iiinova — where your digital self keeps evolving

CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 29/09/2026

New in #JAMIA Open📃 Led by @peteredewitt.bsky.social, biomedical researchers @cuanschutz.bsky.social developed medicalcoder, an R package designed to help researchers apply comorbidity algorithms consistently. Read the paper here ➡️ cudbmi.info/medicalcoder-jamia-1

person typing on a desktop computer with a stephescope sitting on the top of the desk in the foreground.

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 24/09/2026

The @alice.soragnilab.com at @cuanschutz.bsky.social is using patient tumor organoids to study rare cancers, including sarcoma, and explore how different tumors respond to treatment. Their work is advancing functional precision medicine. Learn more ➡️ cudbmi.info/sarcoma

graphic with a black background and a subtle, 3d gold neural network imagery in the back. The text reads "TECH SPOTLIGHT Q&A" on the left column and on the right there is a portrait of Alice Soragni, PhD.

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 22/09/2026

A new @cuanschutz.bsky.social study of nearly 396,000 women found that menopause appeared nearly 7x more often in participant surveys than in electronic health records. The findings point to major gaps in women's health data. Learn more: cudbmi.info/menopause-ehr-1

woman wearing white lab coat and a stethoscope sitting at a desk looking at a computer monitor. Th background is partially blurred but more computer monitors are visible across the counter.

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 18/09/2026

Can AI recognize when it doesn’t know something? @cuanschutz.bsky.social researcher Andrea Sikora, PharmD, is studying how large language models handle uncertainty in high-stakes settings like pharmacy—and where they can fall short. Learn more: cudbmi.info/ai-idk-1

clinician with white coat and badge around her neck looking at a computer screen while writing on a clipboard.

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 17/09/2026

New in Nature Aging: @cuanschutz.bsky.social researcher @bstranger.bsky.social collaborates on report about how sex differences shape health and aging across the lifespan. This highlights how big data and AI can improve sex-aware risk prediction and personalized medicine ➡️ cudbmi.info/nia-1

family walking facing away from camera including multiple generations across diverse ages

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 03/09/2026

AI agents are gaining significant attention in science—but what exactly distinguishes an 'AI agent' from chatbots and other tools? Expert researchers and software engineers at @cuanschutz.bsky.social gave us the story ➡️ cudbmi.info/ai-scientists-1

graphic containing an old computer from the 80s/90s with vertical binary coming down the center of the screen. The background is beige, and there is a grid pattern. In the corners of the image, the grid contains pictures. In the top left is a picture of Cs, Gs, Ts, and As, representing DNA sequencing. In the top right is two clinicians at a computer. In the bottom left is a researcher at a microscope. In the bottom right is a few researchers in a lab. There are circlular graphics connected with lines/arrows that represent computational intelligence and agentic AI, such as one that has "Large Language Model" in IPA, and another that has math script.

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 31/08/2026

How can we get more useful feedback from software users? Researchers at @cuanschutz.bsky.social developed LadderTeam, an LLM framework that probes vague survey responses for actionable feedback. They’ll present LadderTeam tonight at the ACM AI Summit. Learn more: cudbmi.info/ladderteam-1

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 22/08/2026

LLMs offer promise for collecting Social Determinants of Health data at-scale, but evaluation methods are needed. @cuanschutz.bsky.social researchers, including biomedical researcher James Mitchell, PhD, developed a rubric and iterative evaluation approach. Learn more ➡️ cudbmi.info/sdoh-1

clinician looks at tablet with patient in a healthcase setting. The clinician is holding up the tablet, suggesting evaluation of large language model chatbot for SDoH data collection.

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 06/08/2026

Researchers in the Way Lab at @cuanschutz.bsky.social, led by biomedical researcher Greg Way, develop and leverage open-source tools to help discover new therapeutics for diseases with unmet need.  Learn more about their suite of open-source tools in our newsroom ➡️ cudbmi.info/cyto-1

graphic with a quote on the left half and an image on the right half. The left half is the CU Gold background with black text reading "Complex diseases change how cells look and behave. Using image-based profiling, we study cell shape and structure to identify disease-specific patterns, and test how drugs or genetic interventions can shift the cell back towards a healthy phenotype.This work helps narrow the funnel of promising therapies and improve the speed of medical drug discovery." Quote is by Gregory Way, PhD, Associote Professor of Biomedical nformatics at CU Anschutz. Graphic on the right side shows a gloved hand in a wet lab pointing to a computer monitor with images of cells.

