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JAMA Network Open

@jamanetworkopen.com
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JAMA Network Open is a member of the JAMA Network, a consortium of peer-reviewed, general medical and specialty publications. 🌐 JAMANetworkOpen.com

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JAMA Network Open @jamanetworkopen.com · 14/09/2026
📈 Integrating #SmokingCessation treatment into #LungCancerScreening was cost-saving vs screening alone, with higher-intensity pharmacotherapy and counseling associated with the greatest long-term health gains. ja.ma/4j91hUu
A scatter plot shows QALYs (thousands) on Y-axis vs. total lifetime costs (million $) on X-axis. 'HighMED + HighCSL' shows highest QALYs (2269k) at $1545M cost. 'Screening alone' is lowest at 2240k QALYs for $1630M. Other strategies vary between.
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JAMA Network Open @jamanetworkopen.com · 14/09/2026
📈 Among infants who were tested for respiratory syncytial virus (#RSV) in 2 Canadian provinces, receipt of #Nirsevimab was associated with lower risk of RSV-related emergency department visits, hospitalization, and intensive care unit admission. ja.ma/4gTRRLd
Bar and line graph showing the number of infants with positive RSV test results (bars) and infants with nirsevimab immunization (line) from Oct 27, 2024 to Feb 23, 2025. RSV peaks around 75 in early Dec, while immunization peaks around 60 in early Nov, then both decline.
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JAMA Network Open @jamanetworkopen.com · 14/09/2026
📊 Among patients at #HRSA health centers, #FoodInsecurity was associated with more referrals to food assistance, but more than one-third of food-insecure patients reported receiving neither SNAP or WIC nor a referral. ja.ma/4yBbfCH
Bar chart shows patient percentages by food security (insecure/secure) and DRHC referral status (No DRHC/DRHC). Bars represent SNAP/WIC enrollment and referral source: from health center (dark gray/orange) or no referral from health center (light blue/light orange).
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JAMA Network Open @jamanetworkopen.com · 14/09/2026
📊 Among older inpatients with #Malnutrition at admission, implementation of a nutrition clinical framework was associated with lower in-hospital mortality and shorter length of stay. ja.ma/4xoHNPm
Five line graphs compare "Wards without framework" (dark circles) to "Wards with framework" (orange squares, dashed line) from January 2022 to January 2026. Metrics are in-hospital, 6-month, 1-year, and overall mortality, and length of stay. "Wards with framework" generally show lower values across all metrics. A shaded area and dotted line mark a period in late 2023-early 2024.
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JAMA Network Open @jamanetworkopen.com · 14/09/2026
🧠 In #MajorDepressiveDisorder, gray matter volume trajectories over 10 years were associated with cumulative illness burden rather than diagnosis alone or acute symptom fluctuations. ja.ma/46jQsrk
Brain scans highlight dLPFC & Hippocampus. Two graphs show estimated age-adjusted GMV over 10 years by CIS quartile. For both regions, the highest CIS quartile (Q4) exhibits a marked decline in GMV, while lower quartiles remain stable.
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JAMA Network Open @jamanetworkopen.com · 14/09/2026
📊 Among survivors of #BreastCancer in a longitudinal cohort, nonresponsiveness increased over time and was associated with social vulnerability, unhealthy behaviors, symptom burden, and enrollment at smaller centers. ja.ma/4AvsDL9
Stacked bar chart showing patient status from Baseline to Year 6 follow-up. The Y-axis is Patients, %. 'Responsive' patients decline from nearly 100% to ~75%. 'No response from enrolled patients,' 'Lost to follow-up,' and 'Withdrew consent' categories collectively increase, reaching ~25% by Year 6.
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JAMA Network Open @jamanetworkopen.com · 14/09/2026
📊 Perceived good death priorities differed across settings, while patient-caregiver differences were generally small, supporting culturally sensitive #PalliativeCare that reflects both shared and setting-specific end-of-life values. ja.ma/4xY4iMe
JAMA Network Open article: "Perceived Importance of Good Death Components Among Patients With Advanced Cancer and Family Caregivers" by Hammoda Abu-Odah et al. An Original Investigation in Oncology, published online September 14, 2026.
