iiinova — where your digital self keeps evolving

SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 19/06/2026

New preprint: #Salmonella virulence genes may use a stress-adapted codon bias to sustain translation under infection-like conditions. 📖 shorturl.at/8QiGO ✍️ Frédéric Goormaghtigh & Dirk Bumann @ulbruxelles.bsky.social @biozentrum.unibas.ch #Microsky #CodonUsage #Translation #BacterialPathogenesis

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 16/06/2026

UPEC senses neutrophil NETs through the newly identified DanRI regulatory system. NET-derived nucleosomes induce DanRI, which dampens ROS/NET formation and helps UPEC evade inflammation during UTI. ✍️ @immunobladder.bsky.social & coll. 📖 shorturl.at/Z2zWK @cp-cellhostmicrobe.bsky.social

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 31/05/2026

Overall, this work illustrates how natural regulatory polymorphisms can diversify bacterial behavior by rewiring how conserved systems interpret host-relevant signals, thereby tuning virulence programs and potentially the epidemic capacity of tuberculosis bacilli. Editor: @heran.bsky.social

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 31/05/2026

Importantly, these signaling differences are not just biochemical details. The study also links them to differences in virulence in mice, with the PhoPR variant from 𝑀. 𝑏𝑜𝑣𝑖𝑠 AN5 being the only one associated with reduced virulence in this experimental setting.

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 31/05/2026

The results show that these variants do not behave equally. Some respond to acidic pH and Zn, some appear weakly responsive, one seems constitutively active, and one variant from an 𝑀. 𝑏𝑜𝑣𝑖𝑠 strain linked to direct human transmission is poorly induced in vitro yet remains responsive in macrophages.

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 31/05/2026

PhoPR is a major two-component regulatory system controlling key virulence functions in 𝑀. 𝑡𝑢𝑏𝑒𝑟𝑐𝑢𝑙𝑜𝑠𝑖𝑠. In this study, the authors identify Zn and Cd as new inducers of PhoPR, alongside acidic pH, and compare how distinct PhoPR variants behave when expressed in the same HN878 genetic background.

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 31/05/2026

𝐍𝐚𝐭𝐮𝐫𝐚𝐥 𝐏𝐡𝐨𝐏𝐑 𝐯𝐚𝐫𝐢𝐚𝐧𝐭𝐬 𝐟𝐫𝐨𝐦 𝐝𝐢𝐟𝐟𝐞𝐫𝐞𝐧𝐭 𝐓𝐁 𝐛𝐚𝐜𝐢𝐥𝐥𝐮𝐬 𝐥𝐢𝐧𝐞𝐚𝐠𝐞𝐬 𝐬𝐞𝐧𝐬𝐞 𝐡𝐨𝐬𝐭-𝐥𝐢𝐤𝐞 𝐜𝐮𝐞𝐬 𝐝𝐢𝐟𝐟𝐞𝐫𝐞𝐧𝐭𝐥𝐲 Zn and Cd emerge as new PhoPR inducers, and variant-specific signaling differences translate into different virulence outcomes. 📖 shorturl.at/ZBrAh ✍️ E. Meunier & coll. @ipbstoulouse.bsky.social @asm.org

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 14/05/2026

Acquired AmpC β-lactamases can shape more than antibiotic resistance. Some CMY variants improve in vitro fitness, while CMY-2 increases flagella production and pathogenicity, new study reveals. 📖 shorturl.at/UGDGU ✍️ O. Hallal Ferreira Raro & coll. @asm.org #MicroSky #AMR #Microbiology

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 02/05/2026

A cost-effective alveolus-on-chip model reveals that macrophages are key drivers of early 𝑀. 𝑡𝑢𝑏𝑒𝑟𝑐𝑢𝑙𝑜𝑠𝑖𝑠 infection, acting as a permissive niche and promoting spread across the alveolar barrier. #Tuberculosis #OrganOnChip 📖 shorturl.at/G2Jzt ✍️ Deboosere & coll. @ciilofficiel.bsky.social

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 20/04/2026

New in @science.org Sci Transl Med: GPR84 emerges as a key driver of inflammation in Buruli ulcer. Inhibiting this receptor, together with antibiotics, promoted tissue repair in experimental infection. @mel-foulon.bsky.social & coll. 📖 shorturl.at/vyobG

