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Frédérique Le Roux

@fredoleroux.bsky.social
505 followers 360 following 53 posts

Professeure/chaire d'excellence du Canada Université de Montréal Département de microbiologie, infectiologie et immunologie What do I like? Wild things 😜 yet phages are my favorite!

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Frédérique Le Roux @fredoleroux.bsky.social · 15/08/2026
Cette semaine au Café chez Ernest a Montreal, mercredi, 18H, Cecile fait le show!
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Frédérique Le Roux @fredoleroux.bsky.social · 09/08/2026
This week, let's talk about the vagina microbiota, with Karine Dufresne, Café Chez Ernest, mercredi 18H, au plaisir de vous y voir!
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Frédérique Le Roux @fredoleroux.bsky.social · 01/08/2026
Mercredi 5 aout, c'est au tour de Marie de nous raconter guerre et paix chez les bactéries: Café Chez Ernest, 18H
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Frédérique Le Roux @fredoleroux.bsky.social · 26/07/2026
Mercredi prochain, 18h, cafe chez Ernest, l'estivale du Cinq a Science continue
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Frédérique Le Roux @fredoleroux.bsky.social · 26/06/2026
Après la Coupe du monde de foot, place à la tournée du @cinqascience.bsky.social au café Chez Ernest ! Les conférences reprendront tous les mercredis à partir de 18 h (22 juillet-26 aout) : 🍻 30 minutes de présentation 💬 30 minutes de discussion autour d’un verre
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Mark Mandel @markjmandel.bsky.social · 14/05/2026
event.fourwaves.com/vibrio2026/p...
event.fourwaves.com
Vibrio2026: The International Meeting on the Biology of Vibrios
Join Vibrio2026: The International Meeting on the Biology of Vibrios, September 13-16, 2026. Learn more on Fourwaves.
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Frédérique Le Roux @fredoleroux.bsky.social · 10/05/2026
Yes we still love seafood!
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Frédérique Le Roux @fredoleroux.bsky.social · 08/05/2026
So happy to host my old friend Delphine Destoumieux-Garzón for our One Health & Climate Change workshop at the Faculty of Medicine, Université de Montréal. Very inspiring work carried out by her and her colleagues! #Udem #OneHealth #climatechange
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Asher Leeks @asherleeks.bsky.social · 02/05/2026
Want to join us for Social Viruses in Vancouver this summer? One week to go until we start looking at applications (May 7th). To apply: socialviruses.zoology.ubc.ca #socialviruses #evosky #lovevirology #virosky
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Frédérique Le Roux @fredoleroux.bsky.social · 01/05/2026
Cinq à Science goes summer mode ☀️ Join us at Chez Ernest (Saint-Hubert Street) every Wednesday from July 22 to August 26. 🕕 Talks at 6 PM — a friendly space to promote microbiology, make science accessible, and spark discussions over a drink!
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Frédérique Le Roux @fredoleroux.bsky.social · 01/05/2026
Le Cinq à Science passe en mode estival ☀️ Rendez-vous au Chez Ernest (rue Saint-Hubert) tous les mercredis du 22 juillet au 26 août. 🕕 Conférences à 18h — une occasion conviviale de promouvoir la science en microbiologie, la rendre accessible et en discuter autour d’un verre !
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Asher Leeks @asherleeks.bsky.social · 14/04/2026
The Social Lives of Viruses is coming to Vancouver, Canada, from 4th-8th August 2026! This is a free meeting dedicated to all aspects of virus-virus interactions & evolution. To apply: socialviruses.zoology.ubc.ca @sociovirology.bsky.social #socialviruses #evosky #lovevirology #virosky
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Melanie Blokesch @mblokesch.bsky.social · 10/04/2026
Excited to share our new paper out today in @science.org 🎉 We show that HGT via natural competence drives diversification of chromosomal integrons in V. cholerae 🤩 Below a 🧵 on key findings incl. background on natural competence in V. cholerae 1/ #microsky #phagesky www.science.org/doi/10.1126/...
science.org
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Frédérique Le Roux @fredoleroux.bsky.social · 11/04/2026
>1000 lytic vibriophages sequenced. 4 years later… still there. Same genomes. Same vibes. Different story. When nothing changes—but everything does. Congrats to Jeff & Karine et al. and @epcrocha.bsky.social for the intellectual turbulence ;-) www.nature.com/articles/s41...
