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Steven Kleinstein

@skleinstein.bsky.social
1.3K followers 493 following 9 posts

Computational immunologist; Professor at Yale School of Medicine; Co-Director, Computational Biology & Biomedical Informatics; B cell receptor sequencing analysis, immcantation.org + multi-omics signatures of infection, vaccination & autoimmunity.

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Reposted by Steven Kleinstein
fanofactor 🧬💻 @fanofactor.bsky.social · 28/09/2026
🚨 Immcantation users, don't forget to submit your 250-word abstract by October 1st! 👉 Find the template, submission instructions, and registration form here: immcantation.github.io/users-meetin... #immunosky
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Steven Kleinstein @skleinstein.bsky.social · 28/09/2026
🚨 immcantation.org user or interested in #Bcell repertoire analysis? 🗓️Join the FREE virtual 2027 Immcantation Users Group Meeting 📅 Jan 21, 2027 ⏰ 10AM–1:30PM ET 📢 Abstracts due Oct 1, 2026 🔗 immcantation.github.io/users-meetin...
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Reposted by Steven Kleinstein
fanofactor 🧬💻 @fanofactor.bsky.social · 20/08/2026
Save the Date:📅 1/21/27 10-1:30PM (ET). We’re excited to announce the upcoming FREE virtual 2027 Immcantation Users Group Meeting. Stay tuned for updated information, including registration, agenda, and abstract submission deadlines. immcantation.github.io/users-meetin... #immunosky
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Reposted by Steven Kleinstein
Eric Topol @erictopol.bsky.social · 05/08/2026
Severe Covid leads to persistent viral reactivation, with >10 different viruses noted in the first 40 days after hospital admission. Long Covid was specifically associated with reactivation of latent Anelloviridae virus @nature.com www.nature.com/articles/s41...
nature.com
Virus reactivation in acute and long COVID-19 - Nature
Chronic reactivation of distinct herpesviruses and anelloviruses occur during acute and long COVID-19, and track with disease severity, inflammation and outcomes, revealing immune signatures with prog...
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Reposted by Steven Kleinstein
Yale Pathology @yalepathology.bsky.social · 01/04/2026
Congratulations to Cole Jensen, MPH, a PhD Student in Computational Biology & Bioinformatics and a member of the @skleinstein.bsky.social Lab at @yalemedicine.bsky.social, on being chosen for a prestigious National Institutes of Health (NIH) F31 Award bit.ly/4bWbFtB
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Reposted by Steven Kleinstein
AIRR-Community @airr-community.bsky.social · 27/02/2026
🚀 Registration is now OPEN for AIRR Community Meeting VIII: Decoding and Recoding Immunity! Join us June 8–11, 2026 at Yale University (USA) or attend virtually. 💸 Early-bird rates available until April 15! 🔗 Register: tinyurl.com/airrcmeeting8 #AIRRC8 #immunosky
tinyurl.com
AIRR Community Meeting VIII.
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Reposted by Steven Kleinstein
Steven Kleinstein @skleinstein.bsky.social · 07/01/2026
Immcantation.org user or interested in #Bcell & #Tcell repertoire analysis? #AIRRseq 🚨Register now for the "2026 Immcantation Users Group Meeting" 🗓️FREE virtual meeting on January 22, 2026 from 10AM – 1:30PM ET. 🔗Program & registration: immcantation.github.io/users-meetin...
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Steven Kleinstein @skleinstein.bsky.social · 07/01/2026
Immcantation.org user or interested in #Bcell & #Tcell repertoire analysis? #AIRRseq 🚨Register now for the "2026 Immcantation Users Group Meeting" 🗓️FREE virtual meeting on January 22, 2026 from 10AM – 1:30PM ET. 🔗Program & registration: immcantation.github.io/users-meetin...