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Science | AAAS

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 17/04/2026

𝐇𝐨𝐰 𝐝𝐨 𝐛𝐚𝐜𝐭𝐞𝐫𝐢𝐚 𝐭𝐮𝐫𝐧 𝐡𝐨𝐬𝐭 𝐬𝐭𝐫𝐞𝐬𝐬 𝐢𝐧𝐭𝐨 𝐯𝐢𝐫𝐮𝐥𝐞𝐧𝐜𝐞 𝐩𝐫𝐨𝐠𝐫𝐚𝐦𝐬? A new study in @natcomms.nature.com shows that Fe-S cluster damage activates the stringent response in 𝑆𝑎𝑙𝑚𝑜𝑛𝑒𝑙𝑙𝑎, 𝐸𝑛𝑡𝑒𝑟𝑜𝑏𝑎𝑐𝑡𝑒𝑟 and 𝐾𝑙𝑒𝑏𝑠𝑖𝑒𝑙𝑙𝑎. ✍️ @sronneau.bsky.social & coll. 📖 shorturl.at/zP3BB #Microbiology #StringentResponse #ppGpp

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 17/04/2026

🦠 𝐇𝐨𝐰 𝑷𝒔𝒆𝒖𝒅𝒐𝒎𝒐𝒏𝒂𝒔 𝐬𝐮𝐫𝐯𝐢𝐯𝐞𝐬 𝐜𝐞𝐥𝐥 𝐰𝐚𝐥𝐥 𝐬𝐭𝐫𝐞𝐬𝐬 In 𝑃. 𝑎𝑒𝑟𝑢𝑔𝑖𝑛𝑜𝑠𝑎, elongasome dysfunction creates a strong dependence on peptidoglycan recycling, revealing a potential new antibacterial vulnerability. ✍️ @manonjanet.bsky.social & coll. @inaattree.bsky.social 📖 shorturl.at/dgpXX #MicroSky

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Melanie Blokesch @mblokesch.bsky.social · 10/04/2026

Excited to share our new paper out today in @science.org 🎉 We show that HGT via natural competence drives diversification of chromosomal integrons in V. cholerae 🤩 Below a 🧵 on key findings incl. background on natural competence in V. cholerae 1/ #microsky #phagesky www.science.org/doi/10.1126/...

science.org

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 10/04/2026

These early Ca²⁺ signals are linked to dampened NF-κB activation and reduced p65 O-GlcNAcylation, pointing to low extracellular ATP as a fine-tuner of inflammation during EPEC infection. #HostPathogen #Inflammation

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 10/04/2026

The signal depends on a functional type III secretion system and ATP release via the translocon. High-speed imaging and modeling show that even low extracellular ATP can generate whole-cell Ca²⁺ responses with fast, local-like kinetics. #CellBiology

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 10/04/2026

𝐇𝐨𝐰 𝐝𝐨𝐞𝐬 𝐄𝐏𝐄𝐂 𝐭𝐮𝐧𝐞 𝐡𝐨𝐬𝐭 𝐢𝐧𝐟𝐥𝐚𝐦𝐦𝐚𝐭𝐢𝐨𝐧 𝐚𝐭 𝐭𝐡𝐞 𝐯𝐞𝐫𝐲 𝐬𝐭𝐚𝐫𝐭 𝐨𝐟 𝐢𝐧𝐟𝐞𝐜𝐭𝐢𝐨𝐧? A new preprint from @i2bcparissaclay.bsky.social and @ulbruxelles.bsky.social shows rapid, coordinated Ca²⁺ responses in epithelial cells triggered by extracellular ATP. #EPEC #CalciumSignaling

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 02/04/2026

𝐀 𝐬𝐢𝐧𝐠𝐥𝐞 𝐠𝐞𝐧𝐞 𝐥𝐨𝐬𝐬 𝐜𝐚𝐧 𝐫𝐞𝐰𝐢𝐫𝐞 𝐛𝐚𝐜𝐭𝐞𝐫𝐢𝐚𝐥 𝐦𝐞𝐭𝐚𝐥 𝐮𝐩𝐭𝐚𝐤𝐞. New preprint: the yersinopine system shifts from Fe (𝑌. 𝑝𝑠𝑒𝑢𝑑𝑜𝑡𝑢𝑏𝑒𝑟𝑐𝑢𝑙𝑜𝑠𝑖𝑠) to Zn (𝑌. 𝑝𝑒𝑠𝑡𝑖𝑠). Deleting 𝑐𝑛𝑡𝑄 reproduces the switch. A striking example of bacterial adaptation. ✍️ Laffont & coll. 📖 shorturl.at/uRBuP