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 04/08/2026

The Way Lab at @cuanschutz.bsky.social seeks to uncover new therapeutics for diseases with unmet need.  The team develops open-source software to efficiently evaluate thousands of compounds, helping to find the best candidates for future research. Learn more ➡️ cudbmi.info/cyto-1

depiction of the DBMI Wall of Software, where a hexbin orientation of multi-colored hexagonal logos are displayed. The majority of the logos are partially blurred and faded in the background, while four tools of the Cytomining Ecosystem (CytoTable, Pycytominer, coSMicQC, and buscar) are cell-like shapes and are clear and in the foreground.

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 31/07/2026

A new study published in the Gut Microbes journal, led by researchers in the Stanislawski Lab at @cuanschutz.bsky.social, evaluated multi-omic data to uncover features that correlate with individual responses to weight loss efforts. Learn more ➡️ cudbmi.info/multi-omic-bmi-1

gloved hand placing a small vials into a pcr machine in a lab

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 22/07/2026

A study by a team including @cuanschutz.bsky.social researcher Tell Bennett, MD, evaluated Acute Kidney Injury (AKI) risk prediction models in pediatric critical care. The study found that incorporating multi-center data improved model prediction performance ➡️ cudbmi.info/aki-model-1

hospital room with equiptment such as a hospital bed and monitors. white cabinets and drawers along the back wall.

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 22/07/2026

A new study published in @gigascience.bsky.social, led by researchers at @cuanschutz.bsky.social, introduces KG-Microbe: a knowledge graph (KG) framework that harmonizes and standardizes microbial data to support microbiome research. Learn more here ➡️ cudbmi.info/kg-microbe-1

view of a microbial community through a microscope, which is a white circle in the center of the image. the organisms appear blue dots clustered, with one cluster of darker violet dots.

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 20/07/2026

What a fantastic week at #ISMB2026 in Washington, D.C. Our DBMI team from @cuanschutz.bsky.social was well represented, with researchers delivering talks, showcasing posters and facilitating panels throughout the week. Thanks to everyone who connected, collaborated and shared their work.

group picture of researchers from the department of biomedical informatics at CU Anschutz attending the ISMB 2026 Conference in Washington, D.C. photo taken in a conference hall at the Washington Hilton. Researchers in the image include: Keenan Manpearl, Marc Subirana Granes, Mónica Muñoz Torres, Lucas Gillenwater, Emma Lathouwers, Parker Hicks, Arjun Krishnan, Sutanu Nandi, Abhirupa Ghosh, Katerina Terwelp, Alexander McKim, Evan Brenner, Janani Ravi, Kewalin Samart, and Lydia Valtadoros

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 17/07/2026

Congratulations to Aishwarya Mandava, researcher in the Krishnan Lab at @cuanschutz.bsky.social, for winning the TransMed COSI Best Poster Award at #ISMB2026 🎉

aishwarya mandava, researcher at the University of Colorado Anschutz Department of Biomedical Informatics, stands holding an award for the TransMed COSI at ISMB 2026. There is a poster behind her in a poster hall in a conference center.

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 16/07/2026

Final day of #ISMB2026 DBMI has oral presentations from Samantha Lopez Alvarez plus poster presentations from Kewalin Samart, Abhirupa Ghosh and Evan Brenner. Plus visit our booth from 10:00 a.m.–4:40 p.m. Get the details here: cudbmi.info/ismb-2026-1

abhirupa ghosh, researcher at the Department of Biomedical Informatics at CU Anschutz, presents a poster titled "intermittent fasting improves bone health by impacting gut microbiota" to another researcher at the ISMB 2026 conference

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 15/07/2026

Wednesday at #ISMB2026 Don't miss oral presentations from Emma Lathouwers, Lucas Gillenwater, Evan Brenner, Katerina Terwelp, and Akshay Kumar Avvaru. Plus, visit DBMI’s booth from 10 a.m.–4:40 p.m. Get the details here: cudbmi.info/ismb-2026-1

view of a conference presentation in a large conference room at the Washington Hilton where ISMB 2026 is hosted. There are oval shaped architectural features on the ceiling, revealing a teal light. A presenter is standing center-stage, and there are screens on either side of the stage. There is a large audience.