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Steven Kleinstein @skleinstein.bsky.social · 31/10/2025
Interested in pursuing a PhD in Computational Biology and Biomedical Informatics (CBB) at Yale? Join us for a CBB PhD Virtual Open House Tuesday, November 11 | 8:00–9:00 PM ET 👉 Register here: yalesurvey.ca1.qualtrics.com/jfe/form/SV_... @yalecbb.bsky.social
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Reposted by Steven Kleinstein
Armita Nourmohammad @thearmita.bsky.social · 27/10/2025
excited to announce that this January we are relocating to Yale to start a theory initiative at the Center for Systems and Engineering Immunology (CSEI): @yalecsei.bsky.social looking to hire 2 postdocs to join us in this endeavor. more details can be found here: sites.google.com/uw.edu/statp...
sites.google.com
SPE - join us
Postdoctoral position: In January 2026, we are relocating to Yale university to start a theory initiative at the Center for Systems and Engineering Immunology (CSEI). We are looking for talented postd...
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Steven Kleinstein @skleinstein.bsky.social · 16/10/2025
Interested in pursuing a PhD in Computational Biology and Biomedical Informatics (CBB) at Yale? Join us for the CBB PhD Virtual Open House Tuesday, October 21 | 8:00–9:00 PM ET 👉 Register here: yalesurvey.ca1.qualtrics.com/jfe/form/SV_... @yalecbb.bsky.social
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Steven Kleinstein @skleinstein.bsky.social · 01/10/2025
TODAY is the deadline for abstract submission for the 2026 Immcantation Users Group Meeting! immcantation.github.io/users-meetin...
immcantation.github.io
2026 Immcantation Users Group Meeting
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Steven Kleinstein @skleinstein.bsky.social · 24/09/2025
🚨 Immcantation.org user or interested in #Bcell repertoire analysis? 🗓️ Join the FREE virtual 2026 Immcantation Users Group Meeting 📅 Jan 22, 2026 | ⏰ 10AM–1:30PM ET 📢 Abstracts due Oct 1, 2025 🔗 immcantation.github.io/users-meeting/2026 #AIRRseq #Immcantation
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Reposted by Steven Kleinstein
fanofactor 🧬💻 @fanofactor.bsky.social · 24/09/2025
🚨 One week left! 🚨 Don’t forget to submit your 250-word abstract by October 1st! Share how you use Immcantation and contribute to building a supportive, collaborative research community. 🔗 2026 Immcantation Users Group Meeting immcantation.github.io/users-meeting/2026 #airrseq #immunosky
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Reposted by Steven Kleinstein
fanofactor 🧬💻 @fanofactor.bsky.social · 28/08/2025
🚨 Immcantation.org user or interested in #Bcell repertoire analysis? 🗓️ Join the FREE virtual 2026 Immcantation Users Group Meeting 📅 Jan 22, 2026 | ⏰ 10AM–1:30PM ET 📢 Abstracts due Oct 1, 2025 🔗 immcantation.github.io/users-meeting/2026 #AIRRseq #Immcantation
2026 Immcantation Users Group Meeting. Important information summary:
Who: open to the public
When: January 22nd, 2026
Time: 10:00 am - 1:30 pm ET
Where: Virtual
Fee: Free
Abstracts due: October 1st, 2025
Final program: December 1st, 2025
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Reposted by Steven Kleinstein
HIPC @hipcproject.bsky.social · 15/06/2025
Our condolences to family and friends of our long collaborator Atul Butte. Word of his death came from Euan Ashley of @stanfordmedicine.bsky.social #memorial www.linkedin.com/posts/euanas...
linkedin.com
Atul Butte died yesterday. | Euan Ashley
Atul Butte died yesterday. The world lost a giant. A big bear of a man. With a huge smile. With love for everyone. With energy that could power a room. I loved everything about Atul. I loved how he wa...
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Reposted by Steven Kleinstein
HIPC @hipcproject.bsky.social · 02/06/2025
Our collaborators @camilahcoelho.bsky.social @vivianasimonlab.bsky.social (+ others) show that monovalent XBB.1.5 vaccines recall mostly cross-reactive antibodies to ancestral SARS-CoV-2, not robust de novo responses. @lancetmicrobe.bsky.social #ImmuneSky www.thelancet.com/journals/lan...
thelancet.com
Mapping of human monoclonal antibody responses to XBB.1.5 COVID-19 monovalent vaccines: a B cell analysis
Our findings offer key molecular insights into whether strain-specific boosters elicit sufficient protection against SARS-CoV-2 emerging variants. This knowledge can inform decisions on booster design...
