Reposted by Maximilian Friedrich, vertigologistFrederic Schaper @fredschaper.bsky.social · 24/03/2025Is generalized epilepsy a seizure of the whole brain or a specific brain network? In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome. Paper: nature.com/articles/s41... A 🧵 below:nature.comA generalized epilepsy network derived from brain abnormalities and deep brain stimulation - Nature CommunicationsJi et al. identify an idiopathic generalised epilepsy network that links heterogeneously distributed brain abnormalities to a common brain network and deep brain stimulation sites which reduce general... 68428
Maximilian Friedrich, vertigologist @vertigologist.bsky.social · 24/03/2025Best of luck- we’re cheering for ya! 020
Reposted by Maximilian Friedrich, vertigologistMichael Okun @michaelokun.bsky.social · 07/03/2025About 12,000 people globally have signed up and the United States and Canada are lagging behind. It is mostly video content and enjoyable. The course closes for feedback analysis and development at the end of March so I challenge you to jump on board. mooc.utas.edu.au/course/20278... 041
Maximilian Friedrich, vertigologist @vertigologist.bsky.social · 21/02/2025Neurologists use videos to augment the clinical examination, and new AI methods promise to transform these videos into granular biomarkers. Here, we review the fascinating past, present and future of AI-powered video analyses in clinical neurology. Enjoy! jamanetwork.com/journals/jam...jamanetwork.comComputer Vision in Clinical Neurology and AI Augmentation of the Neurological ExaminationThis narrative review outlines recent advances and challenges in technologies arising from computer vision, a branch of artificial intelligence (AI), which has the potential to improve clinical neurol... 062
Maximilian Friedrich, vertigologist @vertigologist.bsky.social · 17/02/2025Pretty sure I don‘t have to introduce Andy, so to make it very short: interested in DBS and brain networks? Check out this super exciting new institute in Cologne! 062
Reposted by Maximilian Friedrich, vertigologistAndrew Pines @andrewpines.bsky.social · 12/02/2025What brain regions are involved in causing psychotic symptoms? Take a moment away from the existential dread about the future of science, and join me in this summary of some incredibly cool stuff that could help patients! 1/n🧵 57234
Reposted by Maximilian Friedrich, vertigologistAndreas Horn @andreashorn.org · 12/02/2025Do lesions that cause psychosis fall into a common brain network? Exciting new work by @andrewpines.bsky.social, @shansiddiqi.bsky.social and colleagues – tweetorial below by the first author, paper here: jamanetwork.com/journals/jam...jamanetwork.comMapping Lesions That Cause PsychosisThis case-control study analyzes published cases of lesion-induced psychosisTo assess whether lesions that cause secondary psychosis have functional connections to a common brain circuit 14018
Reposted by Maximilian Friedrich, vertigologistCenter for Brain Circuit Therapeutics @braincircuits.bsky.social · 12/02/2025New Center paper out at JAMA psychiatry: jamanetwork.com/journals/jam...jamanetwork.comMapping Lesions That Cause PsychosisThis case-control study analyzes published cases of lesion-induced psychosisTo assess whether lesions that cause secondary psychosis have functional connections to a common brain circuit 084
Reposted by Maximilian Friedrich, vertigologistMichael Fox @foxmdphd.bsky.social · 10/01/2025Awesome thread by @andreashorn.org on his recent paper on STN DBS for dystonia. Details a great collaboration and his thought process as the study evolved. @braincircuits.bsky.social 0187
Maximilian Friedrich, vertigologist @vertigologist.bsky.social · 10/01/2025Great thread and interesting work which further supports the idea that axial dystonic symptoms map closer to cerebellar networks. Nicely aligns with old (and some new) lesion and experimental midbrain stim studies 010
Maximilian Friedrich, vertigologist @vertigologist.bsky.social · 02/01/2025What an impressive list of achievements! Congrats Doug! 010
Reposted by Maximilian Friedrich, vertigologistMichael Fox @foxmdphd.bsky.social · 24/12/2024Cool to see our work from @braincircuits.bsky.social featured in @sciam.bsky.social today. Great read on an interesting and bizarre neurological condition. www.scientificamerican.com/article/how-...scientificamerican.comHow Rare ‘Alice in Wonderland Syndrome’ Warps RealityResearchers are learning what causes Alice in Wonderland syndrome, a rare neurological condition that can appear to warp bodies, time and reality itself 2188
