This is one of my favorite recent uses of spatial transcriptomics…pseudotemporal ordering of niche remodeling
www.cell.com/cell/fulltex...
cell.com
Oncogenic and tumor-suppressive forces converge on a progenitor niche at the benign-to-malignant transition
Opposing oncogenic and tumor-suppressive forces establish a progenitor-like state
that builds a self-reinforcing niche to drive benign-to-malignant transition in pancreatic
cancer models. Disruption o...