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 02/03/2026

𝐌𝐨𝐛𝐢𝐥𝐞 𝐠𝐞𝐧𝐞𝐭𝐢𝐜 𝐞𝐥𝐞𝐦𝐞𝐧𝐭𝐬 𝐝𝐨𝐧’𝐭 𝐣𝐮𝐬𝐭 𝐬𝐩𝐫𝐞𝐚𝐝 𝐫𝐞𝐬𝐢𝐬𝐭𝐚𝐧𝐜𝐞: 𝐭𝐡𝐞𝐲 𝐞𝐧𝐜𝐨𝐝𝐞 𝐚𝐧𝐭𝐢𝐛𝐢𝐨𝐭𝐢𝐜 𝐩𝐞𝐫𝐬𝐢𝐬𝐭𝐞𝐧𝐜𝐞, 𝐧𝐞𝐰 𝐬𝐭𝐮𝐝𝐲 𝐫𝐞𝐯𝐞𝐚𝐥𝐬. In 𝐿. 𝑝𝑛𝑒𝑢𝑚𝑜𝑝ℎ𝑖𝑙𝑎, ICE pP36 generates growth heterogeneity, fuels persister formation, and transfers tolerance to clinical isolates. ✍️ @personniclab.bsky.social & coll. 📖 shorturl.at/jNqHS

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 27/02/2026

🔬 New work from the Mazel Lab engineers programmable conjugative plasmids to selectively target MDR bacteria and the resistance plasmid pOXA-48, blocking its spread in complex communities. ✍️ @amazeld.bsky.social & coll. @pasteur.fr 📖 shorturl.at/GZdJu #MicroSky #AntibioticResistance #Conjugation

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 27/02/2026

🔬 Calcium triggers natural transformation in 𝐴𝑐𝑖𝑛𝑒𝑡𝑜𝑏𝑎𝑐𝑡𝑒𝑟 𝑏𝑎𝑢𝑚𝑎𝑛𝑛𝑖𝑖, boosting DNA uptake and resistance acquisition, reports the Charpentier Lab. Opens new doors for genetic engineering. ✍️ @labxc.bsky.social & coll. 📖 shorturl.at/F2GGl #MicroSky #AntibioticResistance #NaturalTransformation

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 25/02/2026

🚨 𝐀𝐈 𝐦𝐞𝐞𝐭𝐬 𝐓𝐁 𝐝𝐫𝐮𝐠 𝐝𝐢𝐬𝐜𝐨𝐯𝐞𝐫𝐲! Imaging 𝐶. 𝑔𝑙𝑢𝑡𝑎𝑚𝑖𝑐𝑢𝑚 (a model for 𝑀. 𝑡𝑢𝑏𝑒𝑟𝑐𝑢𝑙𝑜𝑠𝑖𝑠) + deep learning reveals known, unseen, and novel antibiotic modes of action from images alone, a leap for TB drug discovery. ✍️ @awehenkel.bsky.social & coll. 📖 shorturl.at/9QPDy #Tuberculosis #MicroSky

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 17/02/2026

Nouvelle percée en biologie parasitaire ! Une équipe française révèle comment RCC1-2 et APR8 orchestrent la construction de l’apical complex chez 𝘛𝘰𝘹𝘰𝘱𝘭𝘢𝘴𝘮𝘢 𝘨𝘰𝘯𝘥𝘪𝘪. ✍️ @gissotlab.bsky.social @lebrunlab.bsky.social & coll. 📖 shorturl.at/4q68P

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 15/02/2026

New research shows strain-specific epithelial responses to 𝑆. 𝑝𝑛𝑒𝑢𝑚𝑜𝑛𝑖𝑎𝑒, with invasive strains driving distinct STAT3 signaling compared to carriage isolates, offering insight into asymptomatic carriage vs. inflammation. ✍️ @melanie-hamon.bsky.social & coll @pasteur.fr 📖 shorturl.at/a6aAQ #MicroSky

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CNRS Biologie @cnrsbiologie.bsky.social · 13/02/2026

#ResultatScientifique🔎| La bactérie responsable de la tuberculose est capable d'évacuer les métaux toxiques pour résister au système immunitaire ✍️ @oneyrolles.bsky.social 🤝 @ipbstoulouse.bsky.social 📕 buff.ly/4R5iaMB ▶️

buff.ly

Tuberculose : comment la bactérie évacue les métaux toxiques pour résister au système immunitaire

Le bacille de la tuberculose survit dans les cellules immunitaires en neutralisant des métaux toxiques comme le zinc.