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Reposted by Steven Kleinstein
Prof. Akiko Iwasaki @virusesimmunity.bsky.social · 10/05/2025
Next week, we are hosting an international scientific workshop focused on the pathogenesis of #LongCovid at @yalemed.bsky.social. Please join us on May 15th to learn about what we know and what we need to investigate next to get to the root causes to accelerate therapies 👇🏼👇🏼
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Reposted by Steven Kleinstein
HIPC @hipcproject.bsky.social · 06/05/2025
Don’t forget! 🌺🧪 Our HIPC symposium is happening tomorrow — join us for a great lineup of talks from @bjoernpeters.bsky.social, @lungdrc.bsky.social, @settelab.bsky.social, Victoria Zyulina & Thomas Hagan Tues May 6th | 8:30-10:30 am | Room 313C #Immunology #AAI2025 #HIPC
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Reposted by Steven Kleinstein
HIPC @hipcproject.bsky.social · 23/04/2025
Come get our #immune data, free #FAIRsharing is at @immportdb.bsky.social - from @columbiauniversity.bsky.social @icahn.bsky.social @yalemedicine.bsky.social @stanfordimmunology.bsky.social @benaroyaresearch.bsky.social @lji.org MIT, Seattle Children's #AAI2025 #ImmuneSky #IDsky
Chart shows numbers of studies in data resource for Human Immunology Project consortium. more details at immunespace.org
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Reposted by Steven Kleinstein
David van Dijk @vandijklab.bsky.social · 18/04/2025
What if LLMs could “read” & “write” biology? 🤔 Introducing C2S‑Scale—a Yale and Google collab: we scaled LLMs (up to 27B!) to analyze & generate single‑cell data 🧬 ➡️ 📝 🔗 Blog: research.google/blog/teachin... 🔗 Preprint: biorxiv.org/content/10.1...
research.google
Teaching machines the language of biology: Scaling large language models for next-generation single-cell analysis
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Eric Topol @erictopol.bsky.social · 18/04/2025
Below, from earlier today, confirmed @statnews.com www.statnews.com/2025/04/18/n...
statnews.com
NIH said to have halted awarding of new grants to more top universities
Universities whose NIH funding has been frozen may face further strain as the agency holds off awarding new grants to at least a half dozen of them, according to an internal email.
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Reposted by Steven Kleinstein
HIPC @hipcproject.bsky.social · 03/04/2025
Exciting news!! We are happy to announce that we will have a HIPC Symposium at @aai.org on Tues, May 6th. HIPC will also have a Super Booth at #AAI2025 along with @iedb.bsky.social and the iAKC Project. Check out the full Symposia list, and see you there! 🔗: immunology2025.aai.org/guest-sympos...
immunology2025.aai.org
Guest Symposia - IMMUNOLOGY2025™
Information and details about Guest Symposia to be presented at IMMUNOLOGY2025™!
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Reposted by Steven Kleinstein
Michelle Linterman @linterman.bsky.social · 17/03/2025
Great to have our latest review "The cellular factors that impair the germinal center in advanced age" out @jimmunol.bsky.social. Work led by @wsfoster.bsky.social and Edith Marcial-Juárez. With @sanmarti92.bsky.social creating the beautiful GC images in figure 2. doi.org/10.1093/jimm...
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Reposted by Steven Kleinstein
Stand Up for Science! @standupforscience.net · 02/03/2025
WHERE WILL YOU BE ON MARCH 7TH!? Head to www.standupforscience2025.org/local-event-information/ or the link in our bio to find your closest event—or add one if you're hosting one! #standupforscience2025
Map of Stand Up for Science events, with official SUFS events in Red and solidarity events in Blue
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Reposted by Steven Kleinstein
Stand Up for Science! @standupforscience.net · 21/02/2025
🚨☀️ Hey Bluesky! Know anyone near the following cities that would be willing to help us Stand Up for Science? ☀️🚨 Annapolis, MD Bismarck, ND Boise, ID Charleston, WV Dover, DE Jackson, MS Anchorage or Juneau, AK Montpelier, VT Richmond, VA Send them our way! #standupforscience2025
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Stand Up for Science! @standupforscience.net · 12/02/2025
Welcome to the Bluesky account for Stand Up for Science 2025! Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide! #scienceforall #sciencenotsilence
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Science Magazine @science.org · 19/02/2025
Scientists are now organizing events, called Stand Up for Science, on 7 March in Washington, D.C., and state capitals. So far, they have attracted more than 100 volunteers from some 30 states who are hoping to rally support for research as a public good. scim.ag/4328LAD
scim.ag
‘I really wanted something to happen.’ The students behind the Stand Up for Science protests
New group hopes to turn out researchers for 7 March demonstrations against Trump administration policies
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Reposted by Steven Kleinstein
fanofactor 🧬💻 @fanofactor.bsky.social · 19/02/2025
Presentations from the 2025 Immcantation Users Group Meeting are now available on the Immcantation YouTube channel! Thank you to our speakers and participants! www.youtube.com/playlist?lis... #immcantation #airrseq #immunosky
youtube.com
2025 Immcantation Users Group Meeting - YouTube
The 2025 Immcantation Users Group Meeting (https://immcantation.github.io/users-meeting/2025/index.html) took place on January 30th, 2025. It served as a vir...
