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Leon Walther

@trypsleon.bsky.social
462 followers 1.2K following 17 posts

PhD student @ Faria Lab at University of York. Structural Parasitology | Neglected Tropical Diseases | Trypanosomes | Antigenic Variation | CryoEM | RNA | Trained at @Uni Konstanz, CSSB & EMBL. Passionate backpacker and vulcano hiker. Views are my own.

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Reposted by Leon Walther
British Society for Parasitology @bspparasitology.bsky.social · 10/07/2026
TrypsClub is back! Join us for the next journal club! Date: 16th July 2026 Time: 3:00pm BST Register here: lnkd.in/eh9nSkGA Link to the paper: lnkd.in/e_qhSi5F
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Reposted by Leon Walther
bugbittentweets.bsky.social @bugbittentweets.bsky.social · 19/06/2026
Its all a game of Hide and Seek for African trypanosomes says BugBitten's new blogger Leon Walther -In the evolutionary arms race between humans and pathogens, our immune system has evolved a clever solution to fight with an unlimited diversity of pathogens go.nature.com/4eeZpHa
go.nature.com
The molecular foundation of the sophisticated hide & seek game of African trypanosomes
In the evolutionary arms race between humans and pathogens, our immune system has evolved a clever solution to fight with an unlimited diversity of pathogens
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Reposted by Leon Walther
British Society for Parasitology @bspparasitology.bsky.social · 21/05/2026
An exciting online journal club hosted by the SPPIRIT Network @sppirit-network.bsky.social !
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Leon Walther @trypsleon.bsky.social · 12/05/2026
Join us for our next TrypsClub event! Everyone is welcome!
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Reposted by Leon Walther
British Society for Parasitology @bspparasitology.bsky.social · 12/04/2026
As part of our BSP miniseries showcasing the work and journeys of our members, Christina Naula @christina-naula.bsky.social interviews @glasgow.ac.uk -based PhD student Shannara Eilean Smith @shannaraeilean.bsky.social about her idea and inspiration for the this year's BSP Spring Meeting logo.
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Reposted by Leon Walther
Dr Joanne Power @hanniepower.bsky.social · 11/04/2026
Thank you to Prof Mike Barrett & @christina-naula.bsky.social & anyone else involved in organising our post-#BSP2026 field trip to see William Leishman's former home in Blairmore! We learned so much & got lucky again with the sunshine! www.blairmorehall.com <- Village Hall link to support them!
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Leon Walther @trypsleon.bsky.social · 12/04/2026
Deeply disappointing to see the UK reducing help of millions of people in need of basic essential health care. Years of bad policy making running the country against a wall while scapegoating foreigners for their own misfortune is resulting again in innocent people suffering around the globe.
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Reposted by Leon Walther
British Society for Parasitology @bspparasitology.bsky.social · 09/04/2026
As part of our "Supporting equity and diversity in Parasitology" Workshop, Dr Rafael Henry-Venson from @glasgow.ac.uk is showcasing the concept of Rainbow Office Hours - dedicated office hours hosted by LGBTQ+ staff to support LGBTQ+ students. 🏳️‍🌈
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Leon Walther @trypsleon.bsky.social · 09/04/2026
Join us for the next TrypsClub Career Talk!😊
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Reposted by Leon Walther
British Society for Parasitology @bspparasitology.bsky.social · 08/04/2026
The BSP spring meeting is not just offering great talks - we also have an exciting breakout program! @christina-naula.bsky.social from @glasgow.ac.uk and co-host of @microbetv.bsky.social This Week in Parasitism is interviewing Prof Poppy @lamberton-lab.bsky.social about her scientific career.
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Reposted by Leon Walther
Faria Tryps Lab @fariatrypslab.bsky.social · 30/03/2026
(1/7) How does T. brucei achieve a 140-fold stoichiometric excess of VSG mRNA over upstream ESAGs from a single polycistronic unit? Our latest research in @natmicrobiol.nature.com reveals a mechanism of spatially regulated RNA decay to fine-tune expression of virulence genes
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Reposted by Leon Walther
British Society for Parasitology @bspparasitology.bsky.social · 18/02/2026
The BSP TrypsClub is back from its winter break! Join us for a discussion about #NTDs with Dr. Sabine Specht, Global Clinical Program Excellence Lead at Bayer AG, Switzerland. Sign up here: forms.gle/tXK62GWeqqfr...
