iiinova — where your digital self keeps evolving

Reposted by Rolando Claure

ASN Publications @asnpublications.bsky.social · 12h

Can a kidney failure risk score (KFRE) help predict the risk of heart disease and death in people with chronic kidney disease? Read this article in #ASNKidney360 to find out. kidney.pub/KID1254

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Rolando Claure @runningkidneys.bsky.social · 13h

Glucosuria may offer a simple, objective marker of adherence to SGLT2 inhibitors. In real-world data, glucosuria was strongly associated with SGLT2i use and with lower risks of death, HF hospitalization, and kidney failure. 🔗 journals.lww.com/jasn/pdf/10....

journals.lww.com

Glucosuria as a Marker of Adherence to... : Journal of the American Society of Nephrology

Background:Medication non-adherence contributes to the efficacy-effectiveness gap in real-world practice. Glucosuria, routinely measured on...

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Rolando Claure @runningkidneys.bsky.social · 19h

Finerenone vs steroidal MRAs in CKD: different strengths, different roles. nsMRAs offer robust cardiorenal outcome data in albuminuric CKD, while spironolactone/eplerenone remain key for resistant HTN, proteinuria, & affordability. Patient-centered choice matters. #CKD #MRA

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Rolando Claure @runningkidneys.bsky.social · 29/09/2026

⏱️ Timing may matter in pediatric #AKI. In 197 children on #CKRT, each additional AKI day before CKRT meant 0.42 fewer KRT-free days. With fluid overload >15%, each day of delay reduced the likelihood of dialysis liberation by 18%. doi.org/10.1093/ckj/... #PedsNeph

doi.org

Time from acute kidney injury to continuous renal replacement therapy and outcomes in critically ill children

AbstractObjectives. Literature in adults have demonstrated no differences in mortality based on the timing of renal replacement therapy (RRT) initiation. P

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Reposted by Rolando Claure

ASN Publications @asnpublications.bsky.social · 27/09/2026

Higher urine protein-to-creatinine ratio was strongly associated with faster CKD progression and earlier kidney failure in >2,700 adults with advanced CKD. These findings in #ASNCJASN highlight the value of a simple test for risk stratification in clinical practice. kidney.pub/CJASN1206

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Rolando Claure @runningkidneys.bsky.social · 26/09/2026

💉 Native kidney biopsy: 99% diagnostic yield in 1,384 patients. 14G vs 16G needles yielded >20 glomeruli more often (81% vs 74%), with similar complication rates (7% vs 8%). Female sex, higher SBP & lower Hb predicted complications. 🔗 journals.lww.com/kidney360/pd...

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Rolando Claure @runningkidneys.bsky.social · 24/09/2026

Who says kidneys can't be cute AND useful? 🫘❤️ Meet my little kidney-shaped phone holder! 📱 A daily reminder to love your kidneys and keep them healthy! @WorldKidneyDay #WorldKidneyDay #KidneyHealthMatters

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Rolando Claure @runningkidneys.bsky.social · 23/09/2026

🔬 From regeneration to fibrosis after AKI: What drives maladaptive repair? Tubular cells sense injury, while immune cells and failed-repair tubules sustain fibroblast activation. Understanding these mechanisms may unlock new therapies. 🔗 www.nature.com/articles/s41... #AKI #Nephrology

nature.com

Mechanisms of regeneration and maladaptive repair in acute kidney injury - Nature Reviews Nephrology

The repair trajectory after acute kidney injury (AKI) is determined through the interconnected responses of tubular epithelial cells, immune cells and fibroblasts. This Review describes the current…

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Rolando Claure @runningkidneys.bsky.social · 23/09/2026

🌎 ¡Tu centro puede ser parte de EPILAT-IRA 2! Invitamos a nefrólogos de toda Latinoamérica a participar en este estudio multicéntrico de #SLANH sobre lesión renal aguda comunitaria. 🔬 Generemos evidencia regional juntos. 🏥 ¡Registra tu centro! 🔗 slanh.net/epilat-ira-2/ #EPILATIRA2 #AKI

slanh.net

Estudio epidemiológico longitudinal de Injuria Renal Aguda / Enfermedad Renal Aguda Comunitaria en Latinoamérica. Epilat-IRA 2 - SLANH

Estudio epidemiológico longitudinal de Injuria Renal Aguda / Enfermedad Renal Aguda Comunitaria en Latinoamérica. Epilat-IRA 2 COMITÉ DE INJURIA RENAL AGUDA – SLANH La IRA ha adquirido relevancia como...