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JAMA Network Open @jamanetworkopen.com · 14/09/2026
Among Denmark children, a history of #FebrileSeizures was reassuringly associated with school test performances largely similar to that of unaffected peers. Children with many recurrences or later epilepsy may benefit from additional educational support. ja.ma/4xtiWdc
Table & forest plot showing test score differences by febrile seizure history, age, hospital contacts, and duration. No febrile seizures is reference (55.8). Test scores generally decrease with more hospital contacts or longer contact duration. Largest difference: -5.7 for >=7 hospital contacts. Basic & fully adjusted shown.
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JAMA Network Open @jamanetworkopen.com · 14/09/2026
📈 In Tanzania, simulation-based #NeonatalVentilation training with a low-cost, high-fidelity simulator was associated with improved knowledge and practical performance among students and health professionals. ja.ma/4cFGzrE
Four line graphs display pressure and BPM metrics over 6 trials for Medium-fidelity passive, High-fidelity passive, and High-fidelity active groups vs. a criterion standard. A: Mean pressure, High-fidelity passive is highest, medium-fidelity passive lowest. B: CV pressure, High-fidelity active peaks at trial 4. C: BPM, High-fidelity passive highest. D: CV BPM shows downward trends.
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JAMA Network Open @jamanetworkopen.com · 11/09/2026
📊 In the US, aggregate patient out-of-pocket spending on #GenericDrugs exceeded spending on #BrandName prescription drugs, even though brand-name drugs were more expensive on a per-drug basis. ja.ma/46e8Fqa
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JAMA Network Open @jamanetworkopen.com · 11/09/2026
📊Across US patients with newly diagnosed #Cancer, diagnoses varied by calendar month. Months with a higher proportion of localized-stage diagnosis were also associated with better 5-year survival, suggesting an overlooked temporal dimension of cancer care ja.ma/4yosVkY
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JAMA Network Open @jamanetworkopen.com · 11/09/2026
📈 Funding explicitly allocated for #SuicidePrevention and #CrisisServices in US state budgets increased from 2021 to 2026. Allocations were higher in states with a 988 telecom fee, suggesting this policy approach may support crisis service infrastructure. ja.ma/3UZ5ccx
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JAMA Network Open @jamanetworkopen.com · 11/09/2026
🏥 In hospitalized adults, the End-of-Life Care Index showed moderate to high discrimination for 1-year mortality but poor calibration across 2 large US health systems, indicating potential value for #PalliativeCare but important limits for clinical use. ja.ma/4dmujMG
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JAMA Network Open @jamanetworkopen.com · 11/09/2026
📈 Among children and youths whose mothers experienced violent injury, risk of physical and sexual injury was higher than among unexposed children, indicating an important need for #TraumaInformed #PediatricCare ja.ma/4ynU9Z4
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JAMA Network Open @jamanetworkopen.com · 10/09/2026
📊 Medicaid beneficiaries with #AutismSpectrumDisorder face a 14-year deficit in life expectancy due to excess risk of dying from influenza, pneumonia, malnutrition, drowning, and other preventable causes. ja.ma/4ylThE2
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JAMA Network Open @jamanetworkopen.com · 10/09/2026
📈 Among nulliparous patients, higher #PrepregnancyDietQuality was associated with lower risk of #AdversePregnancyOutcomes, and a a healthier first-trimester cardiometabolic profile ja.ma/4xf0ULN
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JAMA Network Open @jamanetworkopen.com · 10/09/2026
📊 Among UK Biobank participants, lifelong genetic inhibition of #PCSK9 was associated with lower low-density lipoprotein cholesterol without increased liver enzyme levels or incident #ChronicLiverDisease. ja.ma/4yi3tNR
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JAMA Network Open @jamanetworkopen.com · 10/09/2026
This Special Communication synthesizes empirical studies and policy analyses, to examine proposals to regulating adolescent #SocialMedia use, finding that current legislative approaches outpace available evidence. @jasonmnagata @ucsf ja.ma/4dpKQzx
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JAMA Network Open @jamanetworkopen.com · 10/09/2026
📉 Among adults seen in community health centers, #ExtremeHeat exposure was associated with modest reductions in systolic and diastolic #BloodPressure, suggesting physiologic responses to heat that may be relevant for clinical blood pressure measurement. ja.ma/4ynE8SO
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JAMA Network Open @jamanetworkopen.com · 10/09/2026
📈 Among Medicare beneficiaries with #ProstateCancer, spending shifted markedly from radiotherapy and surgery toward #SystemicTherapy from 2012 to 2021, making systemic treatment the dominant component of care expenditures. ja.ma/3TgB77V
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JAMA Network Open @jamanetworkopen.com · 10/09/2026
📊 Meta-analysis: Across randomized clinical trials, #Cefepime was associated with higher odds of all-cause #Mortality vs other β-lactam antibiotics, supporting a nuanced discussion of its role in clinical guidance. ja.ma/465d0fk
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JAMA Network Open @jamanetworkopen.com · 10/09/2026
📊 Children with special health care needs and developmental disorders were more likely to have worse parent-perceived oral health than children without either classification, even though past-year dental visits were common. ja.ma/3V0jz0h
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Oral Health of Children With Special Health Care Needs and Developmental Disorders
This cross-sectional study examines the factors associated with parent-perceived oral health status among children with special health care needs and developmental disorders.
