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Sebastian Baumgarten

@sebbaumgarten.bsky.social
223 followers 141 following 18 posts

Scientist, cyclist and lover of the sea

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Reposted by Sebastian Baumgarten
Nature Microbiology @natmicrobiol.nature.com · 17/09/2026
Out Now! AP2-HS and a GDV1 regulatory feedback loop mediate environmental induction of sexual conversion in Plasmodium falciparum #MicroSky
go.nature.com
AP2-HS and a GDV1 regulatory feedback loop mediate environmental induction of sexual conversion in Plasmodium falciparum
Nature Microbiology, Published online: 17 September 2026; doi:10.1038/s41564-026-02473-6This study describes the complex transcriptional regulatory mechanism enabling fine-tuned and rapid regulation of Plasmodium falciparum investment in transmission under changing blood conditions.
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Reposted by Sebastian Baumgarten
Leonie Anton @leonieanton.bsky.social · 03/09/2026
I am excited to share that I will start my group @embl.org in Grenoble in February 2027, where we will investigate host-pathogen interactions using in situ cryo electron microscopy🦠❄️🔬! I am recruiting PhD students through the current open call of the EMBL PhD Program: www.embl.org/about/info/e...
embl.org
Anton Group – Cellular structural biology of host-pathogen interactions
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Reposted by Sebastian Baumgarten
Thibaut Brunet @thibautbrunet.bsky.social · 02/09/2026
🚨 New preprint alert! 🚨 Choanoflagellates reorganize their global cytoskeletal architecture within seconds to explore confined microspaces. This is the main PhD work of the amazing @maitefreired.bsky.social www.biorxiv.org/content/10.6... A tread 🧵⬇️
biorxiv.org
Rapid repurposing of microvillar content drives a flagellate-to-amoeboid switch in the closest relative of animals
Animal cells extensively remodel their cytoskeleton during differentiation and can notably switch between two major motility modes: flagellum-based swimming and actin-based crawling. We previously sho...
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Reposted by Sebastian Baumgarten
Jiménez-Ruiz Lab @jimenezruizlab.bsky.social · 27/08/2026
Very happy to see our paper finally out in @natcomms.nature.com! 🎉 We uncover a role for lysine methylation in controlling parasite movement: methyltransferases act directly at the apical cytoskeletal machinery to coordinate actin assembly and force generation, enabling motility and invasion.
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Sebastian Baumgarten @sebbaumgarten.bsky.social · 19/08/2026
The singular job of all known ribosomes: synthesizing protein. Enter the malaria parasite. In our new work, we show that Plasmodium evolved an entire new kind that does just the opposite - inhibit mRNA translation. www.biorxiv.org/content/10.6...
biorxiv.org
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Thibaut Brunet @thibautbrunet.bsky.social · 25/07/2026
No, these images are not AI-generated, not even photoshopped. They do look artificial because there is something artificial about them: the extra 150 ppm of CO2 resulting from human activity, which has irretrievably transformed the world.
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Reposted by Sebastian Baumgarten
Phillip Cleves @pcleves.bsky.social · 02/07/2026
Our work on the symbiont-containing organelle that supports coral reefs is published today. Also, new genetic tools to study symbiosis in both corals and Aiptasia. Great work by Shumpei Maruyama, Cat Henderson, and the rest of the fantastic team. #SymbioSky www.cell.com/cell/abstrac...
cell.com
Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs
Corals harbor intracellular algal symbionts in specialized organelles that enable them to build diverse reef ecosystems. Corals and other cnidarians have repeatedly evolved this symbiosis through the ...
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Reposted by Sebastian Baumgarten
Nico Rascovan @nrascovan.bsky.social · 18/03/2026
How did farming reach the Southern Andes? Through migration or cultural transmission? Our new paper in @nature.com combines ancient DNA, isotopes, archaeology & paleoclimate to reconstruct 2,000+ years of history in Uspallata, Mendoza. www.nature.com/articles/s41... A Thread🧵 (1/25+)
nature.com
Local agricultural transition, crisis and migration in the Southern Andes - Nature
In the Uspallata Valley, agriculture was adopted by local populations, as evidenced by genetic continuity from earlier hunter-gatherers to farmers; maize-dependent groups from the same regional p...