Maximilian Friedrich, vertigologist @vertigologist.bsky.social · 24/12/2024Wonderful christmas read featuring our network mapping work on Alice in Wonderland syndrome- a bizarre and fascinating perceptual disorder. Kudos @sciam.bsky.social @foxmdphd.bsky.social @braincircuits.bsky.social www.scientificamerican.com/article/how-...scientificamerican.comHow Rare ‘Alice in Wonderland Syndrome’ Warps RealityResearchers are learning what causes Alice in Wonderland syndrome, a rare neurological condition that can appear to warp bodies, time and reality itself 0174
Reposted by Maximilian Friedrich, vertigologistbioRxiv Neuroscience @biorxiv-neursci.bsky.social · 22/12/2024Spanning spatial scales with functional imaging in the human brain; initial experiences at 10.5 Tesla www.biorxiv.org/content/10.1101/202… 02111
Maximilian Friedrich, vertigologist @vertigologist.bsky.social · 20/12/2024I have one of these and can confirm they induce a cathartic experience. Great for grants and life! 010
Maximilian Friedrich, vertigologist @vertigologist.bsky.social · 15/12/2024Great take. It‘s sometimes bewildering to me just how advanced imaging pipelines are, while at the same time, behavioral assessments are very rudimentary and crude. 020
Reposted by Maximilian Friedrich, vertigologistEmily Moin @emilymoin.com · 11/12/2024I think a fun teaching exercise for medical students would be to each take a common clinical pearl and trace the citations until you find the primary data it's based on. 109122
Reposted by Maximilian Friedrich, vertigologistAndreas Horn @andreashorn.org · 05/12/2024Showed a glimpse of a new atlas that we're building in Paris yesterday. Pretty excited about it and implications for network modeling. 2389
Maximilian Friedrich, vertigologist @vertigologist.bsky.social · 05/12/2024It‘s a wrap! Do you have a video database you‘d like to analyze? Feel free to reach out, or DIY as our code is #opensource. Enjoy the read!media.tenor.coma sign that says we are open with a cartoon character on itALT: a sign that says we are open with a cartoon character on it 000
Maximilian Friedrich, vertigologist @vertigologist.bsky.social · 05/12/2024This machine learning framework uncovers latent, but relevant pathosignatures of dystonia. We envision its integration into the modern canon of neuromodulation, neurotechnology and neuroimaging (did I hear dysfunctome?), powering translational & precision Neurologymedia.tenor.coma man standing in a park with the words " a little more precise " on the bottomALT: a man standing in a park with the words " a little more precise " on the bottom 100
Maximilian Friedrich, vertigologist @vertigologist.bsky.social · 05/12/2024Finally, data driven analyses of head/neck movements converge on an almost identical feature set across different types of dystonia, supporting the idea that dystonia subtype and severity map onto a "kinematic continuum" 100
Maximilian Friedrich, vertigologist @vertigologist.bsky.social · 05/12/2024We also find that phasic (tremulous) and tonic (fixed deviations) dystonia components may map to different circuits. Movement disorders aficionados had this gut feeling for quite a whilemedia.tenor.coma cartoon drawing of a man 's head with a loading bar in front of a green board with math equationsALT: a cartoon drawing of a man 's head with a loading bar in front of a green board with math equations 100
Maximilian Friedrich, vertigologist @vertigologist.bsky.social · 05/12/2024We identified a set of clinically-inspired features from full video assessments that provide additional insights into disease severity, subtype & brain stim effects. We found: tremor matters! (but hasn't even been quantified in scores for a long time...) 100
Maximilian Friedrich, vertigologist @vertigologist.bsky.social · 05/12/2024We develop a visual computer vision framework which extracts a rich, yet intuitively interpretable set of kinematic features of head movement dynamics- from videos taken several years (or decades) ago in 7 different academic centers! 100
Maximilian Friedrich, vertigologist @vertigologist.bsky.social · 05/12/2024Paying homage to "medical cinematography", we develop a deep learning framework to evaluate dystonia severity & characterize effects of brain stimulation, using only standard clinical videos! How?!media.tenor.coma kermit the frog is holding a polaroid camera and saying photo shootALT: a kermit the frog is holding a polaroid camera and saying photo shoot 100