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JAMA Network Open @jamanetworkopen.com · 10/09/2026
📈 Among children living with #HIV in 13 sub-Saharan African countries, maternal HIV care engagement was associated with higher child viral suppression primarily through increased #AntiretroviralTherapy uptake. ja.ma/4xb7t1I
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Maternal Engagement in HIV Care and ART Uptake Among Children With HIV
This cross-sectional study examines the role of antiretroviral therapy (ART) use and viral load suppression among mothers in their children’s viral load suppression in sub-Saharan Africa.
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JAMA Network Open @jamanetworkopen.com · 10/09/2026
📈 Offspring of centenarians had delayed onset of mortality and lower risk of #CardiovascularDisease and #Hypertension across 3 longitudinal cohorts, supporting parental longevity as a model for healthy aging research. ja.ma/4dmSBWV
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Exceptional Parental Longevity and Morbidity and Mortality Among Offspring
This study uses data from 3 cohorts to examine whether centenarians’ offspring exhibit delayed onset of age-related diseases and mortality as well as decreased risk of age-related diseases compared with control groups of offspring without parental longevity.
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JAMA Network Open @jamanetworkopen.com · 10/09/2026
🔬 Among young BRCA1 or BRCA2 carriers with #BreastCancer, bilateral mastectomy increased over time and was most strongly associated with #GeneticTesting performed before or at diagnosis. ja.ma/4ysYAlr
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Surgical Management of Early-Onset Breast Cancer Among Young BRCA1/2 Carriers
This cohort study explores the surgical patterns of care and the factors associated with uptake of bilateral mastectomy among BRCA1 or BRCA2 (BRAC1/2) carriers diagnosed with early-onset breast cancer at age 40 years or younger.
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JAMA Network Open @jamanetworkopen.com · 10/09/2026
📝 In persons with probable #Dementia, diagnosis underreporting remained high after onset and varied by social and care delivery factors, suggesting gaps in diagnostic disclosure and postdiagnosis support. ja.ma/4xeWOTU
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Dementia Diagnosis Underreporting and Care Engagement Among Older Adults
This cohort study compares underreporting of dementia diagnosis with that of other diagnosed conditions among persons with probable dementia and examines associations of underreporting with care engagement and planning.
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JAMA Network Open @jamanetworkopen.com · 10/09/2026
🧠📊 In older married couples, domain-specific cognitive testing identified shared patterns in verbal fluency, naming, and visuospatial function that were not detected by global #CognitiveScreening. ja.ma/465MUZJ
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Domain-Specific Cognitive Concordance in Older Married Couples
This cross-sectional study examines cognitive concordance among older married couples across specific cognitive domains by comparing married couples with demographically and genetically matched control pairs.
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JAMA Network Open @jamanetworkopen.com · 10/09/2026
📊 Counties with low #NeighborhoodOpportunity had higher incidence rates of fatal #PolicePursuits vs counties with high opportunity, even after adjustment for residence, demographic characteristics, and violent crime rates. ja.ma/3TkDqH3
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Neighborhood Opportunity and Fatal Police Pursuits in the US
This cohort study examines the longitudinal association between neighborhood conditions, including access to quality education, healthy environments, and favorable social and economic resources, and county-level incidence rates of fatal police pursuits.
