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Jonathan Zuckerman MD PhD

@jzrenalpath.bsky.social
1.3K followers 166 following 244 posts

Service Chief, Renal Pathology, UCLA Department of Pathology and Laboratory Medicine. Views are my own.

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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 24/09/2026
Pt with myelofibrosis, NR proteinuria, progressive CKD. Hypercellular glomeruli + intracapillary megakaryocytes, + mesangial sclerosis, +chronic microangiopathic changes c/w MPN-related glomerulopathy. Also renal extramedullary hematopeosis. IHC is CD61 #renalpath #pathsky #nephsky
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Reposted by Jonathan Zuckerman MD PhD
ASN Publications @asnpublications.bsky.social · 17/09/2026
Behind every strong publication is thoughtful peer review. During #PRW2026, CJASN recognizes its Top 5 reviewers of 2026: Drs. Steven Coca, Jonathan Zuckerman, Devika Nair, Ilia Beberashvili, and Gangkee Ko. Join us as we spotlight their reflections. #ASNCJASN
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 09/09/2026
Well developed example of medullary angiitis (pubmed.ncbi.nlm.nih.gov/23079202/) in a case of MPO-ANCA associated GN. Neutrophils and hemorrhage in the medulla. Also plenty of active crescents in this case. #renalpath #pathsky #nephsky
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Reposted by Jonathan Zuckerman MD PhD
Kidney International @kidneyint.bsky.social · 10/08/2026
Early Acute T Cell-Mediated Rejection and Kidney Allograft Outcomes doi.org/10.1016/j.kint.2026.06.042 #NephSky #MedSky #pathsky #OpenAccess @uzleuven.bsky.social @inserm.fr
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 21/08/2026
Nice example of multi-cystic renal dysplasia. Metaplastic cartilage, disordered tubules, tubular cysts, and scattered immature appearing tubules with fibromuscular collarets. #renalpath #nephsky #pathsky
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 17/08/2026
Fibrillary GN with linear staining potentially mimicking anti-GBM. Mesangial staining + mesangial expansion by silver weak material not typical for anti-GBM. Also only focal crescents. fibrils infiltrating GBM on EM. #renalpath #pathsky #nephsky
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Grace Choung, MD 박영이 @gracechoung.bsky.social · 11/08/2026
Spectrum of Anti–Factor B-Associated Glomerular Diseases in Adults - American Journal of Kidney Diseases www.ajkd.org/article/S027...
ajkd.org
Spectrum of Anti–Factor B-Associated Glomerular Diseases in Adults
Autoantibodies targeting complement factor B (anti-FB) are among the most recently described alternative pathway anomalies. Although they have been strongly associated with post-infectious glomerulone...
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 02/08/2026
Value of pronase IF in renal path. MN pattern with dominant C3 staining becomes membranous like glomerulopathy with IgG kappa deposits on pronase IF. SAP + confirms diagnosis. #renalpath #nephsky #pathsky
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 31/07/2026
Another interesting case with crescents but this time due to amyloid. A few small cellular crescents in this case of AL-amyloidosis. Massive capillary wall amyloid infiltration. #renalpath #pathsky #nephsky
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 31/07/2026
Fibrin extravasating into Bowman's capsule in this case of MPO-ANCA associated pauci immune GN. Destructive necrotizing cellular crescent. Prominent necrotizing arteritis as well. #renalpath #pathsky #nephsky
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 29/07/2026
This one read the textbook. An unfortunately florid case of TMA with acute and chronic features. Glomerular thrombosis, arterial mucoid intimal edema, and onion skin changes. Fibrinogen highlights thrombi on IF. #renalpath #nephky #pathsky.