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Nature Communications @natcomms.nature.com · 02/02/2026

#Microbiology The anti-tuberculosis drug bedaquiline targets the mycobacterial ATP synthase, but how that leads to bacterial death is unclear Here the authors clarify how bedaquiline works @jnblab.bsky.social @morwan.me #TBSky #antibiotics #AMR dlvr.it/TQjZ0W

Cartoon representing the mycobacterial oxidative phosphorylation system, including cytochromes, NDH-2, and ATP synthase. Taken from Figure 1 of the article.

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 28/01/2026

New from @cascaleslab.bsky.social: A new weapon in the T6SS arsenal. Jonas Desjardins et al. uncover a new family of T6SS toxins that target competitors’ metabolic core, defining a novel NAD(P)⁺ glycohydrolase family, Tne5. 📖 shorturl.at/3QhkS #MicroSky

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 14/01/2026

New research from @pasteur.fr reveals how 𝐿𝑒𝑔𝑖𝑜𝑛𝑒𝑙𝑙𝑎 uses LpDot1 to methylate SFPQ, disrupting paraspeckles & rewiring host splicing, dampening immune genes like NF-κB2 & CD45 for survival. ✍️ @cbuch.bsky.social, @mrolando.bsky.social & coll. 📖 Read the preprint: shorturl.at/kFh8z #MicroSky

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 09/01/2026

New study uncovers mitochondrial DNA G-quadruplexes as druggable targets in Plasmodium falciparum, with RHPS4 showing strong activity against resistant #malaria parasites. ✍️ Mariam Salim & coll. @ipbstoulouse.bsky.social @lcc-cnrs.bsky.social 📖 shorturl.at/wlVit #InfectiousDiseases #DrugDiscovery

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 09/01/2026

New research shows cannabidiol inhibits HIV-1 infection across key mucosal immune cells via TRPV1 activation and CGRP signaling, blocking early transmission events. A promising avenue for future #HIV prevention. ✍️ CC Barbosa Bomfim & coll. @institutcochin.bsky.social 📖 shorturl.at/Fdz7g #Microsky

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 06/01/2026

New study reveals a high-resolution genetic map of how E. coli adapts to the gut, showing diet- and inflammation-dependent metabolism, niche shifts, and unexpected roles for mobile genetic elements. ✍️ @amandinemaire.bsky.social & coll. 📖 shorturl.at/DYSTv #Microbiome #Pathogenesis #Microsky

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 04/01/2026

Epstein-Barr virus protein EBNA-1 targets the nucleolus in G1/S phase, cuts rRNA synthesis by 50%, and triggers oxidative stress, all via EBP2. A new viral survival strategy? ✍️ M. Chabi, N. Jourdan & coll. @ibps.bsky.social 📖 shorturl.at/uReKo #Virology #CancerResearch

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 04/01/2026

New study reveals how Pseudomonas aeruginosa delivers the T6SS phospholipase Tle1 and avoids self-intoxication. Structural and experimental data identify Tli1a as the key immunity protein. ✍️ @del-leica99-98.bsky.social & coll. 📖 shorturl.at/hRHg2 #MiscoSky #TypeVISecretion #Pseudomonas

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The Shigella Meeting @shigellameeting.bsky.social · 15/12/2025

Come and visit me in Paris! #Shigella2026 - travel bursaries deadline tomorrow. Submit your abstracts at www.shigella2026.conferences-pasteur.org/home

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Institut Pasteur | 130 years of biomedical research @pasteur.fr · 08/12/2025