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JAMA Network Open @jamanetworkopen.com · 10/09/2026
📈 Among children with moderate #Asthma exacerbations receiving continuous #Albuterol, early #BilevelPositiveAirwayPressure in the emergency department did not reduce albuterol treatment duration vs sham treatment. ja.ma/4xlxRGw
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Bilevel Positive Airway Pressure and Continuous Albuterol for Pediatric Asthma
This randomized clinical trial examines whether early introduction of bilevel positive airway pressure results in reduced duration of continuous albuterol therapy among pediatric patients with acute asthma exacerbations.
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JAMA Network Open @jamanetworkopen.com · 09/09/2026
📊 Across 4 North American professional sports leagues, #HealthCare delivery organizations accounted for about 1 in 7 primary jersey sponsorships, with representation increasing over time. ja.ma/4ynzSTp
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JAMA Network Open @jamanetworkopen.com · 09/09/2026
📊 Survivors of #Obesity-associated cancers were less likely to attempt weight loss than other adults with #obesity, but clinician counseling was more strongly associated with weight loss attempts when it occurred. ja.ma/3UUPsr1
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JAMA Network Open @jamanetworkopen.com · 09/09/2026
🚑 Before an injurious fall in #OlderAdults, prior #EmergencyMedicalServices encounters were common and often occurred within 90 days, indicating that EMS contact may help identify patients at risk for future falls. ja.ma/4yoCssd
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JAMA Network Open @jamanetworkopen.com · 09/09/2026
📊 Compared with #TraditionalMedicare, #MedicareAdvantage was associated with lower use of discretionary procedures, with larger reductions among White beneficiaries than Black or Hispanic beneficiaries. ja.ma/4ysrToe
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JAMA Network Open @jamanetworkopen.com · 09/09/2026
🩺 Physicians returning after a life-threatening illness often described conflict between professional and patient identities, indicating that relationship-centered #ReturnToWork support may improve retention. ja.ma/4656wgv
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JAMA Network Open @jamanetworkopen.com · 09/09/2026
📊 Persistent variation in #HospitalOnsetBacteremia across Ontario hospitals suggests differences in local care processes and supports its use in hospital infection prevention and quality measurement. ja.ma/4x7zMOs
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JAMA Network Open @jamanetworkopen.com · 09/09/2026
🏥 State-funded #HealthInsurance coverage for noncitizen immigrants in Illinois was associated with lower uncompensated care, indicating a potential policy pathway to strengthen safety-net hospital finances and reduce coverage inequities. ja.ma/4yi3tgP
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JAMA Network Open @jamanetworkopen.com · 09/09/2026
📊 Among older adults undergoing major #Surgery, a perioperative intervention combining psychological management and pharmacologic optimization improved #Depression and #Anxiety symptoms at 3 months vs enhanced usual care. ja.ma/3VgG80L
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JAMA Network Open @jamanetworkopen.com · 09/09/2026
📈 In permanent supportive housing, a brief #SmokeFreeHome intervention did not significantly increase adoption for at least 90 days, but it did increase attempts to adopt smoke-free homes and establish smoke-free home rules. ja.ma/3TfNDEE
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JAMA Network Open @jamanetworkopen.com · 09/09/2026
📊 Among adults with #Urolithiasis and 5 to 10 mm ureteral stones, Guang Jing Qian Cao (Desmodium styracifolium) total flavone capsules increased day 28 stone passage vs placebo, with similar adverse event rates. ja.ma/4ygTuZc
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JAMA Network Open @jamanetworkopen.com · 09/09/2026
📊 A clinically aligned 18-item #InflammatoryBreastCancer knowledge instrument identified important symptom recognition gaps and lower knowledge in several population groups, indicating limits of general awareness alone. ja.ma/3UVs6S8
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A Clinically Aligned Instrument Measuring Inflammatory Breast Cancer Knowledge
This survey study evaluates preliminary, clinically informed exploratory indices to evaluate inflammatory breast cancer knowledge, including symptom and risk-factor recognition.
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JAMA Network Open @jamanetworkopen.com · 09/09/2026
📊 Never receiving #CervicalCancer screening was more common in several structurally vulnerable groups, while regional-stage and distant-stage cervical cancer incidence increased in recent years. ja.ma/4yks2K5
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Rates of Never Receiving Cervical Cancer Screening Among US Women, 2005-2023
This cross-sectional study examines trends in the prevalence of never having been screened for cervical cancer from 2005 to 2023 and assesses trends in cervical cancer incidence by age and stage at diagnosis to determine whether incidence patterns correspond with trends in nonscreening.
