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Carmen Buchrieser

@cbuch.bsky.social
746 followers 217 following 7 posts
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Reposted by Carmen Buchrieser
Ana Elena Pérez-Cobas @anaelenaperezcobas.bsky.social · 25/09/2026
New preprint on how drinking water treatment processes affect water-associated microbial communities, with a focus on opportunistic bacterial pathogens. Always great to work with the lab of @cbuch.bsky.social 😍. www.biorxiv.org/content/10.6...
biorxiv.org
Drinking water treatment drastically modifies multi-kingdom water communities, but clinically relevant opportunistic bacterial pathogens persist
Controlling pathogenic microorganisms during water treatment processes is a major public health concern. However, the impact of different water sources and treatment processes on the drinking water mi...
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Pedro Escoll @pescoll.bsky.social · 04/09/2026
New preprint in the lab! "Single-cell metabolomics reveals infection-specific metabolic reprogramming of human macrophages". Led by Paula Martínez, with @cbuch.bsky.social , Sandrine Aros and @jytinevez.bsky.social How does Legionella pneumophila reshape host metabolism at the single-cell scale? 🧵👇
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Pedro Escoll @pescoll.bsky.social · 04/09/2026
Infected macrophages are heterogeneous and bulk metabolomics hides this diversity. Thus, we developed SpatialMetProfiler: MALDI mass-spectrometry imaging + microscopy + image registration → linking the metabolic spectrum of each macrophage to its infection status. We profiled >11,000 single cells
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Carmen Buchrieser @cbuch.bsky.social · 14/04/2026
It is our great pleasure to Welcome you to the 11th International Conference on Legionella from September 7-11 2026 in Zūrich, legionella2026.com Registration is Open legionella2026.com/registration/ Early Bird fée Till June 25. Come and join us for this exciting Event!!
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Carmen Buchrieser @cbuch.bsky.social · 14/04/2026
It is our great pleasure to Welcome you to the 11th International Conference on Legionella from September 7-11 2026 in Zūrich, legionella2026.com Registration is Open legionella2026.com/registration/ Early Bird fée Till June 25. Come and join us for this exciting Event!!
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Ákos T Kovács @evolvedbiofilm.bsky.social · 27/03/2026
Crucial Gram-positive Type IV Secretion System protein TraF is a structural homolog of Type VII Secretion System protein EssB/YukC in #microLife @femsjournals.bsky.social academic.oup.com/microlife/ad...
academic.oup.com
Crucial Gram-positive Type IV Secretion System protein TraF is a structural homolog of Type VII Secretion System protein EssB/YukC
Abstract. Type IV secretion systems (T4SS) are found in both monoderm and diderm bacteria. The broad-host-range conjugative plasmid pIP501 from Enterococcu
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 27/03/2026
Engineered phages evade the complete defense repertoire of highly phage-resistant MRSA clinical isolates www.biorxiv.org/content/10.64898/20…
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Uday Tak @snowkaryote.bsky.social · 27/03/2026
Happy to share the final version of my postdoc work on bacterial CBASS immunity with @aaronwhiteley.bsky.social published in @cp-cellhostmicrobe.bsky.social www.cell.com/cell-host-mi...
cell.com
Bacterial 2′,3′-cGAMP activates a SAVED effector to form membrane-disrupting filaments and restrict phage replication
Tak et al. discover that bacteria use 2′,3′-cGAMP, the same signaling molecule employed by mammalian cGAS-STING, for phage defense. In response to phage, 2′,3′-cGAMP activates filament formation of Ca...
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Pedro Escoll @pescoll.bsky.social · 02/03/2026
Our last paper is out at IAI @asm.org . With @cbuch.bsky.social, at @pasteur.fr . Congrats Francisco & Paula ! Mitochondrial Complex I emerges as a common energetic checkpoint distinguishing virulent from secretion-deficient bacteria during Legionella and Salmonella infection of human macrophages.
