iiinova — where your digital self keeps evolving

Mohamed-Ali HAKIMI @hakimi.bsky.social · 04/08/2026

🥳 Congratulations on your first paper and on such a promising trajectory! Congrats to all the collaborators and team members. a special bravo to your outstanding mentor @cristelcarles.bsky.social

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PLOS Biology @plosbiology.org · 05/06/2026

Generative AI can make it quicker and easier to write scientific research papers. But as Lucas Bietti & Adrian Bangerter argue in this Perspective, unchecked #AI use risks decoupling #writing from #thinking, undermining the foundation of scientific knowledge. 🧪 #AcademicSky doi.org/10.1371/jour...

A pen and a manuscript, during editing. Image by Lorenzo Cafaro from Pixabay

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 02/06/2026

📢 Save the date! Join us on July 2, 2026, at IAB (#Grenoble) for: 🔬 Parasite Life Cycles Unveiled: Sex, Regulation and Host Adaptation 4 leading scientists will discuss parasite development and host–parasite interactions. 🥙 Free attendance + Lebanese lunch Register: forms.gle/a5fdoVPqgNq3...

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 25/05/2026

few days in Turino felt like walking through an open-air museum. between royal palaces, hidden courtyards and incredible archaeological pieces, every street had its own story to tell (great italian food too 😋). this town has this rare atmosphere: elegant, historic and alive at the same time. ☺️

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Matthew Bowler @mattbowler.bsky.social · 22/01/2026

New Preprint alert! Excited to share our latest work on the #MAPKinases from stellar PhD student Jill von Velsen. First structures of the MAP2K MEK1 activating its substrate MAPK between 2.9 and 3.6A - amazing resolutions for such a small and mobile complex! www.biorxiv.org/content/10.6...

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 05/12/2025

A huge thank you to @inserm.fr 😄 for the visit, for the interest in our vibrant #Grenoble ecosystem, and for shining a light on our research in this short film 🎬 www.youtube.com/watch?v=dkej...

youtube.com

Toxoplasmose : la découverte de Mohamed-Ali Hakimi qui change la prévention entre chats et humains

YouTube video by Inserm

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Inserm @inserm.fr · 25/11/2025

Retrouvez dès maintenant le teaser : www.youtube.com/watch?v=7P9L...

youtube.com

Les lauréats des Prix Inserm 2025 : découvrez l'excellence de la recherche

YouTube video by Inserm

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Inserm @inserm.fr · 27/11/2025

La cérémonie des Prix Inserm 2025 a récompensé 5 lauréates et lauréats !

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 29/11/2025

👏👏👏 Bravo @hakimi.bsky.social on winning the 2025 @inserm.fr Research Prize and the @fondationdefrance.bsky.social Allianz Prize! Hakimi's team is cracking #Toxoplasma's secrets, and developing innovative therapies to block transmission. @academiesciences.bsky.social ©Inserm/François Guénet

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 28/11/2025

What an exceptional week! At the Collège de France, surrounded by my family 🥰 and part of my Dream Team, I was honored with the 2025 Inserm Research Prize! Truly proud. 🙏 INSERM This award goes to an outstanding team and to my loved ones who have carried me through this scientific journey.

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 25/11/2025

What a day at the Académie des Sciences! 🎉 Honored to receive the Allianz Prize / Institut de France. Huge shoutout to my dream team — none of this happens without you. 🙏🏽💥 @ugrenoblealpes.bsky.social @inserm.fr @cnrs.fr

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 09/11/2025

James Watson’s passing marks the loss of a major figure whose work profoundly shaped modern biology. He is also a man whose racist and misogynistic remarks can’t be separated from his legacy. Science isn’t just about discovery; it’s about upholding universal human dignity. Rest in peace.

