iiinova — where your digital self keeps evolving

Reposted by Oliviero Leonardi

Roman Zug @romanzug.bsky.social · 15/10/2025

3 years ago, Tobias Uller (@biologylu.bsky.social) and I proposed that important human brain-/face-related traits evolved through #downregulation of transcriptional regulation (TR) genes for brain/face development, e.g. ARID1B, ARID2, BAZ1B, CUX1, FOXP2, NFIX, SATB2 & TCF20. (1/6) bit.ly/42HvlOg

bit.ly

Evolution and dysfunction of human cognitive and social traits: A transcriptional regulation perspective | Evolutionary Human Sciences | Cambridge Core

Evolution and dysfunction of human cognitive and social traits: A transcriptional regulation perspective - Volume 4

193

Oliviero Leonardi @olivieroleonardi.bsky.social · 14/10/2025

Kicking off the annual #ASHG meeting in Boston with a brilliant plenary session! Inspiring talks from Sarah Tishkoff and Francis Collins on the importance of representing human genetic diversity in genomic research. Loved seeing human evolution highlighted as a key lens to understand human genetics!

040

Oliviero Leonardi @olivieroleonardi.bsky.social · 07/10/2025

Thrilled to share that I’ve successfully defended my PhD thesis on human brain evolution at @humantechnopole.bsky.social 🎓 A heartfelt thank you to everyone who has been part of this journey. Excited for what comes next!

261

Reposted by Oliviero Leonardi

Cedric Boeckx @cedricboeckx.bsky.social · 06/10/2025

Congratulations _Dr_ @olivieroleonardi.bsky.social on a great thesis defense today. It’s been a great privilege for me to work closely with you for the past 5 years. I have enjoyed our many meetings on paleogenomics and human brain evolution, and learned a lot from you 👏

151

Oliviero Leonardi @olivieroleonardi.bsky.social · 22/01/2025

Incredibly happy to finally share this work in which we uncover the impact of CHD2 dosage on neurodevelopmental timing with implications for human evolution and disease! Thread below 🧵⬇️

0100

Reposted by Oliviero Leonardi

Cedric Boeckx @cedricboeckx.bsky.social · 22/01/2025

New preprint 📣! Excited to share the result of several years of work, led by @ellylewerissa.bsky.social & @olivieroleonardi.bsky.social, in collaboration with friends @naelnadifkasri-lab.bsky.social & Giuseppe Testa. On CHD2, a chromatin remodeller, its role in evolution & development [🧵] 🧪🧠🧫🧬

Day 50 cortical organoid stained for KI67 (red), MAP2 (magenta), Hoechst (cyan); image credit: Oliviero Leonardi

DIV 28 iNeuron. Homer1 in green and Synapsin1 in purple showing co-localization of post- and pre-synapses, respectively; image credit: Elly Lewerissa

24421