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Stephen Gordon @steve-myco.bsky.social · 27/02/2026
The genomic diversity and spatial patterns of Mycobacterium bovis in Ireland revealed by whole genome sequencing rdcu.be/e50zT
Unrooted phylogeny indicating the major clades of Mycobacterium bovis found in Ireland.
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Jan-Willem Veening @veeninglab.com · 27/02/2026
New tools for Streptococcal cell biology! congrats to Johann Mignolet and Virginie Libante! doi.org/10.1093/fems...
doi.org
A Modular Genetic Toolbox for Precise Gene Regulation and Multi-Color Imaging in Streptococci
Abstract. Fluorescent labeling is a powerful tool in microbiology allowing live cell imaging and providing insights into dynamic cellular processes, quanti
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FEMS @femsmicro.org · 26/02/2026
Let's celebrate excellence together as we recognize the winners of the 2025 FEMS Journals Article Awards. These awards recognize the outstanding contributions of researchers who have pushed the boundaries of knowledge in the field of microbiology: buff.ly/OZ2eTKA
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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 14/01/2026
New research from @pasteur.fr reveals how 𝐿𝑒𝑔𝑖𝑜𝑛𝑒𝑙𝑙𝑎 uses LpDot1 to methylate SFPQ, disrupting paraspeckles & rewiring host splicing, dampening immune genes like NF-κB2 & CD45 for survival. ✍️ @cbuch.bsky.social, @mrolando.bsky.social & coll. 📖 Read the preprint: shorturl.at/kFh8z #MicroSky
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 13/01/2026
Bacterial targeting of host paraspeckles uncovers a new SFPQ-based regulation www.biorxiv.org/content/10.64898/20…
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Institut Pasteur | 130 years of biomedical research @pasteur.fr · 04/11/2025
🇬🇧🇫🇷 "By working together we can overcome challenges faster" Pasteur Foundation UK launched the formal @institutpasteur x @ox.ac.uk partnership in London. From climate to AMR, cross-border collaboration is science's engine. ↘️ www.pasteurfoundation.uk/pasteur-oxfo...
In Conversation "science knows no country": Professor Sir Stewart Cole and Professor Dame Angela McLean. 
©Pasteur Foundation UK
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FEMS Journals @femsjournals.bsky.social · 21/10/2025
De-DUFing the DUFs 🧩 @franznarberhaus.bsky.social lab uncovers how small DUF1127 proteins regulate #phosphate uptake by binding the sensor kinase PhoR. Their conserved role from Agrobacterium to E. coli highlights how even small DUFs can shape bacterial physiology 🦠 buff.ly/jJd9Eho
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Pedro Escoll @pescoll.bsky.social · 16/10/2025
Thus, single-cell metabolic dynamics can forecast infection outcomes. In the spirit of @stephenwolfram.bsky.social's ideas, bacterial infection exhibits pockets of computational reducibility at the single-cell scale. Might this point to new ways to predict infection progression?
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Pedro Escoll @pescoll.bsky.social · 16/10/2025
So we trained an explainable Machine Learning model using Δψm + mROS dynamics, and the AI model predicted which infected cell will support replication with 83% accuracy before bacterial replication begins
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Pedro Escoll @pescoll.bsky.social · 16/10/2025
What make these permissive macrophages different? Before bacteria replicate, macrophages that will permit bacterial growth already show sustained mitochondrial membrane potential (Δψm) and higher mitochondrial ROS (mROS). These are early mitochondrial signals of permissive cells!
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Pedro Escoll @pescoll.bsky.social · 16/10/2025
We tracked thousands of living primary human macrophages during infection with Legionella pneumophila, using high-throughput live imaging + our BATLI backtracking software. Legionella only replicates in ~20% infected primary macrophages! www.nature.com/articles/s41...
nature.com
Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages - Nature Communications
Computational models can help to explain the dynamics of cellular infection with pathogens. Here the authors use computational models to assess the single cell infection parameters of human macrophage...