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 14/07/2026

DBMI has a full Tuesday at #ISMB2026 Visit our booth from 10:00 a.m.–4:40 p.m., explore posters from Lucas Gillenwater and Abhirupa Ghosh, and attend Mónica Muñoz Torres’ open science panel. Get the details here: cudbmi.info/ismb-2026-1

low-apeture view of of academic research poster with colorful graphics taken from side angle with researchers looking at academic posters faded in the background

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 13/07/2026

Day 2 at #ISMB2026 DBMI’s booth is open today from 10:00 a.m.–4:40 p.m. in the Columbia Ballroom. Come meet our researchers and learn more about biomedical informatics at CU Anschutz. Check out our booth schedule and ISMB Research Showcase here: cudbmi.info/ismb-2026-1

image of an exhibition booth at a conference with a black tablecloth that reads 'CU Departmetn of Biomedical Informatics University of Colorado Anschutz Medical Campus." There is a CU Anschutz poster in the back, and there is swag and literature on the table

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 12/07/2026

We're kicking off #ISMB2026 in Washington, D.C. Stop by our booth in the Columbia Ballroom today from 4:00–9:00 p.m. to connect with our researchers and learn more about our department. Check out our presenter schedule, booth schedule and ISMB Research Showcase here: cudbmi.info/ismb-2026-1

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 17/06/2026

Can AI say "I don't know"? Although Large Language Models (LLMs) have come a long way, they still struggle with declaring uncertainty—a vital task in clinical settings. Read more in the perspective led by @cuanschutz.bsky.social researcher Andrea Sikora, PharmD➡️ cudbmi.info/can-ai-say-idk-1

clinician's hands in front of a laptop with stethoscope in focus in foreground

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 19/05/2026

As healthcare systems expand digital tools, research is raising an important question: who gets left behind? Samantha Stonbraker’s work shows that designing for diverse digital and health literacy levels improves usability, engagement, and outcomes.

cudbmi.info

Designing Digital Health Tools That Work for Everyone

As healthcare moves online, researchers examine how inclusive design can improve digital health tools and reduce disparities for underserved populations.

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 08/05/2026

The medicalcoder R package supports running comorbidity algorithms on datasets—even those with ICD-9 and ICD-10 codes. Today, developer @peteredewitt.bsky.social is presenting medicalcoder at the virtual R/Medicine 2026 conference at 2:06 p.m. ET. Learn more here➡️ cudbmi.info/medcoder-1

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 28/04/2026

Emily Meyer, PhD, and James Mitchell, PhD will be presenting a poster at NORDP. The Facilities and Resources Generator, highlights a software tool that streamlines how facilities and resources sections are created for grant proposals. 🗓️ April 28, 2026 | 12:45–2:00 PM ET 📍 Exhibit Hall, JW Marriott

This image is a promotional poster for a project titled "The Facilities and Resources Generator: a collaborative software project to strengthen grant proposals." It features logos and mentions CU Anschutz. The poster highlights presenters Emily Meyer, PhD, and James Mitchell, PhD, MS, with their photos. Event details are provided: Date - April 28, 2026; Time - 12:45 PM; Location - Exhibit Hall, JW Marriott, Indianapolis.

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 27/04/2026

New research suggests dietary fiber may protect against severe C. difficile infection. Low-fiber diets were linked to higher mortality and sepsis, while fiber supplementation improved outcomes in a preclinical model.

cudbmi.info

Dietary fiber reduces mortality from secondary sepsis in a murine model of Clostridioides difficile infection

Health sciences; Biological sciences; Systems biology; Diet

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 21/04/2026

At CU Anschutz, our researchers are unlocking biological insights from incomplete datasets by providing guidelines to achieve near scRNA-seq accuracy in bulk deconvolution, enabling deeper insight into cell types and states within complex tissues ➡️ cudbmi.info/rna-guidelines-1

A digital illustration of a DNA double helix composed of glowing blue dots and lines, set against a dark, abstract background with interconnected lines and points.