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Rolando Claure @runningkidneys.bsky.social · 20/09/2026

#JustDoItSunday 🏃🏻‍♂️ 🫘 #Run4Kidneys Last run in Taipei 🇹🇼 before starting the final day of the congress, where I’ll be speaking about the social determinants of health and their impact on acute kidney injury. #AP_AKICRRT 2026

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Rolando Claure @runningkidneys.bsky.social · 19/09/2026

Listo ✅ para el segundo día del AP AKI&CRRT 2026 #Run4Kidneys 🏃🏻‍♂️ 🫘 #850Challenge 🎗️

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Rolando Claure @runningkidneys.bsky.social · 19/09/2026

🧠 AI + speech biomarkers in HD. In 41 maintenance HD patients + 22 controls, multimodal ML models combining acoustic & linguistic features best classified MoCA-defined cognitive risk. Verbal fluency tasks showed the strongest discriminatory signal. 🔗https://doi.org/10.1093/ckj/sfag316

doi.org

AI and speech-based identification of cognitive impairment in maintenance haemodialysis - the ASPIRE study

AbstractBackground. Cognitive impairment (CI) is common among individuals receiving maintenance haemodialysis and is associated with impaired treatment adh

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Rolando Claure @runningkidneys.bsky.social · 19/09/2026

💧HypoNa: correction rate is only part of the story. A Perspective argues for a shift toward individualized management—integrating risk stratification, tailored correction thresholds, & competing risks of overcorrection vs persistent hyponatremia. 🔗 journals.lww.com/jasn/pdf/10....

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Rolando Claure @runningkidneys.bsky.social · 18/09/2026

In advanced non-dialysis CKD + AF, apixaban was linked to ↓ ischemic stroke but ↑ major bleeding vs no anticoagulation. Warfarin ↑ bleeding without significant stroke reduction. Apixaban showed a more favorable benefit–risk balance vs warfarin. #CKD 🔗 jamanetwork.com/journals/jam...

jamanetwork.com

Oral Anticoagulants in Patients With AF and Advanced CKD Not Requiring Dialysis

This cohort study compares bleeding and stroke associated with apixaban, warfarin, and no oral anticoagulant use among patients with atrial fibrillation (AF) and chronic kidney disease (CKD) not…

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Rolando Claure @runningkidneys.bsky.social · 18/09/2026

🏃‍♂️ Running Around the 🗺️ for Kidney Health Taipei 🇹🇼 marks another run with a purpose: raising awareness about kidney disease. 🌎 3 continents | 🇧🇴🇺🇸🇮🇹🇨🇱🇹🇼 5 countries | 🏙️ 9 cities in 2026 Keep running. Run for Kidney Health. 💚 #KidneyRunners #850Challenge #Run4Kidneys 🫘

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Rolando Claure @runningkidneys.bsky.social · 16/09/2026

🧩 The 4 pillars in T2D + CKD: 🔹 RAS inhibitors 🔹 SGLT2 inhibitors 🔹 Finerenone 🔹 GLP-1 receptor agonists But what happens in advanced CKD? 📌G4: monitoring-based use is generally supported. 📌G5: decisions become individualized & more extrapolative. doi.org/10.1016/j.xk...

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Rolando Claure @runningkidneys.bsky.social · 16/09/2026

🔬 AKI phenotyping remains challenging. In a KPMP study, AIN was suspected before biopsy in only 54% of patients with adjudicated AIN, while ATI was suspected in 83% of confirmed ATI cases. Kidney biopsy may reveal what the clinical picture misses. 🔗 www.nature.com/articles/s41...

nature.com

Missed acute interstitial nephritis diagnoses without a biopsy - Nature Reviews Nephrology

Nature Reviews Nephrology - Missed acute interstitial nephritis diagnoses without a biopsy

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Rolando Claure @runningkidneys.bsky.social · 15/09/2026

