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Addiction Neuroscience | The Role of Transcriptomics in Addiction | ScienceDirect.com by Elsevier
The generation of RNA transcripts in a cell is one of the first opportunities for interaction between DNA sequence and the environment (both at the organism and cellular level). Although many RNA transcripts get translated into proteins that are active in the cell, many other types of transcripts play critical roles in both the transcription and translation processes and ultimately, in how our bodies respond to our environment. Brain transcriptomics has the potential to mediate our acute responses to drugs of abuse and to reflect the changing cellular environment across the addiction cycle. Furthermore, RNA-based therapeutics are emerging as a significant treatment resource for many diseases. However, our knowledge about non-coding RNA transcripts, differences in transcript processing, and the interdependence among networks of transcripts is far from complete. This Special Issue features novel research into the role of transcriptomics and epigenetics in the neuroscience of addiction including predisposing factors and changing molecular phenotypes across the addiction cycle with the ultimate goal of identifying novel treatment and prevention approaches.
