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Schuller Jan

@schullerjm.bsky.social
277 followers 158 following 56 posts
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Schuller Jan @schullerjm.bsky.social · 05/09/2026
Congratulations! And a huge bonus for the cool name! Respect!
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Rhys Grinter @rhyswg.bsky.social · 18/08/2026
Out now in @natmicrobiol.nature.com: Bacillus subtilis builds protein filaments that act as a pseudomembrane, pulling quinone out of the bilayer and carrying it into the cytosol for reduction by NADH dehydrogenase, well away from the membrane itself. doi.org/10.1038/s415... 1/5
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Francis O'Reilly @fjoreilly.bsky.social · 14/08/2026
PhIX-MS is out in Molecular Cell! Rapid in situ photo-crosslinking traps transient proteasome interactions before purification; crosslinking MS, cryo-EM and AlphaFold tell us where they bind. Paper: doi.org/10.1016/j.mo... Preview: doi.org/10.1016/j.mo...
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Florent Waltz @florentwaltz.bsky.social · 07/08/2026
We've been seeing a lot of "in situ" lately in titles from fancy journals (not pointing any fingers 👀). I’ve delayed posting this, but as more and more come out, I'm afraid "in situ" is becoming an empty buzzword, much like "near-atomic" was for SPA 🔬 1/n #cryo-ET #cryo-EM #cryoET #cryoEM 🧪
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Schuller Jan @schullerjm.bsky.social · 21/07/2026
In this project you will also work very closely with us and try to localise important anaerobe super-assemblies in the cells. This is a perfect project, method development and state of the art application.
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Schuller Jan @schullerjm.bsky.social · 21/07/2026
We currently have an opening for a PhD position in the lab. If you are interested in pursuing some serious structural biology of photosynthetic and chloroplast processes please apply. Prerequisite is previous experience in cryoEM and/or phototrophs. stellenangebote.uni-marburg.de/jobposting/2...
stellenangebote.uni-marburg.de
Doctoral and Postdoctoral Researcher Positions in the Cluster of Excellence ‘Microbes for Climate’
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Laborjournal @laborjournal.bsky.social · 20/07/2026
Das größte bekannte #Enzym? Ein Team um @sophia-pa.bsky.social und @schullerjm.bsky.social vom @synmikro.bsky.social hat einen überzeugenden Kandidaten: einen katalytisch aktiven 8 MDa-Superkomplex aus einem Methan-produzierenden Archaeon … Mehr dazu: 👉https://www.laborjournal.de/editorials/3533.php
3D-Modell des Heterodisulfid-Reduktase-Superkomplexes aus dem Archaeon Methanococcus maripaludis sowie Porträts von Studienleiter Jan Schuller und Erstautorin Sophia Paul. (Fotos: Uni Marburg, Sandra Schuller)
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Gregor Weiss @weiss-lab.bsky.social · 10/07/2026
Some bacteria do not live as individuals. They build multicellular filaments and connect neighboring cells through tiny cell-cell junctions. Cyanobacteria are among the most beautiful examples 😍 In our new paper, we reveal first molecuar insights on the cyanobacterial septal junction architecture 🧵
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Roland Hatzenpichler @environmicrobio.bsky.social · 09/07/2026
Awesome work to determine the structure of a freakin 8MDa enzyme complex with over 600 FeS clusters! Sophia won the poster prize at the recent GRC C1 👏 www.nature.com/articles/s41...
nature.com
Architecture of the 8 MDa Hdr–Vhu–Fwd super-assembly in class I methanogens - Nature
The structure of the Hdr–Vhu–Fwd super-assembly reveals a lineage-specific and modular 8 MDa complex with the ability to adapt to diverse anaerobic niches.
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ProLOEWE @proloewe.bsky.social · 09/07/2026
Huge discovery from Marburg: Prof. Schuller (@synmikro.bsky.social),doctoral stud. @sophia-pa.bsky.social+colleagues have resolved1️⃣of the🧬🔬largest enzymes. Published in Nature, the study shows how methanogenic archaea generate energy under extreme conditions, offering🆕insights into the🌎carbon cycle.
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Sophia Paul @sophia-pa.bsky.social · 08/07/2026
Excited to share my paper! 🥳 Today in #Nature we reveal an 8 MDa Hdr electron bifurcating super-assembly in class I methanogens that couples the first and last steps of hydrogenotrophic methanogenesis. A lineage-specific adaptation to anaerobic niches. www.nature.com/articles/s41...