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Henry Gee 亨利·纪 @endofthepier.bsky.social · 26/02/2026
Salinity tunes mode of multicellularity in a tidepool choanoflagellate www.nature.com/articles/s41... - paper in @nature.com
nature.com
Clonal-aggregative multicellularity tuned by salinity in a choanoflagellate - Nature
The choanoflagellate Choanoeca flexa forms motile and contractile cell monolayers purely clonally, purely aggregatively or through a combination of both processes depending on environmental condi...
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Amy Kristine Bei @thebeilab.bsky.social · 22/12/2025
We recently deployed our favorite “lab in a suitcase” dynamic duo of #BentoLab and ONT #MinION to conduct real-time, in country multiplexed modular malaria amplicon sequencing by #MAD4HatTeR to inform public health policy decisions in Chad! #DecentralizedGenomicSurveillance
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Sebastian Baumgarten @sebbaumgarten.bsky.social · 04/12/2025
Get ready for the best meeting in 2026!
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Sebastian Baumgarten @sebbaumgarten.bsky.social · 02/12/2025
This one is for the best team and colleagues I could wish for! Thank you @pasteur.fr for having us and @embo.org for all the support. Congrats to all other new YIPs, very honored to join this amazing pool of scientists. @jessmbryant.bsky.social @tizvignolini.bsky.social @ju-couble.bsky.social
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Levayer Lab @levayerr.bsky.social · 27/11/2025
There a is a joint call between @pasteur.fr and @cnrsbiologie.bsky.social for a mid career group leader position in AI and genomics (or molecular biology). Don't hesistate to spread the word if you know anyone relevant. research.pasteur.fr/en/call/mid-...
research.pasteur.fr
Mid-career Group Leader position in AI in genomics at Institut Pasteur, Paris - Research
Institut Pasteur and the CNRS are launching a call for a mid-career group leader position in AI in genomics. We are looking for an experienced researcher (typically with > 8 years of research experien...
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mrosjac.bsky.social @mrosjac.bsky.social · 26/11/2025
Just uploaded our new preprint to @ecoevorxiv.bsky.social Multinucleate life really is everywhere...from deep sea forams to slime molds, intracellular parasites, and beyond. 🚀 We explore how scaling, ecology, & evolution intersect when many nuclei share a single cytoplasm. doi.org/10.32942/X2M...
doi.org
Plasticity and scaling through multinucleation: a key adaptation to challenging environments
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Maria Bernabeu @mariabernabeu.bsky.social · 21/10/2025
Pre-print alert 🚨 We answer a longstanding question in the field. Do immune cells cause cerebral malaria? The answer is YES!!!! And independently of P. falciparum accumulation in the brain. www.biorxiv.org/cgi/content/...
biorxiv.org
Innate immune responses to Plasmodium falciparum disrupt the blood-brain barrier
Plasmodium falciparum accumulation at the blood-brain barrier (BBB) is a hallmark of cerebral malaria, a life-threatening complication. Conversely, the contribution of the immune response to vascular ...
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Freddy Frischknecht @freddyfrischknecht.bsky.social · 02/10/2025
Beautiful beasts: excited to see our first volume electron microscopy study on malaria parasites published: advanced.onlinelibrary.wiley.com/doi/10.1002/... revealing new insights into Plasmodium ookinete development. Thanks for great EMBL-Umea-Heidelberg collaboration.
