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Bruce Appel

@bruceappel.bsky.social
2.1K followers 265 following 32 posts

Developmental neurobiologist in the Section of Developmental Biology, Department of Pediatrics, at University of Colorado Anschutz Medical Campus. Zebrafish, neural cell fate specification, glia, myelin, and the great Colorado outdoors.

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Bruce Appel @bruceappel.bsky.social · 08/06/2026
Well deserved! Here is to a terrific colleague!
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Bruce Appel @bruceappel.bsky.social · 23/05/2026
Great to have some of the lab crew together for a @habitatforhumanity.bsky.social work day! Habitat is a terrific organization, building much needed affordable housing, and you get to use power tools! Get involved!
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Reposted by Bruce Appel
Christian Mosimann @chrmosimann.bsky.social · 08/05/2026
Open-rank search: 2 (!) PI positions in Pulmonary Biology at @cuanschutz.bsky.social 🌄 We are looking for new colleagues @cupediatrics.bsky.social, working in lung fibrosis, focusing on #devbio, stem cell, & regen.biology of the lung 🫁🫀. Please help spread the word! cu.taleo.net/careersectio...
cu.taleo.net
Open Rank- Assistant Professor, Associate Professor, or Professor
Click the link provided to see the complete job description.
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Bruce Appel @bruceappel.bsky.social · 31/03/2025
Immensely proud of our CU Pediatrics Dev Bio colleagues! @cupediatrics.bsky.social
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Bruce Appel @bruceappel.bsky.social · 15/03/2025
We've had a great collaboration with Dr. Elena Alberdi's group at the Achurcarro Basque Center for Neuroscience for which we got to host two terrific grad students, Adhara and Uxue, for 4 months each. Our first joint publication is now out! onlinelibrary.wiley.com/doi/epdf/10....
onlinelibrary.wiley.com
Amyloid‐β Dysregulates Oligodendroglial Lineage Cell Dynamics and Myelination via PKC in the Zebrafish Spinal Cord
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Bruce Appel @bruceappel.bsky.social · 14/03/2025
Luuli has been a terrific colleague and friend. It was a true pleasure and privilege to serve on her thesis committee!
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Bruce Appel @bruceappel.bsky.social · 28/02/2025
This has the most information I have been able to learn about the situation at NIH. Unfortunately, the chaos, worry, and hold-up on grant reviewing and awards seems even worse than I had thought.
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Reposted by Bruce Appel
Christian Mosimann @chrmosimann.bsky.social · 11/02/2025
Big congrats to this year's awardees! Basic science matters more than ever - the awardees represent key aspects of what makes #devbio a central biomedical research endeavor of widespread impact. Applause!
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Reposted by Bruce Appel
CU Anschutz Developmental Biology @cudevbio.bsky.social · 31/01/2025
Great to see collaborations such as this "develop" between the Section of Developmental Biology @cupediatrics.bsky.social @cuanschutz.bsky.social and our friends @colorado.edu. Looking forward to many more!
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Reposted by Bruce Appel
CU Anschutz Developmental Biology @cudevbio.bsky.social · 15/01/2025
Congratulations to Dr. Peter Dempsey, Professor in the Section of Developmental Biology, for recieving the 2025 Pediatric Gastroenterology & Developmental Biology Section Research Mentor Award from the American Gastroenterological Association! #devbio 🧪
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Bruce Appel @bruceappel.bsky.social · 30/12/2024
Our first manuscript on maternal nutrition and development, which was driven entirely by postdoc Katie Ranard, is now out. @cudevbio.bsky.social #devbio doi.org/10.1016/j.jl...
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Bruce Appel @bruceappel.bsky.social · 13/12/2024
Love the super creative work from my Dev Bio colleagues JP and Santos. I would never be able to master IU electroporation, but, wow, the things people who have skills can do with it! #devbio 🧪
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Reposted by Bruce Appel
CU Anschutz Developmental Biology @cudevbio.bsky.social · 13/12/2024
Postdoc Austin Adkins noticed that mutant zebrafish he had inherited behaved oddly in their tanks. So he turned them into a new research project. Great demonstration of serendipity and creativity at today's Dev Bio Section meeting. #devbio #zebrafish 🧪
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Bruce Appel @bruceappel.bsky.social · 10/12/2024
Thanks! It’s been awhile since we had a cover!
