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Patrick Mulholland (He/Him)

@mulhollandlab.bsky.social
1.8K followers 2.1K following 25 posts

Alcohol Addiction Neuroscientist at a Medical University in Charleston SC; part time taxi driver for three active kids

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Patrick Mulholland (He/Him) @mulhollandlab.bsky.social · 22/06/2026
Hey #RSA2026, we have open #postdoc slots on our #NIAAA T32 training grant - apply now!!! medicine.musc.edu/departments/...
medicine.musc.edu
NIAAA T32 Training Grant
Trainees are provided with mentorship and direct training, as well as didactic lessons that stress both clinical and basic science aspects of alcohol abuse.
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Charleston ARC @charlestonarc.bsky.social · 16/04/2026
16) Congener Chaos: Darker liquors (bourbon, red wine) contain more congener (byproducts of fermentation) than clear spirits 🍷. These extra chemicals usually lead to significantly more intense hangovers. #alcoholawarenessmonth
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Charleston ARC @charlestonarc.bsky.social · 18/04/2026
17) Chronic Alcohol use slows down neurogenesis (the birth of new neurons, specifically in the hippocampus). 🧠Taking a break from alcohol allows the brain to begin repairing these vital circuits #alcoholawarenessmonth #brainrepair #alcoholresearch
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Charleston ARC @charlestonarc.bsky.social · 18/04/2026
18) Science shows alcohol can actually change how your gene are expressed! 🧬 it adds methyl groups to your DNA, which can turn off tumor-suppressor genes , increasing cancer risk over time #epigenetics #alcoholawarenessmonth #alcoholresearch
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Charleston ARC @charlestonarc.bsky.social · 23/04/2026
19) The Gastritis Gala: Alcohol is an irritant to the stomach lining. If your coffee is hitting a little too hard lately, your gut might just need a vacation from the booze. ☕️🧊 #alcoholawarenessmonth #GIresearch #alcoholresearch
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Charleston ARC @charlestonarc.bsky.social · 23/04/2026
20) Bone Deep: Long-term heavy drinking can actually interfere with calcium balance and bone density. Stay sturdy out there! 🦴💪 #alcoholawarenessmonth #boneresearch #alcoholresearch
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Charleston ARC @charlestonarc.bsky.social · 23/04/2026
21) Cancer Awareness: Many people don't realize alcohol is classified as a Group 1 carcinogen. Reducing intake is one of the most proactive things you can do for long-term health. 🎗️ #alcoholawarenessmonth #alcoholresearch #cancerresearch
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Charleston ARC @charlestonarc.bsky.social · 23/04/2026
22) The "Flash" Reaction: About 8% of the global population has a genetic variant (ALDH2) that makes their body physically unable to fully break down acetaldehyde. For them, one drink isn't a "buzz"—it’s an immediate toxic buildup causing facial flushing and a racing heart. 🧬🚨 #AlcoholAwarenessMonth
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Charleston ARC @charlestonarc.bsky.social · 14/04/2026
12) The “Liver First” Rule: did you know your liver treats alcohol like a VIP guest? 🥂 it stops metabolizing fats and sugars to focus 100% on clearing ethanol. This metabolic “pause” is why chronic drinking leads to fatty liver disease #alcoholawarenessmonth #liverdisease #recovery
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Charleston ARC @charlestonarc.bsky.social · 14/04/2026
13) alcohol slows down the communication between your eyes and your brain 👀. This impairs peripheral vision and contrast sensitivity, making it harder to distinguish between objects and their backgrounds. #alcoholawarenessmonth #visionscience
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Charleston ARC @charlestonarc.bsky.social · 14/04/2026
14) The Proof is in the Gunpowder: the term “100 proof” comes from the 16th century 📚 Sailors would douse gunpowder in rum ; if it’s still ignited, the alcohol content was “proved” (that’s about 57% ABV!) #alcoholawarenessmonth #historyfacts
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Charleston ARC @charlestonarc.bsky.social · 14/04/2026
Age was also a factor. Older participants tended to see more consistent results 🧠. Why does this matter? By identifying these predictors, researchers can better design trials to reach the right people, reducing placebo response and helping with better medications for recovery #alcoholawarenessmonth
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Charleston ARC @charlestonarc.bsky.social · 14/04/2026
Here’s the paper if you want to read more! onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Participant Demographic and Baseline Drinking Factors Can Predict Alcohol Use Disorder Pharmacotherapy Clinical Trial Completion and Drinking Outcomes
Five multisite AUD pharmacotherapy trial data were merged to explore participant prestudy characteristics as outcome predictors. Pre-randomization “days since last drink” significantly predicted thre...
