This study leverages cell type-specific optogenetics in the monkey cerebral cortex to elucidate the unique functional contributions of excitatory and inhibitory neurons in visual form processing. The ...

Dendritic computation contributes to information processing in cortical circuits. Hippocampal CA3 plays a central role in navigation, but how the dendrites of CA3 pyramidal neurons process information...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Bissen et al. show that prey capture learning profoundly reshapes visual cortical circuitry and function during developmental critical periods, but not in adulthood. These learning-induced structural ...

Stable and flexible neural representations of space in the hippocampus are crucial for navigating complex environments, yet how they emerge from the u…

The hippocampus exhibits a CA3-to-CA1 coding transformation that combines fast learning with an efficient, compressed neural code.

YouTube video by Andrew Pruszynski

Flexible learning relies on integrating sensory and contextual information to adjust behavioral output in different environments. The anterolateral motor cortex (ALM) is a frontal area critical for ac...

Associative memory models such as the Hopfield network and its dense generalizations with higher-order interactions exhibit a ``blackout catastrophe''---a discontinuous transition where stable memory ...

Combining intracellular and extracellular recordings, calcium imaging, and holographic circuit mapping, Hendricks et al. identify a feature-specific pyramidal cell-to-somatostatin interneuron microcir...

Nature Human Behaviour - Biba et al. show that episodic memory encoding fluctuates at a theta rhythm of 3–10 Hz.

Dendritic arbors provide just the right scale to study how individual neurons reciprocally interact with their broader circuitry—and are our best bet to bridge cellular and systems neuroscience.

Nature - Parsimonious deep neural network models can be used for prediction of visual neuron responses.

Topography is a well-described and well-known concept for cortical organization in primary sensory and motor cortices of mammalian brains. Similar ...

Topography is a well-described and well-known concept for cortical organization in primary sensory and motor cortices of mammalian brains. Similar ...

Tangtartharakul and Storrs use standardized neuropsychological tests to compare human visual abilities with those of visual language models (VLMs). They report that while VLMs excel in high-level obje...

Even when neocortical neurons form in abnormal locations, they retain their identity and function, revealing that brain circuit formation can be guided by intrinsic developmental programs rather than ...

Auxiliary proteins aren’t just molecular bystanders and supporters, they’re computationally active and play an integral role in intracellular communication.