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Schuller Jan @schullerjm.bsky.social · 08/07/2026
New preprint No7 - molecular architecture of the carbonyl branch enzyme in methanogens. Basically all enzymes of the pathway linked in a super assembly (2 MDa). One would expect a cryoEM study, but we miserably failed, so we used true integrative structural biology. www.biorxiv.org/cgi/content/...
biorxiv.org
Interface swapping orchestrates carbon transfer in the archaeal acetyl-CoA decarbonylase/synthase
The Wood-Ljungdahl pathway is one of biology's most ancient routes for carbon fixation and energy metabolism, used by organisms such as methanogenic archaea. One of its central metabolic complexes is ...
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Schuller Jan @schullerjm.bsky.social · 07/07/2026
I like the anaeronauts - Thanks for the credit and praise. That paper is published but not much more - so here is a latest summary of our journey - in preprints. Without preprints I find it hard to get results out lately. So we do this to an extreme level now. bsky.app/profile/schu...
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Schuller Jan @schullerjm.bsky.social · 07/07/2026
With support by the @dfg.de and the Heisenberg program. www.uni-marburg.de/de/aktuelles...
uni-marburg.de
Heisenberg-Professur für Marburger Biochemiker Jan Schuller
DFG-Förderung für Spitzenwissenschaftler hilft bei Erforschung des Klimawandels
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Schuller Jan @schullerjm.bsky.social · 07/07/2026
And on other news - I have been promoted to full professor at the Phillips University Marburg in the Department of Chemistry. @synmikro.bsky.social
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Schuller Jan @schullerjm.bsky.social · 07/07/2026
Here, I repost my old thread. bsky.app/profile/schu...
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Schuller Jan @schullerjm.bsky.social · 07/07/2026
No 6 - processed in Relion 2.3 - that tells something. We are still arguing with a referee about minor and unimportant processing details. Hopefully, an entire reprocessing and essentially redoing of the paper with modern software might do the trick... www.biorxiv.org/content/10.1...
biorxiv.org
Structural insights into late-stage photosystem II assembly by Psb32
Photosystem II (PSII) assembly is a stepwise process in which intermediate complexes with auxiliary proteins are transiently formed to allow efficient de novo biogenesis or repair of damaged PSII. In ...
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Schuller Jan @schullerjm.bsky.social · 07/07/2026
No 5 - here we had a small part in the resurrection of an entire molecular machine - the eukaryotic RNA exosome. It's an complex story full of wonderful biochemistry and structures. www.biorxiv.org/content/10.6...
biorxiv.org
Coordination of sequential RNase activities in an ancient molecular machine
The evolutionary mechanisms by which molecular machines incorporate catalytic subunits and coordinate their functions are still poorly understood. Here, we study the molecular evolution of the RNA exo...
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Schuller Jan @schullerjm.bsky.social · 07/07/2026
Check the thread by our amazing Postdoc Tomas. bsky.app/profile/toma...
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Schuller Jan @schullerjm.bsky.social · 07/07/2026
No 4 - the craziest machine in anaerobic metabolism - coupling electron confurcation with bifurcation in a unique case of molecular Lego. Anaerobic modularity at its very best. www.biorxiv.org/content/10.6...
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Schuller Jan @schullerjm.bsky.social · 07/07/2026
Follow this amazing thread by Silvia, our amazing cooperation partner. bsky.app/profile/sram...
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Schuller Jan @schullerjm.bsky.social · 07/07/2026
No 3 - we could show that the chloroplast polymerase from green algae forms a 2 MDa assembly - a text book example for entrenchment. www.biorxiv.org/content/10.6...
biorxiv.org
The structure of a 2-MDa chloroplast RNA polymerase reveals unexpected evolutionary complexity
Transcription in chloroplasts depends on the Plastid-Encoded RNA polymerase (PEP), a bacterial-derived enzyme whose catalytic core remains encoded by the highly reduced genome inherited from the cyano...
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Schuller Jan @schullerjm.bsky.social · 07/07/2026
Have a look at the post of the master of everything photosynthetic Gyana. bsky.app/profile/gyan...
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Schuller Jan @schullerjm.bsky.social · 07/07/2026
No 2 - the structure of the cyanobacterial bifunctional Hydrogenase Hoy. It pays of to treat photosynthetic proteins as an anaerobic sample. www.biorxiv.org/content/10.6...
biorxiv.org
Electron confurcation drives photosynthetic H2 production in cyanobacteria
Cyanobacteria are major contributors to global photosynthesis and are intensively studied for sustainable green H2 production. Central to this process is the bidirectional [NiFe]-hydrogenase HoxEFUYH,...
