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Raphael Gottardo

@rgottardo.bsky.social
1.9K followers 914 following 38 posts

Biomedical Data Science Center Director @CHUV. Professor at @UNIL and @EPFL. AI, ML, and statistical learning for high-dimensional (single-cell/spatial) data in clinical and translational medicine. Interdisciplinary scientist passionate about data.

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Raphael Gottardo @rgottardo.bsky.social · 18/02/2026
New preprint 🧫🧬 Spatial transcriptomics (~550,000 cells, 2,432 patient-derived organoids): we map gene expression, shape, and function in space to understand cancer biology and drug response. w/ @marianna-raps.bsky.social @khomicsko.bsky.social and Maxim Norkin www.biorxiv.org/content/10.6...
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Raphael Gottardo @rgottardo.bsky.social · 31/01/2026
Huge congrats to Teofila, Jeremy & Antoine on the 2026 Pfizer Research Prize 👏 #PrecisionDermatolology driven by translational #DataScience at #CHUV & @unil.bsky.social. More to come with #AI & #SpatialBiology. Hats off to Michel Gilliet for this vision. 🔗 www.pfizerresearchprize.ch/awardees-202...
pfizerresearchprize.ch
Loosing connection breaks the heart
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Helena Lucia Crowell @helucro.bsky.social · 21/11/2025
Shout out and thanks to everyone who was a part of this; one couldn’t have done it alone. @rgottardo.bsky.social @markrobinsonca.bsky.social @stephaniehicks.bsky.social @lmweber.bsky.social and many more.
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fbm-unil.bsky.social @fbm-unil.bsky.social · 30/09/2025
@rgottardo.bsky.social @dilibertomd.bsky.social @inserm.fr @hcl-recherche.bsky.social
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fbm-unil.bsky.social @fbm-unil.bsky.social · 10/07/2025
📄 Study published in @natcomms.nature.com and led by Laurence de Leval, @rgottardo.bsky.social @khomicsko.bsky.social & Elo Madissoon. @unil.bsky.social #chuv @owkin.bsky.social
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Raphael Gottardo @rgottardo.bsky.social · 01/07/2025
🧬 New paper out! 🔗 www.nature.com/articles/s41... Frustrated by noisy CITE-seq data? ADTNorm helps normalize it and introduces a staining index to assess antibody quality. Great work by former postdoc Ye Zheng. Supported by @hipcproject.bsky.social #CITEseq #SingleCell #ADTNorm
nature.com
ADTnorm: robust integration of single-cell protein measurement across CITE-seq datasets - Nature Communications
Here the authors present a computational method that expands the potential of multimodal single-cell analyses by delivering an accurate, fast, and user-friendly approach for normalizing and comparing ...
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Raphael Gottardo @rgottardo.bsky.social · 30/06/2025
Big shoutout to our own Jieran Sun onesinglecell.bsky.social for leading this team effort! 🧠📍 Benchmarking clustering in spatial transcriptomics isn’t easy — but here is SACCELERATOR Preprint: www.biorxiv.org/content/10.1... With markrobinsonca.bsky.social, Naveed Ishaque, Ahmed Mahfouz, Brian Long
biorxiv.org
Beyond benchmarking: an expert-guided consensus approach to spatially aware clustering
Spatial omics technologies have revolutionized the study of tissue architecture and cellular heterogeneity by integrating molecular profiles with spatial localization. In spatially resolved transcript...
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Raphael Gottardo @rgottardo.bsky.social · 23/06/2025
Are you interested in #Xenium panel comparisons: 5K vs targeted? Want to increase cell-type resolution with Xenium? Read our paper and check out our SPLIT method. www.biorxiv.org/content/10.1... Collaboration with @khomicsko.bsky.social cc: @10xgenomics.bsky.social #SpatialTranscriptomics
biorxiv.org
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Raphael Gottardo @rgottardo.bsky.social · 22/06/2025
🚀 First MOSAIC consortium paper and MOSAIC Window: a rich 60-patient public (multimodal) dataset accessible via EGA. 📄 www.biorxiv.org/content/10.1... #CancerResearch #SpatialTranscriptomics #SingleCell #PrecisionOncology #AI cc: @owkin.bsky.social @10xgenomics.bsky.social
biorxiv.org
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Raphael Gottardo @rgottardo.bsky.social · 22/06/2025
🎉 New paper alert. We benchmarked Visium, GeoMx, and Chromium for FFPE tumor analysis. Thanks @estellayixingdong.bsky.social for pushing this forward, & MOSAIC collaborators! 📄 www.nature.com/articles/s41... #SpatialTranscriptomics #CancerResearch cc: @owkin.bsky.social @10xgenomics.bsky.social
nature.com
Transcriptome analysis of archived tumors by Visium, GeoMx DSP, and Chromium reveals patient heterogeneity - Nature Communications
Currently, there is an urgent need to evaluate the strengths and limitations of various probe-based full transcriptome methods for formalin-fixed paraffin-embedded tumor tissues. Here, the authors ana...