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Reposted by Bruce Appel
Rytis Prekeris @prekerislab.bsky.social · 20/11/2024
Looking for place to do PhD studies? Molecular Biology Graduate Program is a great place for that. Check it out. Deadline is December 1st.
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Bruce Appel @bruceappel.bsky.social · 20/11/2024
This just out from grad student Samantha Bromley-Coolidge with help from Regis University undergrad Diego Iruegas. By the way, Regis has an awesome neuroscience program. If one of their students applies to your grad program, give them a close look! authors.elsevier.com/a/1k7nr14Yy4...
authors.elsevier.com
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Bruce Appel @bruceappel.bsky.social · 20/11/2024
Sure, study section can be a be a grind but there is a huge perk - the chance to connect with special former students who have relocated to DC. Here with the incomparable Alex Hughes and Nick George. #myelin 🧠🧪
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Bruce Appel @bruceappel.bsky.social · 13/11/2024
Love to see the results of great collaborations between my wonderful colleagues (and hoping I might get picked for the team next time….)!
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Bruce Appel @bruceappel.bsky.social · 13/11/2024
Hey, I think I see some myelin on that lineup! 🧠
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Bruce Appel @bruceappel.bsky.social · 13/11/2024
Not sure how this Bluesky thing is gonna work out for me. I could easily ignore that other platform - now I have a new diversion from grant reviewing….🧪
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Bruce Appel @bruceappel.bsky.social · 13/11/2024
For any of you aiming to advance your biomedical scientific training or pursue your research career among fabulous colleagues in a wonderful part of the world, check us out! 🧪
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Bruce Appel @bruceappel.bsky.social · 13/11/2024
I encourage y’all to check out this work from @emilybateslab.bsky.social. I still remember the first time I heard Emily talk about her fly work that led to this - at a regional SDB meeting in Salt Lake City about 12 years when she was still at BYU. It’s been great to watch the story unfold.
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Bruce Appel @bruceappel.bsky.social · 12/11/2024
Here is an enthusiastic plug for the journal Differentiation, edited by Drs. Crystal Rogers (@rogerslabucd.bsky.social), Rosa Uribe, and Loydie Jerome-Majewska. We just had a very pleasant and unusually (for these days) quick reviewing and proofs experience.
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Bruce Appel @bruceappel.bsky.social · 11/11/2024
Just encouraged a publicity person to get our department on Bluesky, and we will be working to get our Section and grad programs on, too. Shout out to @cuhmggp.bsky.social and @kellydsullivan.bsky.social for leading the way. Please consider doing the same at your institutions if you haven’t already.
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Bruce Appel @bruceappel.bsky.social · 09/11/2024
A big unknown of developmental biology is how environmental exposures and maternal health affect development. Postdoc Katie Ranard is attempting to help fill that gap. Here is our first report on developing a zebrafish model of a maternal nutritional deficiency. www.biorxiv.org/content/10.1...
biorxiv.org
Creation of a novel zebrafish model with low DHA status to study the role of maternal nutrition during neurodevelopment
Docosahexaenoic acid (DHA), a dietary omega-3 fatty acid, is a major building block of brain cell membranes. Offspring rely on maternal DHA transfer to meet their neurodevelopmental needs, but DHA sou...
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Bruce Appel @bruceappel.bsky.social · 09/11/2024
Please check out our new preprint, which describes a new mechanism by which oligodenrocytes recognize specific classes of axons for myelination. Stellar work by graduate student Natalie Carey with important contributions from Dr. Caleb Doll (and I made 2 plasmids!). www.biorxiv.org/content/10.1...
biorxiv.org
Oligodendrocytes use post-synaptic proteins to coordinate myelin formation on axons of distinct neurotransmitter classes
Axon myelination is a powerful method to tune neuronal circuit output through deposition of different patterns, lengths, and thicknesses of sheaths on many axon types. Yet the molecular mechanisms of ...
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Bruce Appel @bruceappel.bsky.social · 09/11/2024
ok, Bluesky, I just quit that other platform. If you are a developmental biologist, glia person, zebrafish person, etc., let me know you are out there.
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