Vocal communication is a conserved vertebrate social behavior that begins at birth with the cries of infants. These neonatal vocal signals vary across contexts to elicit parental care that matches inf...

CRISPR-Cas provides RNA-mediated adaptive immunity, but how its first RNA-guided effector arose is unclear. In this study, we report the discovery of Viral Interference Programmable Repeat (VIPR) syst...

Nature Methods - Getting over ANOVA: estimation graphics for multi-group comparisons

The intrinsic cardiac nervous system (ICNS) is a key node in heart-brain communication and an emerging target for cardiac therapy, yet its physiologic…

Tau pathology spreads cell to cell, but the mechanisms of intercellular tau transmission remain unclear. We find that the neuronal gene Arc is critica…

Why mammals cannot regenerate limbs like amphibians do presents a long-standing puzzle in biology. To uncover the underlying differences, we compared amputation responses of embryonic mouse (Mus musculus) and Xenopus laevis tadpole limbs. Lowering ...

Seahorses have a unique sex role reversal with male pregnancy involving the brood pouch, an evolutionarily novel organ. This study uses single-cell genomics and in vivo experiments to reveal the cellular basis and molecular mechanism of pouch development and diversity in seahorses.

Critical Thinking AI for constructive criticism and science evaluation

Neurophysiology of resting rodents could hold secrets to suspended animation

The biological phenomenon borders on sci-fi.

A state-dependent dopamine filter system in the male Drosophila brain balances threat perception against the drive to mate.

Ambroziak, Nencini, Pohle and colleagues identify a slowly emerging plasticity mechanism in a discrete set of hypothalamic preoptic neurons that is triggered by long-term heat exposure and that drives...

Water deprivation is a life-threatening condition that engages a protective physiological response to couple osmolyte retention with potentiation of thirst. This response, typical for most mammals, sa...