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Leon Walther @trypsleon.bsky.social · 10/10/2025
Registration is open for our next TrypsClub Journal Club! 😊 If you fancy some cool Trypanosome science and a friendly supportive environment to discuss science then join us!
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Reposted by Leon Walther
Dr Joanne Power @hanniepower.bsky.social · 11/09/2025
Save the dates!! @bspparasitology.bsky.social Spring Meeting 2026 will be in Bonnie Glasgow! 7-9 April 2026, with a drinks reception in Glasgow City Chambers on the 6th of April 2026! Keep an eye on the BSP website for registration and abstract submission! Logo by @shannaraeilean.bsky.social! 🦟
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Reposted by Leon Walther
Centre for Structural Systems Biology CSSB @cssbhamburg.bsky.social · 04/09/2025
Researchers from CSSB & @mpi-nat.bsky.social have generated a highly potent nanobody that neutralizes a protein essential for the herpes virus infection. Published in @nature.com, the findings promise new therapies to treat & prevent infections @leibnizliv.bsky.social @uni-hamburg.de t1p.de/cxt7a
3D-Animation of the nanobody (light yellow/semi-transparent) inhibiting HSV-2 glycoprotein B. The different domains of gB are color-coded. Three domains are held together by the footprint of the nanobody. IMAGE: Benjamin Vollmer / Centre for Structural Systems Biology
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Leon Walther @trypsleon.bsky.social · 04/09/2025
Join us for the first Career Talk of the 2025–2026 Tryps Club season! Prof. Paul M. Selzer will give us an insight into anti-parasitic drug development in industry. 📅 Date: 24.09.2025 🕒 Time: 12:00 pm BST 📍 Location: Zoom Register following link or the QR code on the poster lnkd.in/eA7b9QRx
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Leon Walther @trypsleon.bsky.social · 04/09/2025
The British Society for Parasitology (BSP) Tryps Club is pleased to share our upcoming series of events. These sessions will bring together leading experts and the wider community to exchange knowledge, highlight research, and foster collaboration in parasitology. (1/5)
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Richard McCulloch @rmc9z.bsky.social · 15/08/2025
We’re pleased to share our new study, led by @jezieldamasceno.bsky.social, that used long-read, single molecule sequencing to reveal the full (?) picture of Leishmania DNA replication. Thanks, Mike Boemo and helpful reviewers @uofgsii.bsky.social www.sciencedirect.com/science/arti...
sciencedirect.com
Leishmania major chromosomes are replicated from a single high-efficiency locus supplemented by thousands of lower efficiency initiation events
DNA replication initiates at genome sites termed origins. Previous origin mapping approaches in the populations of the protozoan parasite Leishmania m…
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Reposted by Leon Walther
Trends in Parasitology @cp-trendsparasitol.bsky.social · 14/08/2025
Drs @singh-parul.bsky.social @trypsleon.bsky.social‬ Maureen Cabahug @fariatrypslab.bsky.social & @jessmbryant.bsky.social review #Plasmodium & #Trypanosoma #genome organization. #Trypanosome #Transcription #Chromatin #Epigenetics #Nuclear #Compartment www.cell.com/trends/paras...
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Faria Tryps Lab @fariatrypslab.bsky.social · 11/08/2025
How do parasites strategically organise their genomes to influence gene expression? If you’re curious, check our latest review in @cp-trendsparasitol.bsky.social ! @biologyatyork.bsky.social @ybri-uoy.bsky.social @pasteur.fr www.sciencedirect.com/science/arti...
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Leon Walther @trypsleon.bsky.social · 10/08/2025
What a great first experience to take part in a review with such awesome fellow scientists!
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Reposted by Leon Walther
Chris H. Hill @chillzaa.bsky.social · 19/07/2025
New preprint alert! 🚨👇 I'm delighted to share the latest research from @jemmabetts.bsky.social in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨ www.biorxiv.org/content/10.1...
biorxiv.org
A new protein-dependent riboswitch activates ribosomal frameshifting
Programmed -1 ribosomal frameshifting (PRF) is a ubiquitous translational control mechanism in RNA viruses, allowing them to change the relative abundance of proteins encoded in different reading fram...
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Reposted by Leon Walther
Eva Kowalinski @kowaeva.bsky.social · 17/07/2025
Postdoc positions in structural biology of RNA processing complexes. An ERC-funded position will dissect pre-mRNA processing pathways in the infective organism Trypanosoma brucei. An ANR-funded position will characterise large complexes in RNA modification. Details: tinyurl.com/postdoc-RNA-...
tinyurl.com
Postdoc in Structural Biology of RNA processing complexes
Postdoctoral positions in structural biology of macromolecular complexes are available in the laboratory of Dr. Eva Kowalinski at the EMBL Grenoble, France. We are looking for highly motivated and amb...