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Charleston ARC @charlestonarc.bsky.social · 14/04/2026
New research alert 🚨 How can we make clinical trials for Alcohol Use Disorder (AUD) more effective? A study just out in Alcohol,Clinical, and experimental research by Hoffman et al. (2026) analyzed data from 5 major trials to find what predicts better outcomes 🧵👇
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Charleston ARC @charlestonarc.bsky.social · 08/04/2026
7) Alcohol can weaken your immune system. Even moderate drinking can make it harder for your body to fight off illness by reducing your body’s ability to produce infection-fighting cells. This can leave you more vulnerable to illness. Stay strong—inside and out. 💪 #AlcoholAwarenessMonth #Wellness
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Charleston ARC @charlestonarc.bsky.social · 10/04/2026
8)Alcohol can impact your weight. Many drinks are high in calories with little nutritional value—and those calories add up. Alcohol can also slow your metabolism and increase appetite, making it easier to overeat. This can make it harder to maintain a healthy weight. #AlcoholAwarenessMonth
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Charleston ARC @charlestonarc.bsky.social · 10/04/2026
9)Alcohol affects hydration. It acts as a diuretic, causing your body to lose more fluids than it takes in. This can lead to dehydration, headaches, dry skin, and fatigue. Dehydration can also impact focus, energy levels, and overall physical performance. #AlcoholAwarenessMonth #stayHydrated
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Charleston ARC @charlestonarc.bsky.social · 12/04/2026
10) ever wonder why a “liquid diet” can lead to a beer belly?🍺 it’s not just calories- it’s the metabolic hijacking. when you drink, your liver stops burning fat to focus on clearing the alcohol. Basically your fat engine pulls over to let the alcohol pass #alcoholawarenessmonth #metabolism
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Charleston ARC @charlestonarc.bsky.social · 12/04/2026
11) alcohol doesn’t just dehydrate your brain; it’s a thief for your skins glow ✨By triggering inflammation and depleting Vitamin A, it accelerates the breakdown of collagen. Give your skin a break. Your reflection will thank you 😆 #alcoholawarenessmonth #skincarescience
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Charleston ARC @charlestonarc.bsky.social · 06/04/2026
6)Adolescent health isn’t just about the present it’s about the future The Amico-Andrologo survey found that over 10,000 young men shows that heavy alcohol use during adolescence is significantly associated with lower testicular volume #Alcoholawarenessmonth onlinelibrary.wiley.com/doi/pdf/10.1...
onlinelibrary.wiley.com
Risk behaviours and alcohol in adolescence are negatively associated with testicular volume: results from the Amico‐Andrologo survey
Background Risk factors established during adolescence affect health outcomes in adulthood, although little is known about how adolescent health risk behaviours (HRBs) affect testicular development ...
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Charleston ARC @charlestonarc.bsky.social · 02/04/2026
April is #AlcoholAwarenessMonth. We will be posting a fact each day this month to spread the word about alcohol harm and awareness 1) Did you know alcohol drinking is a leading cause of preventable death in the US and it’s harmful effects contribute to 200+ health conditions #recovery #research
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Charleston ARC @charlestonarc.bsky.social · 03/04/2026
2) How much is too much to drink? Heaving drinking is 4+ for women and 5+ for men in one day #AlcoholAwarenessMonth #recovery #soberlife #alcoholresearch
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Charleston ARC @charlestonarc.bsky.social · 03/04/2026
3) Excessive alcohol use isn’t just a health issue—it’s an economic one. 💰 Costs the U.S. ~$249 BILLION annually 📉 72% from lost productivity 🏥 Healthcare, crashes, crime drive the rest That’s ~$807 per person—and rising. We all pay the price. #PublicHealth #AlcoholAwarenessmonth #healthadvocacy
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Charleston ARC @charlestonarc.bsky.social · 06/04/2026
4) Alcohol doesn’t just affect your body, impacts your sleep quality too😴Even small amounts can disrupt REM sleep, leaving you feeling less rested the next day. Over time, poor sleep can affect mood, memory, and overall health.🧠 #AlcoholAwarenessMonth #SleepHealth
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Charleston ARC @charlestonarc.bsky.social · 06/04/2026
5) Alcohol can impact mental health more than many people realize. While it may feel like it helps you relax in the moment, it can actually increase feelings of anxiety and depression over time. #AlcoholAwarenessMonth #MentalHealthMatters
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Charleston ARC @charlestonarc.bsky.social · 30/03/2026
Big changes coming to the NIH landscape!🧬 NIH is streamlining its grant process. By reducing the number of highly specialized announcements, NIH is shifting the focus back to broad, investigator-initiated science. This means more room for innovative ideas! grants.nih.gov/news-events/... #NIH
grants.nih.gov
NIH’s Path to a Simpler Funding Opportunity Landscape | Grants & Funding
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davidhaggerty.bsky.social @davidhaggerty.bsky.social · 27/01/2026
we built squeakpose studio. now there’s a preprint so i can stop explaining it in slides. modern computer vision. ultra-fast training and inference. model-assisted labeling. analysis out of the box. real-time edge deployment on whole frames at 120 fps (which felt reasonable at the time).
biorxiv.org
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Patrick Mulholland (He/Him) @mulhollandlab.bsky.social · 28/02/2026
Here are the Alcohol GRC awardees-Congrats!