Can tubular biomarkers refine kidney risk prediction in CKD? In EMPA-KIDNEY, adding urinary MCP-1, KIM-1 & EGF to creatinine and UACR modestly improved prediction of kidney failure and CKD progression. Expanding to 9 biomarkers added little further gain. 🔗10.2215/CJN.0000001203

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Rolando Claure @runningkidneys.bsky.social · 15/09/2026

Monoclonal gammopathy is not always incidental. In MGCS, even a small B-cell or plasma-cell clone may produce a nephrotoxic monoclonal protein without meeting criteria for malignancy. Recognizing MGRS is key to diagnosis & timely clone-directed therapy. 🔗 doi.org/10.1093/ndt/...

doi.org

Monoclonal gammopathy of clinical significance: a guide for nephrologists

ABSTRACT. Monoclonal gammopathy of undetermined significance (MGUS) is commonly encountered in older individuals. MGUS, by definition, is a benign finding

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Rolando Claure @runningkidneys.bsky.social · 12/09/2026

Pleased to join Asia Pacific AKI CRRT 2026 as faculty and looking forward to exchanging ideas with colleagues and experts from around the world 🗺️. 📍 Taipei, Taiwan 🇹🇼 📅 Sept 18–20, 2026 See you in Taipei! 🔗 www.apakicrrt2026.com #APAKICRRT2026 #AKI #CRRT

apakicrrt2026.com

apakicrrt 2026

Asia Pacific AKI CRRT 2026

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Rolando Claure @runningkidneys.bsky.social · 12/09/2026

Daily assessment for CKRT liberation in children with preserved urine output may improve outcomes. A WE-ROCK analysis using a hierarchical endpoint found more ICU & hospital-free days & offers a framework for future prospective trials. #PedsNeph #AKI 🔗DOI: 10.2215/CJN.0000001127

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Rolando Claure @runningkidneys.bsky.social · 10/09/2026

Creatine supplements are widely used by adolescents & young adults—but are they always kidney-safe? A Nature Reviews Nephrology comment highlights added risk with high protein intake, strenuous exercise, dehydration or NSAIDs. 🔗 www.nature.com/articles/s41...

nature.com

Creatine supplementation and the young kidney - Nature Reviews Nephrology

Creatine supplementation is unlikely to harm healthy kidneys, but a normal estimated glomerular filtration rate does not guarantee low risk. Adolescents and young adults with reduced nephron…

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Rolando Claure @runningkidneys.bsky.social · 10/09/2026

Are we thinking about immunosuppression-related ♋️ risk the right way? In glomerular disease, “net immunosuppression” may matter more than any single 💊—integrating cumulative exposure, kidney function, viral status, age & disease factors. 🔗 www.ovid.com/10.2215/CJN.... #Nephrology

ovid.com

Cancer Risk After Immunosuppressive Therapy in... : Clinical Journal of the American Society of Nephrology

Abstract was not provided for this article.

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Rolando Claure @runningkidneys.bsky.social · 08/09/2026

💉 GLP-1 receptor agonists may offer benefits in hemodialysis. In a cohort of 4,984 patients, their use was associated with 9% fewer hospitalizations and 17% lower mortality. Observational findings that require confirmation. #Nephrology #GLP1RA 🔗 journals.lww.com/cjasn/pdf/10...

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Rolando Claure @runningkidneys.bsky.social · 07/09/2026

🇧🇩 AKI in Bangladesh: preventable causes remain a major challenge, while limited access to kidney care and dialysis compounds the burden. Early recognition, prevention, referral and post-AKI follow-up are essential. #AKI #GlobalKidneyHealth doi.org/10.34067/KID...

