Radulovic et al. show that phosphatidylinositol 3-phosphate (PI3P), produced by the phosphatidylinositol 3-kinase PIK3C3, is formed on ER domains after lysosome damage. ER domain PI3P helps to recruit...

Signal Transduction and Targeted Therapy - Targeting endoplasmic reticulum export disrupts metabolic resilience in multiple myeloma

Bone homeostasis relies on the coordinated activity of osteoblasts and osteoclasts that balances bone formation and resorption, and of osteocytes for biomechanical sensing and hormone secretion. A key...

ER-membrane contact sites are often distorted by existing labeling methods. This study develops an inducible labeling system called LaBeRing that uses the Lamin B receptor to fluorescently tag a varie...

Leukemia - Targeting proteostasis in multiple myeloma through inhibition of LTK

Mechanical forces are critical for virtually all fundamental biological processes, yet quantification of mechanical forces at the molecular scale in vivo remains challenging. Here, we present a new st...

CAR-T and NK cells engineered using a non-viral circular single-stranded DNA system show effective anti-tumor function.

Stem cells perceive and respond to biochemical and physical signals to maintain homeostasis. Yet, it remains unclear how stem cells sense mechanical signals from their niche in vivo. In this work, we ...

Torrino et al. identify the mechanosensitive polyol pathway as a natural mediator of cytoplasmic and nuclear protein condensates through tightly controlled intracellular sorbitol accumulation. Extrace...

Han et al. identify crosstalk between CAFs and pancreatic cancer cells under hypoxia and nutrient scarcity. Lysophosphatidylcholines (LPCs), as the key mediators, can be utilized for phosphatidylcholi...