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 05/11/2025

Nature Com. now live! 🎉 Silvia’s amazing PhD supervised by Alex “the Greatest” & Christopher’s big-bang contribution. Huge thanks to our stellar team & collaborators. We went fishing in the FDA pond and hooked LY2090314 🎣 Blocks GSK3 🎯in #Toxoplasma & #Crypto www.nature.com/articles/s41...

nature.com

Structural and functional characterization of TgGSK3, a druggable kinase in Toxoplasma gondii - Nature Communications

Researchers identify the cancer drug LY2090314 as a potent inhibitor of Toxoplasma gondii and Cryptosporidium and report the first crystal structure of the parasite kinase TgGSK3 bound to it, validati...

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 01/11/2025

A fantastic week in Grenoble hosting my friend Amit Sharma for our @inserm.fr IRP project. With Christopher Swale on board, they pulled off a cryo-EM structure in just a few days! A great reminder that science thrives on teamwork — and friendship. Grateful to @inserm.fr for the support!

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 30/10/2025

Christopher Swale just nailed his HDR — the top academic milestone in France 🎓He can now supervise PhD students on his own. Stellar talk, razor-sharp answers, the jury was impressed. Proud of you, Chris. 👏

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 29/10/2025

Winter’s first snow over Grenoble, straight from the office view.

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 12/10/2025

On Friday, I had the privilege of speaking with a remarkable line-up of Artur Scherf alumni at a symposium devoted to his stellar contributions to parasitology in general and malaria specifically. It was wonderful to pay tribute to a friend and visionary whose legacy continues to inspire.

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 09/10/2025

So proud of my PhD student Martina Shahinas 🌟 She gave a stellar talk and shared her latest results—still chasing the sexual stages of Toxoplasma. embo.org Conference / parafrap.bsky.social was a success with an amazing speaker lineup on the ☀️Île des Embiez, Côte d’Azur.

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 04/10/2025

Oh how fantastic evolution is… every day it drops a new plot twist. 🤯🧬 Nature, who coded you?! 🤩 t.co/yXmctCX6PA

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 27/09/2025

Congrats Dr. Silvia DIAZ MARTIN on a brilliant PhD defense. 🙏to jury Maryse, Thierry, Matthew, Ludovic & Diego for their sharp eval. Shout-out to Alexandre and Christopher for their steady mentorship. You made us proud Silvia and I saw the whole galaxy of family pride reflected in your dad’s eyes.

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 06/09/2025

Zeus had his Hydra ⚔️, now Toxoplasma has its own. Meet Hydra: not a monster, but a brand-new protein domain. It multimerizes like crazy & rewrites the chromatin landscape 🧬 in Toxoplasma. Our team and colleagues from @embl.org #Grenoble just dropped the preprint 👉 www.biorxiv.org/content/10.1...

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Belen Pachano @belenpachano.bsky.social · 30/08/2025

Thrilled to share our latest review! 🎉 It captures the ideas and discussions that have shaped our work in recent years. Big shoutout to the amazing authors 👏 @hakimi.bsky.social www.sciencedirect.com/science/arti...

sciencedirect.com

Decoding the epigenetic blueprint behind Toxoplasma (pre)sexual commitment and chronic persistence

Toxoplasma gondii, a widespread apicomplexan parasite, navigates a complex life cycle in which it switches back and forth between tachyzoites and brad…

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 30/08/2025

Toxoplasma facing career options: 🏃 Tachyzoite (fast life) 😴 Bradyzoite (chronic sleeper) 🙀 Pre-sexual (cat-ready) Spoiler: epigenetics makes the call. Our recent review in Current Opinion in Microbiology decodes how chromatin remodelers, TFs& AP2s orchestrate these fates 👇🏽 doi.org/10.1016/j.mi...

doi.org

Redirecting

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EMBO Molecular Medicine @embomolmed.org · 11/07/2025

Our July issue is online 👉 www.embopress.org/toc/17574684... The cover highlights the article by M Robert, C Swale, MP Brenier-Pinchart, @hakimi.bsky.social‬ & al. that identifies BSM & BCLA as #biomarkers for chronic #ToxoplasmaGondii infection Scientific image by @hakimi.bsky.social @inserm.fr

embopress.org

EMBO Molecular Medicine: Vol 17, No 7

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 11/07/2025

Thrilled to see our work featured on the cover of @embomolmed.org 🎉We identify new biomarkers to track chronic toxoplasmosis—paving the way for improved diagnosis and patient care. doi.org/10.1038/s443... It’s time to bring such tools to the clinic—let’s encourage biotech to take it from here.