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Reposted by Rolando Claure

ASN Publications @asnpublications.bsky.social · 05/09/2026

By integrating implementation science, digital tools, patient advocacy, and health equity considerations, a consensus report published in #ASNCJASN, offers a practical roadmap for bringing evidence-based AKI care to every patient who needs it. kidney.pub/CJASN1205 @runningkidneys.bsky.social

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Rolando Claure @runningkidneys.bsky.social · 04/09/2026

Early SGLT2i after AKI-D? In 4,406 adults with T2D, starting SGLT2i within 30 days vs 31–90 days after discharge was associated with 38% ⬇️risk of adverse kidney events (3.9% vs 6.2%), no difference in mortality or MACE. #AKI #SGLT2i 🔗 10.1001/jamanetworkopen.2026.31231

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Rolando Claure @runningkidneys.bsky.social · 03/09/2026

How do nephrologists manage hypertension in hemodialysis? 🩺 This qualitative study highlights major variation in BP assessment & tx, reinforcing the need for clearer evidence, standardized approaches, & patient-centered strategies in dialysis care. www.ovid.com/jnls/cjasn/f...

ovid.com

A Qualitative Study of Nephrologists' Perceptions... : Clinical Journal of the American Society of Nephrology

Abstract was not provided for this article.

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Rolando Claure @runningkidneys.bsky.social · 03/09/2026

The 5-year Kidney Failure Risk Equation (#KFRE) may do more than predict kidney failure. In CRIC, ⬆️ KFRE scores were associated with increased risks of cardiovascular events and death, supporting dual kidney–CV risk stratification with one simple tool. 🔗 10.34067/KID.0000001254

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Rolando Claure @runningkidneys.bsky.social · 01/09/2026

🤖 Can AI improve diagnostic reasoning in nephrology? In the REFINE trial, GPT-5 assistance increased Top-3 diagnostic accuracy (57.5% vs 37.2%) and Top-1 accuracy (51.5% vs 33%). Nearly 48% of incorrect answers were corrected after AI input. #Nephrology #AI #MedEd

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Rolando Claure @runningkidneys.bsky.social · 01/09/2026

Kidney biopsy reveals distinct trajectories in treated HIV. In 38 patients, 24% had kidney disease progression. Higher baseline albuminuria predicted progression, while histology identified different patterns of chronicity and injury. #HIV #Nephrology 🔗 journals.lww.com/kidney360/pd...

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Rolando Claure @runningkidneys.bsky.social · 01/09/2026

Elevated pre–liver transplant renin may identify patients at higher hemodynamic & kidney risk. In 138 recipients, renin was up to 100× normal and was associated with greater intraoperative vasopressor requirements and posttransplant AKI. #LiverTx #AKI 🔗 journals.lww.com/transplantjo...

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Rolando Claure @runningkidneys.bsky.social · 29/08/2026

Ketoacidosis goes beyond DKA. This Core Curriculum reviews the pathophysiology, diagnosis & treatment of starvation, pregnancy, alcohol, salicylate, SGLT2i and CKRT-associated ketoacidosis—highlighting key differences for timely care. #Nephrology #AKI 🔗 www.ajkd.org/article/S027...

ajkd.org

Pathophysiology of Ketoacidosis: Core Curriculum 2026

Ketoacidosis is a metabolic state characterized by overproduction and accumulation of ketone bodies (ketoacids), leading to potentially life-threatening drops in blood pH. Common to these disorders…

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Rolando Claure @runningkidneys.bsky.social · 28/08/2026

Hepatic ischemia-reperfusion may trigger remote kidney injury through increased hemolysis and impaired hepatic clearance of cell-free hemoglobin/heme. Targeting CFH/heme toxicity could open new strategies to prevent AKI after hepatic injury. #AKI 🔗 doi.org/10.1093/ndt/...

doi.org

Hepatic injury-induced remote kidney injury is associated with impaired hepatic clearance of cell-free hemoglobin

AbstractBackground and Hypothesis. Hepatic ischemia-reperfusion (HIR) injury, often extends beyond the primary site and causes damage in distant organs, in

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Rolando Claure @runningkidneys.bsky.social · 28/08/2026

The future of #CKM care must be community-embedded, digitally enabled & interdisciplinary—built for local realities, including LMICs. Task-sharing, integrated digital care & outcome-based payment may reshape CKM prevention & treatment. #CKM 🔗 journals.lww.com/cjasn/pdf/10...

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Rolando Claure @runningkidneys.bsky.social · 26/08/2026

Hyperammonemia is rare but potentially fatal. Understanding NH₃ physiology is 🔑: toxicity depends not only on peak levels, but also on duration of exposure. Early recognition, rapid treatment, & timely KRT can be critical to preventing neurologic injury. doi.org/10.1053/j.ak...