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Patrick Mulholland (He/Him) @mulhollandlab.bsky.social · 24/02/2026
A little beach volleyball #AlcoholGRC2026
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Patrick Mulholland (He/Him) @mulhollandlab.bsky.social · 10/12/2025
Alcohol GRC attendees - please be careful, as there are spam emails requesting payment. Payment is only thru the GRC website! #alcoholGRC2026 #GRC
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Marie Doyle @mariedoyle.bsky.social · 29/08/2025
Follow these links to apply to present and join the alcohol neuroscience research community! GRS (Trainee pre-meeting, Feb 21-22, 2026): tinyurl.com/35zf3wte GRC (Main meeting immediately following, Feb 22-27, 2026): tinyurl.com/44z957ve
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Marie Doyle @mariedoyle.bsky.social · 29/08/2025
Apply now for the Alcohol & the Nervous System GRS, Feb 21-22, 2026! The GRS kicks off the GRC, giving early-career scientists the perfect platform to launch into a week of cutting-edge science. Submit your abstracts to both by Oct 10th for talk consideration! #alcoholGRC2026 #alcoholGRS2026
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Patrick Mulholland (He/Him) @mulhollandlab.bsky.social · 29/08/2025
We are looking forward to the 2026 #Alcohol GRC in Ventura, CA! The main meeting starts Feb 22, 2026 (GRS Feb 21-22). For both, we will be selecting additional invited talks from the submitted abstracts. For consideration, submit your abstract by Oct 10! #alcoholGRC2026 #alcoholGRS2026
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Alcohol Journal @alcoholjournal.bsky.social · 07/08/2025
Voluntary wheel-running reduces harmful drinking in a genetic risk model for drinking to intoxication #alcoholawareness #alcohol @angelaozburn.bsky.social sciencedirect.com/science/arti...
sciencedirect.com
Voluntary wheel-running reduces harmful drinking in a genetic risk model for drinking to intoxication
Physical activity (PA) may provide an effective and equitable treatment option for addressing the harm associated with Alcohol Use Disorders (AUDs). W…
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Alcohol Journal @alcoholjournal.bsky.social · 28/08/2025
NIAAA Director Dr. Koob's publication now online - A Conceptual Framework for the Intersection of Hyperalgesia and Hyperkatifeia in #Alcohol Addiction #alcoholawareness www.sciencedirect.com/science/arti...
sciencedirect.com
A Conceptual Framework for the Intersection of Hyperalgesia and Hyperkatifeia in Alcohol Addiction
Alcohol use disorder is a chronically relapsing disorder that is characterized by compulsive drug seeking and is hypothesized to result from multiple …
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Alcohol Journal @alcoholjournal.bsky.social · 28/08/2025
Alcohol, aging, and the gut microbiome: Intersections of immunity, barrier dysfunction, and disease @cristinallorente.bsky.social #alcoholawareness www.sciencedirect.com/science/arti...
sciencedirect.com
Alcohol, aging, and the gut microbiome: Intersections of immunity, barrier dysfunction, and disease
Alcohol consumption exerts complex, dose- and context-dependent effects on human health, particularly by influencing the gut microbiome, intestinal ba…
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Alcohol Journal @alcoholjournal.bsky.social · 28/08/2025
Persistent inflammation does not promote aversion-resistant binge-like #alcohol drinking in rats @jmoronconcepcion.bsky.social #alcoholawareness www.sciencedirect.com/science/arti...
sciencedirect.com
Persistent inflammation does not promote aversion-resistant binge-like alcohol drinking in rats
Chronic pain is a leading cause of disability, significantly decreases quality of life, and is highly co-morbid with substance use disorders, includin…
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Alcohol Journal @alcoholjournal.bsky.social · 28/08/2025
The Majchrowicz binge model of #alcohol dependence: A valid model for comparing male and female rats @nixonlab.bsky.social www.sciencedirect.com/science/arti...
sciencedirect.com
The Majchrowicz binge model of alcohol dependence: A valid model for comparing male and female rats
Alcohol use disorders (AUD) among women have steadily risen over the past decade. This increase is due in part to increased rates of drinking among so…
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Alcohol Journal @alcoholjournal.bsky.social · 14/07/2025
Just published: #Alcohol use disorder exacerbates clinical and vascular risks differentially in psychiatric disorders sciencedirect.com/science/arti...