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Pedro Escoll @pescoll.bsky.social · 16/10/2025
New paper finally out on @natcomms.nature.com! Led by first author Maria Dramé with the collaboration of Francisco Garcia, @cbuch.bsky.social and @jytinevez.bsky.social at @pasteur.fr. Early mitochondrial signals in single human macrophages predict later Legionella replication. Link + details👇🧵
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FEMS Journals @femsjournals.bsky.social · 04/10/2025
Some #Pseudomonas aeruginosa strains naturally lack the major virulence system T3SS. 🦠 @inaattree.bsky.social & @cbuch.bsky.social labs reveal that avirulent isolates still produce valuable metabolites (e.g. rhamnolipids, elastase, pyoverdine)—making them promising for #biotech use. buff.ly/JST7ZR1
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Jean-Yves Tinevez @jytinevez.bsky.social · 10/09/2025
Save the date! The @pasteur.fr Pasteur course on image analysis is announced: It will happen from the 1st of June to the 5th 2026. This year there will be only one track: the Early Career Investigator track (beginners). 👇
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Didier Mazel @amazeld.bsky.social · 19/09/2025
I am so proud to be part of this work, that we initiated Fernando de la Cruz and I, when he was on sabbatical in my lab in 2009... it took so much time for this achievement, 1000 thanks to Raúl Fernández-López! this brought me back to my PhD on cyanobacteria genetics. www.pnas.org/doi/10.1073/...
pnas.org
Mutations in the circadian cycle drive adaptive plasticity in cyanobacteria | PNAS
Circadian clocks allow organisms to anticipate daily fluctuations in light and temperature, but how this anticipatory role promotes adaptation to d...
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Sigolène Meilhac @meilhacsigolene.bsky.social · 24/09/2025
New publication | Science Advances www.science.org/doi/10.1126/...
science.org
Plasticity of ventricle position after heart looping in heterotaxy with right isomerism
The left/right position of ventricles needs to be maintained after heart looping, an unexpected step affected in heterotaxy.
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Infect-Net @infect-net.bsky.social · 23/09/2025
🔎 Find us at the 77th #DGHM Meeting in #Jena! Gabriele Pradel, Anja Lührmann, Sandra Reuter, Bärbel Stecher and others are happy to tell you more about our German network for women in infection research! 💜 👩‍🔬@gabrielepradel.bsky.social @sandrareuter.bsky.social @baerboletta.bsky.social
Die Infektionsforscherinnen Anja Lührmann, Sandra Reuter, Gabriele Pradel und Bärbel Stecher stehen stolz vor den Werbebannern von Infect-Net, Verband Deutscher Infektionsforscherinnen.
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FEMS Journals @femsjournals.bsky.social · 27/09/2025
Phages are promising against antibiotic-resistant bacteria—but resistance can emerge. 🦠 New work from @baerboletta.bsky.social lab shows E. coli can resist phages in the lab, but in the gut that resistance comes at a cost: context is crucial for #PhageTherapy success. buff.ly/NLOjnE2
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Zamin Iqbal @zaminiqbal.bsky.social · 25/09/2025
Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols. Thread 1/n
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Enninga Lab @enningalab.bsky.social · 18/09/2025
🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫 Thread coming soon!
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Géraldine Laloux @lalouxlab.bsky.social · 17/09/2025
🇪🇺 Smooth publishing experience with #microLife, the new @femsjournals.bsky.social journal of the European Academy for Microbiology. 🙏 @erc.europa.eu, F.R.S-FNRS & WEL-RI for support 4/4
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Géraldine Laloux @lalouxlab.bsky.social · 17/09/2025
🚨New paper out! #MicroSky Studying obligate predators like Bdellovibrio bacteriovorus is tricky—essential genes for predation are also essential for survival. We expanded its genetic toolbox: 🧬promoters to fine-tune expression 🧬IPTG-inducible system 🧬CRISPRi for rapid knockdown bit.ly/46GUn2c 1/4
academic.oup.com
Expanding the genetic toolbox of the obligate predatory bacterium Bdellovibrio bacteriovorus with inducible gene expression and CRISPR interference
Inducible gene expression and CRISPR interference-mediated depletion in the predatory bacterium Bdellovibrio bacteriovorus.