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JAMA Network Open @jamanetworkopen.com · 09/09/2026
📊 Female physicians were more likely to consider and work part-time, and parenthood was associated with working part-time, indicating persistent workforce pressures in #PhysicianWorkforce scheduling and retention. ja.ma/4yoCv7n
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Factors in Considering and Working Part-Time Among Early-Career Physicians
This cohort study of survey responses from US physicians who recently completed residency training examines demographic and work status factors associated with preference for part-time work.
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JAMA Network Open @jamanetworkopen.com · 09/09/2026
📈 In acute care hospital ICUs and non-ICUs, an educational quality improvement program for #MRSA prevention was associated with lower rates of hospital-onset methicillin-resistant Staphylococcus aureus bacteremia. ja.ma/3UZ5bW1
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Hospital-Onset MRSA Prevention in Acute Care Hospitals
This quality improvement study examines whether an educational quality improvement program is associated with improved evidence-based practices and prevention of methicillin-resistant Staphylococcus aureus (MRSA) infections among hospitalized patients.
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JAMA Network Open @jamanetworkopen.com · 09/09/2026
📝 Prior mental health encounters were associated with lower risk of #Psychotherapy dropout in adults with #Depression, while recent medical admission and certain comorbid conditions were associated with higher risk. ja.ma/46ES1QG
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Identifying Patients at Risk for Psychotherapy Dropout in Community Settings
This prognostic study assesses the prevalence and predictors of psychotherapy dropout in a large community health care setting.
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JAMA Network Open @jamanetworkopen.com · 09/09/2026
📊 Among adults with type 2 diabetes recovering from dialysis-requiring #AcuteKidneyInjury, early #SGLT2 inhibitor use was associated with fewer adverse kidney events than later use, with no significant difference in mortality or cardiovascular events. ja.ma/4ylThnw
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Early SGLT-2 Inhibitor Use After Acute Kidney Injury in Type 2 Diabetes
This cohort study examines the outcomes associated with early vs late sodium-glucose cotransporter-2 inhibitor initiation after discharge among patients with type 2 diabetes recovering from dialysis-requiring acute kidney injury.
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JAMA Network Open @jamanetworkopen.com · 09/09/2026
📊 Among recipients of solid organ transplant, posttransplant malignant neoplasms followed distinct time-dependent patterns, indicating that long-term cancer surveillance may need to vary by transplanted organ and cancer subtype. ja.ma/4yfrVzA
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Posttransplant Malignant Neoplasms in Solid Organ Transplant Recipients
This cohort study examines temporal trends in cancer incidence following solid organ transplant.
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JAMA Network Open @jamanetworkopen.com · 09/09/2026
💡 Among women receiving chemotherapy for #BreastCancer, brief cognitive behavior therapy for insomnia improved insomnia symptoms more than treatment without cognitive behavior therapy for insomnia. ja.ma/3V0jwBD
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Cognitive Behavior vs Bright Light Therapy for Insomnia in Women With Breast Cancer
This randomized clinical trial examines the effectiveness of cognitive behavior therapy for insomnia compared with bright light therapy for treating insomnia and fatigue symptoms in Australian women undergoing chemotherapy for breast cancer.
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JAMA Network Open @jamanetworkopen.com · 09/09/2026
🔬 Among at-risk relatives in families with #HereditaryCancer, a bilingual navigator-supported digital intervention was associated with greater cascade #GeneticTesting completion, informed decision-making, and readiness to pursue testing. ja.ma/4656ANh
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A Multilevel Intervention to Identify Individuals for Genetic Testing and Treatment
This pilot randomized clinical trial assesses a bilingual navigator- and web platform–based intervention designed to reduce informational, logistical, and psychosocial barriers to cascade genetic testing in families with hereditary breast and ovarian cancer syndrome or Lynch syndrome among medically...
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JAMA Network Open @jamanetworkopen.com · 08/09/2026
📈 In Flint, children aged 6 years or younger living in homes with #Lead service lines had higher blood lead level exceedance rates than those in homes with copper service lines from 2010 to 2019. ja.ma/468AnEU
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JAMA Network Open @jamanetworkopen.com · 08/09/2026
📊 Among adults with prenatal #Breastfeeding goals after full-term delivery, unmet goals were associated with higher odds of anxiety, depression, diabetes, hypertension, and breastfeeding challenges. ja.ma/4yosS8M
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