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Here, using a mouse model of tauopathy, the authors reveal that disruption of the gut microbiome drives tau pathology and cognitive decline, and identify five microbial metabolites that directly promo...

Deep mutational scanning (DMS) has emerged as a transformative tool for dissecting individual protein function and broader cell biology. DMS methods enable comprehensive interrogation of sequence–func...

YouTube video by ASM - Microbes Make Our World

The Hypothesis Fund enables scientists to take intelligent risks. To defy the predominant expectations in their field. To go after their big ideas.

Chemist Tim Cernak has a wild to-do list: Cure sea turtle cancer. Save frogs from fungal diseases. Take on avian flu.

Hypothesis Fund supports early-stage innovative research that aims to improve the health of people and the planet.

Hypothesis Fund supports early-stage innovative research that aims to improve the health of people and the planet.

Podcast Episode · Out of Patients with Matthew Zachary · May 14 · Bonus · 12m

Abstract. Tyro3, Axl, and Mer are receptor tyrosine kinases that comprise the TAM receptor family. These receptors, originally identified as orphan receptors, do not bind growth factors but rather lig...

In this study, Luo and colleagues identify previously unknown viruses that actively infect highly productive chemoautotrophs. These findings provide new insights into key trophic interactions and&nbsp...

Groundwater viruses are less well studied. Here, using large-scale sequencing, the authors uncover extensive, largely uncharacterized viral diversity in groundwater, showing that viruses infect domina...