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Sebastian Baumgarten @sebbaumgarten.bsky.social · 08/09/2025
Come apply with us to unravel some beautiful malaria genetics! This is a great program with plenty benefits specifically for international students
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Reposted by Sebastian Baumgarten
Jessica Bryant @jessmbryant.bsky.social · 10/08/2025
We @singh-parul.bsky.social teamed up with the amazing @fariatrypslab.bsky.social @trypsleon.bsky.social to highlight how recent technological advances have revealed exciting new features of parasite genome architecture and its impact on survival and pathogenicity: www.cell.com/trends/paras...
cell.com
Parasite genome organization: come together, right now!
Links between genome organization and transcription have been extensively studied in model eukaryotes; however, recent application of state-of-the-art chromosome conformation capture techniques to kin...
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Maria Bernabeu @mariabernabeu.bsky.social · 07/08/2025
We are happy to show one ourt first exciting papers. We have developed a blood-brain barrier model to study the disruptive effects caused by the malaria parasite, Plasmodium falciparum. First, congratulations to the fearless @liviapiatti.bsky.social and @alinabatzi.bsky.social rdcu.be/ezBl7
rdcu.be
Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier model
Nature Communications - Here the authors show that Plasmodium falciparum egress products disrupt endothelial barrier and activate JAK-STAT and interferon type response in a 3D blood-brain barrier...
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Seb Besteiro @s-besteiro.bsky.social · 29/07/2025
🚨 2-year post-doc position available in my lab. More details below. Please repost! acrobat.adobe.com/id/urn:aaid:...
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Didier Mazel @amazeld.bsky.social · 28/07/2025
A 2-year postdoc position in my lab, under the supervision of P-Alex Kaminski, on Z-DNA phages and the benefit given by ZTGC DNA and the replication machinery, with attempt to create a Z based minireplicon research.pasteur.fr/en/job/a-two...
research.pasteur.fr
A two year post-doctoral position at the BacterialGenome Plasticity Unit starting October 1st - Research
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Cassandra Koh 🦟🔬🧪 @cassandrakoh.bsky.social · 28/07/2025
📣 I'm recruiting a postdoc researcher to join my team for a project on mosquito-specific viruses and host interactions. Peep the job description & how to apply below. Perfect for soon-to-be or recent PhD graduates in mosquito vector biology 🦟 or arbovirology 🦠 🗓️ Application deadline 31 August 2025
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fra-florini.bsky.social @fra-florini.bsky.social · 17/07/2025
Preprint Alert 🚨 Check out the latest piece of work from the @kirkdeitsch.bsky.social lab, where we characterized the sophisticated molecular layers controlling var2csa expression and antigenic variation in P. falciparum
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Reposted by Sebastian Baumgarten
Maria Bernabeu @mariabernabeu.bsky.social · 11/07/2025
Pre-print alert 🚨: We have developed 2D and 3D stable iPSC endothelial-differentiation models through dox inducible ETS expression. We demonstrate endothelial identity and used these models for studying malaria pathogenesis research. www.biorxiv.org/content/10.1...
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Jessica Bryant @jessmbryant.bsky.social · 30/06/2025
June was a productive month: brought two things into this world, both of which were great collaborative efforts and about nine months in the making. Check out where we map P. falciparum genome architecture at high resolution with Micro-C here: www.nature.com/articles/s41...
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Sebastian Baumgarten @sebbaumgarten.bsky.social · 30/06/2025
How does the malaria parasite regulate co-expression of genes? By recruiting them into transcription factories, courtesy of MORC et al. A fantastic team effort led by @jessmbryant.bsky.social with Jacques Serizay @singh-parul.bsky.social, @ju-couble.bsky.social @rkoszul.bsky.social
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François Mayer @francoismayer.bsky.social · 13/06/2025
Awesome malaria study out now in Nature Microbiology: An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission By Franziska Hentzschel, Matthias Marti, Freddy Frischknecht & colleagues! @freddyfrischknecht.bsky.social www.nature.com/articles/s41...
nature.com
An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission - Nature Microbiology
A unique Arp2/3 complex in malaria parasites enables DNA segregation during the rapid formation of male gametes by safeguarding the attachment of chromosomes to the mitotic spindle.