sciencedirect.com
Alcohol use disorder exacerbates clinical and vascular risks differentially in psychiatric disorders
Alcohol Use Disorder (AUD) is a major public health concern with detrimental effects on cognitive and neurological function, yet its impact on psychia…
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Alcohol Journal @alcoholjournal.bsky.social · 14/07/2025
Just Published: Explaining increased efficacy of naltrexone in the treatment of #alcohol dependent patients with a family history of AUD: A systematic review on the role of reward sensitivity and sweet liking www.sciencedirect.com/science/arti...
sciencedirect.com
Explaining increased efficacy of naltrexone in the treatment of alcohol dependent patients with a family history of alcohol use disorder: A systematic review on the role of reward sensitivity and swee...
A positive family history of alcohol use disorder (FHA+) is one of the strongest risk factors for developing alcohol use disorder (AUD) compared. Impo…
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Alcohol Journal @alcoholjournal.bsky.social · 14/07/2025
Just Published: Effect of high mobility group box 1 pathway inhibition on gene expression in the prefrontal cortex of mice exposed to #alcohol www.sciencedirect.com/science/arti...
sciencedirect.com
Effect of high mobility group box 1 pathway inhibition on gene expression in the prefrontal cortex of mice exposed to alcohol
The high mobility group box 1 (HMGB1) pathway plays a pivotal role in the development of alcohol-induced brain injury. Glycyrrhizinic acid (GlyA) is w…
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Alcohol Journal @alcoholjournal.bsky.social · 14/07/2025
Just Published: Integrating TWAS and GWAS identifies gut microbiota–immune interactions to #alcohol dependence genetics in European sample www.sciencedirect.com/science/arti...
sciencedirect.com
Integrating TWAS and GWAS identifies gut microbiota–immune interactions to alcohol dependence genetics in European sample
Alcohol dependence (AD) is a global public health concern with strong genetic characteristics. The purpose of this study was to explore the underlying…
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Alcohol Journal @alcoholjournal.bsky.social · 14/07/2025
Just Published: #Alcohol consumption during early adulthood increases the vulnerability of locus coeruleus neurons and amyloid beta pathology in female APP/PS1 mice #AlcoholAwareness sciencedirect.com/science/arti...
sciencedirect.com
Alcohol consumption during early adulthood increases the vulnerability of locus coeruleus neurons and amyloid beta pathology in female APP/PS1 mice
Alcohol use disorder is the most common substance misuse disorder and Alzheimer's disease (AD) is the most common neurodegenerative disease. Evidence …
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Dr. Jen Rinker @drjrink.bsky.social · 26/06/2025
Absolutely crushing it, congrats Kathy!!!!
media.tenor.com
a man applauds with the words way to go super proud of you behind him
ALT: a man applauds with the words way to go super proud of you behind him
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Patrick Mulholland (He/Him) @mulhollandlab.bsky.social · 26/06/2025
First the #RSA 3-min thesis inaugural winner and now the Gordis Award for @kathylindquist.bsky.social #proud-mentor #rsa2025 #rsa_isbra2025 @drjrink.bsky.social
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Patrick Mulholland (He/Him) @mulhollandlab.bsky.social · 23/06/2025
Hey #alcohol researchers, what are non-NIH funding mechanisms to support alcohol research? Please share any information #rsa2025 #rsa_isbra2025
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Alcohol Journal @alcoholjournal.bsky.social · 20/06/2025
Alcohol research community: thank you for your submissions to #Alcohol - we are excited to share that our Impact Factor has climbed to 2.9, our highest IF to date #rsa2025 @dougmat-uwec.bsky.social
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Patrick Mulholland (He/Him) @mulhollandlab.bsky.social · 06/05/2025
Congrats to @kathylindquist.bsky.social for winning the 3MT competition for preclinical students - way to go, Kathy!!! @drjrink.bsky.social
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Tom Kash @superkash.bsky.social · 29/03/2025
oh hey, this paper is out now! Led by JR Haun, former Kash lab postdoc! pubmed.ncbi.nlm.nih.gov/40153436/
pubmed.ncbi.nlm.nih.gov
Septo-hypothalamic regulation of binge-like alcohol consumption by the nociceptin system - PubMed
High-intensity alcohol drinking during binge episodes contributes to the socioeconomic burden created by alcohol use disorders (AUDs), and nociceptin receptor (NOP) antagonists have emerged as a promi...
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Dr. Jen Rinker @drjrink.bsky.social · 20/03/2025
Defending soon? Come postdoc with us - MUSC is a great place to prepare you for your next career move, in or outside of academia!
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