A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

Here they combine in vivo imaging with proteomics to characterize a protein complex comprised of Ccdc78 and Ccdc33 that acts at the extreme distal tip of 9 + 2 motile cilia to control tip architecture...

Nature Communications - Breast cancer cells interact with neighbouring adipocytes, but the mechanisms are not fully understood. Here, the authors show that triple-negative breast cancer (TNBC)...

Marin et al. report the role of lamin proteins and the lamin B receptor (LBR) in chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse embryonic stem cells leads to h...

Primary cilia orchestrate several signaling pathways, and their disruption results in pleiotropic disorders called ciliopathies. Bardet Beidl syndrome (BBS), one such ciliopathy, provides insights int...

Cell biologist Fred Chang, MD, PhD, has been named a fellow in the American Association for the Advancement of Science (AAAS), a highly esteemed lifetime honor within the scientific community.

The 2025 Gordon Research Conference on Fibronectin, Integrins and Related Molecules will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.

The 2025 Gordon Research Seminar on Cilia, Mucus and Mucociliary Interactions (GRS) will be held in Pomona, California. Apply today to reserve your spot.

The 2025 Gordon Research Seminar on Cilia, Mucus and Mucociliary Interactions (GRS) will be held in Pomona, California. Apply today to reserve your spot.

McCafferty et al. use cross-linking/mass spectrometry to map the motile cilia interactome, identifying over 4,700 unique amino acid interactions, offering new insights into ciliary structure and function. This research enhances our understanding of ciliary diseases and provides a valuable resource for further studies on these essential cellular components.

Hundreds of high confidence autism genes have been identified, yet the relevant etiological mechanisms remain unclear. Gene ontology analyses have repeatedly identified enrichment of proteins with ann...

Wong et al. identify Slc6a2 as a marker of pulmonary venous endothelial cells and demonstrate that these cells differentiate into capillary endothelial cells during vascular regeneration after lung in...

Ultrastructure expansion microscopy (U-ExM) involves the physical magnification of specimens embedded in hydrogels, which allows for super-resolution imaging of subcellular structures using a convent...

The relative contributions of intraflagellar transport (IFT) and cilia structure to sensory neuron responses remains unclear. This study reveals unexpected complexity in the contribution of IFT and ci...