, the successor to one of our flagship tool, #𝗯𝗲𝗱𝘁𝗼𝗼𝗹𝘀! Based on ideas we conceived of long ago (!), this was achieved thanks to the dedication of Brent Pedersen. 1/n

quinlanlab.org

Intro to Bedder – The Quinlan Lab

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Wouter De Coster @wdecoster.bsky.social · 27/11/2025

Does someone know if there public @nanoporetech.com or @pacbio.bsky.social genome sequencing data from individuals with pathogenic repeat expansions?

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Ensembl @ensembl.org · 04/11/2025

As new human assemblies become available on beta.ensembl.org - which human reference genome will you choose? This article explores the question with insights from Ensembl’s own Fergal Martin - www.nature.com/articles/s41... #HumanGenomics #Pangenomes #ReferenceGenomes

nature.com

Choose your human genome reference wisely - Nature Methods

Scientists can choose between multiple human genome references, and a pangenome reference is coming. Deciding what to use when is not quite straightforward.

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Rasmus Kirkegaard @kirk3gaard.bsky.social · 04/11/2025

Did not expect to see disk space become an issue but after a disk clean up and restart I ended up with 243 and 244 gbp for these two @nanoporetech.com flowcells 🎉🚀🧬 💚🟩💚🟩💚🟩

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Benjamin Schuster-Böckler @dagams.bsky.social · 21/10/2025

I am looking to get my hands on some #Illumina 5-base methylation data - does anyone have a bam file that I could use for some testing? Please RT for reach!

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Wouter De Coster @wdecoster.bsky.social · 21/10/2025

My current favorite strategy for using LLMs to code (specifically, GitHub Copilot agent mode) is to write a paragraph or more of instructions, and finish with "Do not start writing any code yet. First, tell me all the questions you still have about this plan".

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Philipp Bayer @philippbayer.bsky.social · 17/10/2025

Why yes Windows, I did want to save this email attachment in C:\Users\pbayer\AppData\Local\Microsoft\Olk\Attachments\ooa-6b0f86af-a548-4060-9a83-7d943fcaa440\157ef8591494ef374d2433d75c318962f8bc4054af4a1be24c8e02b89b6d5ec9 that's just a logical place for it

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Jerry Chen @jcsalterego.bsky.social · 11/10/2025

(forgetting the word for antibiotics) do i need cancel culture

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KOJAMF🤘🖤🤘 @kojamf.bsky.social · 05/10/2025

Dr. Jane Goodall filmed an interview with Netflix in March 2025 that she understood would only be released after her death.

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Wouter De Coster @wdecoster.bsky.social · 26/09/2025

We are hiring a postdoctoral researcher to identify genes involved in frontotemporal dementia using short- and long-read sequencing data. More information is available at jobs.vib.be/j/124543/pos....

jobs.vib.be

Postdoctoral researcher - VIB

The Laboratory of Advanced and Translational Neurogenomics at the VIB-Center for Molecular Neurology, led by Dr. Rosa Rademakers, is seeking a highly motivated and talented postdoctoral researcher to ...

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