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 25/07/2026
When it's not just diabetes. Pt with DM, CKD, and worsening proteinuria. Biopsy with diabetic glomerulopathy with superimposed IgG3-k restricted MPGN c/w PGNMID. #renalpath #pathsky #nephsky
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 23/07/2026
Not often caught on sections but example of penetrating vessels within the renal capsuled demonstrating the small amount of collateral circulation to the subcapsular cortex. #renalpath #pathsky #nephsky
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 21/07/2026
Haven't seen one of these in a while. Example of atheroembolism in a older pt with subacute kidney injury and peripheral vascular disease. Cholesterol clefts and giant cells filling the arterial lumen. #renalpath #pathsky #nephsky
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Reposted by Jonathan Zuckerman MD PhD
Grace Choung, MD 박영이 @gracechoung.bsky.social · 18/07/2026
Association of Histological Features of Cortical and Medullary Peritubular Capillaries With Progressive CKD - American Journal of Kidney Diseases www.ajkd.org/article/S027...
ajkd.org
Association of Histological Features of Cortical and Medullary Peritubular Capillaries With Progressive CKD
Peritubular capillary (PTC) rarefaction occurs in chronic kidney disease (CKD), but the independent association of PTC histological features with CKD progression is uncertain. Assessment of this relat...
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 08/07/2026
Interesting case of polytypic ITGN with masked deposits in a patient found to have sarcoidosis. No lymphoproliferative disorder. See report here: www.sciencedirect.com/science/arti... #renalpath #pathsky #nephsky
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 07/07/2026
PR3-ANCA associated GN with vasculitis. Temporal heterogeneity can be seen in the vasculitis lesion with both active fibrinoid necrosis and transmural sclerosis with mural disruption c/w old scared vasculitic lesions. Acitve crescents too. #renalpath #pathsky #nephsky.
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 17/06/2026
Feature of chronic active glomerular microangiopathy in a pt with a bone marrow transplant. Mesangiolysis and capillary wall double contours. Few schistocytes as well. Subendothelial floculent material seen by EM. #renalpath #pathsky #nephsky
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 16/06/2026
Pt with SLE and sjogren with hematuria and proteinuria. +++RF, low C3/C4, IgM-k MGUS. Biopsy revealed IgM-k dominant GN with cryo plugs + vasculitis + abundant pure microtubular deposits c/w cryoGN. Some deposits being engulfed by macrophages. #renalpath #pathsky #nephsky
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Reposted by Jonathan Zuckerman MD PhD
Grace Choung, MD 박영이 @gracechoung.bsky.social · 16/06/2026
C3 Glomerulopathy with Occult Gammopathy Treated with Low-Dose, Fixed Duration Venetoclax - Kidney International Reports www.kireports.org/article/S246...
kireports.org
C3 Glomerulopathy with Occult Gammopathy Treated with Low-Dose, Fixed Duration Venetoclax
C3 glomerulopathy, when associated with monoclonal gammopathy (C3G-MG), is now characterized as a monoclonal gammopathy of renal significance (MGRS)-associated disorder, in which the monoclonal immuno...
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Reposted by Jonathan Zuckerman MD PhD
kireports.bsky.social @kireports.bsky.social · 05/06/2026
#mRNA Sequencing to Identify #Aberrant Splicing in X-linked #Alport Syndrome #VisualAbstract by Susan Thanabalasingam www.kireports.org/article/S2468-024…
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 03/06/2026
Sometime the casts have eyelashes. Amyloidogenic variant of light chain cast nephropathy. #renalpath #nephsky #pathsky
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 02/06/2026
Interesting finding of large multi-nucleated endothelial cells in a txp biopsy with chronic active AMR. IHC stain is ERG (endothelial cell marker). Probably just a manifestation of chronic endothelial cell injury in this setting #renalpath #pathsky #nephsky
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 18/05/2026
Exuberant capillary wall spicules in this case of amyloidosis, AHL type. Amyloid spike by EM ('Bart Simpson sign'). #renalpath #pathsky #nephsky
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 17/05/2026
Case of HTRA1 Membranous Nephropathy With Polytypic IgG Concurrent With New Plasma Cell Dyscrasia. Coincidence or related? www.sciencedirect.com/science/arti... #renalpath #pathsky #nephsky
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 17/05/2026
Interesting case of Contactin-1 Associated Membranous Nephropathy after multiple mRNA 1273 COVID-19 Vaccinations without neuropathy. #renalpath #nephsky #pathsky karger.com/gdz/article/...