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LabEx ParaFrap @parafrap.bsky.social · 14/05/2025
📢 Big Announcement: Registration & abstract submission open for EMBO Workshop "Host-Parasite Relationship: From Mechanisms to Control Strategies" organized by ParaFrap @parafrap.bsky.social @embo.org 🗓️ 5-8 Oct 2025 - Les Embiez Island-France 🔚Deadline: 15 Jul 2025 meetings.embo.org/event/25-hos...
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Sebastian Baumgarten @sebbaumgarten.bsky.social · 23/05/2025
As usual, fantastic science at #EMBLMalaria. Special thanks for the travel support from @pasteur.fr in the new EMBL-Pasteur initiative and the organization @lilianamancio.bsky.social @sturalph.bsky.social @events.embl.org
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Kirk Deitsch @kirkdeitsch.bsky.social · 16/05/2025
Very happy to congratulate @fra-florini.bsky.social and Joe Visone for the publication of their recent work on antigenic variation by malaria parasites: rdcu.be/emjbn and an earlier version here: www.biorxiv.org/content/10.1.... Francesca will present some of this work next week at BioMalPar 2025.
rdcu.be
scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance
Nature Microbiology - Single-cell transcriptomics revealed that malaria parasites have unexpected flexibility in surface antigen expression, potentially providing parasites with greater adaptive...
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SheinerLab @sheinerlab.bsky.social · 19/05/2025
Parasites need mitochondrial respiration to infect and spread. Effective anti-malaria and ani-toxoplasmosis drugs target respiratory complexes (e.g. atovaquone)! But how do the parasite complexes work and how do drugs inhibit them? Read Andrew Maclean and Alex Mühleip phenomenal work on this! 👇
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knuepferlab.bsky.social @knuepferlab.bsky.social · 06/05/2025
The KnuepferLab is hiring! Our team is looking for a highly motivated, experienced molecular parasitologist to expand our group as a postdoctoral researcher at the RVC. Follow either link below for more information on the project and the job offer: lnkd.in/eprgmaE9 www.jobs.ac.uk/job/DMY962/p...
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Michael Delves @mjdelves.bsky.social · 09/04/2025
Looking forward to joining @lshtm-malaria.bsky.social’s #WorldMalariaDay event to reflect on what’s next for malaria research and how we can continue to drive change. Details here www.lshtm.ac.uk/newsevents/e... | LSHTM #Malaria #GlobalHealth #WorldMalariaDay
Invitiation to attend "Prioritising in a crisis: What next for malaria research?" Friday 25th April 12.30 BST
https://www.lshtm.ac.uk/newsevents/events/prioritising-crisis-what-next-malaria-research
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Sebastian Baumgarten @sebbaumgarten.bsky.social · 04/04/2025
Ready for the most beautifully sophisticated m6A modification program out there? It’s sex-specific, controls a developmental transition and is temperature-sensitive. Dream team led by Selina, with @ameyasinha.bsky.social @jessmbryant.bsky.social @tizvignolini.bsky.social @ju-couble.bsky.social
doi.org
N6-methyladenosine primes the malaria parasite for transmission
Sudden environmental changes are a recurring challenge for unicellular organisms, but a necessity for many to progress through their lifecycle. To transmit from its human host to mosquito vector, mala...
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Sebastian Baumgarten @sebbaumgarten.bsky.social · 02/04/2025
The first joint labretreat with @anarbgomes.bsky.social, @jessmbryant.bsky.social and @amtalman.bsky.social is in the books. Thank you so much for hosting us, great science and fun. @ecoliswatchingu.cpesr.fr @tizvignolini.bsky.social @pasteur.fr @ird-fr.bsky.social @umontpellier.bsky.social
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ParasitesRule @parasitesrule.org · 30/03/2025
From Data to Insight – A Practical Introduction to Interpreting Malaria Genetics for Surveillance, a free, self-paced online course offered by the PlasmoGenEpi network and developed with funding from the Gates Foundation. 🔗plasmogenepi.org/OnlineCourse
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Sebastian Baumgarten @sebbaumgarten.bsky.social · 26/03/2025
Malaria parasites are an extreme example of ribosome heterogeneity. But how do they control which ribosomal RNA to express when? Check out this mountain of work led by @ju-couble.bsky.social with @tizvignolini.bsky.social @jessmbryant.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
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veupathdb.org @veupathdb.org · 04/03/2025
The VEuPathDB survey asked users to estimate the impact on their lab's productivity (from 0-100) if VEuPathDB resources were to disappear altogether. We also asked them to describe the impact. ✏️The infographic lists a few key themes that emerged from nearly 1500 comments!