🔬 Call to create junior research groups at the Institut Pasteur Focus: Infectious diseases, host-microbe interactions, vaccines Special interest: AI methodologies 📅 Deadline: Feb 9, 2026 👥 2-12 years post-PhD Apply now 📝 research.pasteur.fr/en/call/crea... #JobOpportunity #Research

research.pasteur.fr

Creation of new junior research groups at the Institut Pasteur - Call for applications 2026 - Research

The Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 30/11/2025

🧬 A new “Life Identification Number (LIN)” system aims to modernize bacterial classification with a clearer, more stable hierarchy. A step forward for genomic taxonomy! 📖 shorturl.at/vkQuS ✍️ @sylvainbrisse.bsky.social & coll. @pasteur.fr @ox.ac.uk @monashuniversity.bsky.social @lshtm.bsky.social

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 29/11/2025

👏👏👏 Bravo @hakimi.bsky.social on winning the 2025 @inserm.fr Research Prize and the @fondationdefrance.bsky.social Allianz Prize! Hakimi's team is cracking #Toxoplasma's secrets, and developing innovative therapies to block transmission. @academiesciences.bsky.social ©Inserm/François Guénet

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 27/11/2025

Scientists can now visually track full-length #HIV genomes hiding inside cells, in real time. This new imaging technique reveals where silent viral reservoirs form, offering a powerful path toward curative strategies. #HIVresearch #CureHIV 📖 shorturl.at/ZN6hC ✍️ F. Di Nunzio & coll. @pasteur.fr

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 22/11/2025

Infections don’t enter the body in one big burst, they trickle in over time, new study reveals. This changes how we understand disease and could help us spot early warning signs sooner! 📖 shorturl.at/RxxXo ✍️ @nemopeeters.bsky.social & coll. @lipme-toulouse.bsky.social #MicroSky #PlantScience

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 19/11/2025

Viral coinfections aren’t additive, order matters. Flu often blocks COVID via strong IFN responses, RSV can boost later flu, and each pairing triggers unique cell programs. Timing shapes outcomes for care and modeling. 📖 shorturl.at/KH8cf ✍️ @olivierterrier.bsky.social & coll. @ciri-lyon.bsky.social

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 18/11/2025

Two M. tuberculosis RelE toxins don’t cut mRNA, they slice 16S rRNA itself, shutting down translation in a totally unexpected way, new study reveals. A big leap in understanding TB’s survival tricks and new angles for therapies. 📖 shorturl.at/Z8MVX ✍️ @genevauxpierre.bsky.social & coll. #MicroSky

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 14/11/2025

🚨 MONTHLY ANTIBIOTOLERANCE WEBINAR SERIES 2025-2026 Friday Nov 14, 3 PM Invited speakers: Sophie Helaine & Audrey Menegaz Proenca More info and registration here 👉 www.sfm-microbiologie.org/evenement/mo... #Microbiology #Microsky

sfm-microbiologie.org

MONTHLY ANTIBIOTOLERANCE WEBINAR SERIES - Société Française de Microbiologie

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 14/11/2025

🚨 Save the date! The Annual Congress of the French Society for Microbiology is heading to Lyon, Oct 7-9, 2026! An unmissable event for all microbe lovers. More information coming soon #SFM2026 #Microbiology #MicroSky @sfmicrobiologie.bsky.social

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 14/11/2025

In flies and worms, more pathogenic viruses caused greater aging acceleration, and the effect lingered even after clearance, new study reveals. #Aging #Infection #MicroSky #Virology 📖 shorturl.at/OeYVp ✍️ @rubengonzalez.bsky.social @castellosanjuan.bsky.social @salehlabparis.bsky.social @pasteur.fr

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IPBS Toulouse @ipbstoulouse.bsky.social · 04/11/2025

Exciting #postdoc opportunity in KL Ung's group! Understanding the molecular mechanisms of cell wall remodeling in pathogens Learn more: shorturl.at/gPuFV Deadline: January 15, 2026 Contact: recruit@ipbs.fr #Protein #Biochemistry #StructuralBiology #Biophysics #CryoEM

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 15/10/2025

Excessive Ca²⁺ signaling fuels inflammation in a zebrafish model of #cysticfibrosis, and verapamil, an FDA-approved Ca²⁺ channel blocker, restores balance & limits inflammation, new study reveals. A promising repurposing opportunity for CF therapy! 📖 shorturl.at/Fxg9F ✍️ @sarahdja.bsky.social & coll.

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