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 07/05/2026
One of my favorite incidental EM findings. Crystalline proto-renin granules in JGA cells. #renalpath #nephsky #pathsky
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 05/05/2026
It's not always diabetic nephropathy. Pt with DN, HTN, and nephrotic range proteinuria. Elevated K/L ratio. Bx with Light and Heavy Chain deposition disease mimicking nodular diabetic glomerulopathy. #renalpath #pathsky #nephsky
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 04/05/2026
Striking viral inclusion in this case of polyomavirus nephropathy. SV40 stain is confirmatory. #renalpath #pathsky #nephsky
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 22/04/2026
Fibrillary or amyloid? How about both! Concurrence of ALECT amyloidosis and DNAJB9+ FGN. EM shows admixed but distinct fibril population. Mass spec was required for definitive diagnosis. www.sciencedirect.com/science/arti... #renalpath #nephsky #pathsky
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 22/04/2026
Txp biopsy with rare probable cystine crystals in interstitial mononuclear cells in a patient with history of cystinosis. Rarely seen post-txp not clinically significant to my knowledge. #renalpath #pathsky #nephsky
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 17/04/2026
MPO+ANCA GN with concurrent low grade membranous nephropathy. MPO positivity in the MN deposits helps support a unifying etiology is such cases. pubmed.ncbi.nlm.nih.gov/40485711/ #renalpath #nephsky #pathsky
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 13/04/2026
Autopsy case with incidental ALECT2 amyloidosis with lung involvement. Essentially invisible by light microscopy. Wonder how often this is overlooked. 94% of cases had alveolar involvement in this study (PMID: 26912093). #pathksy #renalpath
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 02/04/2026
Transplant bx for renal dysfunction in a patient with shortness of breath. Granulomatous tubulointerstitial nephritis. AFB stain +. Sputum + for TB. Good sample key for making the diagnosis. 2 rounds of AFB stain to find the organism. #renalpath #pathksy #nephsky
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Reposted by Jonathan Zuckerman MD PhD
aspneph.bsky.social @aspneph.bsky.social · 27/03/2026
A pediatric case of C3 glomerulonephritis initially misclassified as IgA nephropathy with a favorable response to C3-targeted therapy #nephsky
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A pediatric case of C3 glomerulonephritis initially misclassified as IgA nephropathy with a favorable response to C3-targeted therapy - Pediatric Nephrology
C3 glomerulopathy is an ultra-rare kidney disease driven by dysregulation of the alternative complement pathway fluid phase C3 convertase. We report the case of a previously healthy 13-year-old girl…
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 29/03/2026
Bx for pt with AKI and nephrotic range proteinuria. Hx of IV drug abuse (with skin popping), and chronic staph infections. AA amyloidosis was the unsurprising finding. #renalpath #pathsky #nephsky
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 28/03/2026
Bx for AKI in a pt on checkpoint inhibitor: neutrophil rich tubulointerstitial nephritis. We would usually think pyelonephritis, high risk neutrophil rich variants of CKI inhibitor AIN have been characterized. pubmed.ncbi.nlm.nih.gov/41727781/ #renalpath #pathsky #nephsky
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 25/03/2026
Classic powdery electron dense deposits along GBMs, TBMS, and in vascular walls by EM in this case of light chain deposition disease. #renalpath #pathsky #nephsky
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 20/03/2026
Don't confuse these for crystals. Limiting membrane of peroxisomes in proximal tubules. Normal tubular structure. Mimic of light chain proximal tubulopathy. #renalpath #pathsky #nephsky
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JD Foster @kidneyvet.bsky.social · 19/03/2026
Yes- horses can get membranous nephropathy! Really nice spikes and holes on the silver stain and subepithelial complexes confirmed on EM. This horse had nephrotic edema and hypoalbuminemia. UPC was 5.8. #vetneph
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 15/03/2026
The Armanni-Ebstein (not Epstein😅) lesion in a nondiabetic patient The glycosuria from flozination can cause these, very interesting phenomenon www.kidney-international.org/article/S008... in Kidney International #RenalPath
Figure 1 Light and electron microscopy reveal epithelial cell vacuolation in acute tubular injury. (a) Light microscopy shows focal acute tubular injury at the corticomedullary junction, with significant swelling of tubular epithelial cells caused by optically transparent vacuoles. Hematoxylin and eosin staining. Bar = 50 μm. (b) The vacuoles contain periodic acid–Schiff–positive material. Bar = 50 μm. (c) Electron microscopy of paraffin-fixed tissue reveals the outline of tubular epithelial cell membranes, partial cell nuclei, and degenerated organelles, with obvious intracellular cavitation. Bar = 10 μm. To optimize viewing of this image, please see the online version of this article at www.kidney-international.org.
