Modified medication targets the cells implicated in the condition’s tell-tale lesions.

Why do so many promising immunotherapies fail to reach their potential? Adrian Hayday argues that transformative clinical advances depend on protecting specialized ‘squares of discovery’ in which deep...

Hu et al. integrate spatial multi-omics to identify stem-like lymphoid niches (SLNs) organized by CD70+ ILC2s and Tpex cells that predict PD-1/PD-L1 immunotherapy responses in hepatocellular carcinoma (HCC). They reveal that Bacillus cereus-PI-PLC increases SLN abundance and synergizes with PD-L1 blockade, highlighting microbiota-driven enhancement of cancer immunotherapy through SLNs therapeutically in HCC.

In this issue of Cancer Cell, Vuong et al. perform a cross-species functional and molecular analysis of the mechanisms of response and adaptation to VEGFR kinase inhibitors and immunotherapy, identifying SPP1+ tumor-associated macrophages as key players of response to therapy. They further demonstrate that chronic treatment promotes metastatic spread.

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Rade et al. present a longitudinal single-cell atlas of BCMA CAR-T therapy in multiple myeloma, revealing that cilta-cel drives potent CD4⁺ cytotoxic responses and superior outcomes. Their findings identify plasmacytoid dendritic cells as unexpected BCMA-expressing targets and suggest therapeutic potential in blastic plasmacytoid dendritic cell neoplasm.

Rheumatoid joints contain macrophages with reparative potential, yet inflammation persists. Huang et al. demonstrate that these homeostatic macrophages lose their protective role by undergoing PANoptotic death. Mechanistically, C1q activates the mitochondrial enzyme SARM1, driving NAD⁺ cleavage into cADPR, which precipitates metabolic collapse and PANoptosis. The resulting macrophage death amplifies autoimmune tissue inflammation through the release of pro-inflammatory mediators.

Heinen et al. show that the mitochondrial import complex recruits lipid droplets to the mitochondrial outer membrane. The mitochondrial import complex binds to the lipid metabolism enzyme Ayr1 and con...

Nature Protocols, Published online: 06 March 2026; doi:10.1038/s41596-025-01308-8This Protocol presents a detailed guide for generating and analyzing single-cell multiomic data from low-input samples with the Seq-Well S3 platform.

This work presents SUM-seq, an ultra-high-throughput method for co-profiling chromatin accessibility and gene expression in single nuclei across multiplexed samples, advancing the study of gene regula...

Early trials of the drug VIR-5500 showed it shrinking tumours in some patients

UCL Discovery is UCL's open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.

Li et al. show that SPOP mutations and USP7 overexpression promote TREX1 upregulation, leading to increased cytosolic DNA degradation and suppression of cGAS-STING-mediated immune activation. Targeting USP7 enhances the effectiveness of radiotherapy combined with immune checkpoint blockade, providing a new strategy to overcome resistance and improve therapy outcomes.

Commensal microbes shape host immunity at barrier tissues and promote resistance to infection. Xu et al. identify a commensal Corynebacterium-derived lipid that activates IL-17⁺ γδ T cells via T cell receptor and IL-1 signaling, enhancing barrier defenses. This finding highlights the translational potential of a microbe-informed therapeutic strategy at barrier surfaces.

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Polyamines prevent the action of kinases on acidic phosphorylatable motifs in spliceosomal proteins, thus providing a mechanism for metabolite-mediated regulation of alternative splicing in cells.

The microbial metabolite trimethylamine (TMA), the precursor of TMAO, which is associated with adverse cardiometabolic outcomes, is shown to have beneficial metabolic and anti-inflammatory effects in the host in the context of obesity.

Diet and cancer Dual impacts of serine/glycine-free diet in enhancing antitumor immunity and promoting evasion via PD-L1 lactylation Tong et al, Zhen Lei Hubing Shi ∙ Xuelei Ma. Dietary restriction…

Until today, the aggressiveness of prostate cancer has been assessed primarily using the Gleason grading system—an analysis of cancer tissue in a pathology laboratory that is highly subjective. An int...

APC/C activity is transiently inhibited to generate a pulse of glycolysis that is required for mammalian cell cycle entry.

Nature, Published online: 16 July 2025; doi:10.1038/d41586-025-02215-4 The US science crisis presents an opportunity to reinvent funding and management of the global research enterprise.

The Wellcome Photography Prize brings together visual stories of health, science and human experience.

Nature Reviews Cancer, Published online: 02 July 2025; doi:10.1038/s41568-025-00849-0Although disulfide stress in cancer cells under glucose starvation is known to trigger disulfidptosis, its role in the tumour microenvironment has remained unclear. A recent study in Nature Cell Biology reveals that in intratumoural CD8+ T cells, disulfidptosis promotes T cell exhaustion and thereby limits antitumour imunity.

An immigration crackdown makes the United States less attractive. These locations could steal its crown and make conferences more globally inclusive.

Nature Protocols, Published online: 12 June 2025; doi:10.1038/s41596-025-01188-yWe present a protocol for the design, fabrication and use of a microfluidic probe for nanospray desorption electrospray ionization mass spectrometry imaging (nano-DESI MSI) that achieves a spatial resolution of 8–10 µm and 10-fold improvement in experimental throughput.

Lei et al. reveal that radiotherapy (RT) elevates mitochondrial copper and induces cuproptosis by upregulating CTR1 and depleting mitochondrial glutathione. Furthermore, BACH1 downregulation confers radioresistance by upregulating MT1E/X-mediated cuproptosis defense. Correspondingly, copper-loaded copper ionophores restore RT sensitivity by enhancing cuproptosis, highlighting a therapeutic strategy to overcome tumor radioresistance.

This Review discusses the impact of the gut microbiota on cancer and on cancer therapy, highlighting the importance of developing microbiota-targeting strategies to improve cancer therapy outcomes

SAVANA is a new tool designed for accurate detection of structural variations in clinical samples.

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Competing political and economic goals on immigration are resulting in the loss of valuable skills and talent in the UK