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Charlie Allen

@charlieallen.bsky.social
150 followers 278 following 45 posts

she/they | scientist in the Buchwalter Lab at UCSF studying the nuclear periphery | California Community College alum

PostsRepliesMedia
Charlie Allen @charlieallen.bsky.social · 06/10/2026
I should give a five day cycle a try, think I’m feeling the dip at day 6/7.
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Charlie Allen @charlieallen.bsky.social · 27/09/2026
pretty sure 200mg p4 puts me well out of the optimum of the dose-response curve and into the just more androgenic effects range
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Charlie Allen @charlieallen.bsky.social · 27/09/2026
ok, not necessarily the best or my favorite, but games that are/were important to me
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Charlie Allen @charlieallen.bsky.social · 25/09/2026
I would love to see if opus 5.5 fixes how Claude talks but unfortunately I am a biologist
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Charlie Allen @charlieallen.bsky.social · 22/09/2026
Go check out my labmate's preprint!
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Charlie Allen @charlieallen.bsky.social · 22/09/2026
progesterone is a weird drug
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Sydney Bauer @sydney-bauer.com · 20/09/2026
I would like the general public to recognize that this issue is beyond over blown and then for a *second* think beyond “this isn’t an issue” to “why are there so few trans people playing sports?”
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Charlie Allen @charlieallen.bsky.social · 20/09/2026
good foggy sunday morning to spend in lab doing a billion gel extractions and stewing on queer legibility
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bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 18/09/2026
Cardiomyocyte vulnerability to lamin polymer disruption revealed by saturation mutagenesis www.biorxiv.org/content/10.64898/20…
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Charlie Allen @charlieallen.bsky.social · 17/09/2026
not happy to be in the timeline where the time i spent on lurking on lesswrong is relevant to understanding the present situation
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Charlie Allen @charlieallen.bsky.social · 16/09/2026
New preprint from the lab!
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Katelyn Burns @katelynburns.com · 14/09/2026
The trans girls in sports policy we had in 2020? Compromise. Puberty blockers were literally a compromise.
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Katelyn Burns @katelynburns.com · 14/09/2026
One of the more insidious phrasings I've seen with the Dems/trans rights discourse lately is the idea that trans people are being greedy and demanding a "maximalist" approach to trans rights. No, you cannot call the state of rights American trans people had as recently as 2023 "maximalist," sorry.
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Charlie Allen @charlieallen.bsky.social · 10/09/2026
they gotta fix claudes combo of anxiety and extreme hyperfocus because it’s driving me insane
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Eric Panzer @ericpanzer.bsky.social · 08/09/2026
What on earth were @calfire.bsky.social and California State Parks thinking by moving forward with a prescribed burn on a day where winds are slack, temperatures are dangerously hot, and people are desperate to ventilate their apartments? @buffywicks.bsky.social @jessearreguin.bsky.social
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aly @aly.codes · 02/09/2026
bodily autonomy + exogenous hormones for those who want them is good. all of the scare-keywords here--VC, telehealth, etc--equally apply to HRT for trans people. there are communities of women who have been fighting to be able to get both supplemental estrogen and testosterone for decades.
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Charlie Allen @charlieallen.bsky.social · 24/08/2026
five years(!!) in the buchwalter lab
A picture of Charlie in lab five years agoA picture of Charlie in lab now
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Charlie Allen @charlieallen.bsky.social · 15/08/2026
Now seated for:
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Infrastructure Weak @infrastructureweak.bsky.social · 22/07/2026
Now out! Part 2 on the Geary metro, discussing its East Bay connection, downtown alignment, and yard location.
medium.com
Geary metro, purpose-built for SF
Part 2: East Bay connection, downtown alignment, and the yard
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Sarah T Roberts, PhD @ubiquity75.xyz · 22/07/2026
One other thing: UCLA Faculty Association had to sue our own administrators in order to view the DOJ letter of which they were in receipt. They would not share it with faculty pursuing this very lawsuit and tried to block them in court. That’s where their resources went. They lost.
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Infrastructure Weak @infrastructureweak.bsky.social · 21/07/2026
I've just published this article, Part 1 of 4 about the choices that will enable San Francisco to finally build a Geary metro. medium.com/@infrastruct...
medium.com
Plan the Geary metro right, right now
Part 1: Strong corridor; tight station spacing; frequent trains
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Grace @gracekind.net · 26/06/2026
Amazing load-bear.ing
load-bear.ing
load-beari.ng — Honest Take
What's the load-bearing observation everyone is missing here?
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Charlie Allen @charlieallen.bsky.social · 22/06/2026
no, this is specifically targeting research into animal models of gaht, and it would be nice if both scientists and media could actually acknowledge what’s happening instead of treating it like a big joke