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Zeynep Baharoglu @zeynepbaharoglu.bsky.social · 06/09/2025
So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!
science.org
Uridine as a potentiator of aminoglycosides through activation of carbohydrate transporters
Uridine boosts aminoglycoside treatment efficiency against antibiotic-susceptible as well as antibiotic-resistant E. coli strains.
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Pedro Escoll @pescoll.bsky.social · 05/09/2025
New preprint in the lab! How the mitochondrial ETC works during infection of human macrophages with #Legionella or #Salmonella? Spoiler: there are some similarities and also pathogen-specific differences. Work led by Francisco Garcia and Paula Martínez, with @cbuch.bsky.social at @pasteur.fr
Figure 5. Working model for pathogen-specific ETC modulations that preserve the ∆ψm in hMDMs. (A) L. pneumophila: T4SS effectors dampen OxPhos early during
infection and preserve the ∆ψm by engaging the reverse mode of the FOF1 -ATPase. The ∆ψm remains high enough that ANT stays in forward mode, limiting cytosolic ATP
drain. All ETC complexes (I-IV) contribute to maintaining the ∆ψm. Complex I is uniquely essential during WT infection. (B) S. Typhimurium: T3SS SPI-1/2 effectors reduce
respiration and preserve the ∆ψm without inducing the reverse mode of the FO F1 -ATPase. Virulent bacteria rely on Complex I-driven electron entry with obligatory Complex
III/IV proton pumping, while Complex II contributes in all infection conditions. Secretion-defective mutants fail to establish the Complex I-dependent configuration.
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FEMS Journals @femsjournals.bsky.social · 13/08/2025
🔬 We’re past the midpoint of the year; perfect time to look back at what’s been discovered so far. From how Salmonella slows its escape from immune cells to the microbes thriving in oil reservoirs, these are the most-read #microLife papers of 2025 so far: buff.ly/TfhOvEc
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Andre @debattierbar.bsky.social · 13/08/2025
I was very honored to receive on of the Poster prizes at FEMS MICRO 2025 in Milan a few weeks back. It was such a great conference, heard so many interesting and stimulating talks & poster discussions.
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Ákos T Kovács @evolvedbiofilm.bsky.social · 22/08/2025
Avirulent Pseudomonas aeruginosa T3SS-negative strains belonging to Clade 5 produce variable quantities of secondary metabolites @femsjournals.bsky.social #microLife from @inaattree.bsky.social with @cbuch.bsky.social academic.oup.com/microlife/ad...
academic.oup.com
Avirulent Pseudomonas aeruginosa T3SS-negative strains belonging to Clade 5 produce variable quantities of secondary metabolites
Abstract. Pseudomonas species are ubiquitous in the environment and serve as valuable source of enzymes and secondary metabolites for industrial applicatio
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Victor de Lorenzo (CNB, Madrid) @vdlorenzo.bsky.social · 27/07/2025
This 👇
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Lauren Palmer @laurenpalmer.bsky.social · 25/07/2025
Congratulations to 2025 GRC Microbial Adhesion and Signal Transduction Poster Award Winners!! 🎆🥂🙌 Thank you @cp-cell.bsky.social and @femsmicro.org for sponsoring! From, Your secret judges 🤫
Michael Patnode with Rachel Washburn, Jessica Aycock, and Mason Clark, winners of GRC MAST poster awards from Cell Press and FEMS
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Institut Pasteur | 130 years of biomedical research @pasteur.fr · 16/07/2025
Congratulations @cbuch.bsky.social ! 👏
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FEMS @femsmicro.org · 14/07/2025
FEMS MICRO Milan 2025 is off to a great start with Prof. Carmen Buchrieser presenting her keynote on Legionella pneumophila and the fascinating ways this pathogen mimics eukaryotic cells.