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Leon Walther @trypsleon.bsky.social · 20/06/2025
🧬 Join us for the 3rd Journal Club hosted by the BSP TrypsClub! 🧬 Everyone is welcome — whether you're deep into Trypanosomatid research or just curious to explore fascinating biology, this is a great space to connect, learn, and discuss exciting new science!
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Reposted by Leon Walther
Faria Tryps Lab @fariatrypslab.bsky.social · 27/05/2025
So happy to share the first preprint from our lab on post-transcriptional regulation at the VSG expression-site body in trypanosomes. @ybri-uoy.bsky.social @york.ac.uk
biorxiv.org
Specialised RNA decay fine-tunes monogenic antigen expression in African trypanosomes
Antigenic variation is a sophisticated immune evasion strategy employed by many pathogens. Trypanosoma brucei expresses a single Variant-Surface-Glycoprotein (VSG) from a large genetic repertoire, whi...
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Leon Walther @trypsleon.bsky.social · 08/05/2025
Join us in our first TrypsClub Career Talk featuring Julius Lukeš! Everyone interested in Trypanosomes is welcome (except PI's - sorry)!
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Reposted by Leon Walther
Drugs for Neglected Diseases initiative (DNDi) @dndi.org · 14/04/2025
🎬 This #WorldChagasDay, we're excited to announce our next short film, 'The Children of the Sierra,' about working with Indigenous Wiwa communities in #Colombia to test and treat people affected by #ChagasDisease. 📽️ Moronga Films
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Reposted by Leon Walther
WHO @who.int · 14/04/2025
#ChagasDisease has the most severe impact among Latin America's impoverished communities but it is increasingly detected in other parts of the world. 100M people are at risk of infection. bit.ly/3vFipLv
WHAT IS
CHAGAS DISEASE?
A potentially life-threatening illness, transmitted through contact with the faeces or urine of a triatomine bug (kissing bug) found mainly in
Latin America.
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Abhinay Ramaprasad @abhinay.bsky.social · 10/04/2025
A GRIP-ing and Tryp-ing seminar tomorrow - Joana Faria from the University of York! 2 pm (GMT) | 3 pm (CET) | 9 am (EDT) Link - uofglasgow.zoom.us/j/8897218018... Passcode: 987702
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Leon Walther @trypsleon.bsky.social · 25/03/2025
Join us for our next TrypsClub Journal Club!
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Reposted by Leon Walther
Faria Tryps Lab @fariatrypslab.bsky.social · 24/03/2025
Delighted to have been part of this great work driven by @marketanovotna.bsky.social in the Horn lab, showing the power of precision editing to study the direct role of histone modifications on gene expression regulation! Check it out! www.biorxiv.org/content/10.1...
biorxiv.org
Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes
Transcription of protein coding genes in trypanosomatids is atypical and almost exclusively polycistronic. In Trypanosoma brucei, approximately 150 polycistrons, and 8000 genes, are constitutively tra...
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Reposted by Leon Walther
Chris H. Hill @chillzaa.bsky.social · 21/03/2025
New cryo-EM/ET story - a brilliant collaboration with Sergey Melnikov's lab in Newcastle @sergeymelnikov.bsky.social and Stefan Pfeffer's lab in Heidelberg @pfeffercryolab.bsky.social. Great work in particular by Karla Helena-Bueno and @sophiekopetschke.bsky.social www.nature.com/articles/s41...
nature.com
Structurally heterogeneous ribosomes cooperate in protein synthesis in bacterial cells - Nature Communications
Cells can simultaneously produce structurally dissimilar ribosomes, suggesting functional specialization of distinct ribosome populations. Here, the authors show that distinct ribosomes cooperate rath...
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Emma Marie Briggs @emmamariebriggs.bsky.social · 17/03/2025
Funded PhD project with myself, Prof. Paul Denny at Durham University and Dr Kalesh Karunakaran at Teeside University now open for applications! www.findaphd.com/phds/project...
findaphd.com
Uncovering the adaptation mechanism that generate dormant forms of Leishmania microbes with omics approaches at Newcastle University on FindAPhD.com
PhD Project - Uncovering the adaptation mechanism that generate dormant forms of Leishmania microbes with omics approaches at Newcastle University, listed on FindAPhD.com
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Wojtek Galej @wojtekgalej.bsky.social · 12/02/2025
Happy to share this highlight of our latest work on the minor spliceosome structure
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Leon Walther @trypsleon.bsky.social · 12/02/2025
Attention fellow Trypanosomatid researchers! Join the first Journal Club hosted by the newly founded TrypsClub. It's a fantastic opportunity to connect with fellow Tryps researchers, discuss exciting science, and network with peers from around the world!