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Eduardo Rocha @epcrocha.bsky.social · 08/04/2026
Finally, oysters serve as hotspots of horizontal gene transfer betw bacteria, mediated by mobile genetic elements. Which, considering the high density of bacteria in marine animals (rel. environment), could be quite general. Great work led by Jeff Liang, Karine Cahier. With @fredoleroux.bsky.social
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Eduardo Rocha @epcrocha.bsky.social · 08/04/2026
Our ms on re-sampling 4 years apart vibrio phage in natural environments is now out with some improvements. First, clearer evidence of cryptic population dynamics between phage and vibrio, presumably because of genetic diversity. www.nature.com/articles/s41...
nature.com
Complex temporal dynamics of phage-bacteria populations in an animal-associated marine system - Nature Communications
It remains unclear how viral genomes remain relatively stable over time, given the rapid co-evolution seen within hosts. Here, authors explore complex marine phage-bacteria dynamics using over 1000 ph...
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José R Penadés @jrpenades.bsky.social · 05/04/2026
Latest from the lab! Between clinical S. aureus, most gene transfer mechanisms are blocked, yet lateral transduction remains highly efficient. Restriction modification-defective strains act as gateways for horizontal gene transfer, enabling DNA flow across populations. rdcu.be/fbNQK
rdcu.be
Immune-deficient bacteria serve as gateways to genetic exchange and microbial evolution
Nature Communications - The efficiency of horizontal gene transfer between different bacterial lineages is often unclear. Here, Figueroa et al. show that lateral transduction is the primary driver...
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Frédérique Le Roux @fredoleroux.bsky.social · 20/02/2026
Lundi 9 mars, 12H, évènement CERC Le Roux/decanat UdeM, journée internationale de la femme. Projection documentaire et débat "sur la libération de la parole et de l'écoute de personnes ayant vécu de l’oppression basée sur le genre." Pavillon Jean-Brillant – Salle B-0245 . Inscription avant 2 mars.
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Frédérique Le Roux @fredoleroux.bsky.social · 20/02/2026
www.facebook.com/medecine.umo...
facebook.com
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Frédérique Le Roux @fredoleroux.bsky.social · 07/01/2026
Seeking expressions of interest from researchers abroad for a Canada Impact+ Research Chair ($1M/year × 8 + up to $6M CFI) in AI-enabled antibiotic discovery and/or AMR, phage & phage-based derivatives. Email me a short vision, CV, and 3–5 key papers. Deadline: March 10, 2026 (Intake 2: June 15).
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Zeynep Baharoglu @zeynepbaharoglu.bsky.social · 31/10/2025
🦠💊 L’Institut @pasteur.fr vient de publier un communiqué de presse sur nos récents travaux, qui décrivent une nouvelle piste pour augmenter l’efficacité des antibiotiques. #Pasteurdon #Recherche #Science #AMR Merci à toutes celles et ceux qui ont contribué. 📘 English version coming soon!
pasteur.fr
Une piste prometteuse pour augmenter l’efficacité des antibiotiques
Les aminosides sont des antibiotiques efficaces contre de très nombreuses bactéries telles que Escherichia coli, Pseudomonas aeruginosa ou Staphylococcus aureus. Mais jusqu’à présent, personne ne sava...