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FEMS @femsmicro.org · 14/07/2025
What an inspiring first day at FEMS MICRO Milan! We heard from FEMS Pres. Antonio Ventosa at the Opening while former Pres. Hilary Lappin-Scott helped connect new attendees. Thanks to keynotes Profs. Carmen Buchrieser and Gian Rossolini for sharing their expertise. #FEMS2025
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Victor de Lorenzo (CNB, Madrid) @vdlorenzo.bsky.social · 15/07/2025
One of the most controversial sessions of the @femsmicro.org Congress—run by Malick Gibani—deals with the so-called *Human challenge studies* of pathogens ie deliberate inoculation of human subjects with virulent agents. The benefits are clear but … is informed consent enough 🤔?
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Victor de Lorenzo (CNB, Madrid) @vdlorenzo.bsky.social · 15/07/2025
Four leading researchers on bacterial computing in the @femsmicro.org Workshop on the the topic during the Congress—quite amazing talks by @angelgm.bsky.social, Yolanda Schaerli, Manish Kushwaha & Samgram Bagh. Do bacteria compute? Can we make them to compute wth our logic or do they have their own?
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Kimberly Kline 🏔 @kimingeneva.bsky.social · 16/07/2025
At my 1st @femsmicro.org congress (in Milan!) - it's a fantastic meeting. I co-chaired a superb session on Microbial Dark Matter with @jlewillett.bsky.social, who also kicked off the session with a talk on her lab's work. 🤩 We also heard from my FEMS Microbes co-EIC Kathleen Scott! 💪🏽 #FEMS2025
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Ana Elena Pérez-Cobas @anaelenaperezcobas.bsky.social · 24/01/2025
Delighted to have contributed to this fascinating paper led by Prof. Timmis on how helpful microbes can be for humanity at different scales! "The future is not set. There is no fate but what we make for ourselves". -John Connor (Terminator) @microbiotech.bsky.social
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Alvaro San Millan @sanmillan.bsky.social · 24/01/2025
New preprint from the lab!! Check it out!
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Ana Elena Pérez-Cobas @anaelenaperezcobas.bsky.social · 29/04/2025
New mini-review on the respiratory microbiome and its contribution to human health from biotechnology 🫁🦠 @tmcoque.bsky.social @microbiotech.bsky.social enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
enviromicro-journals.onlinelibrary.wiley.com
The Respiratory Tract Microbiome and Human Health
The respiratory tract microbiome (RTM) trains the immune system and protects against infections. Changes in the RTM are linked to various respiratory diseases. High-throughput methodologies and compu...
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Ana Elena Pérez-Cobas @anaelenaperezcobas.bsky.social · 15/07/2025
Congratulations to @cbuch.bsky.social on the FEMS-Lwoff Award!!! Well-deserved ❤️#FEMS2025
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ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 29/06/2025
ᑎEᗯ IᑎᑎᗩTE IᗰᗰᑌᑎE EᖴᖴEᑕTOᖇ! Anaya-Sanchez et al Infected macrophages switch to aerobic glycolysis, generating toxic METHYLGLYOXOL Bacteria lacking detox enzyme 𝘨𝘭𝘰𝘈 become highly mutagenic, lose virulence Boosting methylglyoxal helps control 𝘓𝘪𝘴𝘵𝘦𝘳𝘪𝘢 or TB infection www.cell.com/cell-host-mi...
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Institut Pasteur | 130 years of biomedical research @pasteur.fr · 21/06/2025
🎶 Straight from the Lab to the Mic: when a Pasteur scientist turns her thesis into a rap 🎶 #FeteDeLaMusique
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