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Schuller Jan @schullerjm.bsky.social · 07/07/2026
Check out this amazing summary by Tristan bsky.app/profile/tris...
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Schuller Jan @schullerjm.bsky.social · 07/07/2026
No1 - The amazing anaerobic MTR complex. We found now an L cluster in all methanogensis specific proteins. This adds a new functional dimension to redox cluster biology and replaces the biggest mystery of anaerobic metabolism with an even bigger one. www.biorxiv.org/content/10.6...
biorxiv.org
The anaerobic cryo-EM structure of the methanogenic Mtr complex reveals a nitrogenase-like [Fe₈S₉C] cluster bound to its active site
Methanogenic archaea conserve energy by coupling methyl-group transfer to the generation of a chemiosmotic sodium-ion (Na+) gradient. This central energy-conserving step is catalyzed by the membrane-b...
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Schuller Jan @schullerjm.bsky.social · 07/07/2026
Okay the lab is now really living preprints to accelerate Science. It takes so long to publish a story in journals. So the only option to talk openly about our work are preprints. We currently have 6 preprints - check them out! More coming, one currently uploading and another one ready soon.
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Sven T. Stripp @stripplab.bsky.social · 06/07/2026
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trisre.bsky.social @trisre.bsky.social · 06/07/2026
1/ Happy to share our preprint! The Mtr complex catalyses the second-to-last step of the methanogenesis and is an essential bioenergetic machine in most methanogenic archaea. Anaerobic cryo-EM of Mtr reveals a nitrogenase-like metallocluster bound at its active site! www.biorxiv.org/content/10.6...
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Ben Engel @cellarchlab.com · 03/07/2026
Super excited to launch this search for a new endowed professor at the @biozentrum.unibas.ch! Join us to build a research cluster in Climate Biophysics! 🌍🌊🌾🔬🧪 This is a unique opportunity to create a community in Basel🇨🇭working together on this timely topic! ⏳🌡️ Questions? Please reach out! 👩‍🔬👨‍🔬
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Ricardo D. Righetto @lifeonthewedge.bsky.social · 15/04/2026
Crazy biochemistry is the norm for @schullerjm.bsky.social, but here I wanna say I have witnessed up close the amazing effort from @tomaspascoa.bsky.social and @tamb-o.bsky.social to chase the BCRII complex in situ 🤩 Big congrats to Lena Appel and @rnfr2d2.bsky.social for the cryoEM structure too 👏🏽
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Ben Engel @cellarchlab.com · 14/04/2026
Across scales from cells🦠 to atoms⚛️ – We reveal how anaerobic #bacteria break down very stable aromatic compounds found e.g. in oil spills 🛢️ #Bioremediation #TeamTomo 🧪 🧶🧬 🔬 Awesome collab with Lena, Matthias, @schullerjm.bsky.social @rnfr2d2.bsky.social @tomaspascoa.bsky.social @tamb-o.bsky.social
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Ben Engel @cellarchlab.com · 14/04/2026
Thanks for the fun collaboration into this fascinating “oil eating” biomachine. I learned a lot! 🧪 #TeamTomo
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James Lingford @jameslingford.bsky.social · 15/04/2026
Amazing paper. A megadalton enzyme complex that: - combines both electron bifurcation AND confurcation steps - has a new type of iron-sulfur cluster - a new kind of weird electron transfer path - super charges electrons to reduce aromatic rings - also powers respiration 😳
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Schuller Jan @schullerjm.bsky.social · 14/04/2026
Yes that is nature's Lego in extreme. When you think you have seen it all... Go to anaerobes. ;)
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Anuj @rnfr2d2.bsky.social · 14/04/2026
How do “LEGO-like” electron-bifurcating modules combine to drive degradation in BTEX-contaminated ecosystems? Check out our latest preprint, where we use cryo-EM and cryo-ET to reveal how the 1 MDa BCRII complex powers extremely endergonic aromatic ring reduction. www.biorxiv.org/content/10.6...
biorxiv.org
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Schuller Jan @schullerjm.bsky.social · 14/04/2026
Happy to present our latest story: the BCRII complex with the Boll and @cellarchlab.com . Months of processing by @rnfr2d2.bsky.social. Also @tomaspascoa.bsky.social and @tamb-o.bsky.social managed an in-situ tour de force. And Lena Appel did amazing biochemistry. This story has it all. Enjoy it.