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Eduardo Rocha @epcrocha.bsky.social · 14/10/2025
Many thanks to all those involved, including Jeffrey Liang, who stayed in our lab for several months, our own Charles Bernard and, of course, @fredoleroux.bsky.social and the usual suspects @agencerecherche.bsky.social @erc.europa.eu @cnrsbiologie.bsky.social @pasteur.fr @umontreal.ca etc
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Eduardo Rocha @epcrocha.bsky.social · 14/10/2025
Two intensive sampling periods of oyster-associated vibrio and their phage, 4 years apart, and many surprises. Despite being washed by the Atlantic, wide tides, and vibrio (almost?) disappearing most of the year, we can find the exact same virulent phages 4 years later (down to 0 SNP)! preprint👇
Lytic phages form modular isolation networks and exhibit long-term genetic stability
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Frédérique Le Roux @fredoleroux.bsky.social · 12/10/2025
Phages evolve fast, or do they? In oysters, some stay identical for years. With >1,200 phages & 600 Vibrio genomes, we reveal long-term stability and new mobile elements. Proud of this collaborative work across our teams (Roscoff-UdeM and @epcrocha.bsky.social www.biorxiv.org/cgi/content/...
biorxiv.org
Ecological constraints foster both extreme viral-host lineage stability and mobile element diversity in a marine community
Phages are typically viewed as very rapidly evolving biological entities. Little is known, however, about whether and how phages can establish long-term genetic stability. We addressed this eco-evolut...
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José R Penadés @jrpenades.bsky.social · 09/09/2025
Thrilled to share our two latest papers with the @tcostalab.bsky.social lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species. @imperialcollegeldn.bsky.social www.cell.com/cell/fulltex...
cell.com
Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization
Capsid-forming PICIs (cf-PICIs) produce their own capsids and exploit phage tails from unrelated species to transfer their DNA across bacterial hosts. This tail piracy enables broad dissemination and ...
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Kranzusch Lab @kranzuschlab.bsky.social · 09/09/2025
Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization: Cell www.cell.com/cell/fulltex...
cell.com
Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization
Capsid-forming PICIs (cf-PICIs) produce their own capsids and exploit phage tails from unrelated species to transfer their DNA across bacterial hosts. This tail piracy enables broad dissemination and ...
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Ákos T Kovács @evolvedbiofilm.bsky.social · 05/09/2025
The ecology and evolution of microbial immune systems: a look on the wild vibrio side Phil. Trans. R. Soc. B by @fredoleroux.bsky.social royalsocietypublishing.org/doi/10.1098/...
royalsocietypublishing.org
The ecology and evolution of microbial immune systems: a look on the wild vibrio side | Philosophical Transactions of the Royal Society B: Biological Sciences
Natural populations of vibrio beyond the well-studied pandemic strains of Vibrio cholerae, provide a powerful model for investigating the eco-evolutionary dynamics of microbial immune systems. Their genetic diversity, ecological versatility, ease of ...
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Frédérique Le Roux @fredoleroux.bsky.social · 09/06/2025
👉 Next stop: Montréal! 🇨🇦 Thrilled to join the Canada Society of Microbiology (CSM) conference, June 17-20. Science, community, and reconnecting with old friends — can’t wait!
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Université de Montréal - News @umontreal-en.bsky.social · 09/06/2025
The study involves our‪ microbiologist @fredoleroux.bsky.social, whom we profiled in late 2023 as a new hire and Canada Excellence in Research Chair: nouvelles.umontreal.ca/en/article/2...
nouvelles.umontreal.ca
How do we minimize the use of antibiotics?
New to UdeM and flush with an $8M, federally funded research chair, microbiologist Frédérique Le Roux looks to solve the problem of infectious diseases of bacterial origin in farmed marine species.
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Frédérique Le Roux @fredoleroux.bsky.social · 29/05/2025
Allo Montreal, 11 juin –18H au café La brassée: "Des sphères aux spirales, des extrémophiles aux probiotiques: plongez dans l’univers fascinant des bactéries ! " Appéro- Science, qui dit mieux? #cinqascience #5ascience
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ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 01/06/2025
commemorating pride from the clinical microbiology lab
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Jesse Shapiro @bjesseshapiro.bsky.social · 29/05/2025
And I've written a few reviews on the subject over the years, but this one is pretty short, so why not start there ;) www.sciencedirect.com/science/arti...
sciencedirect.com
How clonal are bacteria over time?