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Charlie Allen @charlieallen.bsky.social · 22/06/2026
described the presenting symptoms and initial lab tests of a family members visit to the hospital to claude it put the ultimate diagnosis at the top of the differential immediately, something that took the actual doctors weeks and was maybe a deadly delay
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Rory Stolzenberg @rorystolzenberg.bsky.social · 10/06/2026
lmao
User	Model	Thinking
I	-	oh
mixed	-	first
bleach	-	person
with	-	bleach
some	-	chemical
ammonia	-	mixing
-based	-	TOXIC
cleaner	-	CHLORAMINE
to	-	GAS
get	-	immediate
this	-	danger
tough	-	need to
bathroom	-	ACT
stain	STOP	person
out	-	being
.	PLEASE	exposed
It’s	STOP	to
working	-	toxic
great	LEAVE	gas
but	THE	no
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Charlie Allen @charlieallen.bsky.social · 20/05/2026
having the realization that the most relaxing time of the week right now is the hour i spend having an electric needle repeatedly stuck in my face
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Charlie Allen @charlieallen.bsky.social · 15/03/2026
last minute catch up on the best picture nominees and there's no way F1 and Frankenstein belong in the top 10 movies of last year
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Zoe TunnHELL ➡️ NYCC @zoewithasword.bsky.social · 26/02/2026
This is what I need cis folks to understand. It's been a decade. Imagine living TEN FUCKING YEARS watching as a blatant, artificial campaign to erase your personhood, your identity and your safety chugs along, increasing in power every single day, and most people don't care or dismiss it
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Katelyn Burns @katelynburns.com · 04/02/2026
you don't say? at some point we're going to acknowledge what every study ever on this subject has said, right? right? www.independent.co.uk/news/science...
independent.co.uk
Trans athletes may not have fitness advantage in women’s sport, landmark study finds
Findings suggest physical performance in trans women converges toward that of cis women over time
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Charlie Allen @charlieallen.bsky.social · 04/02/2026
someday i must figure out how to get the right balance between not having enough to do and feeling vaguely overwhelmed all of the time
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Charlie Allen @charlieallen.bsky.social · 14/01/2026
suspect that i have results in this experiment to discover if I really need to be on three different migraine preventatives at once
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Charlie Allen @charlieallen.bsky.social · 05/01/2026
i'm so happy to be back at work
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Charlie Allen @charlieallen.bsky.social · 01/01/2026
should have learned my lesson by now that taking long vacations is not healthy for me
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Charlie Allen @charlieallen.bsky.social · 02/12/2025
Oh no 😭
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Charlie Allen @charlieallen.bsky.social · 27/11/2025
would rather be in lab cloning right now
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Katelyn Burns @katelynburns.com · 09/11/2025
For @teenvogue.com I wrote about the death of trans athlete Lia Smith and how trans youth kind themselves with central pillars of their lives being constantly ripped away from them because of politics. www.teenvogue.com/story/politi...
teenvogue.com
Politicizing Transgender Athletes Is Dangerous. Lia Smith Deserved Better.
"Let her passing be an inflection point for how you think about trans rights and trans people more generally."
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Katelyn Burns @katelynburns.com · 29/09/2025
I'm so glad you said this, because about 30 seconds ago, I published a newsletter piece detailing how conservatives have dump-trucked through all of the previously established common sense, nuanced, compromise positions on trans rights to get here: burns-notice.ghost.io/what-would-t...
burns-notice.ghost.io
What Would Trans Compromise Even Look Like? (The Right Won't Accept It)
Conservatives and complicit centrists have obliterated every trans compromise position, so I don't know what we're supposed to do now. How would you react if I said that puberty blockers were once th...
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Charlie Allen @charlieallen.bsky.social · 23/07/2025
I'm happy people can read the final version of this paper! See what happens when we detach heterochromatin from the nuclear periphery in mouse stem cells:
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Abby Buchwalter @abbybuch.bsky.social · 21/07/2025
And yep - we found that the nuclear membrane protein LAP2b cooperates with lamin B1 to maintain nuclear integrity. When both are depleted, we see lamina defects and nuclear ruptures that look like this (cyan is nuclear lamina, magenta is nuclear integrity reporter): (5/n)
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Abby Buchwalter @abbybuch.bsky.social · 21/07/2025
The nuclear lamina strengthens the nucleus and organizes the genome. So what happens when you acutely degrade it in living cells? Not what we thought! (1/n) www.molbiolcell.org/doi/10.1091/...
molbiolcell.org
Lamin B1 and LAP2β resist cytoskeletal force to maintain lamin A/C meshwork organization and preserve nuclear integrity | Molecular Biology of the Cell
The nuclear lamins are extremely long-lived proteins in most cell types. As a consequence, lamin function cannot be effectively dissected with temporal precision using standard knock-down approaches. ...
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