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Reposted by Jonathan Zuckerman MD PhD
haysamrady @sodatroubles.bsky.social · 10/03/2026
Crystalglobulin-Induced Nephropathy and Cardiac Non-amyloidotic Immunoglobulin Deposition Disease: A Fatal Case Report #nephsky #nephrology www.kidneymedicinejournal.org/article/S259...
kidneymedicinejournal.org
Crystalglobulin-Induced Nephropathy and Cardiac Non-amyloidotic Immunoglobulin Deposition Disease: A Fatal Case Report
Crystal-induced nephropathy (CIN) is a rare renal disorder associated with multiple myeloma (MM), characterized by crystal-induced damage in multiple organs, with diagnosis based on the identification...
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 06/03/2026
Autolysis versus ATN in an autopsy specimen. Autolytic tubules show detachment of epithelial cells from tubular BM and seem to fall off into the lumen (yellow circle). Rest of tubules with ATN: epithelial cells on the BM but thin + loss of brush borders. #renalpath #pathsky
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 27/02/2026
Allograft biopsy for AKI after belatacept conversion. Yikes! Acute cellular rejection grade III with necrotizing arteritis. #renalpath #pathsky #nephsky
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 26/02/2026
Some large KW nodules in this case of diabetic nephropathy. Unfortunately a common occurrence in my biopsy practice. #renalpath #pathsky #nephsky
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 24/02/2026
Another chronic glomerulopathy case. EM stage IV of IV resorbed deposits in a pt with PLA2R+ Membranous nephropathy with persistent proteinuria. #renalpath #pathsky #nephsky
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 20/02/2026
Recent bxs are so important for clinical trial enrolment. Bx in pt with hx of lupus nephritis (IV+V) with worsening proteinuria. Bx for trial enrollment. Chronic changes only, 0 activity, resorbed deposits by EM, min IF staining. #nephsky #renalpath #Pathsky
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 19/02/2026
Bx in older F pt for subnephrotic proteinuria reveals numerous myelin figures in podocytes. Concern for Fabry + other genetic diseases. Subsequently learned the pt was on long term to Plaquenil. Genetics pending, but may all be HCQ tox. #renalpath #pathsky #nephsky
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Reposted by Jonathan Zuckerman MD PhD
Juan Carlos Q Vélez, MD @juancarlosqvelez.bsky.social · 10/02/2026
Kidney biopsy day, real-time renal US-guided; adequacy verification, cortex obtained, glomeruli visualized. Come join us to learn more about this in the #KidneyBiopsyAcademy hands-in workshop at @kidneycon.bsky.social 2026
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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 09/02/2026
Somewhat subtle case of light chain cast nephropathy by LM. Mostly fine granular casts. Rare PAS pale + two toned color casts. No cellular reaction. IF with K restricted casts confirmatory. EM demonstrates LC precipitation with uromodulin. #renalpath #nephsky #pathsky
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