How do you teach the immune system to recognize a cancer cell? Researchers are taking clues from the tumor itself, selecting unusual protein fragments and putting them into a vaccine.

Background Over the past two decades, chronic kidney disease (CKD) of unknown aetiology (CKDu) has emerged as a significant public health challenge in several tropical, low- and middle-income countrie...

Researchers identify the cytokine-mediated mechanism sustaining CD8+ T cell inflammation in lupus kidneys, opening pathways for targeted immunotherapy.

C3 glomerulonephritis (C3GN) is a rare glomerular disease caused by alternative complement pathway dysregulation. ANLN gene mutations have been previously associated with podocytopathies but not linke...

A physiotherapist-led model of care in the emergency department reduced length of stay among patients presenting with uncomplicated musculoskeletal conditions, without compromising health outcomes or ...

This qualitative analysis of US patients with end-stage kidney disease, their caregivers, and their nephrologists examines reasons patients chose conservative kidney management over dialysis.

Neural epidermal growth factor-like 1 (NELL1) is a novel antigen in membranous nephropathy (MN). Our observations indicate that a subset of patients with NELL1-associated MN demonstrate focal positive...

Host polyamines and osmotic stress shape MRSA adaptation in the renal inner medulla.

Early changes in albuminuria and glomerular filtration rate (GFR) have been proposed as markers of treatment efficacy for individual patients. Here, we evaluated the relationship between changes in GF...

Acute kidney injury (AKI) requiring dialysis is associated with higher risk of kidney failure, warranting risk mitigation.

Treatment with retatrutide resulted in substantial improvements in bodyweight and was associated with improvements in glycaemic control in participants with obesity and type 2 diabetes, with a safety ...

Signal Transduction and Targeted Therapy - CAR T cells for HLA desensitization: a new era in kidney transplantation

Neural epidermal growth factor-like 1 (NELL1) is a novel antigen in membranous nephropathy (MN). Our observations indicate that a subset of patients with NELL1-associated MN demonstrate focal positive...

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Anti-CD20 agent obinutuzumab (Gazyva) gets green light for patients as young as 2 years

Read more about Open letter to the NIH regarding proposed changes to K awards at The American Society for Clinical Investigation

Background Children with idiopathic nephrotic syndrome (INS) receive prolonged glucocorticoids that can suppress the hypothalamic–pituitary–adrenal (HPA) axis and cause adrenal insufficiency (AI). We ...

People with CKDu don’t have the classic risk factors of kidney disease, like hypertension or diabetes.

The risk of developing chronic kidney disease (CKD) or heart failure (HF), or dying, following a type 2 diabetes (T2D) diagnosis increases substantially over time, according to new research being presented at the annual meeting of the European Association for the Study of Diabetes (EASD) in Milan, Italy, Sept.

Background Atypical hemolytic uremic syndrome (aHUS) is a rare form of thrombotic microangiopathy (TMA) caused by complement-mediated injury of the vascular endothelium. We present Clinical Practice R...

Jeong, Lake and colleagues map changes in the human and mouse kidney DNA methylomes at single-cell resolution across disease and aging, respectively. They identify disease-associated epithelial states...

Brain and Behavior, Volume 16, Issue 9, September 2026.

Ndumele, C. E. et al. Cardiovascular-kidney-metabolic health: a presidential advisory from the American Heart Association. Circulation 148, 1606–1635 https://doi.org/10.1161/CIR.0000000000001184 (2023). Shankar, A. et al. Markers of inflammation predict the long-term risk of developing chronic kidney disease: a population-based cohort study. Kidney Int. 80, 1231–1238 https://doi.org/10.1038/ki.2011.283 (2011). Schiattarella, G. G., Rodolico, D. & Hill, J. A. Metabolic inflammation in heart failure with preserved ejection fraction. Cardiovasc. Res. 117, 423–434 https://doi.org/10.1093/cvr/cvaa217 (2021). Braam, B., Joles, J. A., Danishwar, A. H. & Gaillard, C. A. Cardiorenal syndrome — current understanding and future perspectives. Nat. Rev. Nephrol. 10, 48–55 https://doi.org/10.1038/nrneph.2013.250 (2014). Bertero, E. & Maack, C. Metabolic remodelling in heart failure. Nat. Rev. Cardiol. 15, 457–470 https://doi.org/10.1038/s41569-018-0044-6 (2018). Wang, W. & Seale, P. Control of brown and beige fat development. Nat. Rev. Mol. Cell Biol. 17, 691–702 https://doi.org/10.1038/nrm.2016.96 (2016). Patel, K. P., Katsurada, K. & Zheng, H. Cardiorenal syndrome: the role of neural connections between the heart and the kidneys. Circ. Res. 130, 1601–1617 https://doi.org/10.1161/CIRCRESAHA.122.319989 (2022). Patel, R. N., Sharma, A., Prasad, A. & Bansal, S. Heart failure with preserved ejection fraction with CKD: a narrative review of a multispecialty disorder. Kidney Med. 5, 100705 https://doi.org/10.1016/j.xkme.2023.100705 (2023). Bansal, N., Zelnick, L. R., Scherzer, R.,...

Joint International Society of Renal Nutrition and Metabolism (ISRNM) and International Society for Peritoneal Dialysis (ISPD) Practice Recommendation on Nutrition Management in Peritoneal Dialysis

YouTube video by Ottawa Nephrology

I’m confident in my mastery over what doctors do — and less confident about my continued mastery of an ever-evolving universe of facts.