Bacteria and archaea reproduce clonally (vertical descent), but exchange genes by recombination (horizontal transfer). Recombination allows adaptive m…
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Frédérique Le Roux @fredoleroux.bsky.social · 29/05/2025
Allo Montreal, 11 juin –18H au café La brassée: "Des sphères aux spirales, des extrémophiles aux probiotiques: plongez dans l’univers fascinant des bactéries ! " Appéro- Science, qui dit mieux? #cinqascience #5ascience
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Institut Pasteur | 130 years of biomedical research @pasteur.fr · 22/05/2025
🧬 Bacteria fight both antibiotics and viruses with the same genetic tool: integrons! New study (Institut Pasteur, CNRS, Université Paris Cité & Montréal): ~10% of gene cassettes may defend against phages. 🛠️ One step closer to smarter therapies. 🔗 www.pasteur.fr/en/research-...
Bacteriophages infecting an Escherichia coli bacterium.
Credit: Institut Pasteur/Chantal Le Bouguénec (Pathogenic Gram-Positive Bacteria Biology Unit) and Laurent Debarbieux (Molecular Biology of the Gene in Extremophiles Unit). Imaging by Perrine Bomme, Ultrastructural Microscopy Platform. Colorization by Jean-Marc Panaud.
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Melanie Blokesch @mblokesch.bsky.social · 22/05/2025
Exciting news!! Our latest paper is out in Nat. Microbiol. @natmicrobiol.nature.com We show that a sub-lineage of 7th pandemic V. cholerae has acquired mobile genetic elements packed with phage defense systems—rendering it multi-phage resistant 😳 ..... 1/3 www.nature.com/articles/s41...
nature.com
West African–South American pandemic Vibrio cholerae encodes multiple distinct phage defence systems - Nature Microbiology
The West African–South American lineage of Vibrio cholerae contains multiple distinct anti-phage defence systems that provide resistance to various phage families, including vibriophage ICP1, a key pr...
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Frédérique Le Roux @fredoleroux.bsky.social · 13/05/2025
Allo Montréal, prochain Cinq à Science, 14 mai, le microbiote intestinal par Corinne Maurice, mc Gills 🙂
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Baptiste Darracq @baptistedarracq.bsky.social · 09/05/2025
Have also a look at our back-to-back study for mobile integrons by Nicolas Kieffer from @jaescudero.bsky.social group ! www.science.org/doi/10.1126/... + a similar story in V. parahaemolyticus by @landongetz.bsky.social from @themaxwelllab.bsky.social www.nature.com/articles/s41...
science.org
Mobile integrons encode phage defense systems
Integrons are bacterial genetic elements that capture, stockpile, and modulate the expression of genes encoded in integron cassettes. Mobile integrons (MIs) are borne on plasmids, acting as a vehicle ...
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Baptiste Darracq @baptistedarracq.bsky.social · 09/05/2025
An enormous thanks for the great co-first author @eloilittner.bsky.social and for our supervisors @celineloot.bsky.social @epcrocha.bsky.social @amazeld.bsky.social @fredoleroux.bsky.social. Many thanks to all co-authors !!
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Baptiste Darracq @baptistedarracq.bsky.social · 09/05/2025
On the bioinformatic side, eloilittner.bsky.social found a diverse arsenal of anti-phage defenses in SCIs. Strikingly, systems in integrons are always compact (< 3 genes), and smaller than their homologs outside integrons (likely due to cassette size constraints)
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Baptiste Darracq @baptistedarracq.bsky.social · 09/05/2025
The integron of our favorite model Vibrio cholerae was mostly “dark matter” as most cassettes had no known role. We found this intriguing and cloned 88 cassettes, testing them for phage resistance. We found 16 defensive cassettes and named the systems after gallic mythology
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Baptiste Darracq @baptistedarracq.bsky.social · 09/05/2025
White smoke, we have a new pope and also 16 new anti-phages systems in sedentary integrons (SCIs) ! In collaboration with the Rocha lab, we show in our new paper that cassettes of these large platforms encode many known anti-phage defenses, and uncovered 16 new ones. www.science.org/doi/10.1126/...
science.org
Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems
Integrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes, t...