Maximilian Friedrich, vertigologist @vertigologist.bsky.social · 05/12/2024🧐 Dystonia is a neurological movement disorder characterized by complex, twisting and tremulous movement abnormalities. Clinical scores are simple and easy to administer, but fail to capture the true complexity of the dystonic phenotype. 110
Maximilian Friedrich, vertigologist @vertigologist.bsky.social · 05/12/2024Can computer vision help us turn clinical videos into quantifiable digital biomarkers of Dystonia? Our recent paper suggests yes! Let‘s recap first. www.nature.com/articles/s41...nature.comHead movement dynamics in dystonia: a multi-centre retrospective study using visual perceptive deep learning - npj Digital Medicinenpj Digital Medicine - Head movement dynamics in dystonia: a multi-centre retrospective study using visual perceptive deep learning 182
Reposted by Maximilian Friedrich, vertigologistScience News @scinews.bsky.social · 03/12/2024Hypothalamic deep brain stimulation augments walking after spinal cord injury (SCI). #NatureMedicine #medsky #scisky "Targeting specific brain regions to maximize the engagement of spinal cord-projecting neurons in the recovery of neurological functions after SCI." www.nature.com/articles/s41...nature.comHypothalamic deep brain stimulation augments walking after spinal cord injury - Nature MedicineWhole-brain anatomical and activity surveys identify the lateral hypothalamus as a key driver of recovery from spinal cord injury, leading to a deep brain stimulation therapy that augments the recover... 05018
Reposted by Maximilian Friedrich, vertigologisteLife @elife.bsky.social · 01/12/2024Combining electrophysiological, anatomical and functional brain maps reveals networks of beta neural activity that align with dopamine uptake. buff.ly/4eQnzETbuff.lyBrain Activity: Unifying networks of a rhythmCombining electrophysiological, anatomical and functional brain maps reveals networks of beta neural activity that align with dopamine uptake. 0216
Maximilian Friedrich, vertigologist @vertigologist.bsky.social · 02/12/2024@isaiahneuro.bsky.social 010
Reposted by Maximilian Friedrich, vertigologistM.J. Crockett @mjcrockett.bsky.social · 01/12/2024Our new paper in @science.org shows that misinformation evokes more outrage than trustworthy news, and when it does it’s shared more & read less. bsky.app/profile/will... 528070
Reposted by Maximilian Friedrich, vertigologistMaximilian Friedrich, vertigologist @vertigologist.bsky.social · 18/11/2024Have you ever felt like you're in a surreal world where sizes and scales are all warped? No, it's not a fantasy—it's a real medical condition! Come dive with me into this mind-bending phenomenon called Alice in Wonderland Syndrome (AIWS): onlinelibrary.wiley.com/doi/abs/10.1... 1178
Maximilian Friedrich, vertigologist @vertigologist.bsky.social · 28/11/2024Spot on. Plus, menscheln has a fairly benign connotation of „the human condition“- which is dearly needed in these heated times! 010
Maximilian Friedrich, vertigologist @vertigologist.bsky.social · 28/11/2024I strongly endorse the introduction of the concept „to menscheln“ globally :-) Enjoy the run! 110
Reposted by Maximilian Friedrich, vertigologistJournal of Cognitive Neuroscience (JoCN) @jocn.bsky.social · 26/11/2024dlvr.itEffects of Vergence Eye Movement Planning on Size Perception and Early Visual ProcessingAbstractOur perception of objects depends on non-oculomotor depth cues, such as pictorial distance cues and binocular disparity, and oculomotor depth cues, such as vergence and accommodation. Although vergence eye movements are always involved in… 011
Maximilian Friedrich, vertigologist @vertigologist.bsky.social · 24/11/2024Feel free to add me, too @vertigologist.bsky.social 000
Reposted by Maximilian Friedrich, vertigologistMaximilian Friedrich, vertigologist @vertigologist.bsky.social · 22/11/2024Tremor is common, and measuring its dynamic characteristics is important for disgnosis and prognostication. Marker-based motion capture helps, but is very resource-intensive. What if we could analyze tremor just with a smartphone video?! 🧠 www.nature.com/articles/s41...nature.comValidation and application of computer vision algorithms for video-based tremor analysis - npj Digital Medicinenpj Digital Medicine - Validation and application of computer vision algorithms for video-based tremor analysis 063