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LabEx ParaFrap @parafrap.bsky.social · 25/02/2025
📅 Save the Date! The EMBO Workshop "Host-Parasite Relationship: From Mechanisms to Control Strategies" organized by @ParaFrap will take place on October 5-8, 2025, at Les Embiez Island. Stay updated on registration opening —enter your email here: coming-soon.embo.org/w25-83 #Science #Parasite
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Meissner Lab @meissnerlab.bsky.social · 19/02/2025
Happy to share this with you! Together with the Längst lab (Uni Regensburg) we characterized PfSnf2L as essential regulator for „just in time“ transcription. A big thanks to our collaboration partners (Marti lab) and Llinas lab (@llinaslab.bsky.social). www.nature.com/articles/s41...
nature.com
Plasmodium blood stage development requires the chromatin remodeller Snf2L - Nature
Plasmodium falciparum Snf2L is an ISWI-related ATPase that actively repositions P. falciparum nucleosomes in vivo.
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EMBL @embl.org · 17/02/2025
EMBL, @pasteur.fr, MIMS, HZI, and the @sangerinstitute.bsky.social awarded Amplifying Funds grants to seven new projects. 🦠 👏 The collaborative projects will foster interdisciplinary research in infection biology across Europe. Discover more here: www.embl.org/about/info/i... 🧪 #AcademicSky
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EMBL @embl.org · 11/02/2025
📢 Calling all female African scientists. Applications open for the EMBL-UNESCO 3-month residencies in infection biology: 🪴 Grow your network 🧪Develop your skills 🧠Exchange knowledge with international colleagues Deadline: 31 March 2025 www.embl.org/about/info/s... #WomenInSTEM #WomenInScience
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ParasitesRule @parasitesrule.org · 21/01/2025
The MPM XXXVI page is now live. Sept 14th to Sept 18th. More updates will be coming soon. Check it out on the parasitesrule.com website. Organized this year by Richarch McCulloch @rmc9z.bsky.social, Photini Sinnis, Marc-Jan Gubbels, Deepali Ravel & Omar Harb @omarharb.bsky.social
parasitesrule.com
Molecular Parasitology Community
The MPM XXXVI website is now online
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Institut Pasteur | 130 years of biomedical research @pasteur.fr · 14/01/2025
Welcome to the official Bluesky page of the Institut Pasteur! 🔬 Explore with us the frontiers of biomedical research 🧪 Follow us to uncover groundbreaking discoveries 💡 Share knowledge for global health 🌍 Join a community passionate about progress and open science.
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Women in Malaria @womeninmalaria.bsky.social · 08/01/2025
📢Reminder that the early bird registration for the 2nd Women in Malaria Online conference is closing Feb 14, 2025 (50 USD)! Fee waiver applications are available for LMICs & you can also buy fee waivers for others. Register/apply here: womeninmalaria.es/wim-conferen... Please re-share 💛
Conference registration flyer for the 2nd Women in Malaria Online Conference. Early bird registration 50 USD (closes Feb 14, 2025) and late registration 60 USD (closes March 7, 2025). Fee waivers applications available for LMICs and you can also buy fee waivers for others. Conference partners: The University of Edinburgh and Arizona State University. Conference Sponsors: Open Philanthropy, New England Biolabs, eLIFE and Nature Springer.
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