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Reposted by Leon Walther
Stephen Curry @scurry.bsky.social · 12/02/2025
Now almost 450 signatories to my open letter calling on the @royalsociety.org to stand up for its values & deal with the widespread concerns raised by Elon Musk's Fellowship. Please consider signing & sharing: forms.gle/miDciq35oxyw... List of signatories here: occamstypewriter.org/scurry/2025/...
forms.gle
Open letter to the President of the Royal Society – time to stand up for your values
If you wish to show your support for the letter below regarding apparent inaction by the Royal Society in the face of breaches of its code of conduct by Elon Musk FRS, please sign below. I invite anyo...
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Faria Tryps Lab @fariatrypslab.bsky.social · 16/01/2025
Are you interested in #trypanosomes #biomolecularcondensates and/or #geneexpression? We are looking for a highly motivated postdoc to work with with us in the beautiful city of York! Please share! jobs.york.ac.uk/vacancy/post...
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Andreia Wendt @albuquerqueafrr.bsky.social · 03/01/2025
rdcu.be/d5o3U it's out!!
rdcu.be
TransLeish: Identification of membrane transporters essential for survival of intracellular Leishmania parasites in a systematic gene deletion screen
Nature Communications - A systematic gene deletion screen targeting all predicted transmembrane transporters of the protozoan parasite Leishmania identified forty mutants that had a significant...
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Madhu Pai, MD, PhD @madhupai.bsky.social · 31/12/2024
Africans are least represented in global health organizations, boards, conferences, and publications Read this importance piece to know how visa inequities play a role www.nature.com/articles/d44...
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Faria Tryps Lab @fariatrypslab.bsky.social · 10/12/2024
Are you interested in genome maintenance, organisation and replication? What about all that in the context of immune evasion? We have a BBSRC funded PhD position to use multi ‘omics’ approaches to tackle this problem! @rmc9z.bsky.social @uofglasgow.bsky.social @york.ac.uk
findaphd.com
Making sense of antigenic variation in trypanosomes: a nuclear factory with a switching problem… at University of York on FindAPhD.com
PhD Project - Making sense of antigenic variation in trypanosomes: a nuclear factory with a switching problem&#8230; at University of York, listed on FindAPhD.com
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Leon Walther @trypsleon.bsky.social · 04/12/2024
For everyone interested in Kinetoplastid research :) Doesnt work perfectly but is very helpful! bsky.app/profile/kine...
bsky.app
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Leon Walther @trypsleon.bsky.social · 03/12/2024
Just another prime example of the detrimental consequences of UK educational policies. www.bbc.co.uk/news/article...
bbc.co.uk
Universities enrolling foreign students with poor English, BBC finds
Institutions may be overlooking inadequate language skills to receive high fees from overseas students.
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Keith Matthews @keithrmatthews.bsky.social · 02/12/2024
What good way to start with Bluesky! Delighted to share our paper on how non-tsetse transmitted trypanosomes lose the ability to make stumpy forms (and adapt to the monomorphic life style) and so can spread outside Africa. A great reward after years of hard work from Guy Oldrieve ! rdcu.be/d13YK
rdcu.be
Mechanisms of life cycle simplification in African trypanosomes
Nature Communications - African trypanosomes can reduce their requirement for tsetse fly transmission, allowing an expanded geographical range. Here, molecular analyses of field and laboratory...
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Latin American Review of Books @latamrob.bsky.social · 28/11/2024
A sickness within a sickness. Read our latest review: Maraña: War and Disease in the Jungles of Colombia, Lina Pinto-García @linapintogarcia @ConnectedMinds3 @YorkUniversity @UChicagoPress #LatinAmerica #Colombia #publichealth #imperialism latamrob.substack.com/p/the-imperi...
latamrob.substack.com
The imperial infection
Neocolonial conflict shapes the pathology of leishmaniasis. Review: Maraña: War and Disease in the Jungles of Colombia, Lina Pinto-García, by Gavin O'Toole
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