Reposted by Will Giardino
The function is not in the neurotransmiter but in the circuit it's acting. This is why full agonist and antagonist are tricky as a medication, because you might solve the problem on one side of the brain and make it worse on the other side.... doi.org/10.1038/s41...
nature.com
Nociceptin orphanin F/Q Pathways are dysregulated by stress and modulate reward responsiveness and motivated behavior across species
Molecular Psychiatry - Nociceptin orphanin F/Q Pathways are dysregulated by stress and modulate reward responsiveness and motivated behavior across species