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Tomas Pascoa @tomaspascoa.bsky.social · 14/04/2026
1/ Excited to share our preprint! 🥳 Degradation of aromatic compounds, including BTEX pollutants, requires highly endergonic aromatic ring reduction. Using #cryoEM and in situ #cryoET, we show how BCRII couples electron bifurcation modules in one giant redox machine www.biorxiv.org/content/10.6...
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georghochberg.bsky.social @georghochberg.bsky.social · 04/04/2026
I will probably be hiring either a PhD or a Postdoc in the near future. If you are interested in deep biochemical history or molecular mechanisms of evolution please get in touch.
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Schuller Jan @schullerjm.bsky.social · 28/03/2026
Congratulations 🎉 Anuj. This is well earned and I am a proud supervisor. There is much more coming. @rnfr2d2.bsky.social will present a paradigm shifting story this year at the GRC C1 and EBEC.
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Sven T. Stripp @stripplab.bsky.social · 24/03/2026
Carbonic anhydrase catalyses the interconversion of CO2 and HCO3- and helps increasing the net-CO2 concentration inside cells. Why? CO2-reducing enzymes like RuBisCO are notoriously slow and ineffective. However, import of HCO3- is typically coupled to ATP consumption...
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Duncan Kountz @dkountz.bsky.social · 15/01/2026
Thrilled to be able to finally post my first adventure into secondary metabolism!: Flavoaffinins, Elusive Cellulose-Binding Natural Products from an Anaerobic Bacterium pubs.acs.org/doi/full/10.... Co-authors: Ruocheng Yu, f. undergrad Jessie Lee, @katherinem.bsky.social , and Emily Balskus!
pubs.acs.org
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Fidel Ramírez-Amador @fidelormz.bsky.social · 08/12/2025
Last Friday was the defense of my PhD thesis entitled "Structural basis of anaerobic enzymes mediated by noncanonical metalloclusters" after 4 yrs at the @synmikro.bsky.social 🎓🎓 Big thanks to my supervisor @schullerjm.bsky.social and the whole Schuller lab for their continuous and massive support!
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Schuller Jan @schullerjm.bsky.social · 25/11/2025
The largest challenge of the day. Try to assemble 5 structural biology papers (each more than 100 pages incl. Supplements) in a single pdf with less than 15MB to upload as a document for a prize nomination for a student. Not sure compression algorithms are that good...
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Martin Thanbichler @thanbichlerlab.bsky.social · 02/11/2025
📢 Postdoc position: Cell Biology of Cyanobacteria in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany. More information at shorturl.at/wNnDT (see Project 2) 🔗Apply at shorturl.at/VsEDl 📅Deadline: Nov 16, 2025 Please repost. #Postdoc
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Schuller Jan @schullerjm.bsky.social · 23/10/2025
Congratulations Johannes. A milestone work! Thanks for including us in this exciting project. We are always happy to assist! What a beautiful structure and amazing evolutionary implications.
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Schuller Jan @schullerjm.bsky.social · 28/09/2025
Really looking forward to it. It's a great opportunity to meet friends and make new ones. We are also excited to present our latest structural work on the methyl branch of methanogens. Unpublished and highly exciting!
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Schuller Jan @schullerjm.bsky.social · 25/09/2025
www.nature.com/articles/s41... By any chance??? It is a cyanobacteria right?
nature.com
Emergence of fractal geometries in the evolution of a metabolic enzyme - Nature
Citrate synthase from the cyanobacterium Synechococcus elongatus is shown to self-assemble into Sierpiński triangles, a finding that opens up the possibility that other naturally occurring molecular-scale fractals exist.
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georghochberg.bsky.social @georghochberg.bsky.social · 24/09/2025
A new preprint from the lab. I won't do a tweetorial until this is peer reviewed, but I think it's a banger, led by @JedNzy. It's about Rubisco and what chaperones are really for. He's on the market, get him while you can. www.biorxiv.org/content/10.1...
biorxiv.org
Origin of chaperone dependence and assembly complexity in Rubisco biogenesis
Molecular chaperones assist with the folding and assembly of protein clients. Consequently, they are essential to diverse cellular functions. In most aerobic photosynthetic organisms such as B-cyanoba...
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Schuller Jan @schullerjm.bsky.social · 23/09/2025
Oh wow, let's hope with our new discoveries we don't outdate it too fast ;)
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