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Reposted by Steven Kleinstein
HIPC @hipcproject.bsky.social · 19/02/2025
Our collaborators identify multi-omic factor that predicts #LongCovid Among 50+ authors include @sesmalab.bsky.social @joanndarce.bsky.social @bjoernpeters.bsky.social @slimfourati.bsky.social @droferlevy.bsky.social @leying2024.bsky.social #IDsky #MedSky www.biorxiv.org/content/10.1...
biorxiv.org
Identification of a multi-omics factor predictive of long COVID in the IMPACC study
Following SARS-CoV-2 infection, ∼10-35% of COVID-19 patients experience long COVID (LC), in which often debilitating symptoms persist for at least three months. Elucidating the biologic underpinnings ...
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HIPC @hipcproject.bsky.social · 17/02/2025
Our collaborators @rgottardo.bsky.social and Ken Stuart (+ others) describe tagtango, an application to compare #single-cell annotations. #bioinformatics academic.oup.com/bioinformati...
academic.oup.com
tagtango: an application to compare single-cell annotations
AbstractSummary. In this article, we present tagtango, an innovative R package and web application designed for robust and intuitive comparison of single-c
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Reposted by Steven Kleinstein
The Daily Pub @thedailypub.bsky.social · 13/01/2025
Unlocking new insights with nipalsMCIA. This tool speeds up data analysis for big datasets by clustering and visualizing info faster than before. Check it out for both bulk and single cell data on Bioconductor with how-to guides and extras online.
doi.org
nipalsMCIA: Flexible Multi-Block Dimensionality Reduction in R via Nonlinear Iterative Partial Least Squares.
Published in Bioinformatics (Oxford, England)
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Reposted by Steven Kleinstein
bioRxiv Bioinfo @biorxiv-bioinfo.bsky.social · 10/06/2024
nipalsMCIA: Flexible Multi-Block Dimensionality Reduction in R via Nonlinear Iterative Partial Least Squares www.biorxiv.org/content/10.1101/202…
biorxiv.org
nipalsMCIA: Flexible Multi-Block Dimensionality Reduction in R via Nonlinear Iterative Partial Least Squares https://www.biorxiv.org/content/10.1101/2024.06.07.597819v1
Motivation: With the increased reliance on multi-omics data for bulk and single cell analyses, the a
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Steven Kleinstein @skleinstein.bsky.social · 30/01/2025
Interested in B cell receptor repertoire analysis? We have a great set of speakers lined up for the “2025 Immcantation Users Group Meeting!” Check out the UPDATED program and register for this free virtual meeting taking place on 1/30/25 10AM-1:40PM (ET) at: immcantation.github.io/users-meetin...
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fanofactor 🧬💻 @fanofactor.bsky.social · 29/01/2025
Don’t miss the “2025 Immcantation Users Group Meeting” on 1/30/25 10AM-1:40PM (ET) to learn how AIRR-seq can be used to study infection, vaccination, clonal lineages, and more. **UPDATED PROGRAM** and registration: immcantation.github.io/users-meetin... #immcantation #AIRRseq #immunosky #immunology
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Steven Kleinstein @skleinstein.bsky.social · 17/01/2025
Looking forward to hearing from the great speakers lined up for the “2025 Immcantation Users Group Meeting!” Check out the program and register for this free virtual meeting 1/30/25 10AM-1:40PM (ET) at: immcantation.github.io/users-meetin... @immcantation.bsky.social
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HIPC @hipcproject.bsky.social · 27/12/2024
Find some of our over 50 investigators in Starter Pack. If you are one in our collaboration - please reply OR write a DM to @rgottardo.bsky.social to ask to be added. (Know you need adding - @camilacoelho.bsky.social and @joanndarce.bsky.social ) bsky.app/starter-pack...