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 05/07/2025

Huge congrats @belenpachano.bsky.social on your PhD! Honored to have shared the journey. Your brilliance shines through your articles — past and future. You’ll be missed, but my lab will always be your home. Come back anytime. You’ve earned every success!

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 11/06/2025

I hear you, brother. Loud and clear. Your courage speaks volumes. Standing strong with you—and with Palestine. You're not alone.

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 20/05/2025

🙏🏽the editors, and the reviewers for their warm reception of our manuscript. @embomolmed.org is clearly an excellent journal to highlight—especially to the industrial sector—the importance of incorporating these markers into the portfolio of toxoplasmosis detection tests.

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 19/05/2025

🧵 Ever wondered what Toxoplasma is doing in your brain years after that undercooked steak 🥩 or a sip of contaminated water? Turns out, it's been hiding in your brain 🧠and we finally have a way to spot it. New study just dropped in EMBO Molecular Medicine 👇 doi.org/10.1038/s443...

doi.org

Uncovering biomarkers for chronic toxoplasmosis detection highlights alternative pathways shaping parasite dormancy | EMBO Molecular Medicine

imageimageDespite their clinical relevance, bradyzoite-filled cysts - the hallmark of chronic toxoplasmosis - are largely overlooked in current diagnostics. This study highlights bradyzoite serologica...

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Nature Microbiology @natmicrobiol.nature.com · 14/04/2025

🚨 Out now! Toxoplasma gondii ISWI remodeller TgSNF2h forms a complex that insulates active genes, regulates MORC-driven sexual commitment and ensures precise gene expression, safeguarding the parasite’s developmental program. #MicroSky 🦠 www.nature.com/articles/s41...

nature.com

Toxoplasma gondii evolved two ISWI remodellers, TgSNF2h and TgSNF2L. TgSNF2h forms a complex that insulates active genes, regulates MORC-driven sexual commitment and ensures precise gene expression, s...

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 11/04/2025

In the silence of chromatin, Toxoplasma whispers change. TgSNF2h sculpts the genome - MORC in the backseat. Some genes wake. Others sleep. A dance of nucleosomes shaping space for life parasite stages to unfold. Now in Nature Microbiology: rdcu.be/ehkWp

rdcu.be

Nature Microbiology - Toxoplasma gondii evolved two ISWI remodellers, TgSNF2h and TgSNF2L. TgSNF2h forms a complex that insulates active genes, regulates MORC-driven sexual commitment and ensures...

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 11/04/2025

A humorous reflection on the first article from my stellar PhD student, Belen Pachano. communities.springernature.com/posts/open-s...

communities.springernature.com

Open Sesame: The Protein Behind Parasite Stage Switching

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 11/04/2025

rdcu.be

Nature Microbiology - Toxoplasma gondii evolved two ISWI remodellers, TgSNF2h and TgSNF2L. TgSNF2h forms a complex that insulates active genes, regulates MORC-driven sexual commitment and ensures...

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Mohamed-Ali HAKIMI @hakimi.bsky.social · 04/03/2025

Huge congrats to colleagues & friends for uncovering PfSnf2L, the chromatin remodeler that Plasmodium relies on to shape its gene expression. A new inhibitor wrecks the blueprint, blocking parasite growth & transmission. Next up: Toxoplasma SNF2L/h—stay tuned! t.co/IqO4O3tWQX

t.co

https://www.nature.com/articles/s41586-025-08595-x

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Retraction Watch @retractionwatch.com · 13/02/2025

Thrilled to announce the creation of the @elisabethbik.bsky.social Science Integrity Fund to provide "funding for training programs, grants, or awards for science integrity advocates." Thanks to @science.org for covering this. Help us grow the fund with a tax-deductible donation.

science.org

Renowned scientific integrity investigator endows fund to support fellow sleuths

Microbiologist Elisabeth Bik donates $200,000 to support training, travel

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