Cytomegalovirus (CMV) remains a prevalent infectious complication following kidney transplantation. Although antiviral treatments have substantially improved outcomes, CMV continues to cause morbidity...

Permanent immunity to varicella zoster virus (VZV) develops following infection in most patients, with reinfections extremely rare. Here, we report a 6-year-old boy with refractory nephrotic syndrome…

C3 glomerulopathy (C3G) is an uncommon form of complement-mediated glomerular disease marked by dysregulation of the alternative complement pathway, sometimes associated with monoclonal light-chain de...

Posttransplant lymphoproliferative disorder is a serious life-threatening complication which can occur in renal transplant recipients. Vincristine is a commonly used chemotherapeutic agent in such cas...

AbstractBackground. Currently available options for managing uncontrolled and resistant hypertension are limited by safety concerns and their inability to

Hypertensive emergency is a life-threatening condition that can often prompt for evaluations of secondary endocrine causes such as pheochromocytoma. Medication withdrawal remains an underrecognized an...

Fibrillary glomerulonephritis (FGN) and amyloidosis are disorders with fibrillary deposits, which share overlapping morphologic features on biopsy. Differentiating between these 2 diagnoses often requ...

Gitelman syndrome is a rare, hereditary salt-losing tubulopathy caused by loss-of-function of the sodium chloride co-transporter (NCC) in the distal tubule characterized by hypokalemia, hypomagnesemia...

Background:Kidney failure affects approximately 800,000 adults in the United States, and African Americans carry a disproportionate burden of...

The liver has a central role in cardiovascular–kidney–metabolic syndrome but is absent from the current definition. A cardiovascular–kidney–liver–metabolic framework that recognizes steatotic liver di...

Hyperkaliemia is a common electrolyte disorder resulting from an imbalance between potassium intake, transcellular potassium shifts, and renal excretion. In some cases, etiological investigation may b...

KTRs with vector-borne dengue experienced a high observed case-fatality rate. Organ or blood transmission led to life-threatening outcomes. The rapid test screening was associated with low transmissio...

Researchers led by Dr. Ralph Witzgall, a professor at the Chair of Molecular and Cellular Anatomy at the University of Regensburg, have deciphered a key disease mechanism underlying the hereditary kidney disorder nail-patella syndrome and identified a potential therapeutic strategy.

Targeted therapies directed against oncogenic KRAS mutations have significantly improved outcomes in non-small cell lung cancer (NSCLC), yet the renal safety profile of combined KRAS pathway inhibitio...

Nephrogenic ascites is a rare complication of end-stage renal disease, with limited treatment options beyond kidney transplantation. Management typically involves intensive hemodialysis and paracentes...

Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disorder, predominantly caused by pathogenic variants in the PKD1 and PKD2 genes. Variants in other genes, including ALG9, have eme...

Peritoneal dialysis (PD) catheter function is vital to long-term PD success; however, catheter breakage is rare and may be clinically occult. We report a case of late PD catheter breakage that was not...

Acute kidney injury (AKI) remains a crucial condition associated with poor prognosis in critically ill patients. Renal oxygenation resulting from...

AbstractBackground. Heart failure and chronic kidney disease (CKD) are biologically entwined and clinically difficult to disentangle. The 2026 Second Unive

Patients with end-stage kidney disease (ESKD) on dialysis face an increased risk of morbidity and mortality following SARS-CoV-2 infection, with concerns that their antibody response to COVID-19 vaccination may be lower than that of the general population. However, the effectiveness of the COVID-19 vaccination in ESKD patients remains unclear. This nationwide retrospective cohort study examined the association between COVID-19 vaccination and the risk of SARS-CoV-2 infection in ESKD patients on dialysis.

Infection-related glomerulonephritis (IRGN) is typically associated with bacterial infections, although viral and zoonotic pathogens are increasingly recognized. We report a rare case of IRGN in an im...

Nolan reports the results of a US study comparing the use of a polypill containing metoprolol succinate with enhanced usual care in people with symptomatic heart failure: the polypill group showed bet...

Fibrillary glomerulonephritis (FGN) is an uncommon form of kidney disease that can occasionally present in a diffuse crescentic variant. This may sometimes mimic antiglomerular basement membrane (anti...

ObjectivePosterior reversible encephalopathy syndrome (PRES) is a clinico-radiological syndrome characterised by seizures, hypertension, visual disturbances ...

AbstractObjective. To evaluate the efficacy of hemodynamic profiling (HDpro)-guided antihypertensive therapy in elderly patients with uncontrolled morning

Acute interstitial nephritis (AIN) is a frequent cause of acute kidney injury (AKI) and is commonly drug-induced. Corticosteroids are widely used for treatment; however, outcomes in cases with incompl...

Testing Tolvaptan versus 3% saline and the rate of rise of serum sodium in healthy volunteers.

IgA vasculitis (IgAV) is an immune-mediated disease characterized by the inflammation of small blood vessels because of the deposition of IgA1-dominant immune complexes. IgAV treatment primarily focus...

Alport syndrome (AS) is the most common inherited glomerular disease,1 caused by pathogenic (P) or likely pathogenic (LP) variants in three collagen IV genes: COL4A5, which leads to X-linked AS (XLAS)...

Gastrointestinal symptoms are common in patients undergoing hemodialysis (HD) and closely associated with mesenteric ischemia, a life-threatening condition with high mortality. Nonocclusive mesenteric...

How do you teach the immune system to recognize a cancer cell? Researchers are taking clues from the tumor itself, selecting unusual protein fragments and putting them into a vaccine.

Background Over the past two decades, chronic kidney disease (CKD) of unknown aetiology (CKDu) has emerged as a significant public health challenge in several tropical, low- and middle-income countrie...

Researchers identify the cytokine-mediated mechanism sustaining CD8+ T cell inflammation in lupus kidneys, opening pathways for targeted immunotherapy.