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Raphael Gottardo @rgottardo.bsky.social · 22/06/2025
New expanded @hipcproject.bsky.social starter pack: go.bsky.app/AozZWPx
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Raphael Gottardo @rgottardo.bsky.social · 28/03/2025
Congratulations @rrmsky.bsky.social !
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HIPC @hipcproject.bsky.social · 17/02/2025
Our collaborators @rgottardo.bsky.social and Ken Stuart (+ others) describe tagtango, an application to compare #single-cell annotations. #bioinformatics academic.oup.com/bioinformati...
academic.oup.com
tagtango: an application to compare single-cell annotations
AbstractSummary. In this article, we present tagtango, an innovative R package and web application designed for robust and intuitive comparison of single-c
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Raphael Gottardo @rgottardo.bsky.social · 15/01/2025
#NIH HIPC consortium starter pack with added members @slimfourati.bsky.social @bjoernpeters.bsky.social @joanndarce.bsky.social @immunespace.bsky.social go.bsky.app/AozZWPx
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Raphael Gottardo @rgottardo.bsky.social · 22/12/2024
Precision Dermatology 2.0: #DataScience + #Immunology + #Genomics + #Clinical Science. Interdisciplinary collaboration at its best at the @CHUV. www.chuv.ch/fr/chuv-home... Paper on @naturecomms.bsky.social www.nature.com/articles/s41...
chuv.ch
Eczéma, psoriasis, lupus et autres maladies inflammatoires de la peau : des signatures génomiques pour améliorer le diagnostic et le traitement
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Raphael Gottardo @rgottardo.bsky.social · 22/12/2024
An older article on why I remain cautiously optimistic about generative #AI in #healthcare: www.rts.ch/info/science...
rts.ch
L'IA générative dans le secteur de la santé: une révolution imminente
Les avancées de l'intelligence artificielle générative dans le domaine de la santé ouvrent de nouvelles perspectives. Alors que Google lance Med-PaLM 2, un outil d'IA médicale, des professionnels suis...
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Atul Butte @atulbutte.bsky.social · 06/12/2024
Very cool! One genomic test can diagnose nearly any infection! Comes out of the lab of Charles Chiu @ucsfhealth.bsky.social www.ucsf.edu/news/2024/11...
ucsf.edu
1 Genomic Test Can Diagnose Nearly Any Infection
A decade-long effort has resulted in a new, rapid genomic test to diagnose rare infectious diseases in the brain and lungs.
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Raphael Gottardo @rgottardo.bsky.social · 05/12/2024
Thanks #Spotify for letting me know that #Vulfpeck was my #1 artist for 2024. Top 0.05% of listeners worldwide. Almost significant! Of course, not surprised.
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Raphael Gottardo @rgottardo.bsky.social · 05/12/2024
By popular demand, I have updated our starter pack in Stats, ML & Omics. Let me know if you'd like to be added. #ML #AI #singlecell #spatial #omics #statistics go.bsky.app/73rcuJn
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Raphael Gottardo @rgottardo.bsky.social · 05/12/2024
Great news! Thrilled about this new appointment at EPFL to strengthen collaborations in biomedical data science across CHUV, @unil.bsky.social, and the EPFL. Excited to work closely with EPFL colleagues and students ! #datascience #AI #medicine #biology actu.epfl.ch/news/two-app...
actu.epfl.ch
Two appointments at the School of Life Sciences
The Board of the Swiss Federal Institutes of Technology has announced the appointment of professors at EPFL. Among them, are Professors Markus Jeschek and Raphael Gottardo at the School of Life Scienc...