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Rolando Claure @runningkidneys.bsky.social · 26/08/2026

RAAS inhibition remains a cornerstone of supportive care in IgA nephropathy—but may not be enough in high-risk patients. A meta-analysis found an average annual eGFR decline of −4.5 mL/min/1.73 m² with maximally tolerated RAASi alone. 🔗 journals.lww.com/cjasn/pdf/10...

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Rolando Claure @runningkidneys.bsky.social · 25/08/2026

Monoclonal gammopathies can cause a broad spectrum of kidney injury even without overt hematologic malignancy. This review provides a practical update on MGRS, patterns of renal involvement, diagnosis, and management from a nephrology perspective. 🩺🫘 🔗 journals.lww.com/kidney360/pd...

journals.lww.com

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Rolando Claure @runningkidneys.bsky.social · 23/08/2026

Recovery ❤️‍🩹 run #Run4Kidneys 🫘 🏃🏻 #850Challenge 🎗️

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Rolando Claure @runningkidneys.bsky.social · 22/08/2026

High-volume post-dilution HDF was associated with a 28% lower risk of all-cause mortality vs high-flux HD in a target trial emulation of 19,758 European dialysis patients. At 2 years, mortality was 20.6% vs 22.3%. Important real-world evidence 🔗 10.1681/ASN.0000001225

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Rolando Claure @runningkidneys.bsky.social · 21/08/2026

In patients with CKD, PPI initiation was associated with a ⬆️risk of kidney failure requiring RRT (HR 1.39), while discontinuation within 90 days was associated with ⬇️risk (HR 0.85). A reason to reassess the indication for long-term PPI use. 🔗 doi.org/10.1016/j.ek...

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Reposted by Rolando Claure

ISNkidneycare @theisn.org · 19/08/2026

Stay up to date with the latest advances in nephrology research. Explore a special edition of ISN TrialWatch, featuring selected kidney-related clinical trials from 2025 and early 2026 that are shaping the future of kidney care. Read the special edition ISN TrialWatch ➡️ bit.ly/4wMQ8wN

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Rolando Claure @runningkidneys.bsky.social · 18/08/2026

Can SGLT2 inhibitors be started during AKI? In DEFENDER (100 dapagliflozin; 112 controls), dapagliflozin was not linked to more deaths, dialysis, or hemodynamic/metabolic instability over 5 days. Feasibility data—not proof of benefit. 🔗 doi.org/10.1016/j.jc...

doi.org

Redirecting

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Rolando Claure @runningkidneys.bsky.social · 18/08/2026

Cockcroft–Gault still guides trial eligibility and dosing despite the shift to race-free eGFR—risking misclassification and limiting external validity. @asnpublications.bsky.social authors propose indexed eGFR for eligibility and absolute GFR for dosing. doi.org/10.1681/ASN....

doi.org

Cockcroft–Gault in Contemporary Clinical Trials : Journal of the American Society of Nephrology

Abstract was not provided for this article.

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Rolando Claure @runningkidneys.bsky.social · 18/08/2026

CRRT: diffusion vs convection. Meta-analysis (13 studies, n=1,146): CVVHD and CVVH had similar mortality, renal recovery & ICU LOS. Diffusion reduced filter clotting (RR 0.69). Choose by circuit performance, solute goals & local expertise. 🔗 doi.org/10.1002/1744...

doi.org

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Rolando Claure @runningkidneys.bsky.social · 16/08/2026

A great success for the International Nephrology Meeting – #SLANH - @senefrologia.bsky.social Symposium in Sucre, Bolivia 🇧🇴. Science, knowledge exchange, and collaboration to strengthen nephrology across our region. Congratulations to the organizers and participants! 👏🩺 #TodosSomosSLANH

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Rolando Claure @runningkidneys.bsky.social · 14/08/2026

Perioperative dapagliflozin may reduce AKI after ❤️‍🩹surgery. In a recent trial of 778 patients, dapagliflozin 10 mg daily for 4 doses reduced 7-day postoperative AKI from 52% to 28%, without an ⬆️ in AF or reoperation. 🔗 doi: 10.1001/jama.2026.9268 #AKI #CardiacSurgery #SGLT2i

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