Maximilian Friedrich, vertigologist @vertigologist.bsky.social · 22/11/2024Tremor is common, and measuring its dynamic characteristics is important for disgnosis and prognostication. Marker-based motion capture helps, but is very resource-intensive. What if we could analyze tremor just with a smartphone video?! 🧠 www.nature.com/articles/s41...nature.comValidation and application of computer vision algorithms for video-based tremor analysis - npj Digital Medicinenpj Digital Medicine - Validation and application of computer vision algorithms for video-based tremor analysis 063
Reposted by Maximilian Friedrich, vertigologistAndreas Horn @andreashorn.org · 21/11/2024Very much looking forward to this talk tomorrow by our very own @fredschaper.bsky.social together with Stanford's Robert Fisher on Epilepsy and How to get jobs in Academia! Join us on stimulatingbrains.org! @stimulatingbrains.org 0134
Reposted by Maximilian Friedrich, vertigologistAltmetric @altmetric.com · 18/11/2024We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how: docs.bsky.app/docs/advance... #AcademicSky #HigherEd #Altmetricsdocs.bsky.appAction Intent Links | BlueskyAuthors, websites, and apps can use action intent links to implement "Share on Bluesky" buttons, or similar in-app actions. Logged-in users will be directed to the corresponding action view in the Blu... 166113164572
Reposted by Maximilian Friedrich, vertigologistAlan Carson @alancarson15.bsky.social · 14/11/2024www.neurology.org/doi/10.1212/... Mark Hallett’s Wartenberg lecture, dedicated to his mentor the late David Marsdenneurology.orgFunctional Neurologic Disorder, La Lésion Dynamique | NeurologyFunctional neurologic disorder is common and a significant cause of disability and stress in neurologic patients. The nature of this disorder has been unclear. Originally called hysteria, the disorder... 0103
Reposted by Maximilian Friedrich, vertigologistAlfonso Fasano @alfonsofasano.bsky.social · 14/11/2024One of most overlooked issues of past literature is the 'miracle' of #brain surgery in #functional patients. Cooper was a pioneer in the field but some of his success came from this, as we discussed recently in www.neurology.org/doi/10.1212/... 0174
Reposted by Maximilian Friedrich, vertigologistAbhimanyu Mahajan @amahajanmd.bsky.social · 18/11/2024PSA BlueSky allows you to curate your feed. In addition to “following”, you can choose (in your settings) to only see the feed you prefer. I deleted “discover” and replaced it with “popular with friends”. Less noise, more signal.media.tenor.coma black and white photo of a man in a suit covering his face with his hands .ALT: a black and white photo of a man in a suit covering his face with his hands . 2143
Maximilian Friedrich, vertigologist @vertigologist.bsky.social · 18/11/2024I think that‘s an important feature as my experience with the feed on here has been somewhat suboptimal. I am trying to locate the feature you mentioned… 120
Maximilian Friedrich, vertigologist @vertigologist.bsky.social · 18/11/2024I‘d love to be added, too Trey 010
Maximilian Friedrich, vertigologist @vertigologist.bsky.social · 18/11/2024Thank you @foxmdphd.bsky.social @braincircuits.bsky.social @fredschaper.bsky.social and many others. Media coverage: @newscientist.bsky.social newscientist.com/article/2414767-alice-in-wonderland-syndrome-mapped-in-the-brain-to-improve-treatments/ and nautilus mag nautil.us/falling-down.... Enjoy!newscientist.comAlice in Wonderland syndrome mapped in the brain to improve treatmentsScientists have mapped the brain circuit behind a form of Alice in Wonderland syndrome, when someone sees themselves or others in distorted proportions, in research that could improve how it is treate... 092
Maximilian Friedrich, vertigologist @vertigologist.bsky.social · 18/11/20248/ As strange as they are, the distortions experienced during AIWS open a window into the fascinating neural networks that shape our perceptual experience, which is obviously very malleable. So better look twice before you believe what you see :-) 110
Maximilian Friedrich, vertigologist @vertigologist.bsky.social · 18/11/20247/ Next, we wondered how the lesion-based AIWS network relates to heterogeneous neuroimaging findings DURING AIWS episodes. We found a truly remarkable convergence, hinting at the validity of our findings beyond lesions. 110