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Raphael Gottardo @rgottardo.bsky.social · 05/12/2024
Interesting work from @deep-mind.bsky.social on probabilistic weather forecasting (aka GenCast) www.nature.com/articles/s41... BUT why didn't they cite previous work in this space by Raftery and colleagues: www.science.org/doi/full/10.... journals.ametsoc.org/view/journal... and many other papers!
nature.com
Probabilistic weather forecasting with machine learning - Nature
GenCast, a probabilistic weather model using artificial intelligence for weather forecasting, has greater skill and speed than the top operational medium-range weather forecast in the world and provid...
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Raphael Gottardo @rgottardo.bsky.social · 28/11/2024
Here is a starter pack for the #NIH Human #Immunology Project Consortium (@hipcproject.bsky.social). #HIPC members, please reach out if you'd like to be added. go.bsky.app/AozZWPx
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Raphael Gottardo @rgottardo.bsky.social · 27/11/2024
Ok, as requested, here’s an updated list with additional people: go.bsky.app/73rcuJn Reach out if you want to be added! #AI #ML #DataScience #Omics #SingleCell #SpatialBiology
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Raphael Gottardo @rgottardo.bsky.social · 26/11/2024
@lpachter.bsky.social Interesting! Also, Louvain/Leiden determine the number of clusters automatically (through the resolution), often leading users to assume the default is optimal! However, identifying the correct number of clusters is a complex statistical problem, which shouldn't be ignored.
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Raphael Gottardo @rgottardo.bsky.social · 25/11/2024
Thanks @tsanglab.bsky.social for putting this together! #immunology #datascience go.bsky.app/PjH2Fuj
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Raphael Gottardo @rgottardo.bsky.social · 24/11/2024
Ok, I’ve added a few more people to the list: go.bsky.app/73rcuJn Please reach out if you want to be added! The more the better. #AI #ML #DataScience #Omics #SingleCell #SpatialBiology
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Raphael Gottardo @rgottardo.bsky.social · 24/11/2024
Ok, I tried to create my own list of people working on developing statistical or machine learning models applied to omics data. I am sure I missed a lot of cool people. If you'd like to be added, let me know. #Stats #ML #Omics go.bsky.app/73rcuJn
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Raphael Gottardo @rgottardo.bsky.social · 23/11/2024
We’re about to get started!
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Raphael Gottardo @rgottardo.bsky.social · 20/11/2024
Jacques Fellay (EPFL) and I (UNIL/CHUV) will be discussing applications of #AI in #Health at 10:30 AM. This is one of the areas where #AI is poised to make the biggest impact in the coming decade. Join us, ask your questions, and be part of the conversation. Don’t miss it—be there or be square! 💡🌍
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Raphael Gottardo @rgottardo.bsky.social · 20/11/2024
Thank you for this incredible honor! 🙏 A huge shoutout to the trainees in my lab—this achievement is thanks to you. Excited for what’s ahead from our Biomedical #DataScience Center at UNIL/CHUV 🚀 #Teamwork #Innovation #AI #HighlyCited2024 clarivate.com/highly-cited... @unil.bsky.social
clarivate.com
Highly Cited Researchers | Clarivate
The Highly Cited Researchers 2024 list identifies and celebrates individuals who have demonstrated significant and broad influence in their fields of research. Through rigorous selection criteria and ...
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Raphael Gottardo @rgottardo.bsky.social · 20/11/2024
Jacques Fellay (EPFL) and I (UNIL/CHUV) will be discussing applications of #AI in #Health at 10:30 AM. This is one of the areas where #AI is poised to make the biggest impact in the coming decade. Join us, ask your questions, and be part of the conversation. Don’t miss it—be there or be square! 💡🌍
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unil.bsky.social @unil.bsky.social · 20/11/2024
🧭 Faites connaissance avec l’UNIL et ses bachelors! Les Journées Découverte des 4 et 5 décembre sont ouvertes aux personnes intéressées à entreprendre un bachelor à l’UNIL. Infos et inscriptions : wp.unil.ch/decouverte/
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unil.bsky.social @unil.bsky.social · 15/11/2024
🧠Le 23 novembre aura lieu la Journée de l’intelligence artificielle organisée par l’UNIL et l’EPFL. L’occasion de parcourir ses bénéfices et risques dans les sciences biomédicales, glaciologiques et criminelles. À lire dans l'uniscope 👉 go.unil.ch/sMZUc
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