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HIPC @hipcproject.bsky.social · 05/12/2024
Investigators, if your name does not appear on the Starter Pack of HIPC investigators, please send a message to @rgottardo.bsky.social and ask to be added, or write a reply to him. We will be reminding you about this in meetings in the next few weeks. bsky.app/starter-pack...
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Reposted by Steven Kleinstein
fanofactor 🧬💻 @fanofactor.bsky.social · 16/12/2024
Immcantation.org user or interested in B cell repertoire analysis? Register now for “2025 Immcantation Users Group Meeting”. FREE virtual meeting 1/30/25 10AM-1:40PM (ET). Info at: immcantation.github.io/users-meetin... #immcantation #AIRRseq #immunosky
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Reposted by Steven Kleinstein
HIPC @hipcproject.bsky.social · 11/12/2024
Our collaborators designed an #immune health metric, a way of calculating the state of the #system. Study from earlier this year. Authors include @tsanglab.bsky.social @skleinstein.bsky.social #IDSky #MedSky @naturemedicine.bsky.social www.nature.com/articles/s41...
nature.com
A unified metric of human immune health - Nature Medicine
A multimodal analysis of patients with 22 different immune-mediated monogenic diseases versus matched healthy controls leads to the development of the immune health metric, which could be implemented ...
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Dr Debbie Burnett @debburnett.bsky.social · 03/12/2024
I’ve tried to put together a starter pack of immunologists/scientists exploring B Cell Repertoires and Antibody Affinities. Please feel free to share/join! go.bsky.app/4P64DmM
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Paul Thomas @pgtimmune.bsky.social · 26/11/2024
ALSO! We are hiring for the last open position (Bioinformatics Research Scientist) in the TIRTL group! Love coding, math, robotics, and uncovering the immune system's secrets? You know you do, so join us! (stjude.wd1.myworkdayjobs.com/stjude/job/M...).
stjude.wd1.myworkdayjobs.com
Bioinformatics Research Scientist (TIRTL Bluesky)
The Bioinformatics Research Scientist is responsible for designing, developing, improving, modifying, and operating data analysis pipelines. Manages projects and coordinates other efforts related to a...
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Raphael Gottardo @rgottardo.bsky.social · 25/11/2024
Thanks @tsanglab.bsky.social for putting this together! #immunology #datascience go.bsky.app/PjH2Fuj
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Raphael Gottardo @rgottardo.bsky.social · 24/11/2024
Ok, I tried to create my own list of people working on developing statistical or machine learning models applied to omics data. I am sure I missed a lot of cool people. If you'd like to be added, let me know. #Stats #ML #Omics go.bsky.app/73rcuJn
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Kim Good-Jacobson @kimljacobson.bsky.social · 16/11/2024
Save the date! It may be a while to go yet, but I’m very excited for our B-cellapalooza in 2026!
Keystone Symposia conference in 2026 for B cells and plasma cells, in Keystone Colorado
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Jamie Heather @jamieheather.bsky.social · 18/11/2024
Inspired by @rodrahimi.bsky.social 's noble efforts linking immunologists together over here, let's try and get more specifically TCR/BCR/AIRR/repertoire chat going with this starter park go.bsky.app/Gi2dcGd Drop me a beep to get added or suggest others!
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Steven Kleinstein @skleinstein.bsky.social · 20/11/2024
Are you an Immcantation.org user or interested in B cell repertoire analysis? Register now for the 2025 Immcantation Users Group Meeting! The meeting will feature talks from users showcasing how they use Immcantation in their research. Info and registration at: immcantation.github.io/users-meetin...
immcantation.org
Immcantation: An Integrated Framework for Adaptive Immune Receptor Repertoire Analysis
Immcantation: An Integrated Framework for Adaptive Immune Receptor Repertoire Analysis
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