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 07/04/2026

Pseudomonas aeruginosa is a pathogen that often dominates infections in vulnerable tissues or hosts. CU Anschutz researchers found resistance only in clinical strains, identifying how antibiotic pressure can increase its threat and complicate treatment ➡️ cudbmi.info/pseudomonas-aeruginosa-1

A person wearing purple gloves holds up a petri dish with green-blue colonies, examining it closely.

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 07/04/2026

No code, no downloads—just insights. The pedbp app makes it easy to explore and visualize pediatric blood pressure percentiles (BPPs) in a user-friendly web app. @cuanschutz.bsky.social researchers designed this tool give consistent access to BPPs.

cudbmi.info

pedbp Web Application: Visualize Pediatric Blood Pressure Percentiles (BPPs)

How to use the pedbp web application as a convenient, reliable method to view pediatric blood pressure percentiles.

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 03/04/2026

A global study of genetic data from 2.9 million people uncovered hundreds of new variants linked to thyroid cancer. CU Anschutz researchers found DNA patterns that may help predict cancer aggressiveness, and guide earlier, more precise care.

cudbmi.info

A Global Study Explores the Genetic Roots of Thyroid Cancer

CU Anschutz Cancer Center members led research that found clues to predict cancer’s aggressiveness in patients.

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 27/03/2026

Pediatric blood pressure isn't the simple 120/80 'healthy' ceiling we learn for adults—it's a function of age, sex and more. Led by @peteredewitt.bsky.social researchers @@cuanschutz.bsky.social developed pedbp: a tool for pediatric blood pressure percentiles. Learn more➡️ cudbmi.info/pedbp1

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 25/03/2026

Resarchers @cuanschutz.bsky.social developed MUSE, one of the first multi-LLM uncertainty algorithms grounded in information-theoretic principles. Instead of relying on a single model’s output, MUSE leverages a subset of models. Learn more➡️ cudbmi.info/muse1

a picture of CU gold nodes with CU gold lines connecting them to represent multi llm uncertainty quantification.

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 14/03/2026

🥧 Pi Day isn’t just about math—it’s also a reminder that precision matters. Researchers at CU Anschutz are using multi-omics to study how hormones, metabolism, genetics, and the gut microbiome work together to shape obesity treatment.

cudbmi.info

What Pi Day Can Teach Us About Precision Obesity Care

Multi-omics research at the University of Colorado shows that successful treatment depends on how every biological layer works together.

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Reposted by CU Department of Biomedical Informatics

Arjun Krishnan @compbiologist.bsky.social · 09/03/2026

Enjoyed working w/ Stephen & Agnes on this! Gave me a chance to think systematically about where AI 🤖 can backstop human 🧑🏼‍🔬 fallibilities in peer review (fatigue, ordering effects, bias) vs. where human judgment remains essential (novelty, feasibility, creative leaps) while grappling w/ the risks.

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 04/03/2026

Using a familiar correlational coefficient like Spearman’s or Pearson’s on molecular data may miss some complex patterns that exist. To overcome this, researchers at @cuanschutz.bsky.social including @miltondp.bsky.social developed CCC—a new statistical framework ➡️ cudbmi.info/ccc-1

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 25/02/2026

Sparse data and lack of reliable models are challenges in estimating biological systems. Researchers at @cuanschutz.bsky.social introduced a multi‑objective data assimilation framework for complex biological systems➡️ cudbmi.info/multiobjective-optimiza…

graphic depicting data chart with oscillations reprinting sparse data prediction

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 23/02/2026

Clinicians have a lot to consider for patient medications. LLMs could support medication management, but medications pose unique challenges for these LLMs. @cuanschutz.bsky.social researchers developed a benchmark suite to evaluate these implementations: cudbmi.info/rx-llm-1

a lot of medication blister packs in a pile containing medications of different color, size, and shape suggesting comprehensive medication management (CMM)

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CU Department of Biomedical Informatics @cubiomedinfo.bsky.social · 22/02/2026

How your body breaks down medication is more unique than you think. Researchers at CU Anschutz’s Claw Lab are mapping the genetic and metabolic differences that shape drug responses, and building models that could help clinicians personalize dosing with greater equity and precision.

cudbmi.info

Inside Pharmacogenetics: How CU Anschutz Researchers Are Using Metabolism to Guide Safer, More Personalized Treatment

Discover how genetics, metabolism, and advanced research at CU Anschutz are shaping safer, personalized medication decisions for every patient.

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