Hedgehog merbecoviruses utilize hedgehog aminopeptidase N, but not the human orthologue, as their entry receptor. Structural resolution of the glycoprotein–receptor interface reveals the molecular int...

Complement C1q and C3 potentiate neutralization activity of anti-S2 antibodies against SARS-CoV-2 variants via the Fc region.

Complement C1q and C3 potentiate neutralization activity of anti-S2 antibodies against SARS-CoV-2 variants via the Fc region.

Complement C1q and C3 potentiate neutralization activity of anti-S2 antibodies against SARS-CoV-2 variants via the Fc region.

Complement C1q and C3 potentiate neutralization activity of anti-S2 antibodies against SARS-CoV-2 variants via the Fc region.

Viruses and their hosts have been co-evolving in a continual arms race for fitness and survival, respectively (1). In humans, the innate and adaptive arms of immunity intimately interact to control infection. Antibodies (Abs), secreted by certain activated B cells, are an essential portion of the adaptive immune response and are a major pillar in the viral clearance of both enveloped viruses as well as some non-enveloped viruses (1–5). Certain antibodies are developed with the ability, through their fragment antigen-binding region, to bind to viral epitopes and, through a variety of methods (e.g., steric obstruction or changing conformation), result in the neutralization of the target antigen (4).

Millions of new proteins with predicted roles in defence against viruses have been identified in bacteria. It was thought that around 0.5% of the average bacterial genome had some involvement in immun...

Virus infected cells release viral particles, which have variable protein content and are functionally diverse. Deciphering this heterogeneity remains a challenge. Here, we adapt flow virometry to det...

Viruses and their hosts have been co-evolving in a continual arms race for fitness and survival, respectively (1). In humans, the innate and adaptive arms of immunity intimately interact to control in...

The tightly closed conformation of the Spike helps SARS-CoV-2 evade the immune system. This cryptic conformation is shaped by increased mannosidic glycosylation and furin cleavage shielding conformati...

HSV-specific antibodies demonstrate improved activity in vitro and in vivo when the IgG Fc domain is rendered insensitive to the viral Fc receptor.

Bats and pangolins are natural reservoirs of betacoronaviruses (β-CoVs) and continue to pose a significant risk for future outbreaks through zoonotic transmissions. This highlights the need for effect...

The first exposure to a pathogen or an antigen profoundly impacts immune responses upon subsequent encounter with related pathogens. This immune imprinting explains that infection or vaccination with ...

Author summary Recent epidemic-causing coronaviruses, including SARS-CoV-2, originated in bats. Large numbers of such viruses circulate in bats and pose clear and present risks to humans. However, our...

Characterization of dipeptidase 1 as a receptor for porcine haemagglutinating encephalomyelitis virus reveals the versatility of embecovirus receptor binding domains and receptor usage.

Large-scale longitudinal health records reveal consistent association of varicella-zoster virus reactivation with dementia.

Interferon-inducible Myxovirus resistance 1 (MX1) proteins are known to restrict influenza A virus (IAV) transcription/replication process. Herein,...

A genome-wide CRISPR screen helps to identify the Epstein–Barr virus receptor desmocollin 2 for primary epithelial cell infection. Additional infection assays revealed that desmocollin 3 also aids infection.

A genome-wide CRISPR screen helps to identify the Epstein–Barr virus receptor desmocollin 2 for primary epithelial cell infection. Additional infection assays revealed that desmocollin 3 also aids infection.

LRP8, an apolipoprotein E and reelin receptor with high expression in the brain, is a receptor for tick-borne encephalitis virus.

A cross-continental joint lab model brings together diverse knowledge, skill sets, working cultures and ideas to tackle the complexity and interdisciplinary nature of research questions in the current...

Non-neutralizing antibodies to influenza A are broadly protective and resist viral escape, offering strong therapeutic potential.

Salivary virome profiling revealed distinct virome profiles in Sjögren’s disease and a role for Vientovirus in triggering autoimmunity through molecular mimicry.

Sarbecoviruses interact with their receptor, angiotensin converting enzyme 2 (ACE2), via the receptor binding domain (RBD) of Spike, the immunodominant target for neutralising antibodies. Understandin...

Study says small editor group handled many problematic manuscripts — and a Nature investigation finds out who they are.

The 2.8-Å resolution structure is presented for a chimeric construct of an emerging tick-borne flavivirus, Powassan virus.

Nature - Feline infectious peritonitis epizootic caused by a recombinant coronavirus

The molecular mechanisms of cell entry for the recently identified highly pathogenic feline coronavirus FCoV-23 are characterized in detail.