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Eloi Littner @eloilittner.bsky.social · 09/05/2025
Habemus paper! Our story on integron-encoded anti-phage defenses is now out in @science.org! 16 new systems, small versions of known ones, and a lot more in this highly-collaborative study. Many thanks to everyone involved, especially my supervisor @epcrocha.bsky.social bsky.app/profile/bapt...
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Frédérique Le Roux @fredoleroux.bsky.social · 03/05/2025
Allo Montréal! Prochain Cinq à Science, le 14 mai, 6pm, Corinne Maurice, Mc Gill, Microbiote intestinal. #cinqascience
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Frédérique Le Roux @fredoleroux.bsky.social · 29/04/2025
Pas de recul. / No retreat. Pas de silence. / No silence. Pas de haine chez nous. / No hate here. 🇨🇦 Liberté, justice, solidarité. / 🇨🇦 Freedom, justice, solidarity. Résistons ensemble! ✊ / Let’s resist together! ✊ #CanadaLibre #DefendDemocracy #LoveWins
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Frédérique Le Roux @fredoleroux.bsky.social · 24/04/2025
🚨 Postdoc Alert! Join my lab @ Montréal’s Faculty of Medicine via the 2025 CIB Fellowship Competition 🧬 Project: “The Paradox of Parasitism” – bioinformatics + marine parasite evolution 💸 $63,819/yr + full benefits (2 yrs) Apply 👉 cibmontreal.ca/en/news/laun...
cibmontreal.ca
Launch of the 2025 postdoctoral fellowship competition
The BIC is proud to launch its first Postdoctoral Fellowship competition. Applications are open from now until May 27, 2025.
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Eduardo Rocha @epcrocha.bsky.social · 16/04/2025
New postdoc position in our lab (2 y+): evolutionary genomics of integrons and MGEs with focus on vibrio-phage interactions. Great environment @pasteur.fr for science, career building. Super collaborators @celineloot.bsky.social @amazeld.bsky.social @fredoleroux.bsky.social 3 weeks to apply!
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Frédérique Le Roux @fredoleroux.bsky.social · 15/04/2025
Allo Montréal, demain, venez écouter Karine Dufresne sur le monde mystérieux du microbiote vaginal! #cinqascience #5ascience
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Eduardo Rocha @epcrocha.bsky.social · 14/04/2025
Great collaboration with @fredoleroux.bsky.social . Kudos for everyone, esp. Charles Bernard & Yannick Labreuche. Thanks to the funders and @pasteur.fr @cnrsbiologie.bsky.social @umontreal.ca @sbroscoff.bsky.social Here's the paper in OA: doi.org/10.1093/isme...
doi.org
Adaptive genomic plasticity in large-genome, broad-host-range vibrio phages
Abstract. The host range of a bacteriophage—the diversity of hosts it can infect—is central to understanding phage ecology and applications. Whereas most w
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EMBL Events @events.embl.org · 18/12/2024
🌏🌿🦈 Mark your calendars and join #EESWildModels! Learn how exploring the wild frontiers of model systems is increasing our understanding of the biology, ecology, and evolution of organisms, ranging from microbes to plants and animals. Submit abstract by 14 Jan 👉🏻 s.embl.org/ees25-02
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Frédérique Le Roux @fredoleroux.bsky.social · 30/03/2025
Allo Montréal, prochain Cinq à Science, venez découvrit le monde mystérieux du microbiote vaginal! #cinqascience #5ascience
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